1. Myocardial Ischemia Induces SDF-1α Release in Cardiac Surgery Patients
- Author
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Andreas Goetzenich, Josefin Soppert, Lisa Schindler, Mareike Jarchow, Norbert Pallua, Christoph Emontzpohl, Denise Jacobs, Gernot Marx, David Simons, Sandra Kraemer, Bong Sung Kim, Christian Stoppe, Heinz Peter Schlemmer, Luisa Averdunk, and Jürgen Bernhagen
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Time Factors ,Heart Valve Diseases ,Ischemia ,Pharmaceutical Science ,Myocardial Reperfusion Injury ,Inflammation ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,law.invention ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,law ,Internal medicine ,Human Umbilical Vein Endothelial Cells ,Genetics ,Cardiopulmonary bypass ,Humans ,Medicine ,Coronary Artery Bypass ,Cells, Cultured ,Genetics (clinical) ,Aged ,Heart Valve Prosthesis Implantation ,Aspirin ,business.industry ,Organ dysfunction ,Perioperative ,Middle Aged ,medicine.disease ,Cell Hypoxia ,Chemokine CXCL12 ,Cardiac surgery ,Treatment Outcome ,030104 developmental biology ,Cardiology ,Molecular Medicine ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,medicine.drug - Abstract
In the present observational study, we measured serum levels of the chemokine stromal cell-derived factor-1α (SDF-1α) in 100 patients undergoing cardiac surgery with cardiopulmonary bypass at seven distinct time points including preoperative values, myocardial ischemia, reperfusion, and the postoperative course. Myocardial ischemia triggered a marked increase of SDF-1α serum levels whereas cardiac reperfusion had no significant influence. Perioperative SDF-1α serum levels were influenced by patients' characteristics (e.g., age, gender, aspirin intake). In an explorative analysis, we observed an inverse association between SDF-1α serum levels and the incidence of organ dysfunction. In conclusion, time of myocardial ischemia was identified as the key stimulus for a significant upregulation of SDF-1α, indicating its role as a marker of myocardial injury. The inverse association between SDF-1α levels and organ dysfunction association encourages further studies to evaluate its organoprotective properties in cardiac surgery patients.
- Published
- 2016
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