1. Silver nanoparticles effect on drug release of metronidazole in natural rubber latex dressing
- Author
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Matheus Carlos Romeiro Miranda, Nicola Carlucci Sato, Giovana Sant’Ana Pegorin Brasil, Rodolfo Debone Piazza, Miguel Jafelicci, Natan Roberto de Barros, Felipe Azevedo Borges, Augusto Batagin-Neto, William de Melo Silva, Rondinelli Donizetti Herculano, Nayrim Brizuela Guerra, Universidade Estadual Paulista (UNESP), Aveiro of University, Terasaki Institute for Biomedical Innovation (TIBI), and University of Caxias Do Sul (UCS)
- Subjects
Biomaterials ,Polymers and Plastics ,Metronidazole ,Materials Chemistry ,Controlled release ,Natural rubber latex ,General Chemistry ,Silver nanoparticles ,Condensed Matter Physics - Abstract
Made available in DSpace on 2022-04-29T08:36:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Natural rubber latex (NRL) from Hevea brasiliensis has shown great potential for dermal applications due to its angiogenesis capacity and biocompatibility. Metronidazole (MET) is a synthetic antibiotic used to treat various infections. However, this drug reports dangerous effects when high concentrations are administered. In this study, we used silver nanoparticles (AgNPs) in order to minimize these toxicological effects. For this, the membranes were characterized by physicochemical, molecular modeling, in vitro release and hemocompatibility assays. In the release assays, 14.25% of the MET and 27.28% of the AgNP + MET complex were released simultaneously, indicating that these nanoparticles work as drug carriers. Molecular modeling simulation helped to explain the in vitro release results, showing that AgNPs can interact more efficiently with MET molecules. Moreover, similarities in reactivity between NRL and MET suggested that some drug molecules may remain in the matrix during the release process. The membranes did not present significant hemolytic activity after 24 h of incubation. These results demonstrated that the NRL + AgNP + MET membrane can be used as a dressing in the treatment of infectious processes. School of Pharmaceutical Sciences São Paulo State University (UNESP) Institute of Chemistry São Paulo State University (UNESP) Centre for Environmental and Marine Studies (CESAM) Aveiro of University School of Sciences Humanities and Languages São Paulo State University (UNESP) Terasaki Institute for Biomedical Innovation (TIBI) São Paulo State University (UNESP), Campus of Itapeva Institute of Biotechnology São Paulo State University (UNESP) Area of Exact Sciences and Engineering University of Caxias Do Sul (UCS) School of Pharmaceutical Sciences São Paulo State University (UNESP) Institute of Chemistry São Paulo State University (UNESP) School of Sciences Humanities and Languages São Paulo State University (UNESP) São Paulo State University (UNESP), Campus of Itapeva Institute of Biotechnology São Paulo State University (UNESP)
- Published
- 2021