1. Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research
- Author
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Caj Haglund, Elisa Lappi-Blanco, Tiina Vesterinen, Teijo Kuopio, Harri Mustonen, Kaisa Salmenkivi, Olli Carpén, Paula Vainio, Timo Paavonen, Aija Knuuttila, Johanna Arola, HUSLAB, Institute for Molecular Medicine Finland, Department of Pathology, University of Helsinki, Helsinki Institute of Life Science HiLIFE, HUS Abdominal Center, Clinicum, Department of Surgery, Department of Medicine, Keuhkosairauksien yksikkö, HUS Heart and Lung Center, Precision Cancer Pathology, Olli Mikael Carpen / Principal Investigator, Medicum, Research Program in Systems Oncology, Research Programs Unit, II kirurgian klinikka, CAN-PRO - Translational Cancer Medicine Program, and Faculty of Medicine
- Subjects
Male ,0301 basic medicine ,Lung Neoplasms ,Proliferation index ,biopankit ,Disease ,Neuroendocrine tumors ,keuhkosyöpä ,Pulmonary carcinoid ,Tumour tissue ,0302 clinical medicine ,RARE ,Registries ,INDEX ,Finland ,Biological Specimen Banks ,OUTCOMES ,rare cancer ,SURGICAL RESECTION ,General Medicine ,Middle Aged ,Prognosis ,Biobank ,3. Good health ,biobank ,030220 oncology & carcinogenesis ,Mediastinal lymph node ,SURVIVAL ,Original Article ,Female ,BURDEN ,pulmonary carcinoid ,Adult ,medicine.medical_specialty ,3122 Cancers ,Carcinoid Tumor ,Pathology and Forensic Medicine ,03 medical and health sciences ,Internal medicine ,medicine ,QUALITY ,Humans ,harvinaiset taudit ,Molecular Biology ,business.industry ,Rare cancer ,ennusteet ,Cell Biology ,medicine.disease ,Carcinoma, Neuroendocrine ,Cancer registry ,Pulmonary carcinoid tumour ,030104 developmental biology ,EXPERIENCE ,prognosis ,3111 Biomedicine ,business ,NEUROENDOCRINE TUMORS - Abstract
Finnish hospital-integrated biobanks administer millions of formalin-fixed paraffin-embedded tissue samples collected within the clinical diagnostics. According to the Finnish Biobank Act, these samples can be coupled with patients’ clinical follow-up data and the data retrieved from national health registries. We collected a nationwide pulmonary carcinoid tumour series from Finnish biobanks to study prognostic factors as well as to explore how the number of tumours found in the Finnish biobanks corresponds to the number of tumours registered by the Finnish Cancer Registry (FCR). Finnish biobanks identified 88% of the tumours registered by the FCR and were able to deliver 63%. The main reasons for lacking samples were paucity of resected primary tumour tissue, incompatible primary diagnosis, and the absence of tissue blocks in the archives. The main bottleneck in the sample application process was retrieving patient data. Altogether, we received 224 tumour samples with appropriate patient data and identified six prognostic factors for shorter disease-specific survival: age over 56 years at the time of diagnosis, tumour size over 2.5 cm, atypical histology, Ki-67 proliferation index higher than 2.5%, hilar/mediastinal lymph node involvement at the time of diagnosis, and the presence of metastatic disease. In conclusion, the Finnish biobank infrastructure offers excellent opportunities for tissue-based research. However, to be able to develop the biobank operations further, involving more medical knowledge in the sample and data acquisition process is a necessity. Also, when working with tissue samples collected over decades, histological expertise is essential for re-evaluation and re-classification of the samples.
- Published
- 2019
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