17 results on '"Morrione A"'
Search Results
2. p53 signaling in cancer progression and therapy
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Marei, Hany E., primary, Althani, Asmaa, additional, Afifi, Nahla, additional, Hasan, Anwarul, additional, Caceci, Thomas, additional, Pozzoli, Giacomo, additional, Morrione, Andrea, additional, Giordano, Antonio, additional, and Cenciarelli, Carlo, additional
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- 2021
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3. Clinical aspects and diagnostic relevance of neuroautonomic evaluation in patients with unexplained falls
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Andrea Ungar, Francesca Tesi, Niccolò Marchionni, V. M. Chisciotti, Alessandro Morrione, Martina Rafanelli, Alice Ceccofiglio, M. A. Brunetti, and E. Ruffolo
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Male ,Aging ,medicine.medical_specialty ,Unexplained falls ,Supine position ,Poison control ,Blood Pressure ,Syncope ,Tilt-Table Test ,Internal medicine ,Injury prevention ,Prevalence ,medicine ,Humans ,In patient ,Aged ,Massage ,business.industry ,Carotid sinus ,Middle Aged ,Carotid Sinus ,Blood pressure ,medicine.anatomical_structure ,Physical therapy ,Accidental Falls ,Female ,Geriatrics and Gerontology ,business - Abstract
To evaluate the diagnostic relevance of neuroautonomic evaluation in patients with unexplained falls compared to those with a syncope etiologically unexplained after initial evaluation. It is an observational study, comparing 298 patients with unexplained fall with 989 patients with unexplained syncope. Each patient underwent supine and upright blood pressure measurement, tilt testing (TT) and carotid sinus massage (CSM). Patients with unexplained falls were older (75.3 ± 11.1 vs. 63.2 ± 19.2 years, p
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- 2013
- Full Text
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4. Oral and Poster Papers Submitted for Presentation at the 5th Congress of the EUGMS 'Geriatric Medicine in a Time of Generational Shift September 3–6, 2008 Copenhagen, Denmark
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M. T. Lonergan, B. Hovmand, M. Sánchez Cuervo, M. Tange Kristensen, C. Yau, Stefano Volpato, K. Christensen, K. Guha, J. Duggan, Y. Sawayama, J. F. M. de Jonghe, R. Rosenberg, K. Goupal, N. R. Jørgensen, P. Jordá, H. Kubšová, B. Riou, M. Monami, L. Özdemir, B. R. Duus, J. M. Fernandez Ibanez, Add Neuromed Study, S. Maertens, R. Winder, N. Akdemir, Carmelinda Ruggiero, F. Cambien, D. Bonnet, G. Barban, M. Fuentes, C. Datu, B. Ni Mhaille, D. G. Seymour, Toshio Hayashi, S. Lord, I. Kjeken, E. J. Schaefer, I. Raducanu, E. Tung, A. Truyols Bonet, D. Power, N. Morel, S. Edwards, C. Vigder, K. Promsopa, C. Geny, L. Derame, A. Dukat, A. Vilches-Moraga, K. Lihavainen, Z. Yang, R. M. Pircalabu, P. Huber, C. Eddy, A. Cella, C. Napoli, A. B. L. Pedersen, A. Fedeli, I. Sleiman, P. Weber, W. Kitisomprayoonkul, E. L. Marcus, K. Given, J. Sinclair-Cohen, S. O. Mahony, S. Vinkler, M. Krogseth, S. Otaguro, C. V. U. Øresund, D. Schoevaerdts, R. Pircalabu, B. Brack, H. Sasaki, F. Retornaz, I. Ionescu, M. Dubiel, J. Florian, L. Rokkedal, N. Quinlan, G. Dell’aquila, B. Way, C. Ionescu, T. Bermejo Vicedo, P. Eikelenboom, D. O’neill, T. Koga, A. Kachhia, M. R. Padilla Clemente, G. Batist, K. Moynier Vantieghem, P. Moerland, J. M. Bjordal, A. Pilotto, M. Michelet, R. Shafiei, Mirko Petrovic, J. Sulicka, J. Wagle, T. B. Wyller, J. Hrubanová, B. Stensrød, R. Ferretti, E. Turcu, S. Opris, A. Moreira, A. Zamora Mur, F J Martín Sánchez, N. Cogan, Marcello Maggio, Y. Kreslov, D. Ni Chroinin, G. Hanson, L. Kaiser, P. A. Kocaturk, S. Trainor, P. Takahashi, D. R. Collins, L. Campos, A. Björg Jönsdóttir, M. Cappuccio, V. Massart, T. Pattison, G. Notaridis, S. L. Ktvelä, S. Ghiorghe, Ruth Piers, L. Viati, M. Hollmann, Anja Velghe, Mikko P. Björkman, A. Zwinderman, K. Damkjær, P. Marsden, G. Cuneo, N. Bartoli, P. Gómez De Abia, A. Vilches Moraga, P. Campbell, Didem Sener Dede, B. Kirby, J. Oristrell, C. O’regan, T. Sander Pedersen, A. Hickey, R. Rozzini, B. Jansen, G. Fisher, N. Vogt-Ferrier, E. Kovari, B. Gasperini, K. Kalisvaart, N. Rye Jørgensen, K. Soda, U. Muster, K. Overgaard, J. Duiez-Domingo, M. Urbano, A. Oto, M. C. Cavallini, R. J. Van Marum, F. Gozukara, M. Cabrera Orozco, M. T. Olcoz-Chiva, A. Colvez, M. Di Bari, I. Cilesi, M. Migale, W. He, C. Dwyer, S. Engels, F. Hermmann, D. Small, Adam L. Gordon, Roberto Bernabei, R. Hnidei, C. Gonzalez-Rios, L. B. Husted, B. Dallapiccola, A. Moreau, R. Baron, U. Sveen, D. Chaiwanichsiri, A. Lopez Sierra, D. Villaneau, A. Mathur, G. Vedel Sørensen, P. Hemmi, F. Lattanzio, T. Frühwald, C. Marquis, A. Forest, B. Dalla Piccola, S. Lee, E. Ogawa, F. Coindreau, C. Rada, F. Lally, M. Yamada, K. Bakker, F. Comte, L. C. P. G. M. De Groot, H. L. Jørgensen, A. T. Isk, P. Schwarz, E. Portegijs, M. Kawakami, P. Giannakopoulos, A. Escolante Melich, M. O’ Connor, M. Rafanelli, P. Abete, M. Trabucchi, G. Clpaera, J. Vierendeels, M. Ramos, A. Salpakoski, G. Ziere, M. Ai, T. Fujisawa, K. I. Sørensen, C. Berard, K. Cobbaert, R. Fellin, M. Angel Mas, Phyo K. Myint, Burcu Balam Yavuz, K. Benmedjahed, P. Lampela, S. White, L. del Bianco, E. O. Ospedali Galliera, A. Frøland, L. Kozlov, M. T. Pacitti, P. Dave, B. Oeser, K. Kanaya, M. Rachita, Jean-Pierre Michel, Nadia Sourial, D. O’ Mahony, A. A. Piette, H. O’brien, K. Eiklid, A. J. Cruz-Jentoft, C. Shou, T. Bruun Wyller, J. Geerts, J. Korevaar, A. H. Johansen, P. Nimann Kannegaard, T. Korfitsen, A. Ayub, P. Baker, C. Scarcelli, A. Juszczak, L. S. Seest, A. Blundell, S. Bandinelli, P. A. F. Jansen, A. Maraviglia, E. S. Cankurtaran, B. Orhan, J. Vanakoski, K. J. Kalisvaart, M. Sakai, J. Oh, M. Henry, I. Kiviranta, S. Sanders, T. Mariani, A. H. Ranhoff, Mehmet Cankurtaran, B. Böhmdorfer, A. Tekeira, A. Lund, A. M. J. Maclullich, J. Hayashi, M. J. Lopez-Sanchez, S. M. I. Park, S. Willicombe, B. L. Langdahl, E. Lupeanu, A. Michael, R. Dias, G. Berrut, E. Ruffolo, D. Giet, Marianne Schroll, G. Onose, S. D. Shenkin, J. Driesen, T. Katsuya, C. Moe, M. San-Martin, Koenraad Vandewoude, A. Bambi, E. Shelley, C. Lamanna, B. Mc Eniry, B. Yoo, C. Colombi, H. Ekstrom, P. Gallagher, O. Mkhailova, A. Hnidei, F. P. Cariello, I. Moy, J. M. Vega Andion, G. Balci, F. Orso, W. Schrauwen, Patrizia Mecocci, J. L. Gallais, J. Saunders, M. Koefoed, J. Petrovicova, E. Paredes-Galan, C. Gutiérrez Fernández, Simon Lovestone, N. Berg, N. Weerasuriya, S. Biswas, K. Van Puyvelde, C. Chamot, T. Rantanenv, C. Rosen, K. O’connor, J. Ryg, L. Le Saint, D. A. Jones, M. Boncinelli, S. Baldasseroni, P. Barbisoni, E. Jones, C. F. Ambien, N. Dzerovych, P. Barry, A. Falanga, M. T. Olcoz Chiva, A. Skerris, S. Samandel, Antonio Cherubini, N. Binkley, A. Landi, P. Belli, G. Ditloto, M. Mellingsaeter, K. Wieczorowska-Tobis, L. Alonso Boix, C. Fernandez, V. Strelkova, G. Carmona, S. Amici, S. Mehrabian, J. Lietava, M. Iso-Aho, M. Masotti, I. G. Ftta, J. Carbonero Malberti, I. Carriere, A. Toornvliet, N. Grygoryeva, J. Soubeyrand, M. Cavalieri, Z. Malla, K. D. Pedersen, G. Clapera, J. M. Anton, N. R. Chopra, P. Eiken, S. Kapucu, G. Ventura, E. Cirinei, O. Vazquez, M. Checa, M. Filipa Seabra Pereira, R. Sylvest Mortensen, A. Osawa, J. Cunniffe, M. White, V. Batalha, A. Chatterjee, K. Bjøro, D. Zintchouk, E. Guillemard, R. Vreeswijk, C. Quinn, B. Romboli, G. Pepe, F. Simonsen, B. Morosanu, S. S. Celik, E. Kaykov, C. Bouras, B. Schousboe, N. van der Velde, P. Mowinckel, L. Toutous Trellu, J. Frimann, N. Vergis, T. Wulff, M. Salonoja, H. Doruk, A. Gonzalez, Dominique Benoit, L. Santos, Y. Ben-Israel, B. Grandal Leiros, F. Addante, C. Twomey, C. Sieber, C. Bonomini, P. Ziccardi, D. Carratelli, T. Jørgensen, F. Kasagi, A. Cebrian, M. Frisher, M. S. Brandt, W. Hussain, J. Mora, M. Alen, Maurits Vandewoude, C. Lidy, M. Burke, M. Mørch, A. Lyager, F. Huwez, J González Del Castillo, M. Cankuran, C. Prete, S. Anniss, S. Briggs, E. Bozoglu, S. Sipila, C. Fernandez Rios, H. Nomura, N. Faucher, L. Al-Dhahi, M. Gross, M. G. Longo, C. Schiaffini, H. Petersen, S. Crane, K. Brixen, C. Yucel, A. Leiro Manso, B. Yavuz, J. Petermans, W. Nielsen, T. Jokinen, C. L. Tofteng, D. Wan-Chow-Wah, B. Fantino, I. Barat, M. J. Lopez Sanchez, A. E. Larsen, E. Farrelly, S. Rostoft Kristjansson, J. M. Vega-Andion, V. Andrei, E. Pressel, B. Ni Bhuachalla, Steven Boonen, D. Simoni, M. G. Matera, E. Santillo, R. Sival, Dirk Vogelaers, Anna Skalska, S. Van Der Mark, H. Hirai, V. M. Chisciotti, R. Scoyni, M. Kallinen, A. Lopez-Sierra, E. Paredes Galan, D. Hagedorn, J. B. Lauritzen, Sölve Elmståhl, P. Mikes, M. Cohen, T. Vahlberg, L. E. Matzen, Gerda Verschraegen, H. Blain, E. Rees, R. Melton, T. L. J. Tammela, D. Aw, R. Miralles, E. Lopilato, M. van Zutphen, S. Ghorghe, N. Nissen, M. Lopponen, A. Oestergaard, A. Sorva, F. O’sullivan, M. Vanmeerbeek, A. Sclater, V. Juliebo, M.E. Fuentes Ferrer, S. Prada, E. Bryden, I. Maeve Rea, N. Furusyo, K. Cho, H. Cronin, F. Tigoulet, V. Povoroznyuk, F. Paris, P. Clarkson, P. E. Cotter, S. Rodriguez-Justo, F. Mazzella, E. de Waele, S. Trasciatti, O. Beauchet, E. Mannucci, K. N. Raun, C. Verdejo, S. Pautex, M. M. Mørch, P. Giniès, R. Garavan, J. Nobrega, S. Kinsella, L. Skippari, Howard Bergman, J. E. B. Jensen, T. Lee, P. Godart, B. Montero Errasquin, C. Nyhuus, Reijo S. Tilvis, G. Mancioli, D. Dawe, M. D’imperio, I. Miralles, J. Serra, M. Baglioni, C. Fallon, Y. Tatsukawa, J. Forristall, J. C. Leners, G. D’onofrio, J. de Backer, K. Flekkøy, L. Kyne, V. Dubois-Ferrière, C. Ryan, M. P. Sibret, A. Nesbakken, V. Ochiana, T. Iwamoto, E. Lotti, M. Marchionni, A. Clemmensen, J. Puustinen, S. Amor Andres, L. Wileman, Anette Hylen Ranhoff, S. Gillett, F. Lauretani, M. Gullo, H. Meluzínová, M. Seidahamd, P. de Antonio, A. Sgadari, E. Jespersen, A. Morelli, Palacios Huertas, C. Fraguglia, A. S. Rigaud, H. E. Andersen, B. Wizner, D. Fedak, J. Boddaert, Shaun T. O'Keeffe, D. O. ’Neill, B. Felli, C. Morales Ballesteros, S. Mcintosh, P. Such, O. Akyol, I. S. Young, J. M. Guralnik, A. Leiro-Manso, L. P. D’ambrosio, S. Rooij, G. Gold, H. Lee, C. Sohrt, A. Egan, D. Susanne Nielsen, C. Gravina, P. Rinaldi, C. Lestrup, S. F. Syed Farooq, M. Nuotio, L. Rexach Cano, C. Maraldi, F. Mangiaasche, Z. Mikes, E. M. Damsgaard, C. Di Serio, S. Pecchioni, S. Caplan, E. Gonzalez, M. Baccini, Y. Caine, J. Gladman, J. M. Ribera, B. Lundgren, V. Sharma, M. Morocutti, Sara Ercolani, B. H. C. Stricker, C. Popescu, M. Carpena-Ruiz, M. Verny, B. Hofman, A. Ungar, Y. Kumei, E. Topikova, L. Franceschi, S. Hussain, V. Serafini, K. Shipman, F. Sioulis, T. Coughlan, S. Bhat, B. Comert, K. Engedal, B. Kream, A. Iguchi, D. F. Vitale, M. Fornal, K. Kristiansen, I. Palma-Reis, E. Sixt, C. H. Foss, R. Rizzoli, M. Bartley, B. Fure, P. Freitas, C. Fernández Alonso, R. Njemini, F. Kelleher, A. Zamora Catevilla, S. Hoeck, F. Rashidi, J.M. Ribera Casado, M. Honing, A. Rajska-Neumann, B. D. Pedersen, A. Martins, C. M. J. Van Der Linden, D. Sharpe, R. Grue, Denis O'Mahony, J. Van der Heyden, J. Cristoffersen, Marianna Noale, U. Sommeregger, V. Goffredo, A. Qvist, Y. Akkuþ, M. T. E. Puts, M. Luque, M. P. De Antonio García, T. Takagi, N. Carroll, A. Salakowski, M. Belladonna, A. Hylen Ranhoff, S. Otokozawa, C. Ekdahl, E. Delgado Silveira, Stijn Blot, H. Mcgee, U. Senin, G. C. Parisi, S. Pedersen, F. Rengo, A. Renom, E. Vestbo, Y. Akkus, G. Van Hal, S. Murphy, V. Ducasse, G. Ryzhak, M. I. Arranz Peña, W. Knol, V. Lesauskaite, F. Patacchini, S. Abe, M. Narro-Vidal, C. Lund, N. Hayashi, M. van Breemen, H. Ohnishi, M. Torrente-Carballido, B. Bogen, H. Kayihan, Z. Tuna, C. Verdejo-Bravo, B. Battacharya, F. M. Borgbjerg, Kudret Aytemir, A. C. Drenth-Van Maanen, F. Gori, O. Duems, T.J.M. van der Cammen, Servet Ariogul, P. Villarroel, M. Kat, N. Petitpierre, I. Akyar, M. Franceschi, M. Ohishi, S. Cassano, Roy L. Soiza, T. Patel, A. M. Herghelegiu, M. Clarfield, S. Ballentyne, L. Lambertucci, Cm. Pena, A. Bayer, A. Salam, E. Moriarty, C. Roux, Y. Takasugi, M. García, C. Rodriguez-Pascual, P. Mikus, Y. Akyar, M. Torrente Carballido, V. Vayda, F. Rønholt, M. Khayat, K. Ina, O. Hazer, M. Falconer, H. N. Jacobsen, R. Custureri, H. Kasem, T. Bandholm, A. Allue Bergua, M. Levi, R. Rehman, M. Monette, C. Verdejo Bravo, O. Millot, N. Caffrey, Y. Kano, C. Cherubini, J. Kolesar, S. Maeshima, J. Fox, P. Aarnio, E. Henderson, J. Monette, M. MacMahon, L. Rytter, J. Nurminen, A. Abbas, A. S. Whitehead, G. Longobardi, Zekeriya Ulger, M. Hamada, A. Sofia Duque, Luigi Ferrucci, P. Lavikainen, J. Kennedy, I. Saez, E. Hegarty, Stefania Maggi, J. Touchon, A. Chandra, A. Bhangu, M. Labib, A. Rnould, A. Bojan, S. Mukherjee, N. Ferrara, F. Raschilas, G. Popescu, C. Annweiler, D. Hevey, D. Seripa, C. Danneels, I. Crome, M. Karlsson, Y. Kamiya, C. Carvell, I. Trani, T. van der Ploeg, G. Zulian, J. Bencke, V. Curran, P. Gherasim, B. Sejtved, R. Meade, Rose Anne Kenny, V. Curiale, A. Yu-Ballard, E. Azevedo, A. Leiros, P. Gil Gregorio, J. Gonzalez Armengol, H. Rakugi, M. C. Esculier, O. Poire, R. Raz, R. Gugliotta, M. Carpena Ruiz, Tony Mets, Ivan Bautmans, T. Karasevskaya, P. Eoin Cotter, T. Masud, C. Jeandel, K. Leckie, J. P. Lopes, R. Isoaho, A. E. Evans, F. Lacoin, C. Cho, B. Vincent, M. Lazaro, R. Cecchetti, M. Carpena, A. Kavanagh, S. Juhl Pedersen, Niccolò Marchionni, C. Swine, François Herrmann, G. O. Kavas, F. J. Garcia Garcia, S. Quintela, G. I. Prada, C. Hertogh, S. Sun Kapucu, P. Granberg, S. Byrne, R. Mcdermott, R. Van Der Stichele, A. M. Mello, A. Waldir Bezerra, J. de Jonghe, L. F. Moreno Ramiez, A. de Tena Fontaneda, M. H. Saldanha, H. Kehlet, G. V. Sørensen, M. Jylhä, J. Silvestre, K. Czabanowska, L. Gowran, F. Albertí Homar, M. de Saint-Hubert, R. Huupponen, P. le Lous, T. Bertsch, P. Dieppe, R. Topor-Madry, R. Van Gara, W. Bemelmans, V. Polcarová, C. Donnellan, B. Jørgensen, G. Leandro, S. L. Kivela, C. Boubakri, Sirpa Hartikainen, K. Ferguson, Z. Barrou, E. Costanzi, H. Hilleret, L. Danbaek, A. O’hanlon, C. Hürny, O. G. Olaru, V. Seux, C. Divoy, M. Mowe, E. Holm, H. J. Heppner, J. Martin, M. Isik, B. Gryglewska, A. Lilja, E. Romero, I. Pillay, V. Kijowska, M. Therese Lonergan, A. Alfaro Acha, M. Uyanik, A. Gabelle, P. Bueso, S. Sinha, M. Corritore, T. Shingo, E. Lacey, L. Cascavilla, R. Sulkava, K. Terumalai, S. Pellerito, Gaetano Crepaldi, R. Moe-Nilssen, Francesco Cacciatore, J. Breda, J. M. Del Rey, J. Teixeira, N. B. Nielsen, E. Granot, D. Speijer, S. A. Anstey, G. Masotti, I. G. Fita, S. Krajèík, P. Brynningsen, S. Maeda, N. Vanden Noortgate, J. Wiersinga, M. Teixeira Veríssimo, J. Cooke, N. Van Den Noortgate, K. Daly, M. M. Bisschop, A. Galmés Truyols, W.A. van Gool, J. Fernandez Soria, C. Sánchez Castellano, A. M. Cervera, E. Mossello, T. Lindhardt, C. Boulanger, E. Oziol, C. Hendriksen, A. M. Pazienza, L. Farner, P. Bastiani, F. Horgan, A. Deniz, P. Ammann, H. Takeoka, J. Lauritsen, L. Sandvik, S. S. Kapucu, I. Nakagawa, A. Jung, L. Brewer, Anne-Marie Schott, S. Zanieri, A. Teixeira, G. Parisi, P. Lund Nielsen, J. Holckova, P. Alcalde, B. Whelan, K. Toyoda, B. Dieudonne, G. Guerra, Meltem Halil, E. Garcia-Villar, R. Paz Maya, C. E. Mogensen, M. O’connor, A. Bonnerup Vind, L. Vich Martorell, F. Tarantini, Katarzyna Szczerbińska, I. Ozerov, R. Turk, M. Kamigaki, E. Mirewska, H. Bayes, S. Arino, P. Lyngholm-Kxærby, B.C. van Munster, F. Konishi, A. Morrione, C. Pena, P. Harbig, D. Gradinaru, F. Kee, B. Knold, L. Aiello, T. de Man, Renaat Peleman, Taina Rantanen, P. Birschel, P. Crome, R. Meyling, V. Khavinson, D. H. Kim, T. Luukkaala, Q. Garcia, K. Elkholy, D. Gillain, M. L. Seux, S. Greffard, P. Kjear, S. Sihvonen, Patricia M. Kearney, Tomasz Grodzicki, F. Favier, Dominique Vandijck, E. Palummeri, F. Caldi, Y. Parel, E. Jorge, L. O’connor, S. Dahlin Ivanoff, L. Tiret, K. Adie, G. Lucchetti, M. Lauridsen, A. C. Berggren, M. Simon, D. Adane, P. O. Lang, and V. Niro
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Gerontology ,Geriatrics ,0303 health sciences ,medicine.medical_specialty ,Nutrition and Dietetics ,030309 nutrition & dietetics ,Geriatrics gerontology ,business.industry ,media_common.quotation_subject ,Alternative medicine ,Medicine (miscellaneous) ,03 medical and health sciences ,Presentation ,0302 clinical medicine ,medicine ,030212 general & internal medicine ,Geriatrics and Gerontology ,business ,Quality of Life Research ,media_common - Published
- 2008
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5. The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells
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Barbara Belletti, Magali Navarro, Renato Baserga, Michael Dews, Barbara Valentinis, Krzysztof Reiss, Gaetano Romano, and Andrea Morrione
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MAPK/ERK pathway ,Cancer Research ,medicine.medical_specialty ,Morpholines ,Cellular differentiation ,Protein Serine-Threonine Kinases ,Biology ,Hippocampus ,Cell Line ,Receptor, IGF Type 1 ,Proto-Oncogene Proteins ,Internal medicine ,Genetics ,medicine ,Animals ,Insulin-Like Growth Factor I ,Molecular Biology ,Protein kinase B ,Neurons ,CD40 ,Kinase ,Ribosomal Protein S6 Kinases ,Cell Differentiation ,Phosphoproteins ,female genital diseases and pregnancy complications ,Rats ,IRS1 ,Cell biology ,Enzyme Activation ,Insulin receptor ,Endocrinology ,Chromones ,Cell culture ,embryonic structures ,Insulin Receptor Substrate Proteins ,biology.protein ,Mitogen-Activated Protein Kinases ,Proto-Oncogene Proteins c-akt - Abstract
H19-7/IGF-IR cells are rat hippocampal cells expressing a human IGF-I receptor, which differentiate to a neuronal phenotype when stimulated by IGF-I at 39 degrees C. H19-7/IGF-IR cells have low levels of expression of insulin receptor substrate-l (IRS-1), a major substrate of the IGF-IR. IGF-I induces serine-phosphorylation and down-regulation of the endogenous IRS-1 upon differentiation of H19-7/IGF-IR cells. The profound influence of IRS-1 on differentiation of H19-7/IGF-IR cells was confirmed by transfecting these cells with a plasmid expressing mouse IRS-1. Over-expression of wild type IRS-1 in H19-7/IGF-IR cells abolishes IGF-I-induced differentiation at 39 degrees C. A mutant of IRS-1 lacking the PTB domain loses the ability to inhibit the differentiation program. H19-7/IGF-IR/IRS-1 cells at 39 degrees C show a stronger and prolonged activation of Akt, when compared to H19-7/IGF-IR cells. The role of Akt in the inhibition of the differentiation program was confirmed by using the inhibitor of Class I PI3 kinases LY29400, which restores IGF-I-induced differentiation of H19-7/IGF-IR/IRS-1 cells. H19-7/IGF-IR/IRS-1 cells show a strong reduction in MAP kinases signaling, which is related to the superactivation of Akt. This was confirmed by expressing in H19-7/IGF-IR cells a constitutively active Akt, which inhibited MAP kinases activation in these cells. These experiments confirm the importance of MAPK in the mechanism of IGF-I-mediated differentiation of H19-7/IGF-IR cells
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- 2001
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6. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation
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Jin-Ying Wang, Andrea Morrione, Webster K. Cavenee, Renato Baserga, Frank B. Furnari, Xiao Tu, Gaetano Romano, and Krzysztof Reiss
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Male ,Cancer Research ,Cellular differentiation ,Mice, Nude ,Receptor, IGF Type 1 ,Mice ,Germline mutation ,Growth factor receptor ,Cell Movement ,LNCaP ,Cell Adhesion ,Tumor Cells, Cultured ,Genetics ,Animals ,Humans ,PTEN ,Genes, Tumor Suppressor ,Neoplasm Invasiveness ,Cell adhesion ,Molecular Biology ,Germ-Line Mutation ,biology ,Oncogene ,Tumor Suppressor Proteins ,PTEN Phosphohydrolase ,Prostatic Neoplasms ,Phosphoric Monoester Hydrolases ,Gene Expression Regulation, Neoplastic ,Cancer cell ,Cancer research ,biology.protein ,Signal Transduction - Abstract
LNCaP prostatic cancer cells are characterized by having a PTEN mutation, low levels of type 1 insulin-like growth factor receptor (IGF-IR) and no IRS-1, one of the major substrates of the IGF-IR. The absence of IRS-1, an activator of PI3-kinase, is compensated in these cells by the mutation in PTEN, an inhibitor of PI3-kinase. However, IGF-IR signaling in the absence of IRS-1 can cause cell differentiation and growth arrest. We hypothesized that these three characteristics may not be unrelated, specifically that, together, they may favor the metastatic spread of prostatic cancer cells without decreasing their growth potential. In support of this hypothesis, we report here that: (1) IRS-1 expression increases cell adhesion and decreases cell motility; (2) over-expression of the IGF-IR, in the absence of IRS-1, causes growth arrest and (3) a combination of IGF-IR and IRS-1 restores the transformed phenotype of LNCaP cells. These findings suggest a mechanism by which prostatic cancer cells can achieve metastatic potential without interfering with their growth potential. Oncogene (2000).
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- 2000
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7. Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion
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Andrea Morrione, Barbara Valentinis, Francesca Peruzzi, Krzysztof Reiss, Marco Prisco, and Renato Baserga
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Cancer Research ,medicine.medical_specialty ,Cell Survival ,Morpholines ,Retroviridae Proteins, Oncogenic ,Apoptosis ,Biology ,Receptor, IGF Type 1 ,Mice ,Phosphatidylinositol 3-Kinases ,Growth factor receptor ,Internal medicine ,Genetics ,medicine ,Animals ,Humans ,Anoikis ,Enzyme Inhibitors ,Insulin-Like Growth Factor I ,Phosphorylation ,Fibroblast ,Receptor ,Molecular Biology ,Protein kinase B ,Polyhydroxyethyl Methacrylate ,Phosphoinositide-3 Kinase Inhibitors ,Mitogen-Activated Protein Kinase 1 ,Mice, Inbred BALB C ,Mitogen-Activated Protein Kinase 3 ,Kinase ,Wild type ,3T3 Cells ,Fibroblasts ,Extracellular Matrix ,Cell biology ,Androstadienes ,Oncogene Protein v-akt ,medicine.anatomical_structure ,Endocrinology ,Chromones ,Calcium-Calmodulin-Dependent Protein Kinases ,ras Proteins ,Mitogen-Activated Protein Kinases ,Signal transduction ,Wortmannin ,Signal Transduction - Abstract
The type 1 insulin-like growth factor receptor (IGF-IR) is known to protect cells from a variety of apoptotic injuries. In several instances, the anti-apoptotic effect of the wild type IGF-IR is more evident under conditions of anchorage-independence than in cells in monolayer cultures. We have investigated IGF-IR signaling in cells in anoikis, a form of apoptosis that occurs when cells are denied attachment to the extra-cellular matrix. IGF-I protects mouse embryo fibroblasts (MEF) from anoikis caused by withdrawal of growth factors. Survival is dependent on the concentration of IGF-I and a sufficient number of functional IGF-I receptors. In this model, IGF-I protection correlates best with ras activation and cell-to-cell aggregation, while PI3-kinase, Akt and MAP kinases seem to play a lesser, alternative role.
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- 1999
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8. [Untitled]
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Andrea Morrione, Marco Prisco, and Renato Baserga
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education.field_of_study ,Programmed cell death ,Cell division ,Cell growth ,business.industry ,Growth factor ,medicine.medical_treatment ,Cellular differentiation ,Population ,Cell cycle ,Growth factor receptor ,Cancer research ,Medicine ,Cardiology and Cardiovascular Medicine ,education ,business - Abstract
It has been known for several years that the number of cells in any population, whether normal or abnormal, depends on both the rate of cell division and the rate of cell death [1]. When the two rates are equal, the cell population is said to be in a steady state; when the rate of cell death exceeds the rate of cell division, atrophy ensues, and conversely, the cell population will increase when the number of cells produced per unit time exceeds the number of cells that die in the same period. More precisely, the three mechanisms that produce an increase in cell number of any given cell population are 1) a shortening of the cell cycle, i.e., the cells divide more frequently; 2) an increase in the number of cells participating in the cell cycle, i.e., the G0 fraction decreases; and 3) a decrease in the rate of cell death. The third mechanism was all but neglected until recently, when apoptosis suddenly became the fashionable way for cells to die. But it was clear several years ago that the rate of cell proliferation was not suf~cient to explain the growth of tumors. When Baserga and Kisieleski [2] showed that one of the fastest-growing tumors of mice did not proliferate faster than the normal cells of the epithelial lining of the small intestine, their results brought home not only an important fact but also a concept. The concept was that the cells of the epithelial lining of the small intestine, while proliferating vigorously, also continuously die, so that, at least in the adult animal, this population is in a steady state. Later, Bresciani et al. [3] showed that, in human squamous cell carcinomas of the skin, tumor cells died in large amounts—unfortunately, not large enough to cause the tumors to regress. These tumors grew because the rate of cell division always exceeded the rate of cell death. Cell death in general and apoptosis in particular occur not only in tumors but also during normal development and aging [4], consequently, we can say that the growth of a cell population, in development or in abnormal growth, always rests on a delicate balance between cell division and cell death. How is this balance achieved? The size of any population of cells, whether normal or abnormal, depends on environmental signals, among which growth factors are the most important. But, until recently, growth factors were looked upon merely as mitogenic agents, or, in the case of inhibitory growth factors, as antimitogenic agents. It is only in recent years that two new aspects of growth factors have been emerging: 1) the association of growth factors with viral oncogenes [5] in mediating the action of these oncogenes; and 2) the ability of growth factors to protect cells from apoptosis [6]. This last property will be the subject of the present article. Since growth factors invariably act through their receptors in determining their effects on cell survival, the terms ligands and receptors will be used interchangeably. This article will place particular emphasis on the role of the insulin-like growth factor 1 (IGF-I) receptor activated by its ligands, since that this receptor seems to transmit not the only but certainly the most effective antiapoptotic signal among the growth factor receptors.
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- 1998
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9. Social causation and interpretive processes: Herbert Blumer's theory of industrialization and social change
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David R. Maines and Thomas J. Morrione
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Social order ,Social psychology (sociology) ,Sociology and Political Science ,Social philosophy ,Social reality ,Political Science and International Relations ,Social change ,Social movement theory ,Sociology ,Social science ,Symbolic interactionism ,Social theory ,Epistemology - Abstract
In the course of analyzing "macro" level social phenomena, one of which is industralization, Herbert Blumer (1900-1987) developed his core ideas for a recursive model of social organization which accentuates the interdependence of individual and collective action with social structure. His discussion of industrialization as an agent of social change, which is the topic for our essay, gives ample evidence of the relevance of symbolic interaction to handling large-scale and complex social phenomena. In ex? ploring that relevance, we call attention to the essential features of social life he depicts and note that they, in turn, give form to generic social processes of individual and collective action. These characteristics of social reality inform his view of the relation between social action and social or? ganization, an area of relevance that transcends industrialization. Given that relevance, industrialization may be viewed as a case study used by Blumer to develop a perspective of broad theoretical significance. In par? ticular, we will focus on processes of adjustment, since that concept lies at the heart of his analysis. Blumer's interest in industrialization dated from the early 1940's, and was well nourished by his work as labor arbitrator for both the United Packinghouse Workers and for U.S. Steel. From the early 1940's to late 1950's, he published a half dozen or so articles and chapters on issues of industrial relations, interest group tensions, and power relations. In 1958 59, he was appointed to the position of Deputy Director of the Latin American Center for Research in the Social Science for UNESCO, and ""Herbert Blumer. Industrialization as an Agent of Social Change: A Critical Analysis. Edited with an Introduction by David R. Maines and Thomas J. Morrione, New York: Aldine de Gruyter, 1990.
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- 1991
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10. Clinical aspects and diagnostic relevance of neuroautonomic evaluation in patients with unexplained falls
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Rafanelli, M., primary, Ruffolo, E., additional, Chisciotti, V. M., additional, Brunetti, M. A., additional, Ceccofiglio, A., additional, Tesi, F., additional, Morrione, A., additional, Marchionni, N., additional, and Ungar, A., additional
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- 2013
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11. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer
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Vecchione, A, primary, Fassan, M, additional, Anesti, V, additional, Morrione, A, additional, Goldoni, S, additional, Baldassarre, G, additional, Byrne, D, additional, D'Arca, D, additional, Palazzo, J P, additional, Lloyd, J, additional, Scorrano, L, additional, Gomella, L G, additional, Iozzo, R V, additional, and Baffa, R, additional
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- 2008
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12. Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571
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Klejman, Agata, primary, Rushen, Lori, additional, Morrione, Andrea, additional, Slupianek, Artur, additional, and Skorski, Tomasz, additional
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- 2002
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13. The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells
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Morrione, Andrea, primary, Navarro, Magali, additional, Romano, Gaetano, additional, Dews, Michael, additional, Reiss, Krzysztof, additional, Valentinis, Barbara, additional, Belletti, Barbara, additional, and Baserga, Renato, additional
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- 2001
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14. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation
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Reiss, Krzysztof, primary, Wang, Jin-Ying, additional, Romano, Gaetano, additional, Furnari, Frank B, additional, Cavenee, Webster K, additional, Morrione, Andrea, additional, Tu, Xiao, additional, and Baserga, Renato, additional
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- 2000
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15. Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion
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Valentinis, Barbara, primary, Morrione, Andrea, additional, Peruzzi, Francesca, additional, Prisco, Marco, additional, Reiss, Krzysztof, additional, and Baserga, Renato, additional
- Published
- 1999
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- View/download PDF
16. Social causation and interpretive processes: Herbert Blumer's theory of industrialization and social change
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Maines, David R., primary and Morrione, Thomas J., additional
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- 1991
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17. Social interaction and stereotypic responses to homosexuals
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Farrell, Ronald A., primary and Morrione, Thomas J., additional
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- 1974
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