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Either effortful swallowing exercise or repetitive transcranial magnetic stimulation (rTMS) is considered as an effective method to treat dysphagia after stroke. Thus, synchronizing these two interventions may improve the efficiency of treatment. This trial intended to explore the effects of rTMS and effortful swallowing exercise on the recovery of swallowing function in patients after stroke. A total of 56 patients with post-stroke dysphagia who were able to actively cooperate with the training were analyzed in this study. We experimented with different intervention effects of rTMS synchronization with effortful swallowing training (group 1), rTMS (group 2), and traditional swallowing training alone (group 3). Every patient completed conventional swallowing training 5 days a week for 2 weeks. Patients in group 1 and group 2 underwent 10 consecutive sessions of 5 Hz rTMS over the affected mylohyoid cortical region. Fiberoptic endoscopic dysphagia severity scale (FEDSS), penetration/aspiration scale (PAS), standardized swallowing assessment (SSA), and functional oral intake scale (FOIS) were assessed and compared across the groups. No significant difference in FEDSS, PAS, SSA, or FOIS scores was found at baseline among the three groups. The mean change values of the FEDSS score, PAS score, SSA score, and FOIS score between baseline and post-intervention of the three groups (H = 16.05, P 0.001; H = 21.70, P 0.001; F (2, 53) = 9.68, P 0.001; H = 18.26, P 0.001; respectively) were statistically significant. In addition, the mean change values of FEDSS, PAS, SSA, and FOIS scores in participants in group 1 (all P 0.001) and group 2 (P = 0.046; P = 0.045; P = 0.028; P = 0.032; respectively) were significantly higher than in group 3. Similarly, the mean change values of FEDSS, PAS, SSA, and FOIS scores were significantly higher in participants in group 1 than in group 2 (P = 0.046; P = 0.038; P = 0.042; P = 0.044; respectively). The results revealed that the conjunction of rTMS and effortful swallowing training was an effective method to facilitate the recovery of swallowing function in stroke patients. The present clinical trial provided a new treatment method for the functional restoration of swallowing in stroke patients, which may further facilitate the recovery of swallowing function in stroke patients with swallowing disorders.

We design a novel nano-gap electrode to measure the current of DNA molecule, by which the current–voltage characteristics of individual native DNA, Ag-DNA and Ni-DNA molecules are obtained, respectively. The results show that the voltage gap of Ag- and Ni-DNA is higher than that of native DNA, and the conductance is lower than native DNA in neutral environment. The structure transition from B- to Z-DNA is observed in the presence of high concentrations of nickel ions and Ag-DNA appears chaos state by STM image and U-V spectra characterization. But in alkaline environment, the conductance of Ni-DNA rises and the voltage gap decreases with the increasing of nickel ion concentration denotes that the conductive ability of Ni-DNA is higher than that of native DNA.

Dispersion equation of planar-wiggler free-electron laser with background plasma is derived using linear fluid theory. The characteristic of this plasma FEL is analyzed in detail. It is shown that reasonable background plasma density tends to improve FEL growth rate. We also find there exits a critical plasma density for FEL operating. When the background plasma density is higher than critical density, the FEL can no longer be excited.

A set of nonlinear three-dimension equations for the FEM amplifier with elliptical waveguide and planar wiggler is derived. Based on these equations, a universal numerical simulation program is developed independently. The characterisitics of this FEM including the evolution of power, saturation efficiency and bandwidth are investigated. Electron momentum spread and wiggler taper are also considered.

FEM amplifier with a novel elliptic-groove guide is proposed and three-dimensional nonlinear theory for the elliptic-groove guide FEM amplifier is developed. A set of coupled nonlinear differential equations is derived and the characteristics of this FEM amplifier are numerically analyzed in detail including the evolution of power, efficiency and bandwidth. The effects on saturation efficiency due to electron momentum spread and wiggler taper are also studied.