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To provide a basis for further optimization of the polio sequential immunization schedule, this study evaluated the effectiveness of booster immunization with one dose of bivalent oral poliovirus vaccine (bOPV) at 48 months of age after different primary polio immunization schedules. At 48 months of age, one dose of bOPV was administered, and their poliovirus types 1–3 (PV1, PV2, and PV3, respectively)-specific neutralizing antibody levels were determined. Participants found to be negative for any type of PV-specific neutralizing antibody at 24, 36, or 48 months of age were re-vaccinated with inactivated polio vaccine (IPV). The 439 subjects who received a bOPV booster immunization at the age of 48 months had lower PV2-specific antibody levels compared with those who received IPV. One dose of IPV during basic polio immunization induced the lowest PV2-specific antibody levels. On the basis of our findings, to ensure that no less than 70% of the vaccinated have protection efficiency, we recommend the following: if basic immunization was conducted with 1IPV + 2bOPV (especially Sabin strain-based IPV), a booster immunization with IPV is recommended at 36 months of age, whereas if basic immunization was conducted with 2IPV + 1bOPV, a booster immunization with IPV is recommended at 48 months of age. A sequential immunization schedule of 2IPV + 1bOPV + 1IPV can not only maintain high levels of antibody against PV1 and PV3 but also increases immunity to PV2 and induces early intestinal mucosal immunity, with relatively good safety. Thus, this may be the best sequential immunization schedule for polio in countries or regions at high risk for polio.

This study investigated the role of calpain in Eimeria tenella-induced host cell apoptosis. Chick embryo cecal epithelial cell culture technology, flow cytometry, enzyme-linked immunosorbent assays, and fluorescence quantitative PCR were used to detect the E. tenella host cell apoptotic rate, Bax and Bid expression levels, and calpain activity. The results demonstrated that Bax, Bid, and calpain levels were upregulated and apoptosis was increased following E. tenella infection at 24-120 h. Calpain levels were reduced by pharmacological inhibition of calpain using SJA6017 or by blocking Ca

BACKGROUND: Ferroptosis has attracted increasing interest in cancer therapy. Emerging evidences suggest that naturally occurring naphthoquinones exhibit potent anti-glioma effects via various mechanisms. METHODS: The anti-glioma effects of plumbagin were evaluated by in vitro and in vivo experiments. Anti-glioma mechanism of plumbagin was studied by proteomics, flow cytometry, MDA assay, western blot, and RT-PCR. Gene knockdown/overexpression, molecular docking, PharmMappper database, and coimmunoprecipitation were used to study the targets of plumbagin. RESULTS: Plumbagin showed higher blood–brain barrier penetration ability than that of lapachol and shikonin and elicited significant growth inhibitory effects in vitro and in vivo. Ferroptosis was the main mechanism of plumbagin-induced cell death. Mechanistically, plumbagin significantly downregulated the protein and mRNA levels of xCT and decreased GPX4 protein levels. NAD(P)H quinone dehydrogenase 1 (NQO1) was revealed as a plumbagin predictive target using PharmMappper database and molecular docking. Plumbagin enhanced NQO1 activity and decreased xCT expression, resulting in NQO1-dependent cell death. It also induced GPX4 degradation via the lysosome pathway and caused GPX4-dependent cell death. CONCLUSIONS: Plumbagin inhibited in vitro and in vivo glioma growth via targeting NQO1/GPX4-mediated ferroptosis, which might be developed as a novel ferroptosis inducer or anti-glioma candidate.

Natural gas is increasingly seen as the fossil fuel of choice for China as it transitions to renewable sources. The significant development of China’s LNG vehicle application and fueling stations and the urgency of climate changes make it particularly important to quantify methane emission from LNG stations, where the data are extremely rare. We carried out a pilot study on direct measurement and quantitative analysis of methane emission from five LNG fueling stations located in Shandong, China following the standard stationary EPA OTM 33A method. The measured methane emission of these five stations vary from 0.01 to 8.76 kg/h. The loss rates vary from 0.004 to 0.257%. We demonstrated that the emission from LNG stations consist of continuous and intermittent contents. The intermittent emission shows a strong temporal variation. If a station is only monitored for 20 min, it may either under-estimate or over-estimate the total emission. Both the distribution of emission events and total emission rates among different stations are highly skewed. We found that these LNG fueling station emission can be categorized into 3 grades, as low, medium and high, corresponding to emission rates below 0.1 kg/h; between 0.1 and 1 kg/h and above 1 kg/h, which can be characterized by the measured average methane concentration enhancement.

To derive and validate a prediction score for cardiovascular disease (CVD) risk in hemodialysis patients in China. Three hundred and eighty-eight patients with regular hemodialysis for more than 3 months were recruited from January 1, 2015 to September 30, 2019 and followed up till May 31, 2020. We derived a prediction score using all participants as a training data set and validated using a bootstrap validation data set. Discriminatory ability of the prediction score was assessed by the area under the receiver operating characteristic curve (AUC). Of 388 patients without CVD at baseline, 132 developed first CVD events during an average follow-up of 3.27 (inter-quartile range = 3.08) years. Of 26 clinical parameters, age, hypertension, diabetes and abnormal white blood cell (WBC) count were identified as significant predictors and included in the prediction model. Compared to those without any of these risk factors, those with one, two, and three to four points showed increased risks of CVD, with the adjusted hazards ratio and 95% confidence interval (CI) being 3.29 (1.17–9.26), 7.42 (2.68–20.51) and 15.43 (5.44–43.75), respectively. The score showed satisfactory discriminatory ability in both training and validation data set (AUC = 0.7025, 95% CI 0.6520–0.7530, and 0.6876, 95% CI 0.6553–0.7200, respectively). We derived and validated a prediction score for CVD risk in hemodialysis patients in China. Given there is a rapid increase in the number of hemodialysis patients, this simple point score can be used to identify high-risk individuals in clinical practice for more precise and efficient personalized treatment.

Improving carbon emission efficiency (CEE) would promote the development of the green and low-carbon economy in the Beijing-Tianjin-Hebei (BTH) region, China. This paper uses the EBM model of unexpected output to measure the city-level CEE of the BTH region from 2007 to 2016. The spatial distribution characteristics and evolution law of CEE are analyzed with respect to overall and local aspects, and the spatial quantile regression model is used to verify the influencing factors of CEE. The main findings are as follows: (1) The carbon emission in the BTH region is considered to be of medium efficiency, and there are eight cities within the region at middle- and high-efficiency levels. The overall efficiency values show a downward trend. Beijing, Cangzhou, Baoding have high-CEE values, whereas Handan, Tangshan, and Zhangjiakou have low-CEE values. (2) The CEE values for BTH show significant spatial agglomeration characteristics at both the global and local levels. The “H–H” agglomeration areas are primarily distributed in the central region, and the “L-L” agglomeration areas are chiefly distributed in the southern and northern regions. The spatial pattern change is generally stable. (3) The selected factors, URB, PGDP, DS, ISG, FDI, and TEL, have different regression coefficients on CEE at different quantiles.

The paper proposes a new structure of the receiving coil, which features horizontal and vertical position detection of inspection robot, which eliminates the system dependence on complex detection control circuit and simplifies the circuit design of the receiving end. The proposed design obtains the position information by comparing the induced voltage difference of the four-coil sets. Besides, the receiving coil is optimized in terms of the shape, dimension and the magnetic shielding structure by finite element analysis. Finally, the effectiveness of the receiving coil position detection is verified by the experiment with misalignment disturbance. The results illustrate the effectiveness of the four-coil system to detect the load position and the position adjustment by the adjustment control system.

Due to the high power density characteristics of permanent magnet (PM) traction motors and the strict loading conditions of electric vehicle (EV) engine compartments, the excessive losses inside the motors can elevate rapidly the temperature rises, deteriorate the magnetic property of PMs, limit the output torques, and even cause the overheating damages of the machines. In order to guarantee the operational reliability, it’s of vital importance to research and develop the effective, reliable and economical cooling systems for improving the working performances of the PM traction motors. In this paper, the three-dimensional (3D) fluidic-thermal coupled model of a high power density interior PM traction motor is established based on the basic theory of computational fluid dynamics (CFD) and numerical heat transfer. The fluid flow and thermal distributions are analyzed based on finite volume method (FVM), and verified by experimental results. According to the heating characteristics of the motor, the external water frame structure of the motor shell is modified to improve the cooling efficiency. Taguchi method is used to optimize the cooling structural parameters, so as to reduce the steady-state temperature rise of the motor. The research work in this paper has certain reference significance for the design and development of high power density PM traction motors used in EV applications.

Conformal cooling channels (CCCs) are a cooling passageway which follows the profile of the mold cavity or core to perform uniform cooling process effectively in the injection molding process. The production cost is closely related to productivity. To further improve productivity, the injection mold was equipped with CCCs to shorten the cooling time of the injection molded part. To investigate the relationship between the cooling channel layout and cooling efficiency of the CCCs, silicone rubber molds (SRMs) with different layouts of cooling systems were designed and constructed in this study. Simulation software was utilized to study the cooling performance. To verify the results of the simulation, SRM with different cooling systems were fabricated for low-pressure wax injection molding. It was found that the cooling time of the injection molded part is indeed affected by the total surface area of the heat exchange between the coolant and the SRM. The cooling system with four inlets and four outlets seems to be the optimum layout of the SRM in the case study in terms of the difficulty of mold making, total surface area of the heat exchange between the coolant and the SRM, and total cooling flow length of each segment. The saving in the cooling time about 2796 s and improvement of cooling efficiency about 76% can be obtained when the SRM with four inlets and four outlets was used for injection molding. The findings in this study can be used as a reference to design CCCs of injection mold built with AM technology.

Parallel back-building convective lines are often observed extending to the southwest of some mesoscale convective systems (MCSs) embedded in the mei-yu front in China. The convective lines with echo training behavior can quickly develop into a stronger convective group of echoes, resulting in locally heavy rainfall within the mei-yu front rainband. The initiation mechanism of the back-building convective lines is still unclear and is studied based on high-resolution numerical simulation of a case that occurred during 27–28 June 2013. In the present case, the new convection along the convective lines was found to be forced by nonuniform interaction between the cold outflow associated with the mei-yu front MCSs and the warm southerly airflow on the south side of the mei-yu front, which both are modified by local terrain. The mei-yu front MCSs evolved from the western to the eastern side of a basin surrounded by several mesoscale mountains and induced cold outflow centered over the eastern part of the basin. The strong southwest airflow ahead of the mei-yu front passed the Nanling Mountains and impacted the cold outflow within the basin. The nonuniform interaction led to the first stage of parallel convective line formation, in which the low mountains along the boundary of the two airflows enhanced the heterogeneity of their interaction. Subsequently, the convective group quickly developed from the first stage convective lines resulted in apparent precipitation cooling that enhanced the cold outflow and made the cold outflow a sharp southward windshift. The enhanced cold outflow pushed the warm southerly airflow southward and impacted the mountains on the southeast side of the basin, where the roughly parallel mountain valleys or gaps play a controlling role in a second stage formation of parallel convective lines.

In this paper, a new organic–inorganic hybrid compound [Co(L)2]2[W6O19](1) (HL = 2-acetylpyridine thiosemicarbazone) was prepared and characterized. The compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus, 0.06 µg·mL−1) and Escherichia coli (E. coli, 0.24 µg·mL−1), respectively. Furthermore, the potential mechanism of compound 1 was studied in detail. The potential causes of bacteria death were cell wall/membrane disruption, inhibition of intracellular respiratory chain dehydrogenases (RCD) activity, destruction of reactive oxygen species (ROS) and depletion of glutathione (GSH).

The exploration of new highly efficient and durable for the oxidation of amines to imines has gained immense attention. In this work, a new polyoxometalate-based metal–organic framework (POMOF) {Cu4(C26H16N4O4)4(CH3CN)2[SiW12O40]}·4H2O (SiW-Cu-DPNDI) was constructed with a catalytic oxidant Keggin-type [SiW12O40]4− anion, a photosensitizer N,N'-bis(4-pyridylmethyl)naphthalene diimide (DPNDI) ligand, and a Cu(I) cation via self-assembling. Although single-crystal X-ray diffraction, power X-ray diffraction (PXRD), infrared (IR) spectroscopy, etc., were employed to confirm the hierarchical structure of SiW-Cu-DPNDI, critical analyses through, such as the magnetic susceptibility measurements, the Mott–Schottky measurements, and the electron spin resonance studies were successfully applied to elucidate the properties of POMOF. SiW-Cu-DPNDI was highly active in the heterogeneous photocatalysis of the oxidation of amines to imines under mild conditions. Additionally, this catalyst exhibited high stability and reusability without losing its activity during the photocatalysis. The possible mechanism of the oxidation coupling was extensively investigated under visible-light (Vis)-irradiation.

The novel temperature-stable microwave dielectric ceramics of Ce0.5Sm0.5O1.75 were fabricated via the mixed oxide reaction method, with the detail information including crystal phase, microstructure, sintering behavior and microwave dielectric properties being systematically investigated. For crystal phase, all the diffraction patterns were indexed as cubic fluorite-type structure with Fm-3m (225) space group and exhibited a single phase with no obvious peak position shift. The grain growth was analyzed by density and average grain size. For microwave dielectric properties of Ce0.5Sm0.5O1.75 ceramics, the dielectric constant value (er) was dependent on density. The quality factors (Q × f values) were investigated considered with average grain size. And the temperature coefficient of resonant frequency (τf value) had no significant change during the sintering temperature range, which was found consistent with the trend of the dielectric constant value. The Ce0.5Sm0.5O1.75 ceramics sintered at 1475 °C for 4 h exhibited good microwave dielectric performances with er = 18.21, Q × f = 70,500 GHz, and τf = − 16.4 ppm/°C.

The toluene poses a serious threat to the atmospheric environment and human health. Herein, the reduced graphene oxide (rGO)/TiO2 immobilized on the activated carbon fiber (ACF) are fabricated by ultrasonic assisted sol-gel impregnation method to photodegrade dynamic toluene. Characterizations of rGO/TiO2/ACF composites reveal that the majority of graphene oxide (GO) is reduced to rGO and rGO/TiO2 is evenly loaded onto the ACF surface in the form of a smooth film. Furthermore, the photoelectrochemical experiments demonstrate both rGO and ACF can enhance significantly the separation efficiency of electron-hole pairs. The maximum removal efficiency of rGO/TiO2/ACF-0.75% can be up to 85% under ultraviolet irradiation. The rGO/TiO2/ACF exhibits more excellent adsorption and photodegradation activity for dynamic toluene than both rGO/TiO2 and ACF due to the synergetic effect rather than a simple linear combination of the rGO/TiO2 and ACF for toluene conversion. The possible photodegradation pathway is proposed according to intermediates measured by GC-MS, and adsorption coupling photocatalytic mechanisms are discussed.

The hierarchical nanostructured g-C3N4/TiO2/activated carbon fiber (ACF) composites are fabricated by simple ultrasonic assisted sol–gel method to removal toluene gas. The results show g-C3N4/TiO2 is evenly loaded onto the ACF surface in the form of a smooth film. The g-C3N4/TiO2/ACF possess strong photocatalytic activity, and its removal efficiency is twice as high as that of TiO2. Compared with TiO2, photoluminescence fluorescence (PL) intensity of g-C3N4/TiO2/ACF decreases nearly 10 times. Interestingly, the significantly enhanced removal efficiency is due to the synergetic effects of adsorption coupling photodegradation and the formation of Ti–O–C bonds between g-C3N4/TiO2 and ACF. The chemical bonding interaction accelerates the separation efficiency of photogenerated charge carriers. The removal efficiency and adsorption amount can be up to 94% and 140.55 mg/g for toluene concentration of 400 mg/m3 and space velocity of 1000 h−1 with 6% g-C3N4/TiO2/ACF. The space-time-yield of g-C3N4/TiO2/ACF reaches 141.06 g h−1 L−1 much higher than that of ACF (73.29 g h−1 L−1) and g-C3N4/TiO2 (64 g h−1 L−1). The possible photodegradation pathway and mechanisms are proposed. Therefore, the g-C3N4/TiO2/ACFs porous composites possess excellent application potential for elimination volatile organic compounds from atmospheric environment.

A regional ensemble Kalman filter (EnKF) data assimilation (DA) and forecast system was recently established based on the Gridpoint Statistical Interpolation (GSI) analysis system. The EnKF DA system was tested with continuous three-hourly updated cycles followed by 18-h deterministic forecasts from every three-hourly ensemble mean analysis. Initial tests showed negative to neutral impacts of assimilating satellite radiance data due to the improper bias correction procedure. In this study, two bias correction schemes within the established EnKF DA system are investigated and the impact of assimilating additional polar-orbiting satellite radiance is also investigated. Two group experiments are conducted. The purpose of the first group is to evaluate the bias correction procedure. Two online bias correction methods based on GSI 3DVar and EnKF algorithms are used to assimilate AMSU-A radiance data. Results show that both variational and EnKF-based bias correction procedures effectively reduce the observation and background radiance differences, achieving positive impacts on forecasts. With proper bias correction, we assimilate full radiance observations including AMSU-A, AMSU-B, AIRS, HIRS3/4, and MHS in the second group. The relative percentage improvements (RPIs) for all forecast variables compared to those without radiance data assimilation are mostly positive, with the RPI of upper-air relative humidity being the largest. Additionally, precipitation forecasts on a downscaled 13-km grid from 40-km EnKF analyses are also improved by radiance assimilation for almost all forecast hours.

A CuIn1-xGaxSe2 (CIGS) thin film solar cell model with MoSe2 transition layer was established, using SCAPS-1D software. The influence of MoSe2 interface layer formed between absorption layer CIGS and the back contact Mo on the solar cell performance was investigated. By changing the doping concentration, thickness and bandgap of MoSe2 layer, it is found that the MoSe2 and the variation of parameters have a significant effect on the electrical characteristics and photovoltaic parameters of CIGS thin film solar cells. Based on the energy band, the interfaces of Mo/MoSe2 and MoSe2/CIGS are analyzed. It is considered that Mo/MoSe2 is a Schottky contact, MoSe2/CIGS is an ohmic contact. When suitable parameters of MoSe2 layer are formed into the interface, it will provide a new path for designing CIGS solar cells with thinner absorption layer.

The bifunctional photocatalytic-adsorbent AgZnO/polyoxometalates (AgZnO/POMs) nanocomposites were synthesized by combining AgZnO hybrid nanoparticles and polyoxometalates [Cu(L)2(H2O)]H2[Cu(L)2(P2Mo5O23)]⋅4H2O (HL = C6H6N2O) into nanostructures via a sonochemical method. Transmission electron microscopy (TEM) indicated that AgZnO/POMs nanocomposites were uniform with narrow particle size distribution and without agglomeration. X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis confirmed the nanostructure and composition of AgZnO/POMs nanocomposites. The ultraviolet–visible spectra (UV–Vis) and photoluminescence spectra (PL) confirmed excellent optical properties of the AgZnO/POMs nanocomposites. 94.13% ± 0.61 of basic magenta (BM) in aqueous solution could be removed using the AgZnO/POMs nanocomposites through adsorption and photocatalysis. The kinetic analysis showed that both the adsorption and photocatalysis process conform to pseudo-second-order kinetics. In addition, the removal rate of AgZnO/POMs nanocomposites was found to be almost unchanged after 5 cycles of use. The bifunctional photocatalytic-adsorbent AgZnO/POMs nanocomposites with high stability and cycling performance have broad application prospects in the treatment of refractory organic dye wastewater containing triphenylmethane.

Background Lockdown policies were widely adopted during the coronavirus disease 2019 (COVID-19) pandemic to control the spread of the virus before vaccines became available. These policies had significant economic impacts and caused social disruptions. Early re-opening is preferable, but it introduces the risk of a resurgence of the epidemic. Although the World Health Organization has outlined criteria for re-opening, decisions on re-opening are mainly based on epidemiologic criteria. To date, the effectiveness of re-opening policies remains unclear. Methods A system dynamics COVID-19 model, SEIHR(Q), was constructed by integrating infection prevention and control measures implemented in Wuhan into the classic SEIR epidemiological model and was validated with real-world data. The input data were obtained from official websites and the published literature. Results The simulation results showed that track-and-trace measures had significant effects on the level of risk associated with re-opening. In the case of Wuhan, where comprehensive contact tracing was implemented, there would have been almost no risk associated with re-opening. With partial contact tracing, re-opening would have led to a minor second wave of the epidemic. However, if only limited contact tracing had been implemented, a more severe second outbreak of the epidemic would have occurred, overwhelming the available medical resources. If the ability to implement a track-trace-quarantine policy is fixed, the epidemiological criteria need to be further taken into account. The model simulation revealed different levels of risk associated with re-opening under different levels of track-and-trace ability and various epidemiological criteria. A matrix was developed to evaluate the effectiveness of the re-opening policies. Conclusions The SEIHR(Q) model designed in this study can quantify the impact of various re-opening policies on the spread of COVID-19. Integrating epidemiologic criteria, the contact tracing policy, and medical resources, the model simulation predicts whether the re-opening policy is likely to lead to a further outbreak of the epidemic and provides evidence-based support for decisions regarding safe re-opening during an ongoing epidemic. Keyords COVID-19; Risk of re-opening; Effectiveness of re-opening policies; IPC measures; SD modelling.

Background Vitamin A deficiency (VAD) and sleep disturbances have been reported in children with autism spectrum disorder (ASD). The influence of vitamin A (VA) levels on sleep regulation and sleep disturbances in ASD has garnered concern. The present study aimed to characterize the association of VA levels with sleep disturbances in children with ASD. Methods This cross-sectional study compared children with ASD (n = 856) to typically developing children (TDC; n = 316). We used the Children’s Sleep Habits Questionnaire to assess sleep disturbances, Childhood Autism Rating Scale to evaluate the severity of autism symptoms, and Autism Behavior Checklist and Social Responsiveness Scale to assess autism behaviors. Serum VA levels were estimated using high-performance liquid chromatography. Multivariable linear regression and two-way analysis of variance were performed to investigate if VAD was related to sleep disturbances in children with ASD. Results Children with ASD had lower serum VA levels and a higher prevalence of sleep disturbances than TDC did. The incidence of VAD in ASD children with sleep disturbances was higher, and the symptoms more severe than those without sleep disturbances and TDC. Interestingly, the interaction between VAD and sleep disturbances was associated with the severity of autism symptoms. Conclusion VAD and sleep disturbances are associated with the core symptoms of ASD in children. Regular monitoring of sleep and VA levels may be beneficial for children with ASD. Trial registration Chinese Clinical Trial Registry, registration number: ChiCTR-ROC-14005442, registration date: December 9th 2014.

MgO was designed as a new additive to optimize the microwave dielectric properties of LaNbO4 ceramics, and consequently the Q × ƒ values of LaNbO4 ceramics were effectively increased. The effects of MgO additive on phase composition, microstructure and microwave dielectric properties were discussed. LaNbO4, indexed as the main phase, had no obvious change, while the secondary phase related to MgO varied with different MgO content. The grain growth was evaluated by grain size and its distribution. The dielectric constant (er) was generally stable among the whole designed sintering temperature, but had some decrease with MgO (low permittivity) content increasing. The Q × ƒ values were not only affected by bulk densities during the sintering process, but also depended on the grain size and its distribution with different MgO contents. Sintered at 1425 °C for 4 h with x = 0.5, LaNbO4–xMgO ceramics possessed excellent performance: er = 19.8, Q × f = 94,440 GHz, τƒ = 6.1 ppm/°C.

Dual-polarization (dual-pol) radar can measure additional parameters that provide more microphysical information of precipitation systems than those provided by conventional Doppler radar. The dual-pol parameters have been successfully utilized to investigate precipitation microphysics and improve radar quantitative precipitation estimation (QPE). The recent progress in dual-pol radar research and applications in China is summarized in four aspects. Firstly, the characteristics of several representative dual-pol radars are reviewed. Various approaches have been developed for radar data quality control, including calibration, attenuation correction, calculation of specific differential phase shift, and identification and removal of non-meteorological echoes. Using dual-pol radar measurements, the microphysical characteristics derived from raindrop size distribution retrieval, hydrometeor classification, and QPE is better understood in China. The limited number of studies in China that have sought to use dual-pol radar data to validate the microphysical parameterization and initialization of numerical models and assimilate dual-pol data into numerical models are summarized. The challenges of applying dual-pol data in numerical models and emerging technologies that may make significant impacts on the field of radar meteorology are discussed.

A new Keggin-type heteropolyoxometalates compound, {[Cd(DMA)4]2(bibp)(SiW12O40)}n (1), (DMA = N, N-dimethylacetamide, bibp = 4,4′-bis(1-imidazolyl) biphenyl) has been synthesized and characterized by single-crystal X-ray diffraction, IR spectrum, elemental analysis, powder X-ray diffraction, thermogravimetric (TG) analysis and electrochemical analysis. Compound 1 is crystallized in orthorhombic with Pbca space group. The [SiW12O40]4− anions and bibp ligands are linked by coordinated Cd2+ ions alternately into a zigzag-like chain, and the chains are extended into a three-dimensional (3D) framework by the C–H···O hydrogen bonds. The cyclic voltammetry analyses show that compound 1 presences of W-centered reversible redox processes and that 1 has electrocatalytic activities towards the reduction of nitrite.