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84 results on '"Nelson, Christopher"'

1. Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing

Author

Al-Turki, Taghreed M., primary, Maranon, David G., additional, Nelson, Christopher B., additional, Lewis, Aidan M., additional, Luxton, Jared J., additional, Taylor, Lynn E., additional, Altina, Noelia, additional, Wu, Fei, additional, Du, Huixun, additional, Kim, JangKeun, additional, Damle, Namita, additional, Overbey, Eliah, additional, Meydan, Cem, additional, Grigorev, Kirill, additional, Winer, Daniel A., additional, Furman, David, additional, Mason, Christopher E., additional, and Bailey, Susan M., additional

Published
2024
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2. Genetic influence on vascular smooth muscle cell apoptosis

Author

McVey, David G., primary, Andreadi, Catherine, additional, Gong, Peng, additional, Stanczyk, Paulina J., additional, Solomon, Charles U., additional, Turner, Lenka, additional, Yan, Liu, additional, Chen, Runji, additional, Cao, Junjun, additional, Nelson, Christopher P., additional, Thompson, John R., additional, Yu, Haojie, additional, Webb, Tom R., additional, Samani, Nilesh J., additional, and Ye, Shu, additional

Published
2024
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3. ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

Author

Yang, Sile F., primary, Nelson, Christopher B., additional, Wells, Jadon K., additional, Fernando, Madushan, additional, Lu, Robert, additional, Allen, Joshua A. M., additional, Malloy, Lisa, additional, Lamm, Noa, additional, Murphy, Vincent J., additional, Mackay, Joel P., additional, Deans, Andrew J., additional, Cesare, Anthony J., additional, Sobinoff, Alexander P., additional, and Pickett, Hilda A., additional

Published
2024
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4. The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Author

Nelson, Christopher B., primary, Rogers, Samuel, additional, Roychoudhury, Kaushik, additional, Tan, Yaw Sing, additional, Atkinson, Caroline J., additional, Sobinoff, Alexander P., additional, Tomlinson, Christopher G., additional, Hsu, Anton, additional, Lu, Robert, additional, Dray, Eloise, additional, Haber, Michelle, additional, Fletcher, Jamie I., additional, Cesare, Anthony J., additional, Hegde, Rashmi S., additional, and Pickett, Hilda A., additional

Published
2024
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5. Is atrial fibrillation in HFpEF a distinct phenotype? Insights from multiparametric MRI and circulating biomarkers

Author

Dattani, Abhishek, primary, Brady, Emer M., additional, Kanagala, Prathap, additional, Stoma, Svetlana, additional, Parke, Kelly S., additional, Marsh, Anna-Marie, additional, Singh, Anvesha, additional, Arnold, Jayanth R., additional, Moss, Alastair J., additional, Zhao, Lei, additional, Cvijic, Mary Ellen, additional, Fronheiser, Matthew, additional, Du, Shuyan, additional, Costet, Philippe, additional, Schafer, Peter, additional, Carayannopoulos, Leon, additional, Chang, Ching-Pin, additional, Gordon, David, additional, Ramirez-Valle, Francisco, additional, Jerosch-Herold, Michael, additional, Nelson, Christopher P., additional, Squire, Iain B., additional, Ng, Leong L., additional, Gulsin, Gaurav S., additional, and McCann, Gerry P., additional

Published
2024
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6. Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation

Author

Adlam, David, Berrandou, Takiy-Eddine, Georges, Adrien, Nelson, Christopher P, Giannoulatou, Eleni, Henry, Joséphine, Ma, Lijiang, Blencowe, Montgomery, Turley, Tamiel N, Yang, Min-Lee, Chopade, Sandesh, Finan, Chris, Braund, Peter S, Sadeg-Sayoud, Ines, Iismaa, Siiri E, Kosel, Matthew L, Zhou, Xiang, Hamby, Stephen E, Cheng, Jenny, Liu, Lu, Tarr, Ingrid, Muller, David WM, D'Escamard, Valentina, King, Annette, Brunham, Liam R, Baranowska-Clarke, Ania A, Debette, Stéphanie, Amouyel, Philippe, Olin, Jeffrey W, Patil, Snehal, Hesselson, Stephanie E, Junday, Keerat, Kanoni, Stavroula, Aragam, Krishna G, Butterworth, Adam S, CARDIoGRAMPlusC4D, MEGASTROKE, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group, Tweet, Marysia S, Gulati, Rajiv, Combaret, Nicolas, DISCO Register, Kadian-Dodov, Daniella, Kalman, Jonathan M, Fatkin, Diane, Hingorani, Aroon D, Saw, Jacqueline, Webb, Tom R, Hayes, Sharonne N, Yang, Xia, Ganesh, Santhi K, Olson, Timothy M, Kovacic, Jason C, Graham, Robert M, Samani, Nilesh J, Bouatia-Naji, Nabila, Adlam, David [0000-0002-0080-9884], Berrandou, Takiy-Eddine [0000-0002-0525-3002], Georges, Adrien [0000-0003-4208-2393], Nelson, Christopher P [0000-0001-8025-2897], Finan, Chris [0000-0002-3319-1937], Braund, Peter S [0000-0001-8540-5709], Iismaa, Siiri E [0000-0003-2409-7356], Zhou, Xiang [0000-0002-4331-7599], Hamby, Stephen E [0000-0002-6215-5791], Muller, David WM [0000-0002-5281-0166], Brunham, Liam R [0000-0002-3686-3807], Debette, Stéphanie [0000-0001-8675-7968], Amouyel, Philippe [0000-0001-9088-234X], Olin, Jeffrey W [0000-0003-3374-616X], Hesselson, Stephanie E [0000-0002-4521-5086], Kanoni, Stavroula [0000-0002-1691-9615], Aragam, Krishna G [0000-0003-3223-9131], Butterworth, Adam S [0000-0002-6915-9015], Combaret, Nicolas [0000-0003-4905-0765], Fatkin, Diane [0000-0002-9010-9856], Hingorani, Aroon D [0000-0001-8365-0081], Saw, Jacqueline [0000-0002-7027-984X], Webb, Tom R [0000-0001-5998-8226], Hayes, Sharonne N [0000-0003-3129-362X], Yang, Xia [0000-0002-3971-038X], Olson, Timothy M [0000-0003-2716-9423], Kovacic, Jason C [0000-0003-4555-769X], Graham, Robert M [0000-0002-1042-2587], Bouatia-Naji, Nabila [0000-0001-5424-2134], and Apollo - University of Cambridge Repository

Subjects
Myocardial Infarction, Humans, Female, Vascular Diseases, Coronary Artery Disease, Genome-Wide Association Study
Abstract

Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and implicated in extracellular matrix biology. One locus containing the tissue factor gene F3, which is involved in blood coagulation cascade initiation, appears to be specific for SCAD risk. Several associated variants have diametrically opposite associations with CAD, suggesting that shared biological processes contribute to both diseases, but through different mechanisms. We also infer a causal role for high blood pressure in SCAD. Our findings provide novel pathophysiological insights involving arterial integrity and tissue-mediated coagulation in SCAD and set the stage for future specific therapeutics and preventions.

Published
2023

8. Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution

Author

Taherian Fard, Atefeh, primary, Leeson, Hannah C., additional, Aguado, Julio, additional, Pietrogrande, Giovanni, additional, Power, Dominique, additional, Gómez-Inclán, Cecilia, additional, Zheng, Huiwen, additional, Nelson, Christopher B., additional, Soheilmoghaddam, Farhad, additional, Glass, Nick, additional, Dharmaratne, Malindrie, additional, Watson, Ebony R., additional, Lu, Jennifer, additional, Martin, Sally, additional, Pickett, Hilda A., additional, Cooper-White, Justin, additional, Wolvetang, Ernst J., additional, and Mar, Jessica C., additional

Published
2023
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9. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Author

Aragam, Krishna G, Jiang, Tao, Goel, Anuj, Kanoni, Stavroula, Wolford, Brooke N, Atri, Deepak S, Weeks, Elle M, Wang, Minxian, Hindy, George, Zhou, Wei, Grace, Christopher, Roselli, Carolina, Marston, Nicholas A, Kamanu, Frederick K, Surakka, Ida, Venegas, Loreto Muñoz, Sherliker, Paul, Koyama, Satoshi, Ishigaki, Kazuyoshi, Åsvold, Bjørn O, Brown, Michael R, Brumpton, Ben, De Vries, Paul S, Giannakopoulou, Olga, Giardoglou, Panagiota, Gudbjartsson, Daniel F, Güldener, Ulrich, Haider, Syed M Ijlal, Helgadottir, Anna, Ibrahim, Maysson, Kastrati, Adnan, Kessler, Thorsten, Kyriakou, Theodosios, Konopka, Tomasz, Li, Ling, Ma, Lijiang, Meitinger, Thomas, Mucha, Sören, Munz, Matthias, Murgia, Federico, Nielsen, Jonas B, Nöthen, Markus M, Pang, Shichao, Reinberger, Tobias, Schnitzler, Gavin, Smedley, Damian, Thorleifsson, Gudmar, Von Scheidt, Moritz, Ulirsch, Jacob C, Danesh, John, Arnar, David O, Burtt, Noël P, Costanzo, Maria C, Flannick, Jason, Ito, Kaoru, Jang, Dong-Keun, Kamatani, Yoichiro, Khera, Amit V, Komuro, Issei, Kullo, Iftikhar J, Lotta, Luca A, Nelson, Christopher P, Roberts, Robert, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Webb, Thomas R, Baras, Aris, Björkegren, Johan LM, Boerwinkle, Eric, Dedoussis, George, Holm, Hilma, Hveem, Kristian, Melander, Olle, Morrison, Alanna C, Orho-Melander, Marju, Rallidis, Loukianos S, Ruusalepp, Arno, Sabatine, Marc S, Stefansson, Kari, Zalloua, Pierre, Ellinor, Patrick T, Farrall, Martin, Ruff, Christian T, Finucane, Hilary K, Hopewell, Jemma C, Clarke, Robert, Gupta, Rajat M, Erdmann, Jeanette, Samani, Nilesh J, Schunkert, Heribert, Watkins, Hugh, Willer, Cristen J, Deloukas, Panos, Kathiresan, Sekar, Butterworth, Adam S, Aragam, Krishna G [0000-0003-3223-9131], Goel, Anuj [0000-0003-2307-4021], Kanoni, Stavroula [0000-0002-1691-9615], Wolford, Brooke N [0000-0003-3153-1552], Atri, Deepak S [0000-0001-8139-5419], Weeks, Elle M [0000-0002-4317-4444], Wang, Minxian [0000-0002-3753-508X], Zhou, Wei [0000-0001-7719-0859], Roselli, Carolina [0000-0001-5267-6756], Kamanu, Frederick K [0000-0001-7208-1047], Koyama, Satoshi [0000-0002-9286-0360], Ishigaki, Kazuyoshi [0000-0003-2881-0657], Åsvold, Bjørn O [0000-0003-3837-2101], Brumpton, Ben [0000-0002-3058-1059], Gudbjartsson, Daniel F [0000-0002-5222-9857], Güldener, Ulrich [0000-0001-5052-8610], Helgadottir, Anna [0000-0002-1806-2467], Kessler, Thorsten [0000-0003-3326-1621], Li, Ling [0000-0002-3280-9475], Mucha, Sören [0000-0002-1647-2526], Munz, Matthias [0000-0002-4728-3357], Murgia, Federico [0000-0002-3608-845X], Pang, Shichao [0000-0002-4111-2864], Smedley, Damian [0000-0002-5836-9850], Thorleifsson, Gudmar [0000-0003-4623-9087], von Scheidt, Moritz [0000-0001-7159-8271], Ulirsch, Jacob C [0000-0002-7947-0827], Costanzo, Maria C [0000-0001-9043-693X], Flannick, Jason [0000-0002-3618-795X], Ito, Kaoru [0000-0003-1843-773X], Khera, Amit V [0000-0001-6535-5839], Komuro, Issei [0000-0002-0714-7182], Kullo, Iftikhar J [0000-0002-6524-3471], Roberts, Robert [0000-0002-6792-4633], Webb, Thomas R [0000-0001-5998-8226], Baras, Aris [0000-0002-6830-3396], Björkegren, Johan LM [0000-0003-1945-7425], Holm, Hilma [0000-0002-9517-6636], Morrison, Alanna C [0000-0001-6381-4296], Orho-Melander, Marju [0000-0002-3578-2503], Stefansson, Kari [0000-0003-1676-864X], Farrall, Martin [0000-0003-4564-2165], Finucane, Hilary K [0000-0003-3864-9828], Clarke, Robert [0000-0002-9802-8241], Erdmann, Jeanette [0000-0002-4486-6231], Samani, Nilesh J [0000-0002-3286-8133], Schunkert, Heribert [0000-0001-6428-3001], Watkins, Hugh [0000-0002-5287-9016], Willer, Cristen J [0000-0001-5645-4966], Kathiresan, Sekar [0000-0002-3711-7101], Butterworth, Adam S [0000-0002-6915-9015], and Apollo - University of Cambridge Repository

Subjects
692/699/75/2, 631/208/205/2138, article, Humans, Coronary Artery Disease, Genome-Wide Association Study
Abstract

Funder: K.G.A. has received support from the American Heart Association Institute for Precision Cardiovascular Medicine (17IFUNP3384001), a KL2/Catalyst Medical Research Investigator Training (CMeRIT) award from the Harvard Catalyst (KL2 TR002542), and the NIH (1K08HL153937)., Funder: B.N.W is supported by the National Science Foundation Graduate Research Program (DGE 1256260)., Funder: I.S. is supported by a Precision Health Scholars Award from the University of Michigan Medical School., Funder: I.K., S.Ko., and K.It. are funded by the Japan Agency for Medical Research and Development, AMED, under Grant Numbers JP16ek0109070h0003, JP18kk0205008h0003, JP18kk0205001s0703, JP20km0405209, and JP20ek0109487. The BioBank Japan is supported by AMED under Grant Number JP20km0605001., Funder: J.L.M.B. acknowledges research support from NIH R01HL125863, American Heart Association (A14SFRN20840000), the Swedish Research Council (2018-02529) and Heart Lung Foundation (20170265) and the Foundation Leducq (PlaqueOmics: Novel Roles of Smooth Muscle and Other Matrix Producing Cells in Atherosclerotic Plaque Stability and Rupture, 18CVD02., Funder: P.S.dV was supported by American Heart Association grant number 18CDA34110116 and National Heart, Lung, and Blood Institute grant R01HL146860. The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services (contract numbers HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700004I and HHSN268201700005I), R01HL087641, R01HL059367 and R01HL086694; National Human Genome Research Institute contract U01HG004402; and National Institutes of Health contract HHSN268200625226C. The authors thank the staff and participants of the ARIC study for their important contributions. Infrastructure was partly supported by Grant Number UL1RR025005, a component of the National Institutes of Health and NIH Roadmap for Medical Research., Funder: O.G. has received funding from the British Heart Foundation (BHF) (FS/14/66/3129)., Funder: T.K. is supported by the Corona-Foundation (Junior Research Group Translational Cardiovascular Genomics) and the German Research Foundation (DFG) as part of the Sonderforschungsbereich SFB 1123 (B02)., Funder: D.S.A. has received support from a training grant from the NIH (T32HL007604)., Funder: N.P.B., M.C.C., J.F., and D.-K.J. have been funded by the National Institute of Diabetes and Digestive and Kidney Diseases (2UM1DK105554)., Funder: A.V.K. has been funded by 1K08HG010155 from the National Human Genome Research Institute., Funder: C.P.N. and T.R.W received funding from the British Heart Foundation (SP/16/4/32697)., Funder: The Trøndelag Health Study (The HUNT Study) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology), Trøndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public Health. The K.G. Jebsen Center for Genetic Epidemiology is financed by Stiftelsen Kristian Gerhard Jebsen; Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology; and Central Norway Regional Health Authority. Whole genome sequencing for the HUNT study was funded by HL109946., Funder: O.M. was funded by the Swedish Heart- and Lung Foundation, the Swedish Research Council, the European Research Council ERC-AdG-2019-885003 and Lund University Infrastructure grant ”Malmö population-based cohorts” (STYR 2019/2046)., Funder: This work was supported by the European Commission (HEALTH-F2–2013-601456) and the TriPartite Immunometabolism Consortium [TrIC]- NovoNordisk Foundation (NNF15CC0018486), VIAgenomics (SP/19/2/344612), the British Heart Foundation, a Wellcome Trust core award (M.F., H.W., 203141/Z/16/Z) and support from the NIHR Oxford Biomedical Research Centre. M.F. and H.W. are members of the Oxford BHF Centre of Research Excellence (RE/13/1/30181). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health., Funder: J.D. is a British Heart Foundation Professor, European Research Council Senior Investigator, and National Institute for Health Research (NIHR) Senior Investigator., Funder: J.C.H. acknowledges personal funding from the British Heart Foundation (FS/14/55/30806) and is a member of the Oxford BHF Centre of Research Excellence (RE/13/1/30181)., Funder: R.C. has received funding from the British Heart Foundation and British Heart Foundation Centre of Research Excellence., Funder: This research was supported by BHF (SP/13/2/30111) and conducted using the UK Biobank Resource (application number 9922)., Funder: The GerMIFs gratefully acknowledge the support of the Bavarian State Ministry of Health and Care, furthermore founded this work within its framework of DigiMed Bayern (grant No: DMB-1805-0001), the German Federal Ministry of Education and Research (BMBF) within the framework of ERA-NET on Cardiovascular Disease (Druggable-MI-genes: 01KL1802), within the scheme of target validation (BlockCAD: 16GW0198K), within the framework of the e:Med research and funding concept (AbCD-Net: 01ZX1706C), the British Heart Foundation (BHF)/German Centre of Cardiovascular Research (DZHK)-collaboration (VIAgenomics) and the German Research Foundation (DFG) as part of the Sonderforschungsbereich SFB 1123 (B02) and the Sonderforschungsbereich SFB TRR 267 (B05)., Funder: C.J.W. is funded by NIH grant R35-HL135824., Funder: This work was supported by the British Heart Foundation (BHF) grant RG/14/5/30893 (P.D.) and forms part of the research themes contributing to the translational research portfolios of the Barts Biomedical Research Centre funded by the UK National Institute for Health Research (NIHR)., The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a Japanese GWAS yielded 38 additional new loci. We prioritized likely causal variants using functionally informed fine-mapping, yielding 42 associations with less than five variants in the 95% credible set. Similarity-based clustering suggested roles for early developmental processes, cell cycle signaling and vascular cell migration and proliferation in the pathogenesis of CAD. We prioritized 220 candidate causal genes, combining eight complementary approaches, including 123 supported by three or more approaches. Using CRISPR–Cas9, we experimentally validated the effect of an enhancer in MYO9B, which appears to mediate CAD risk by regulating vascular cell motility. Our analysis identifies and systematically characterizes >250 risk loci for CAD to inform experimental interrogation of putative causal mechanisms for CAD.

Published
2022
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10. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Author

Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Moore, Tim, Hemerich, Daiane, Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Ahluwalia, Tarunveer S., Bartz, Traci M., Bentley, Amy R., Bielak, Lawrence F., Chong, Mike, Chu, Audrey Y., Berry, Diane, Dorajoo, Rajkumar, Dueker, Nicole D., Kasbohm, Elisa, Feenstra, Bjarke, Feitosa, Mary F., Gieger, Christian, Graff, Mariaelisa, Hall, Leanne M., Haller, Toomas, Hartwig, Fernando P., Hillis, David A., Huikari, Ville, Heard-Costa, Nancy, Holzapfel, Christina, Jackson, Anne U., Johansson, Åsa, Jørgensen, Anja Moltke, Kaakinen, Marika A., Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Koolhaas, Chantal M., Kutalik, Zoltan, Lagou, Vasiliki, Lind, Penelope A., Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Metzendorf, Christoph, Monroe, Kristine R., Pacolet, Alexander, Pérusse, Louis, Pool, Rene, Richmond, Rebecca C., Rivera, Natalia V., Robiou-du-Pont, Sebastien, Schraut, Katharina E., Schulz, Christina-Alexandra, Stringham, Heather M., Tanaka, Toshiko, Teumer, Alexander, Turman, Constance, van der Most, Peter J., Vanmunster, Mathias, van Rooij, Frank J. A., van Vliet-Ostaptchouk, Jana V., Zhang, Xiaoshuai, Zhao, Jing-Hua, Zhao, Wei, Balkhiyarova, Zhanna, Balslev-Harder, Marie N., Baumeister, Sebastian E., Beilby, John, Blangero, John, Boomsma, Dorret I., Brage, Søren Karl, Braund, Peter S., Brody, Jennifer A., Bruinenberg, Marcel, Ekelund, Ulf, Liu, Ching-Ti, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Esko, Tõnu, Enroth, Stefan, Faul, Jessica D., Fernandez-Rhodes, Lindsay, Fohner, Alison E., Franco, Oscar H., Galesloot, Tessel E., Gordon, Scott D., Grarup, Niels, Hartman, Catharina A., Heiss, Gerardo, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Joshi, Peter K., Jung, Taeyeong, Kähönen, Mika, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Kuusisto, Johanna, Launer, Lenore J., Li, Aihua, Linneberg, Allan, Luan, Jian’an, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Moscati, Arden, Musk, Bill, Nelson, Christopher P., Nolte, Ilja M., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Reedik, Mägi, Reiner, Alex P., Ridker, Paul M., Rudan, Igor, Ryan, Kathy, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Sidney, Stephen, Siggeirsdottir, Kristin, Smith, Albert V., Smith, Jennifer A., Sonestedt, Emily, Strøm, Marin, Tai, E. Shyong, Teo, Koon K., Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Uitterlinden, Andre G., Vangipurapu, Jagadish, van Schoor, Natasja, Völker, Uwe, Willemsen, Gonneke, Williams, Kayleen, Wong, Quenna, Xu, Huichun, Young, Kristin L., Yuan, Jian Min, Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bis, Joshua C., Boehnke, Michael, Bouchard, Claude, Chasman, Daniel I., Smith, George Davey, de Geus, Eco J. C., Deldicque, Louise, Dörr, Marcus, Evans, Michele K., Ferrucci, Luigi, Fornage, Myriam, Fox, Caroline, Garland, Theodore, Gudnason, Vilmundur, Gyllensten, Ulf, Hansen, Torben, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Johnson, W. Craig, Kardia, Sharon L. R., Kiemeney, Lambertus A., Laakso, Markku, Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, Swertz, Morris, Wijmenga, Tjitske Nienke, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Wolffenbuttel, Bruce H. R., Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Oldehinkel, Albertine J., Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Penninx, Brenda W. J. H., Pers, Tune H., Polasek, Ozren, Prokopenko, Inga, Rotimi, Charles N., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Timpson, Nicholas J., van Dam, Rob M., van der Velde, Nathalie, van Duijn, Cornelia M., Vollenweider, Peter, Völzke, Henry, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Weir, David R., Wichmann, Heinz-Erich, Wilson, James F., Hevener, Andrea L., Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I., Loos, Ruth J. F., Hoed, Marcel den, Epidemiology, Internal Medicine, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of Clinical Physiology and Nuclear Medicine, Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J, Moore, Tim, Hyppönen, Elina, den Hoed, Marcel, Lifelines Cohort Study, Alizadeh, B.Z., Boezen, H.M., Franke, L., Swertz, M., Wijmenga, C., van der Harst, P., Navis, G., Rots, M., Wolffenbuttel, BHR, Wang, Zhe [0000-0002-8046-4969], Emmerich, Andrew [0000-0002-0908-9924], Pillon, Nicolas J [0000-0003-1107-9490], Moore, Tim [0000-0003-4250-3370], Ameur, Adam [0000-0001-6085-6749], Bis, Joshua C [0000-0002-3409-1110], Boehnke, Michael [0000-0002-6442-7754], Bouchard, Claude [0000-0002-0048-491X], Chasman, Daniel I [0000-0003-3357-0862], Smith, George Davey [0000-0002-1407-8314], de Geus, Eco JC [0000-0001-6022-2666], Dörr, Marcus [0000-0001-7471-475X], Ferrucci, Luigi [0000-0002-6273-1613], Fornage, Myriam [0000-0003-0677-8158], Garland, Theodore [0000-0002-7916-3552], Gyllensten, Ulf [0000-0002-6316-3355], Hansen, Torben [0000-0001-8748-3831], Horta, Bernardo L [0000-0001-9843-412X], Hyppönen, Elina [0000-0003-3670-9399], Johnson, W Craig [0000-0002-3161-3753], Kiemeney, Lambertus A [0000-0002-2368-1326], Laakso, Markku [0000-0002-3394-7749], Langenberg, Claudia [0000-0002-5017-7344], Lehtimäki, Terho [0000-0002-2555-4427], Magnusson, Patrik KE [0000-0002-7315-7899], Martin, Nicholas G [0000-0003-4069-8020], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Meyre, David [0000-0003-4850-7444], North, Kari E [0000-0002-8903-0366], Ohlsson, Claes [0000-0002-9633-2805], Oldehinkel, Albertine J [0000-0003-3925-3913], Orho-Melander, Marju [0000-0002-3578-2503], Pare, Guillaume [0000-0002-6795-4760], Park, Taesung [0000-0002-8294-590X], Pedersen, Oluf [0000-0002-3321-3972], Pers, Tune H [0000-0003-0207-4831], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Rotimi, Charles N [0000-0001-5759-053X], Sim, Xueling [0000-0002-1233-7642], Snieder, Harold [0000-0003-1949-2298], Sørensen, Thorkild IA [0000-0003-4821-430X], Spector, Tim D [0000-0002-9795-0365], Timpson, Nicholas J [0000-0002-7141-9189], Voortman, Trudy [0000-0003-2830-6813], Waeber, Gérard [0000-0003-4193-788X], Wareham, Nicholas J [0000-0003-1422-2993], Weir, David R [0000-0002-1661-2402], Wilson, James F [0000-0001-5751-9178], Krook, Anna [0000-0002-0891-0258], Zierath, Juleen R [0000-0001-6891-7497], Thomis, Martine AI [0000-0001-9093-2191], Loos, Ruth JF [0000-0002-8532-5087], Hoed, Marcel den [0000-0001-8081-428X], Apollo - University of Cambridge Repository, Center for Liver, Digestive and Metabolic Diseases (CLDM), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Geriatrics, AMS - Ageing & Vitality, APH - Aging & Later Life, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, and AMS - Sports

Subjects
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 631/208/205/2138, 610 Medicine & health, heritability, Actinin/genetics, Cross-Sectional Studies, Exercise/physiology, Genome-Wide Association Study, Humans, Leisure Activities, Sedentary Behavior, apolipoprotein-e genotype, Lifelines Cohort Study, 360 Social problems & social services, 692/308/575, Genetics, Actinin, Exercise, Medicinsk genetik, exercise, APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS, 360 Soziale Probleme, Sozialdienste, 692/308/2056, article, gwas, gene-expression, mortality, 3142 Public health care science, environmental and occupational health, fitness, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], LD score regression, 3111 Biomedicine, 610 Medizin und Gesundheit, Medical Genetics, complex, performance
Abstract

Funder: Kjell och Märta Beijers Stiftelse (Kjell and Marta Beijer Foundation); doi: https://doi.org/10.13039/501100006353, Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.

Published
2022
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11. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Author

Kanoni, Stavroula, primary, Graham, Sarah E., additional, Wang, Yuxuan, additional, Surakka, Ida, additional, Ramdas, Shweta, additional, Zhu, Xiang, additional, Clarke, Shoa L., additional, Bhatti, Konain Fatima, additional, Vedantam, Sailaja, additional, Winkler, Thomas W., additional, Locke, Adam E., additional, Marouli, Eirini, additional, Zajac, Greg J. M., additional, Wu, Kuan-Han H., additional, Ntalla, Ioanna, additional, Hui, Qin, additional, Klarin, Derek, additional, Hilliard, Austin T., additional, Wang, Zeyuan, additional, Xue, Chao, additional, Thorleifsson, Gudmar, additional, Helgadottir, Anna, additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Olafsson, Isleifur, additional, Hwang, Mi Yeong, additional, Han, Sohee, additional, Akiyama, Masato, additional, Sakaue, Saori, additional, Terao, Chikashi, additional, Kanai, Masahiro, additional, Zhou, Wei, additional, Brumpton, Ben M., additional, Rasheed, Humaira, additional, Havulinna, Aki S., additional, Veturi, Yogasudha, additional, Pacheco, Jennifer Allen, additional, Rosenthal, Elisabeth A., additional, Lingren, Todd, additional, Feng, QiPing, additional, Kullo, Iftikhar J., additional, Narita, Akira, additional, Takayama, Jun, additional, Martin, Hilary C., additional, Hunt, Karen A., additional, Trivedi, Bhavi, additional, Haessler, Jeffrey, additional, Giulianini, Franco, additional, Bradford, Yuki, additional, Miller, Jason E., additional, Campbell, Archie, additional, Lin, Kuang, additional, Millwood, Iona Y., additional, Rasheed, Asif, additional, Hindy, George, additional, Faul, Jessica D., additional, Zhao, Wei, additional, Weir, David R., additional, Turman, Constance, additional, Huang, Hongyan, additional, Graff, Mariaelisa, additional, Choudhury, Ananyo, additional, Sengupta, Dhriti, additional, Mahajan, Anubha, additional, Brown, Michael R., additional, Zhang, Weihua, additional, Yu, Ketian, additional, Schmidt, Ellen M., additional, Pandit, Anita, additional, Gustafsson, Stefan, additional, Yin, Xianyong, additional, Luan, Jian’an, additional, Zhao, Jing-Hua, additional, Matsuda, Fumihiko, additional, Jang, Hye-Mi, additional, Yoon, Kyungheon, additional, Medina-Gomez, Carolina, additional, Pitsillides, Achilleas, additional, Hottenga, Jouke Jan, additional, Wood, Andrew R., additional, Ji, Yingji, additional, Gao, Zishan, additional, Haworth, Simon, additional, Yousri, Noha A., additional, Mitchell, Ruth E., additional, Chai, Jin Fang, additional, Aadahl, Mette, additional, Bjerregaard, Anne A., additional, Yao, Jie, additional, Manichaikul, Ani, additional, Hwu, Chii-Min, additional, Hung, Yi-Jen, additional, Warren, Helen R., additional, Ramirez, Julia, additional, Bork-Jensen, Jette, additional, Kårhus, Line L., additional, Goel, Anuj, additional, Sabater-Lleal, Maria, additional, Noordam, Raymond, additional, Mauro, Pala, additional, Matteo, Floris, additional, McDaid, Aaron F., additional, Marques-Vidal, Pedro, additional, Wielscher, Matthias, additional, Trompet, Stella, additional, Sattar, Naveed, additional, Møllehave, Line T., additional, Munz, Matthias, additional, Zeng, Lingyao, additional, Huang, Jianfeng, additional, Yang, Bin, additional, Poveda, Alaitz, additional, Kurbasic, Azra, additional, Lamina, Claudia, additional, Forer, Lukas, additional, Scholz, Markus, additional, Galesloot, Tessel E., additional, Bradfield, Jonathan P., additional, Ruotsalainen, Sanni E., additional, Daw, EWarwick, additional, Zmuda, Joseph M., additional, Mitchell, Jonathan S., additional, Fuchsberger, Christian, additional, Christensen, Henry, additional, Brody, Jennifer A., additional, Vazquez-Moreno, Miguel, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Wang, Zhe, additional, Preuss, Michael H., additional, Mangino, Massimo, additional, Christofidou, Paraskevi, additional, Verweij, Niek, additional, Benjamins, Jan W., additional, Engmann, Jorgen, additional, Tsao, Noah L., additional, Verma, Anurag, additional, Slieker, Roderick C., additional, Lo, Ken Sin, additional, Zilhao, Nuno R., additional, Le, Phuong, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Huo, Shaofeng, additional, Ikeda, Daisuke D., additional, Iha, Hiroyuki, additional, Yang, Jian, additional, Liu, Jun, additional, Demirkan, Ayşe, additional, Leonard, Hampton L., additional, Marten, Jonathan, additional, Frank, Mirjam, additional, Schmidt, Börge, additional, Smyth, Laura J., additional, Cañadas-Garre, Marisa, additional, Wang, Chaolong, additional, Nakatochi, Masahiro, additional, Wong, Andrew, additional, Hutri-Kähönen, Nina, additional, Sim, Xueling, additional, Xia, Rui, additional, Huerta-Chagoya, Alicia, additional, Fernandez-Lopez, Juan Carlos, additional, Lyssenko, Valeriya, additional, Nongmaithem, Suraj S., additional, Bayyana, Swati, additional, Stringham, Heather M., additional, Irvin, Marguerite R., additional, Oldmeadow, Christopher, additional, Kim, Han-Na, additional, Ryu, Seungho, additional, Timmers, Paul R. H. J., additional, Arbeeva, Liubov, additional, Dorajoo, Rajkumar, additional, Lange, Leslie A., additional, Prasad, Gauri, additional, Lorés-Motta, Laura, additional, Pauper, Marc, additional, Long, Jirong, additional, Li, Xiaohui, additional, Theusch, Elizabeth, additional, Takeuchi, Fumihiko, additional, Spracklen, Cassandra N., additional, Loukola, Anu, additional, Bollepalli, Sailalitha, additional, Warner, Sophie C., additional, Wang, Ya Xing, additional, Wei, Wen B., additional, Nutile, Teresa, additional, Ruggiero, Daniela, additional, Sung, Yun Ju, additional, Chen, Shufeng, additional, Liu, Fangchao, additional, Yang, Jingyun, additional, Kentistou, Katherine A., additional, Banas, Bernhard, additional, Nardone, Giuseppe Giovanni, additional, Meidtner, Karina, additional, Bielak, Lawrence F., additional, Smith, Jennifer A., additional, Hebbar, Prashantha, additional, Farmaki, Aliki-Eleni, additional, Hofer, Edith, additional, Lin, Maoxuan, additional, Concas, Maria Pina, additional, Vaccargiu, Simona, additional, van der Most, Peter J., additional, Pitkänen, Niina, additional, Cade, Brian E., additional, van der Laan, Sander W., additional, Chitrala, Kumaraswamy Naidu, additional, Weiss, Stefan, additional, Bentley, Amy R., additional, Doumatey, Ayo P., additional, Adeyemo, Adebowale A., additional, Lee, Jong Young, additional, Petersen, Eva R. B., additional, Nielsen, Aneta A., additional, Choi, Hyeok Sun, additional, Nethander, Maria, additional, Freitag-Wolf, Sandra, additional, Southam, Lorraine, additional, Rayner, Nigel W., additional, Wang, Carol A., additional, Lin, Shih-Yi, additional, Wang, Jun-Sing, additional, Couture, Christian, additional, Lyytikäinen, Leo-Pekka, additional, Nikus, Kjell, additional, Cuellar-Partida, Gabriel, additional, Vestergaard, Henrik, additional, Hidalgo, Bertha, additional, Giannakopoulou, Olga, additional, Cai, Qiuyin, additional, Obura, Morgan O., additional, van Setten, Jessica, additional, Li, Xiaoyin, additional, Liang, Jingjing, additional, Tang, Hua, additional, Terzikhan, Natalie, additional, Shin, Jae Hun, additional, Jackson, Rebecca D., additional, Reiner, Alexander P., additional, Martin, Lisa Warsinger, additional, Chen, Zhengming, additional, Li, Liming, additional, Kawaguchi, Takahisa, additional, Thiery, Joachim, additional, Bis, Joshua C., additional, Launer, Lenore J., additional, Li, Huaixing, additional, Nalls, Mike A., additional, Raitakari, Olli T., additional, Ichihara, Sahoko, additional, Wild, Sarah H., additional, Nelson, Christopher P., additional, Campbell, Harry, additional, Jäger, Susanne, additional, Nabika, Toru, additional, Al-Mulla, Fahd, additional, Niinikoski, Harri, additional, Braund, Peter S., additional, Kolcic, Ivana, additional, Kovacs, Peter, additional, Giardoglou, Tota, additional, Katsuya, Tomohiro, additional, de Kleijn, Dominique, additional, de Borst, Gert J., additional, Kim, Eung Kweon, additional, Adams, Hieab H. H., additional, Ikram, M. Arfan, additional, Zhu, Xiaofeng, additional, Asselbergs, Folkert W., additional, Kraaijeveld, Adriaan O., additional, Beulens, Joline W. J., additional, Shu, Xiao-Ou, additional, Rallidis, Loukianos S., additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Mitchell, Paul, additional, Hewitt, Alex W., additional, Kähönen, Mika, additional, Pérusse, Louis, additional, Bouchard, Claude, additional, Tönjes, Anke, additional, Chen, Yii-Der Ida, additional, Pennell, Craig E., additional, Mori, Trevor A., additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Ohlsson, Claes, additional, Mellström, Dan, additional, Cho, Yoon Shin, additional, Lee, Hyejin, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Rhee, Sang Youl, additional, Woo, Jeong-Taek, additional, Heid, Iris M., additional, Stark, Klaus J., additional, Zimmermann, Martina E., additional, Völzke, Henry, additional, Homuth, Georg, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, Polasek, Ozren, additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, Redline, Susan, additional, Pahkala, Katja, additional, Oldehinkel, Albertine J., additional, Snieder, Harold, additional, Biino, Ginevra, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Bandinelli, Stefania, additional, Dedoussis, George, additional, Thanaraj, Thangavel Alphonse, additional, Kardia, Sharon L. R., additional, Peyser, Patricia A., additional, Kato, Norihiro, additional, Schulze, Matthias B., additional, Girotto, Giorgia, additional, Böger, Carsten A., additional, Jung, Bettina, additional, Joshi, Peter K., additional, Bennett, David A., additional, De Jager, Philip L., additional, Lu, Xiangfeng, additional, Mamakou, Vasiliki, additional, Brown, Morris, additional, Caulfield, Mark J., additional, Munroe, Patricia B., additional, Guo, Xiuqing, additional, Ciullo, Marina, additional, Jonas, Jost B., additional, Samani, Nilesh J., additional, Kaprio, Jaakko, additional, Pajukanta, Päivi, additional, Tusié-Luna, Teresa, additional, Aguilar-Salinas, Carlos A., additional, Adair, Linda S., additional, Bechayda, Sonny Augustin, additional, de Silva, H. Janaka, additional, Wickremasinghe, Ananda R., additional, Krauss, Ronald M., additional, Wu, Jer-Yuarn, additional, Zheng, Wei, additional, Hollander, Anneke Iden, additional, Bharadwaj, Dwaipayan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Lind, Lars, additional, Heng, Chew-Kiat, additional, Nelson, Amanda E., additional, Golightly, Yvonne M., additional, Wilson, James F., additional, Penninx, Brenda, additional, Kim, Hyung-Lae, additional, Attia, John, additional, Scott, Rodney J., additional, Rao, D. C., additional, Arnett, Donna K., additional, Hunt, Steven C., additional, Walker, Mark, additional, Koistinen, Heikki A., additional, Chandak, Giriraj R., additional, Mercader, Josep M., additional, Costanzo, Maria C., additional, Jang, Dongkeun, additional, Burtt, Noël P., additional, Villalpando, Clicerio Gonzalez, additional, Orozco, Lorena, additional, Fornage, Myriam, additional, Tai, EShyong, additional, van Dam, Rob M., additional, Lehtimäki, Terho, additional, Chaturvedi, Nish, additional, Yokota, Mitsuhiro, additional, Liu, Jianjun, additional, Reilly, Dermot F., additional, McKnight, Amy Jayne, additional, Kee, Frank, additional, Jöckel, Karl-Heinz, additional, McCarthy, Mark I., additional, Palmer, Colin N. A., additional, Vitart, Veronique, additional, Hayward, Caroline, additional, Simonsick, Eleanor, additional, van Duijn, Cornelia M., additional, Jin, Zi-Bing, additional, Qu, Jia, additional, Hishigaki, Haretsugu, additional, Lin, Xu, additional, März, Winfried, additional, Gudnason, Vilmundur, additional, Tardif, Jean-Claude, additional, Lettre, Guillaume, additional, Hart, Leen M.‘t, additional, Elders, Petra J. M., additional, Damrauer, Scott M., additional, Kumari, Meena, additional, Kivimaki, Mika, additional, van der Harst, Pim, additional, Spector, Tim D., additional, Loos, Ruth J. F., additional, Province, Michael A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Psaty, Bruce M., additional, Brandslund, Ivan, additional, Pramstaller, Peter P., additional, Rotimi, Charles N., additional, Christensen, Kaare, additional, Ripatti, Samuli, additional, Widén, Elisabeth, additional, Hakonarson, Hakon, additional, Grant, Struan F. A., additional, Kiemeney, Lambertus A. L. M., additional, de Graaf, Jacqueline, additional, Loeffler, Markus, additional, Kronenberg, Florian, additional, Gu, Dongfeng, additional, Erdmann, Jeanette, additional, Schunkert, Heribert, additional, Franks, Paul W., additional, Linneberg, Allan, additional, Jukema, J. Wouter, additional, Khera, Amit V., additional, Männikkö, Minna, additional, Jarvelin, Marjo-Riitta, additional, Kutalik, Zoltan, additional, Francesco, Cucca, additional, Mook-Kanamori, Dennis O., additional, van Dijk, Ko Willems, additional, Watkins, Hugh, additional, Strachan, David P., additional, Grarup, Niels, additional, Sever, Peter, additional, Poulter, Neil, additional, Chuang, Lee-Ming, additional, Rotter, Jerome I., additional, Dantoft, Thomas M., additional, Karpe, Fredrik, additional, Neville, Matt J., additional, Timpson, Nicholas J., additional, Cheng, Ching-Yu, additional, Wong, Tien-Yin, additional, Khor, Chiea Chuen, additional, Li, Hengtong, additional, Sabanayagam, Charumathi, additional, Peters, Annette, additional, Gieger, Christian, additional, Hattersley, Andrew T., additional, Pedersen, Nancy L., additional, Magnusson, Patrik K. E., additional, Boomsma, Dorret I., additional, Willemsen, Allegonda H. M., additional, Cupples, LAdrienne, additional, van Meurs, Joyce B. J., additional, Ghanbari, Mohsen, additional, Gordon-Larsen, Penny, additional, Huang, Wei, additional, Kim, Young Jin, additional, Tabara, Yasuharu, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Zeggini, Eleftheria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Ingelsson, Erik, additional, Abecasis, Goncalo, additional, Chambers, John C., additional, Kooner, Jaspal S., additional, de Vries, Paul S., additional, Morrison, Alanna C., additional, Hazelhurst, Scott, additional, Ramsay, Michèle, additional, North, Kari E., additional, Daviglus, Martha, additional, Kraft, Peter, additional, Martin, Nicholas G., additional, Whitfield, John B., additional, Abbas, Shahid, additional, Saleheen, Danish, additional, Walters, Robin G., additional, Holmes, Michael V., additional, Black, Corri, additional, Smith, Blair H., additional, Baras, Aris, additional, Justice, Anne E., additional, Buring, Julie E., additional, Ridker, Paul M., additional, Chasman, Daniel I., additional, Kooperberg, Charles, additional, Tamiya, Gen, additional, Yamamoto, Masayuki, additional, van Heel, David A., additional, Trembath, Richard C., additional, Wei, Wei-Qi, additional, Jarvik, Gail P., additional, Namjou, Bahram, additional, Hayes, M. Geoffrey, additional, Ritchie, Marylyn D., additional, Jousilahti, Pekka, additional, Salomaa, Veikko, additional, Hveem, Kristian, additional, Åsvold, Bjørn Olav, additional, Kubo, Michiaki, additional, Kamatani, Yoichiro, additional, Okada, Yukinori, additional, Murakami, Yoshinori, additional, Kim, Bong-Jo, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Zhang, Jifeng, additional, Chen, YEugene, additional, Ho, Yuk-Lam, additional, Lynch, Julie A., additional, Rader, Daniel J., additional, Tsao, Philip S., additional, Chang, Kyong-Mi, additional, Cho, Kelly, additional, O’Donnell, Christopher J., additional, Gaziano, John M., additional, Wilson, Peter W. F., additional, Frayling, Timothy M., additional, Hirschhorn, Joel N., additional, Kathiresan, Sekar, additional, Mohlke, Karen L., additional, Sun, Yan V., additional, Morris, Andrew P., additional, Boehnke, Michael, additional, Brown, Christopher D., additional, Natarajan, Pradeep, additional, Deloukas, Panos, additional, Willer, Cristen J., additional, Assimes, Themistocles L., additional, and Peloso, Gina M., additional

Published
2022
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12. Genetic and modifiable risk factors combine multiplicatively in common disease

Author

Pang, Shichao, primary, Yengo, Loic, additional, Nelson, Christopher P., additional, Bourier, Felix, additional, Zeng, Lingyao, additional, Li, Ling, additional, Kessler, Thorsten, additional, Erdmann, Jeanette, additional, Mägi, Reedik, additional, Läll, Kristi, additional, Metspalu, Andres, additional, Mueller-Myhsok, Bertram, additional, Samani, Nilesh J., additional, Visscher, Peter M., additional, and Schunkert, Heribert, additional

Published
2022
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13. Author Correction: Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length

Author

Dempsey, Paddy C., primary, Musicha, Crispin, additional, Rowlands, Alex V., additional, Davies, Melanie, additional, Khunti, Kamlesh, additional, Razieh, Cameron, additional, Timmins, Iain, additional, Zaccardi, Francesco, additional, Codd, Veryan, additional, Nelson, Christopher P., additional, Yates, Tom, additional, and Samani, Nilesh J., additional

Published
2022
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14. Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length

Author

Dempsey, Paddy C., primary, Musicha, Crispin, additional, Rowlands, Alex V., additional, Davies, Melanie, additional, Khunti, Kamlesh, additional, Razieh, Cameron, additional, Timmins, Iain, additional, Zaccardi, Francesco, additional, Codd, Veryan, additional, Nelson, Christopher P., additional, Yates, Tom, additional, and Samani, Nilesh J., additional

Published
2022
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15. A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response

Author

Hilsabeck, Tyler A. U., primary, Liu-Bryan, Ru, additional, Guo, Tracy, additional, Wilson, Kenneth A., additional, Bose, Neelanjan, additional, Raftery, Daniel, additional, Beck, Jennifer N., additional, Lang, Sven, additional, Jin, Kelly, additional, Nelson, Christopher S., additional, Oron, Tal, additional, Stoller, Marshall, additional, Promislow, Daniel, additional, Brem, Rachel B., additional, Terkeltaub, Robert, additional, and Kapahi, Pankaj, additional

Published
2022
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17. Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Author

Hakim, Chady H., primary, Kumar, Sandeep R. P., additional, Pérez-López, Dennis O., additional, Wasala, Nalinda B., additional, Zhang, Dong, additional, Yue, Yongping, additional, Teixeira, James, additional, Pan, Xiufang, additional, Zhang, Keqing, additional, Million, Emily D., additional, Nelson, Christopher E., additional, Metzger, Samantha, additional, Han, Jin, additional, Louderman, Jacqueline A., additional, Schmidt, Florian, additional, Feng, Feng, additional, Grimm, Dirk, additional, Smith, Bruce F., additional, Yao, Gang, additional, Yang, N. Nora, additional, Gersbach, Charles A., additional, Chen, Shi-jie, additional, Herzog, Roland W., additional, and Duan, Dongsheng, additional

Published
2021
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19. Polygenic basis and biomedical consequences of telomere length variation

Author

Codd, Veryan, primary, Wang, Qingning, additional, Allara, Elias, additional, Musicha, Crispin, additional, Kaptoge, Stephen, additional, Stoma, Svetlana, additional, Jiang, Tao, additional, Hamby, Stephen E., additional, Braund, Peter S., additional, Bountziouka, Vasiliki, additional, Budgeon, Charley A., additional, Denniff, Matthew, additional, Swinfield, Chloe, additional, Papakonstantinou, Manolo, additional, Sheth, Shilpi, additional, Nanus, Dominika E., additional, Warner, Sophie C., additional, Wang, Minxian, additional, Khera, Amit V., additional, Eales, James, additional, Ouwehand, Willem H., additional, Thompson, John R., additional, Di Angelantonio, Emanuele, additional, Wood, Angela M., additional, Butterworth, Adam S., additional, Danesh, John N., additional, Nelson, Christopher P., additional, and Samani, Nilesh J., additional

Published
2021
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22. Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival

Author

Timmins, Iain R, Zaccardi, Francesco, Nelson, Christopher P, Franks, Paul W, Yates, Thomas, and Dudbridge, Frank

Abstract

Walking is a simple form of exercise, widely promoted for its health benefits. Self-reported walking pace has been associated with a range of cardiorespiratory and cancer outcomes, and is a strong predictor of mortality. Here we perform a genome-wide association study of self-reported walking pace in 450,967 European ancestry UK Biobank participants. We identify 70 independent associated loci (P

Published
2020

24. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus

Author

Ma, Hongming, primary, Kim, Arthur S., additional, Kafai, Natasha M., additional, Earnest, James T., additional, Shah, Aadit P., additional, Case, James Brett, additional, Basore, Katherine, additional, Gilliland, Theron C., additional, Sun, Chengqun, additional, Nelson, Christopher A., additional, Thackray, Larissa B., additional, Klimstra, William B., additional, Fremont, Daved H., additional, and Diamond, Michael S., additional

Published
2020
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26. Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila

Author

Sharma, Amit, primary, Akagi, Kazutaka, additional, Pattavina, Blaine, additional, Wilson, Kenneth A., additional, Nelson, Christopher, additional, Watson, Mark, additional, Maksoud, Elie, additional, Harata, Ayano, additional, Ortega, Mauricio, additional, Brem, Rachel B., additional, and Kapahi, Pankaj, additional

Published
2020
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27. Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy

Author

Wessel, Alex W., primary, Kose, Nurgun, additional, Bombardi, Robin G., additional, Roy, Vicky, additional, Chantima, Warangkana, additional, Mongkolsapaya, Juthathip, additional, Edeling, Melissa A., additional, Nelson, Christopher A., additional, Bosch, Irene, additional, Alter, Galit, additional, Screaton, Gavin R., additional, Fremont, David H., additional, Crowe, James E., additional, and Diamond, Michael S., additional

Published
2020
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29. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Author

Ntalla, Ioanna, primary, Weng, Lu-Chen, additional, Cartwright, James H., additional, Hall, Amelia Weber, additional, Sveinbjornsson, Gardar, additional, Tucker, Nathan R., additional, Choi, Seung Hoan, additional, Chaffin, Mark D., additional, Roselli, Carolina, additional, Barnes, Michael R., additional, Mifsud, Borbala, additional, Warren, Helen R., additional, Hayward, Caroline, additional, Marten, Jonathan, additional, Cranley, James J., additional, Concas, Maria Pina, additional, Gasparini, Paolo, additional, Boutin, Thibaud, additional, Kolcic, Ivana, additional, Polasek, Ozren, additional, Rudan, Igor, additional, Araujo, Nathalia M., additional, Lima-Costa, Maria Fernanda, additional, Ribeiro, Antonio Luiz P., additional, Souza, Renan P., additional, Tarazona-Santos, Eduardo, additional, Giedraitis, Vilmantas, additional, Ingelsson, Erik, additional, Mahajan, Anubha, additional, Morris, Andrew P., additional, Del Greco M, Fabiola, additional, Foco, Luisa, additional, Gögele, Martin, additional, Hicks, Andrew A., additional, Cook, James P., additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Sundström, Johan, additional, Nelson, Christopher P., additional, Riaz, Muhammad B., additional, Samani, Nilesh J., additional, Sinagra, Gianfranco, additional, Ulivi, Sheila, additional, Kähönen, Mika, additional, Mishra, Pashupati P., additional, Mononen, Nina, additional, Nikus, Kjell, additional, Caulfield, Mark J., additional, Dominiczak, Anna, additional, Padmanabhan, Sandosh, additional, Montasser, May E., additional, O’Connell, Jeff R., additional, Ryan, Kathleen, additional, Shuldiner, Alan R., additional, Aeschbacher, Stefanie, additional, Conen, David, additional, Risch, Lorenz, additional, Thériault, Sébastien, additional, Hutri-Kähönen, Nina, additional, Lehtimäki, Terho, additional, Lyytikäinen, Leo-Pekka, additional, Raitakari, Olli T., additional, Barnes, Catriona L. K., additional, Campbell, Harry, additional, Joshi, Peter K., additional, Wilson, James F., additional, Isaacs, Aaron, additional, Kors, Jan A., additional, van Duijn, Cornelia M., additional, Huang, Paul L., additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Launer, Lenore J., additional, Smith, Albert V., additional, Bottinger, Erwin P., additional, Loos, Ruth J. F., additional, Nadkarni, Girish N., additional, Preuss, Michael H., additional, Correa, Adolfo, additional, Mei, Hao, additional, Wilson, James, additional, Meitinger, Thomas, additional, Müller-Nurasyid, Martina, additional, Peters, Annette, additional, Waldenberger, Melanie, additional, Mangino, Massimo, additional, Spector, Timothy D., additional, Rienstra, Michiel, additional, van de Vegte, Yordi J., additional, van der Harst, Pim, additional, Verweij, Niek, additional, Kääb, Stefan, additional, Schramm, Katharina, additional, Sinner, Moritz F., additional, Strauch, Konstantin, additional, Cutler, Michael J., additional, Fatkin, Diane, additional, London, Barry, additional, Olesen, Morten, additional, Roden, Dan M., additional, Benjamin Shoemaker, M., additional, Gustav Smith, J., additional, Biggs, Mary L., additional, Bis, Joshua C., additional, Brody, Jennifer A., additional, Psaty, Bruce M., additional, Rice, Kenneth, additional, Sotoodehnia, Nona, additional, De Grandi, Alessandro, additional, Fuchsberger, Christian, additional, Pattaro, Cristian, additional, Pramstaller, Peter P., additional, Ford, Ian, additional, Wouter Jukema, J., additional, Macfarlane, Peter W., additional, Trompet, Stella, additional, Dörr, Marcus, additional, Felix, Stephan B., additional, Völker, Uwe, additional, Weiss, Stefan, additional, Havulinna, Aki S., additional, Jula, Antti, additional, Sääksjärvi, Katri, additional, Salomaa, Veikko, additional, Guo, Xiuqing, additional, Heckbert, Susan R., additional, Lin, Henry J., additional, Rotter, Jerome I., additional, Taylor, Kent D., additional, Yao, Jie, additional, de Mutsert, Renée, additional, Maan, Arie C., additional, Mook-Kanamori, Dennis O., additional, Noordam, Raymond, additional, Cucca, Francesco, additional, Ding, Jun, additional, Lakatta, Edward G., additional, Qian, Yong, additional, Tarasov, Kirill V., additional, Levy, Daniel, additional, Lin, Honghuang, additional, Newton-Cheh, Christopher H., additional, Lunetta, Kathryn L., additional, Murray, Alison D., additional, Porteous, David J., additional, Smith, Blair H., additional, Stricker, Bruno H., additional, Uitterlinden, André, additional, van den Berg, Marten E., additional, Haessler, Jeffrey, additional, Jackson, Rebecca D., additional, Kooperberg, Charles, additional, Peters, Ulrike, additional, Reiner, Alexander P., additional, Whitsel, Eric A., additional, Alonso, Alvaro, additional, Arking, Dan E., additional, Boerwinkle, Eric, additional, Ehret, Georg B., additional, Soliman, Elsayed Z., additional, Avery, Christy L., additional, Gogarten, Stephanie M., additional, Kerr, Kathleen F., additional, Laurie, Cathy C., additional, Seyerle, Amanda A., additional, Stilp, Adrienne, additional, Assa, Solmaz, additional, Abdullah Said, M., additional, Yldau van der Ende, M., additional, Lambiase, Pier D., additional, Orini, Michele, additional, Ramirez, Julia, additional, Van Duijvenboden, Stefan, additional, Arnar, David O., additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Sulem, Patrick, additional, Thorleifsson, Gudmar, additional, Thorolfsdottir, Rosa B., additional, Thorsteinsdottir, Unnur, additional, Benjamin, Emelia J., additional, Tinker, Andrew, additional, Stefansson, Kari, additional, Ellinor, Patrick T., additional, Jamshidi, Yalda, additional, Lubitz, Steven A., additional, and Munroe, Patricia B., additional

Published
2020
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31. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Author

Wain, Louise V, Verwoert, Germaine C, O'Reilly, Paul F, Shi, Gang, Johnson, Toby, Johnson, Andrew D, Bochud, Murielle, Rice, Kenneth M, Henneman, Peter, Smith, Albert V, Ehret, Georg B, Amin, Najaf, Larson, Martin G, Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile JW, Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'an, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U, Webster, Rebecca J, Zhang, Feng, Peden, John F, Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I, Trompet, Stella, Bragg-Gresham, Jennifer L, Alizadeh, Behrooz Z, Chambers, John C, Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M, Polašek, Ozren, Boban, Mladen, Nelson, Christopher P, Morrison, Alanna C, Pihur, Vasyl, Ganesh, Santhi K, Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco US, Rivadeneira, Fernando, Sijbrands, Eric JG, Uitterlinden, Andre G, Hwang, Shih-Jen, Vasan, Ramachandran S, Wang, Thomas J, Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L, Kroemer, Heyo K, Völker, Uwe, Völzke, Henry, Glazer, Nicole L, Taylor, Kent D, Harris, Tamara B, Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, Inês, Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M, Penninx, Brenda W, Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco, Fabiola M, Facheris, Maurizio, Collins, Francis S, Bergman, Richard N, Beilby, John P, Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S, Navarro, Pau, Wild, Sarah H, Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco JC, Willemsen, Gonneke, Parker, Alex N, Rose, Lynda M, Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, LifeLines Cohort Study, Van Der Klauw, Melanie M, Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M, Emilsson, Valur, Plump, Andrew, Lindeman, Jan H, Hoen, Peter AC 'T, König, Inke R, EchoGen Consortium, Felix, Janine F, Clarke, Robert, Hopewell, Jemma C, Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L, Fornage, Myriam, AortaGen Consortium, Mitchell, Gary F, CHARGE Consortium Heart Failure Working Group, Smith, Nicholas L, KidneyGen Consortium, Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, CKDGen Consortium, Cardiogenics Consortium, CardioGram, Samani, Nilesh J, Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J, Wichmann, H-Erich, Raitakari, Olli T, Palmas, Walter, Kooner, Jaspal S, Stolk, Ronald P, Jukema, J Wouter, Wright, Alan F, Boomsma, Dorret I, Bandinelli, Stefania, Gyllensten, Ulf B, Wilson, James F, Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D, Palmer, Lyle J, Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth JF, Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J, Oostra, Ben A, Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P, Beckmann, Jacques S, Witteman, Jacqueline CM, Erdmann, Jeanette, Van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M, Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R, Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B, Psaty, Bruce M, Caulfield, Mark J, Rao, Dabeeru C, Tobin, Martin D, Elliott, Paul, and Van Duijn, Cornelia M

Subjects
Genetic Loci, Case-Control Studies, Hypertension, Humans, Blood Pressure, cardiovascular diseases, Arteries, Polymorphism, Single Nucleotide, Linkage Disequilibrium, circulatory and respiratory physiology, Follow-Up Studies, Genome-Wide Association Study
Abstract

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

Published
2018
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34. Targeted transcriptional modulation with type I CRISPR–Cas systems in human cells

Author

Pickar-Oliver, Adrian, primary, Black, Joshua B., additional, Lewis, Mae M., additional, Mutchnick, Kevin J., additional, Klann, Tyler S., additional, Gilcrest, Kylie A., additional, Sitton, Madeleine J., additional, Nelson, Christopher E., additional, Barrera, Alejandro, additional, Bartelt, Luke C., additional, Reddy, Timothy E., additional, Beisel, Chase L., additional, Barrangou, Rodolphe, additional, and Gersbach, Charles A., additional

Published
2019
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35. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Author

Evangelou, Evangelos, primary, Gao, He, additional, Chu, Congying, additional, Ntritsos, Georgios, additional, Blakeley, Paul, additional, Butts, Andrew R., additional, Pazoki, Raha, additional, Suzuki, Hideaki, additional, Koskeridis, Fotios, additional, Yiorkas, Andrianos M., additional, Karaman, Ibrahim, additional, Elliott, Joshua, additional, Luo, Qiang, additional, Aeschbacher, Stefanie, additional, Bartz, Traci M., additional, Baumeister, Sebastian E., additional, Braund, Peter S., additional, Brown, Michael R., additional, Brody, Jennifer A., additional, Clarke, Toni-Kim, additional, Dimou, Niki, additional, Faul, Jessica D., additional, Homuth, Georg, additional, Jackson, Anne U., additional, Kentistou, Katherine A., additional, Joshi, Peter K., additional, Lemaitre, Rozenn N., additional, Lind, Penelope A., additional, Lyytikäinen, Leo-Pekka, additional, Mangino, Massimo, additional, Milaneschi, Yuri, additional, Nelson, Christopher P., additional, Nolte, Ilja M., additional, Perälä, Mia-Maria, additional, Polasek, Ozren, additional, Porteous, David, additional, Ratliff, Scott M., additional, Smith, Jennifer A., additional, Stančáková, Alena, additional, Teumer, Alexander, additional, Tuominen, Samuli, additional, Thériault, Sébastien, additional, Vangipurapu, Jagadish, additional, Whitfield, John B., additional, Wood, Alexis, additional, Yao, Jie, additional, Yu, Bing, additional, Zhao, Wei, additional, Arking, Dan E., additional, Auvinen, Juha, additional, Liu, Chunyu, additional, Männikkö, Minna, additional, Risch, Lorenz, additional, Rotter, Jerome I., additional, Snieder, Harold, additional, Veijola, Juha, additional, Blakemore, Alexandra I., additional, Boehnke, Michael, additional, Campbell, Harry, additional, Conen, David, additional, Eriksson, Johan G., additional, Grabe, Hans J., additional, Guo, Xiuqing, additional, van der Harst, Pim, additional, Hartman, Catharina A., additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Jarvelin, Marjo-Riitta, additional, Kähönen, Mika, additional, Kardia, Sharon L. R., additional, Kühne, Michael, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lahti, Jari, additional, Lehtimäki, Terho, additional, McIntosh, Andrew M., additional, Mohlke, Karen L., additional, Morrison, Alanna C., additional, Martin, Nicholas G., additional, Oldehinkel, Albertine J., additional, Penninx, Brenda W. J. H., additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Rudan, Igor, additional, Samani, Nilesh J., additional, Scott, Laura J., additional, Spector, Tim D., additional, Verweij, Niek, additional, Weir, David R., additional, Wilson, James F., additional, Levy, Daniel, additional, Tzoulaki, Ioanna, additional, Bell, Jimmy D., additional, Matthews, Paul M., additional, Rothenfluh, Adrian, additional, Desrivières, Sylvane, additional, Schumann, Gunter, additional, and Elliott, Paul, additional

Published
2019
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37. Author Correction: Spatially resolved steady-state negative capacitance

Author

Yadav, Ajay K., primary, Nguyen, Kayla X., additional, Hong, Zijian, additional, García-Fernández, Pablo, additional, Aguado-Puente, Pablo, additional, Nelson, Christopher T., additional, Das, Sujit, additional, Prasad, Bhagwati, additional, Kwon, Daewoong, additional, Cheema, Suraj, additional, Khan, Asif I., additional, Hu, Chenming, additional, Íñiguez, Jorge, additional, Junquera, Javier, additional, Chen, Long-Qing, additional, Muller, David A., additional, Ramesh, Ramamoorthy, additional, and Salahuddin, Sayeef, additional

Published
2019
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39. Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy

Author

Nelson, Christopher E., primary, Wu, Yaoying, additional, Gemberling, Matthew P., additional, Oliver, Matthew L., additional, Waller, Matthew A., additional, Bohning, Joel D., additional, Robinson-Hamm, Jacqueline N., additional, Bulaklak, Karen, additional, Castellanos Rivera, Ruth M., additional, Collier, Joel H., additional, Asokan, Aravind, additional, and Gersbach, Charles A., additional

Published
2019
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40. Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

Author

van Setten, Jessica, primary, Verweij, Niek, additional, Mbarek, Hamdi, additional, Niemeijer, Maartje N., additional, Trompet, Stella, additional, Arking, Dan E., additional, Brody, Jennifer A., additional, Gandin, Ilaria, additional, Grarup, Niels, additional, Hall, Leanne M., additional, Hemerich, Daiane, additional, Lyytikäinen, Leo-Pekka, additional, Mei, Hao, additional, Müller-Nurasyid, Martina, additional, Prins, Bram P., additional, Robino, Antonietta, additional, Smith, Albert V., additional, Warren, Helen R., additional, Asselbergs, Folkert W., additional, Boomsma, Dorret I., additional, Caulfield, Mark J., additional, Eijgelsheim, Mark, additional, Ford, Ian, additional, Hansen, Torben, additional, Harris, Tamara B., additional, Heckbert, Susan R., additional, Hottenga, Jouke-Jan, additional, Iorio, Annamaria, additional, Kors, Jan A., additional, Linneberg, Allan, additional, MacFarlane, Peter W., additional, Meitinger, Thomas, additional, Nelson, Christopher P., additional, Raitakari, Olli T., additional, Silva Aldana, Claudia T., additional, Sinagra, Gianfranco, additional, Sinner, Moritz, additional, Soliman, Elsayed Z., additional, Stoll, Monika, additional, Uitterlinden, Andre, additional, van Duijn, Cornelia M., additional, Waldenberger, Melanie, additional, Alonso, Alvaro, additional, Gasparini, Paolo, additional, Gudnason, Vilmundur, additional, Jamshidi, Yalda, additional, Kääb, Stefan, additional, Kanters, Jørgen K., additional, Lehtimäki, Terho, additional, Munroe, Patricia B., additional, Peters, Annette, additional, Samani, Nilesh J., additional, Sotoodehnia, Nona, additional, Ulivi, Sheila, additional, Wilson, James G., additional, de Geus, Eco J. C., additional, Jukema, J. Wouter, additional, Stricker, Bruno, additional, van der Harst, Pim, additional, de Bakker, Paul I. W., additional, and Isaacs, Aaron, additional

Published
2019
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41. Spatially resolved steady-state negative capacitance

Author

Yadav, Ajay K., primary, Nguyen, Kayla X., additional, Hong, Zijian, additional, García-Fernández, Pablo, additional, Aguado-Puente, Pablo, additional, Nelson, Christopher T., additional, Das, Sujit, additional, Prasad, Bhagwati, additional, Kwon, Daewoong, additional, Cheema, Suraj, additional, Khan, Asif I., additional, Hu, Chenming, additional, Íñiguez, Jorge, additional, Junquera, Javier, additional, Chen, Long-Qing, additional, Muller, David A., additional, Ramesh, Ramamoorthy, additional, and Salahuddin, Sayeef, additional

Published
2019
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44. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Author

Prins, Bram P., primary, Mead, Timothy J., additional, Brody, Jennifer A., additional, Sveinbjornsson, Gardar, additional, Ntalla, Ioanna, additional, Bihlmeyer, Nathan A., additional, van den Berg, Marten, additional, Bork-Jensen, Jette, additional, Cappellani, Stefania, additional, Van Duijvenboden, Stefan, additional, Klena, Nikolai T., additional, Gabriel, George C., additional, Liu, Xiaoqin, additional, Gulec, Cagri, additional, Grarup, Niels, additional, Haessler, Jeffrey, additional, Hall, Leanne M., additional, Iorio, Annamaria, additional, Isaacs, Aaron, additional, Li-Gao, Ruifang, additional, Lin, Honghuang, additional, Liu, Ching-Ti, additional, Lyytikäinen, Leo-Pekka, additional, Marten, Jonathan, additional, Mei, Hao, additional, Müller-Nurasyid, Martina, additional, Orini, Michele, additional, Padmanabhan, Sandosh, additional, Radmanesh, Farid, additional, Ramirez, Julia, additional, Robino, Antonietta, additional, Schwartz, Molly, additional, van Setten, Jessica, additional, Smith, Albert V., additional, Verweij, Niek, additional, Warren, Helen R., additional, Weiss, Stefan, additional, Alonso, Alvaro, additional, Arnar, David O., additional, Bots, Michiel L., additional, de Boer, Rudolf A., additional, Dominiczak, Anna F., additional, Eijgelsheim, Mark, additional, Ellinor, Patrick T., additional, Guo, Xiuqing, additional, Felix, Stephan B., additional, Harris, Tamara B., additional, Hayward, Caroline, additional, Heckbert, Susan R., additional, Huang, Paul L., additional, Jukema, J. W., additional, Kähönen, Mika, additional, Kors, Jan A., additional, Lambiase, Pier D., additional, Launer, Lenore J., additional, Li, Man, additional, Linneberg, Allan, additional, Nelson, Christopher P., additional, Pedersen, Oluf, additional, Perez, Marco, additional, Peters, Annette, additional, Polasek, Ozren, additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Rice, Kenneth M., additional, Rotter, Jerome I., additional, Sinner, Moritz F., additional, Soliman, Elsayed Z., additional, Spector, Tim D., additional, Strauch, Konstantin, additional, Thorsteinsdottir, Unnur, additional, Tinker, Andrew, additional, Trompet, Stella, additional, Uitterlinden, André, additional, Vaartjes, Ilonca, additional, van der Meer, Peter, additional, Völker, Uwe, additional, Völzke, Henry, additional, Waldenberger, Melanie, additional, Wilson, James G., additional, Xie, Zhijun, additional, Asselbergs, Folkert W., additional, Dörr, Marcus, additional, van Duijn, Cornelia M., additional, Gasparini, Paolo, additional, Gudbjartsson, Daniel F., additional, Gudnason, Vilmundur, additional, Hansen, Torben, additional, Kääb, Stefan, additional, Kanters, Jørgen K., additional, Kooperberg, Charles, additional, Lehtimäki, Terho, additional, Lin, Henry J., additional, Lubitz, Steven A., additional, Mook-Kanamori, Dennis O., additional, Conti, Francesco J., additional, Newton-Cheh, Christopher H., additional, Rosand, Jonathan, additional, Rudan, Igor, additional, Samani, Nilesh J., additional, Sinagra, Gianfranco, additional, Smith, Blair H., additional, Holm, Hilma, additional, Stricker, Bruno H., additional, Ulivi, Sheila, additional, Sotoodehnia, Nona, additional, Apte, Suneel S., additional, van der Harst, Pim, additional, Stefansson, Kari, additional, Munroe, Patricia B., additional, Arking, Dan E., additional, Lo, Cecilia W., additional, and Jamshidi, Yalda, additional

Published
2018
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47. Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma

Author

Huang, Jianguo, primary, Chen, Mark, additional, Whitley, Melodi Javid, additional, Kuo, Hsuan-Cheng, additional, Xu, Eric S., additional, Walens, Andrea, additional, Mowery, Yvonne M., additional, Van Mater, David, additional, Eward, William C., additional, Cardona, Diana M., additional, Luo, Lixia, additional, Ma, Yan, additional, Lopez, Omar M., additional, Nelson, Christopher E., additional, Robinson-Hamm, Jacqueline N., additional, Reddy, Anupama, additional, Dave, Sandeep S., additional, Gersbach, Charles A., additional, Dodd, Rebecca D., additional, and Kirsch, David G., additional

Published
2017
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48. Basic surface features of nuclear FKBPs facilitate chromatin binding

Author

Leung, Andrew, primary, Jardim, Francy-Pesek, additional, Savic, Neda, additional, Monneau, Yoan R., additional, González-Romero, Rodrigo, additional, Gudavicius, Geoff, additional, Eirin-Lopez, Jose M., additional, Bartke, Till, additional, Mackereth, Cameron D., additional, Ausió, Juan, additional, and Nelson, Christopher J., additional

Published
2017
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49. Tunable and low-loss correlated plasmons in Mott-like insulating oxides

Author

Asmara, Teguh Citra, primary, Wan, Dongyang, additional, Zhao, Yongliang, additional, Majidi, Muhammad Aziz, additional, Nelson, Christopher T., additional, Scott, Mary C., additional, Cai, Yao, additional, Yan, Bixing, additional, Schmidt, Daniel, additional, Yang, Ming, additional, Zhu, Tao, additional, Trevisanutto, Paolo E., additional, Motapothula, Mallikarjuna R., additional, Feng, Yuan Ping, additional, Breese, Mark B. H., additional, Sherburne, Matthew, additional, Asta, Mark, additional, Minor, Andrew, additional, Venkatesan, T., additional, and Rusydi, Andrivo, additional

Published
2017
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50. Large polarization gradients and temperature-stable responses in compositionally-graded ferroelectrics

Author

Damodaran, Anoop R., primary, Pandya, Shishir, additional, Qi, Yubo, additional, Hsu, Shang-Lin, additional, Liu, Shi, additional, Nelson, Christopher, additional, Dasgupta, Arvind, additional, Ercius, Peter, additional, Ophus, Colin, additional, Dedon, Liv R., additional, Agar, Josh C., additional, Lu, Hongling, additional, Zhang, Jialan, additional, Minor, Andrew M., additional, Rappe, Andrew M., additional, and Martin, Lane W., additional

Published
2017
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