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4. Saturation genome editing of DDX3X clarifies pathogenicity of germline and somatic variation

Author

Radford, Elizabeth J., primary, Tan, Hong-Kee, additional, Andersson, Malin H. L., additional, Stephenson, James D., additional, Gardner, Eugene J., additional, Ironfield, Holly, additional, Waters, Andrew J., additional, Gitterman, Daniel, additional, Lindsay, Sarah, additional, Abascal, Federico, additional, Martincorena, Iñigo, additional, Kolesnik-Taylor, Anna, additional, Ng-Cordell, Elise, additional, Firth, Helen V., additional, Baker, Kate, additional, Perry, John R. B., additional, Adams, David J., additional, Gerety, Sebastian S., additional, and Hurles, Matthew E., additional

Published
2023
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5. Shared and distinct genetic etiologies for different types of clonal hematopoiesis

Author

Brown, Derek W., primary, Cato, Liam D., additional, Zhao, Yajie, additional, Nandakumar, Satish K., additional, Bao, Erik L., additional, Gardner, Eugene J., additional, Hubbard, Aubrey K., additional, DePaulis, Alexander, additional, Rehling, Thomas, additional, Song, Lei, additional, Yu, Kai, additional, Chanock, Stephen J., additional, Perry, John R. B., additional, Sankaran, Vijay G., additional, and Machiela, Mitchell J., additional

Published
2023
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6. Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Author

Mathieson, Iain, Day, Felix R, Barban, Nicola, Tropf, Felix C, Brazel, David M, EQTLGen Consortium, BIOS Consortium, Vaez, Ahmad, Van Zuydam, Natalie, Bitarello, Bárbara D, Gardner, Eugene J, Akimova, Evelina T, Azad, Ajuna, Bergmann, Sven, Bielak, Lawrence F, Boomsma, Dorret I, Bosak, Kristina, Brumat, Marco, Buring, Julie E, Cesarini, David, Chasman, Daniel I, Chavarro, Jorge E, Cocca, Massimiliano, Concas, Maria Pina, Davey Smith, George, Davies, Gail, Deary, Ian J, Esko, Tõnu, Faul, Jessica D, FinnGen Study, Franco, Oscar, Ganna, Andrea, Gaskins, Audrey J, Gelemanovic, Andrea, De Geus, Eco JC, Gieger, Christian, Girotto, Giorgia, Gopinath, Bamini, Grabe, Hans Jörgen, Gunderson, Erica P, Hayward, Caroline, He, Chunyan, Van Heemst, Diana, Hill, W David, Hoffmann, Eva R, Homuth, Georg, Hottenga, Jouke Jan, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M Arfan, Jansen, Rick, Johannesson, Magnus, Kamali, Zoha, Kardia, Sharon LR, Kavousi, Maryam, Kifley, Annette, Kiiskinen, Tuomo, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Liew, Gerald, Lifelines Cohort Study, Lind, Penelope A, Luan, Jian'an, Mägi, Reedik, Magnusson, Patrik KE, Mahajan, Anubha, Martin, Nicholas G, Mbarek, Hamdi, McCarthy, Mark I, McMahon, George, Medland, Sarah E, Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Milani, Lili, Missmer, Stacey A, Mitchell, Paul, Møllegaard, Stine, Mook-Kanamori, Dennis O, Morgan, Anna, Van Der Most, Peter J, De Mutsert, Renée, Nauck, Matthias, Nolte, Ilja M, Noordam, Raymond, Penninx, Brenda WJH, Peters, Annette, Peyser, Patricia A, Polašek, Ozren, Power, Chris, Pribisalic, Ajka, Redmond, Paul, Rich-Edwards, Janet W, Ridker, Paul M, Rietveld, Cornelius A, Ring, Susan M, Rose, Lynda M, Rueedi, Rico, Shukla, Vallari, Smith, Jennifer A, Stankovic, Stasa, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Swertz, Morris A, Teumer, Alexander, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A Roy, Timpson, Nicholas J, Turman, Constance, Uitterlinden, André G, Waldenberger, Melanie, Wareham, Nicholas J, Weir, David R, Willemsen, Gonneke, Zhao, Jing Hau, Zhao, Wei, Zhao, Yajie, Snieder, Harold, Den Hoed, Marcel, Ong, Ken K, Mills, Melinda C, Perry, John RB, Mathieson, Iain [0000-0002-4256-3982], Day, Felix R [0000-0003-3789-7651], Vaez, Ahmad [0000-0001-9048-3795], Bitarello, Bárbara D [0000-0001-7676-9367], Gardner, Eugene J [0000-0001-9671-1533], Akimova, Evelina T [0000-0001-8733-3745], Bergmann, Sven [0000-0002-6785-9034], Bielak, Lawrence F [0000-0002-3443-8030], Boomsma, Dorret I [0000-0002-7099-7972], Chasman, Daniel I [0000-0003-3357-0862], Chavarro, Jorge E [0000-0002-4436-9630], Cocca, Massimiliano [0000-0002-1127-7596], Concas, Maria Pina [0000-0003-3598-2537], Davey Smith, George [0000-0002-1407-8314], Davies, Gail [0000-0003-1120-7026], Franco, Oscar [0000-0002-4606-4929], Ganna, Andrea [0000-0002-8147-240X], Gaskins, Audrey J [0000-0001-9195-646X], Gieger, Christian [0000-0001-6986-9554], Girotto, Giorgia [0000-0003-4507-6589], Grabe, Hans Jörgen [0000-0003-3684-4208], Gunderson, Erica P [0000-0002-2039-1964], He, Chunyan [0000-0001-9443-4368], Hoffmann, Eva R [0000-0002-2588-0652], Homuth, Georg [0000-0001-6839-0605], Hottenga, Jouke Jan [0000-0002-5668-2368], Hyppӧnen, Elina [0000-0003-3670-9399], Ikram, M Arfan [0000-0003-0372-8585], Jansen, Rick [0000-0002-3333-6737], Johannesson, Magnus [0000-0001-8759-6393], Kamali, Zoha [0000-0001-6492-5887], Kavousi, Maryam [0000-0001-5976-6519], Kifley, Annette [0000-0002-3764-4905], Kiiskinen, Tuomo [0000-0002-6306-8227], Kraft, Peter [0000-0002-4472-8103], Langenberg, Claudia [0000-0002-5017-7344], Lind, Penelope A [0000-0002-3887-2598], Luan, Jian'an [0000-0003-3137-6337], Magnusson, Patrik KE [0000-0002-7315-7899], Mahajan, Anubha [0000-0001-5585-3420], Mbarek, Hamdi [0000-0002-1108-0371], Metspalu, Andres [0000-0002-3718-796X], Milani, Lili [0000-0002-5323-3102], Møllegaard, Stine [0000-0001-5676-2248], Morgan, Anna [0000-0001-6290-445X], van der Most, Peter J [0000-0001-8450-3518], Nauck, Matthias [0000-0002-6678-7964], Nolte, Ilja M [0000-0001-5047-4077], Noordam, Raymond [0000-0001-7801-809X], Peters, Annette [0000-0001-6645-0985], Peyser, Patricia A [0000-0002-9717-8459], Pribisalic, Ajka [0000-0002-3725-3728], Rietveld, Cornelius A [0000-0003-4053-1861], Ring, Susan M [0000-0003-3103-9330], Smith, Jennifer A [0000-0002-3575-5468], Stankovic, Stasa [0000-0002-6602-1379], Teumer, Alexander [0000-0002-8309-094X], Thurik, A Roy [0000-0002-0242-6908], Timpson, Nicholas J [0000-0002-7141-9189], Uitterlinden, André G [0000-0002-7276-3387], Waldenberger, Melanie [0000-0003-0583-5093], Wareham, Nicholas J [0000-0003-1422-2993], Weir, David R [0000-0002-1661-2402], Zhao, Wei [0000-0001-7388-0692], Zhao, Yajie [0000-0002-2747-0219], Snieder, Harold [0000-0003-1949-2298], den Hoed, Marcel [0000-0001-8081-428X], Ong, Ken K [0000-0003-4689-7530], Mills, Melinda C [0000-0003-1704-0001], Perry, John RB [0000-0001-6483-3771], and Apollo - University of Cambridge Repository

Subjects
Aging, Fertility, Reproduction, Humans, Female, Menopause, Selection, Genetic, FOS: Medical biotechnology, Child
Abstract

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci associated with either number of children ever born (NEB) or childlessness. These loci span diverse aspects of reproductive biology, including puberty timing, age at first birth, sex hormone regulation, endometriosis and age at menopause. Missense variants in ARHGAP27 were associated with higher NEB but shorter reproductive lifespan, suggesting a trade-off at this locus between reproductive ageing and intensity. Other genes implicated by coding variants include PIK3IP1, ZFP82 and LRP4, and our results suggest a new role for the melanocortin 1 receptor (MC1R) in reproductive biology. As NEB is one component of evolutionary fitness, our identified associations indicate loci under present-day natural selection. Integration with data from historical selection scans highlighted an allele in the FADS1/2 gene locus that has been under selection for thousands of years and remains so today. Collectively, our findings demonstrate that a broad range of biological mechanisms contribute to reproductive success.

Published
2023

8. Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency

Author

Shekari, Saleh, primary, Stankovic, Stasa, additional, Gardner, Eugene J., additional, Hawkes, Gareth, additional, Kentistou, Katherine A., additional, Beaumont, Robin N., additional, Mörseburg, Alexander, additional, Wood, Andrew R., additional, Prague, Julia K., additional, Mishra, Gita D., additional, Day, Felix R., additional, Baptista, Julia, additional, Wright, Caroline F., additional, Weedon, Michael N., additional, Hoffmann, Eva R., additional, Ruth, Katherine S., additional, Ong, Ken K., additional, Perry, John R. B., additional, and Murray, Anna, additional

Published
2023
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9. PD-1 signalling defines and protects leukaemic stem cells from T cell receptor-induced cell death in T cell acute lymphoblastic leukaemia

Author

Xu, Xi, primary, Zhang, Wenwen, additional, Xuan, Li, additional, Yu, Yanhui, additional, Zheng, Wen, additional, Tao, Fang, additional, Nemechek, Jacqelyn, additional, He, Chong, additional, Ma, Weiwei, additional, Han, Xue, additional, Xie, Siyu, additional, Zhao, Minyi, additional, Wang, Jian, additional, Qu, Yuhua, additional, Liu, Qifa, additional, Perry, John M., additional, Jiang, Linjia, additional, and Zhao, Meng, additional

Published
2023
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10. Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355

Author

Kepplinger, Bernhard, primary, Mardiana, Lina, additional, Cowell, Joseph, additional, Morton-Laing, Stephanie, additional, Dashti, Yousef, additional, Wills, Corinne, additional, Marrs, Emma C. L., additional, Perry, John D., additional, Gray, Joe, additional, Goodfellow, Michael, additional, Errington, Jeff, additional, Probert, Michael R., additional, Clegg, William, additional, Bogaerts, Jonathan, additional, Herrebout, Wouter, additional, Allenby, Nick E. E., additional, and Hall, Michael J., additional

Published
2022
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12. Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Author

Mills, Melinda C, Tropf, Felix C, Brazel, David M, van Zuydam, Natalie, Vaez, Ahmad, eQTLGen Consortium, BIOS Consortium, Human Reproductive Behaviour Consortium, Pers, Tune H, Snieder, Harold, Perry, John RB, Ong, Ken K, den Hoed, Marcel, Barban, Nicola, Day, Felix R, Mills, Melinda C [0000-0003-1704-0001], Tropf, Felix C [0000-0003-2445-515X], Brazel, David M [0000-0001-5361-2498], Vaez, Ahmad [0000-0001-9048-3795], Pers, Tune H [0000-0003-0207-4831], Snieder, Harold [0000-0003-1949-2298], Perry, John RB [0000-0001-6483-3771], Ong, Ken K [0000-0003-4689-7530], den Hoed, Marcel [0000-0001-8081-428X], Barban, Nicola [0000-0002-4362-4652], Day, Felix R [0000-0003-3789-7651], and Apollo - University of Cambridge Repository

Subjects
Male, Adolescent, Reproduction, Age Factors, Coitus, Parturition, Humans, Female, Polymorphism, Single Nucleotide, Genetic Association Studies
Abstract

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in 1940 to 22% [CI = 19-25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.

Published
2021

13. Genetic analyses identify widespread sex-differential participation bias

Author

Pirastu, Nicola, Cordioli, Mattia, Nandakumar, Priyanka, Mignogna, Gianmarco, Abdellaoui, Abdel, Hollis, Benjamin, Kanai, Masahiro, Rajagopal, Veera M, Parolo, Pietro Della Briotta, Baya, Nikolas, Carey, Caitlin E, Karjalainen, Juha, Als, Thomas D, Van Der Zee, Matthijs D, Day, Felix R, Ong, Ken K, FinnGen Study, 23andMe Research Team, IPSYCH Consortium, Morisaki, Takayuki, De Geus, Eco, Bellocco, Rino, Okada, Yukinori, Børglum, Anders D, Joshi, Peter, Auton, Adam, Hinds, David, Neale, Benjamin M, Walters, Raymond K, Nivard, Michel G, Perry, John RB, Ganna, Andrea, Pirastu, Nicola [0000-0002-5363-3886], Cordioli, Mattia [0000-0002-4872-0520], Mignogna, Gianmarco [0000-0002-3989-7180], Abdellaoui, Abdel [0000-0003-1088-6784], Kanai, Masahiro [0000-0001-5165-4408], Rajagopal, Veera M [0000-0002-5236-168X], Baya, Nikolas [0000-0002-4681-374X], Als, Thomas D [0000-0002-2963-1928], Van der Zee, Matthijs D [0000-0003-4076-9167], Day, Felix R [0000-0003-3789-7651], Ong, Ken K [0000-0003-4689-7530], Okada, Yukinori [0000-0002-0311-8472], Børglum, Anders D [0000-0001-8627-7219], Joshi, Peter [0000-0002-6361-5059], Hinds, David [0000-0002-4911-803X], Neale, Benjamin M [0000-0003-1513-6077], Walters, Raymond K [0000-0001-8422-6530], Perry, John RB [0000-0001-6483-3771], Ganna, Andrea [0000-0002-8147-240X], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Sex Characteristics, Inheritance Patterns, Polymorphism, Single Nucleotide, United Kingdom, Bias, Genetic Loci, Sample Size, Chromosomes, Human, Humans, Female, Artifacts, Biological Specimen Banks, Genome-Wide Association Study
Abstract

Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of participation bias is challenging since it requires the genotypes of unseen individuals. Here we demonstrate that it is possible to estimate comparative biases by performing a genome-wide association study contrasting one subgroup versus another. For example, we showed that sex exhibits artifactual autosomal heritability in the presence of sex-differential participation bias. By performing a genome-wide association study of sex in approximately 3.3 million males and females, we identified over 158 autosomal loci spuriously associated with sex and highlighted complex traits underpinning differences in study participation between the sexes. For example, the body mass index-increasing allele at FTO was observed at higher frequency in males compared to females (odds ratio = 1.02, P = 4.4 × 10-36). Finally, we demonstrated how these biases can potentially lead to incorrect inferences in downstream analyses and propose a conceptual framework for addressing such biases. Our findings highlight a new challenge that genetic studies may face as sample sizes continue to grow.

Published
2021

14. Genetic association study of childhood aggression across raters, instruments, and age

Author

Ip, Hill F., primary, van der Laan, Camiel M., additional, Krapohl, Eva M. L., additional, Brikell, Isabell, additional, Sánchez-Mora, Cristina, additional, Nolte, Ilja M., additional, St Pourcain, Beate, additional, Bolhuis, Koen, additional, Palviainen, Teemu, additional, Zafarmand, Hadi, additional, Colodro-Conde, Lucía, additional, Gordon, Scott, additional, Zayats, Tetyana, additional, Aliev, Fazil, additional, Jiang, Chang, additional, Wang, Carol A., additional, Saunders, Gretchen, additional, Karhunen, Ville, additional, Hammerschlag, Anke R., additional, Adkins, Daniel E., additional, Border, Richard, additional, Peterson, Roseann E., additional, Prinz, Joseph A., additional, Thiering, Elisabeth, additional, Seppälä, Ilkka, additional, Vilor-Tejedor, Natàlia, additional, Ahluwalia, Tarunveer S., additional, Day, Felix R., additional, Hottenga, Jouke-Jan, additional, Allegrini, Andrea G., additional, Rimfeld, Kaili, additional, Chen, Qi, additional, Lu, Yi, additional, Martin, Joanna, additional, Soler Artigas, María, additional, Rovira, Paula, additional, Bosch, Rosa, additional, Español, Gemma, additional, Ramos Quiroga, Josep Antoni, additional, Neumann, Alexander, additional, Ensink, Judith, additional, Grasby, Katrina, additional, Morosoli, José J., additional, Tong, Xiaoran, additional, Marrington, Shelby, additional, Middeldorp, Christel, additional, Scott, James G., additional, Vinkhuyzen, Anna, additional, Shabalin, Andrey A., additional, Corley, Robin, additional, Evans, Luke M., additional, Sugden, Karen, additional, Alemany, Silvia, additional, Sass, Lærke, additional, Vinding, Rebecca, additional, Ruth, Kate, additional, Tyrrell, Jess, additional, Davies, Gareth E., additional, Ehli, Erik A., additional, Hagenbeek, Fiona A., additional, De Zeeuw, Eveline, additional, Van Beijsterveldt, Toos C.E.M., additional, Larsson, Henrik, additional, Snieder, Harold, additional, Verhulst, Frank C., additional, Amin, Najaf, additional, Whipp, Alyce M., additional, Korhonen, Tellervo, additional, Vuoksimaa, Eero, additional, Rose, Richard J., additional, Uitterlinden, André G., additional, Heath, Andrew C., additional, Madden, Pamela, additional, Haavik, Jan, additional, Harris, Jennifer R., additional, Helgeland, Øyvind, additional, Johansson, Stefan, additional, Knudsen, Gun Peggy S., additional, Njolstad, Pal Rasmus, additional, Lu, Qing, additional, Rodriguez, Alina, additional, Henders, Anjali K., additional, Mamun, Abdullah, additional, Najman, Jackob M., additional, Brown, Sandy, additional, Hopfer, Christian, additional, Krauter, Kenneth, additional, Reynolds, Chandra, additional, Smolen, Andrew, additional, Stallings, Michael, additional, Wadsworth, Sally, additional, Wall, Tamara L., additional, Silberg, Judy L., additional, Miller, Allison, additional, Keltikangas-Järvinen, Liisa, additional, Hakulinen, Christian, additional, Pulkki-Råback, Laura, additional, Havdahl, Alexandra, additional, Magnus, Per, additional, Raitakari, Olli T., additional, Perry, John R. B., additional, Llop, Sabrina, additional, Lopez-Espinosa, Maria-Jose, additional, Bønnelykke, Klaus, additional, Bisgaard, Hans, additional, Sunyer, Jordi, additional, Lehtimäki, Terho, additional, Arseneault, Louise, additional, Standl, Marie, additional, Heinrich, Joachim, additional, Boden, Joseph, additional, Pearson, John, additional, Horwood, L. John, additional, Kennedy, Martin, additional, Poulton, Richie, additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Hewitt, John, additional, Copeland, William E., additional, Costello, Elizabeth J., additional, Williams, Gail M., additional, Wray, Naomi, additional, Järvelin, Marjo-Riitta, additional, McGue, Matt, additional, Iacono, William, additional, Caspi, Avshalom, additional, Moffitt, Terrie E., additional, Whitehouse, Andrew, additional, Pennell, Craig E., additional, Klump, Kelly L., additional, Burt, S. Alexandra, additional, Dick, Danielle M., additional, Reichborn-Kjennerud, Ted, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Vrijkotte, Tanja, additional, Kaprio, Jaakko, additional, Tiemeier, Henning, additional, Davey Smith, George, additional, Hartman, Catharina A., additional, Oldehinkel, Albertine J., additional, Casas, Miquel, additional, Ribasés, Marta, additional, Lichtenstein, Paul, additional, Lundström, Sebastian, additional, Plomin, Robert, additional, Bartels, Meike, additional, Nivard, Michel G., additional, and Boomsma, Dorret I., additional

Published
2021
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15. Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank

Author

Lin, Shu-Hong, primary, Brown, Derek W., additional, Rose, Brandon, additional, Day, Felix, additional, Lee, Olivia W., additional, Khan, Sairah M., additional, Hislop, Jada, additional, Chanock, Stephen J., additional, Perry, John R. B., additional, and Machiela, Mitchell J., additional

Published
2021
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16. GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

Author

Zhao, Yajie, primary, Stankovic, Stasa, additional, Koprulu, Mine, additional, Wheeler, Eleanor, additional, Day, Felix R., additional, Lango Allen, Hana, additional, Kerrison, Nicola D., additional, Pietzner, Maik, additional, Loh, Po-Ru, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Ong, Ken K., additional, and Perry, John R. B., additional

Published
2021
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17. Genetic predisposition to mosaic Y chromosome loss in blood

Author

Thompson, Deborah J, Genovese, Giulio, Halvardson, Jonatan, Ulirsch, Jacob C, Wright, Daniel J, Terao, Chikashi, Davidsson, Olafur B, Day, Felix R, Sulem, Patrick, Jiang, Yunxuan, Danielsson, Marcus, Davies, Hanna, Dennis, Joe, Dunlop, Malcolm G, Easton, Douglas F, Fisher, Victoria A, Zink, Florian, Houlston, Richard S, Ingelsson, Martin, Kar, Siddhartha, Kerrison, Nicola D, Kinnersley, Ben, Kristjansson, Ragnar P, Law, Philip J, Li, Rong, Loveday, Chey, Mattisson, Jonas, McCarroll, Steven A, Murakami, Yoshinori, Murray, Anna, Olszewski, Pawel, Rychlicka-Buniowska, Edyta, Scott, Robert A, Thorsteinsdottir, Unnur, Tomlinson, Ian, Moghadam, Behrooz Torabi, Turnbull, Clare, Wareham, Nicholas J, Gudbjartsson, Daniel F, International Lung Cancer Consortium (INTEGRAL-ILCCO), Breast Cancer Association Consortium, Consortium Of Investigators Of Modifiers Of BRCA1/2, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, Prostate Cancer Association Group To Investigate Cancer Associated Alterations In The Genome (PRACTICAL) Consortium, Kidney Cancer GWAS Meta-Analysis Project, EQTLGen Consortium, Biobank-Based Integrative Omics Study (BIOS) Consortium, 23andMe Research Team, Kamatani, Yoichiro, Hoffmann, Eva R, Jackson, Steve P, Stefansson, Kari, Auton, Adam, Ong, Ken K, Machiela, Mitchell J, Loh, Po-Ru, Dumanski, Jan P, Chanock, Stephen J, Forsberg, Lars A, Perry, John RB, Thompson, Deborah [0000-0003-1465-5799], Wright, Daniel [0000-0003-3983-2093], Day, Felix [0000-0003-3789-7651], Dennis, Joe [0000-0003-4591-1214], Easton, Douglas [0000-0003-2444-3247], Wareham, Nicholas [0000-0003-1422-2993], Jackson, Stephen [0000-0001-9317-7937], Ong, Kenneth [0000-0003-4689-7530], Perry, John [0000-0001-6483-3771], and Apollo - University of Cambridge Repository

Subjects
Adult, Genetic Markers, Male, 0303 health sciences, Chromosomes, Human, Y, Mosaicism, Computational Biology, Middle Aged, Genomic Instability, United Kingdom, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Neoplasms, Databases, Genetic, Leukocytes, Humans, Female, Genetic Predisposition to Disease, Chromosome Deletion, 030304 developmental biology, Aged
Abstract

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1-5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues. Single-cell RNA sequencing identifies dysregulated expression of autosomal genes in leukocytes with LOY and provides insights into why clonal expansion of these cells may occur. Collectively, these data highlight the value of studying clonal mosaicism to uncover fundamental mechanisms that underlie cancer and other ageing-related diseases.

Published
2019
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18. Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Author

Dumanski, Jan P., primary, Halvardson, Jonatan, additional, Davies, Hanna, additional, Rychlicka-Buniowska, Edyta, additional, Mattisson, Jonas, additional, Moghadam, Behrooz Torabi, additional, Nagy, Noemi, additional, Węglarczyk, Kazimierz, additional, Bukowska-Strakova, Karolina, additional, Danielsson, Marcus, additional, Olszewski, Paweł, additional, Piotrowski, Arkadiusz, additional, Oerton, Erin, additional, Ambicka, Aleksandra, additional, Przewoźnik, Marcin, additional, Bełch, Łukasz, additional, Grodzicki, Tomasz, additional, Chłosta, Piotr L., additional, Imreh, Stefan, additional, Giedraitis, Vilmantas, additional, Kilander, Lena, additional, Nordlund, Jessica, additional, Ameur, Adam, additional, Gyllensten, Ulf, additional, Johansson, Åsa, additional, Józkowicz, Alicja, additional, Siedlar, Maciej, additional, Klich-Rączka, Alicja, additional, Jaszczyński, Janusz, additional, Enroth, Stefan, additional, Baran, Jarosław, additional, Ingelsson, Martin, additional, Perry, John R. B., additional, Ryś, Janusz, additional, and Forsberg, Lars A., additional

Published
2021
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19. Using human genetics to understand the disease impacts of testosterone in men and women

Author

Ruth, Katherine S, Day, Felix R, Tyrrell, Jessica, Thompson, Deborah J, Wood, Andrew R, Mahajan, Anubha, Beaumont, Robin N, Wittemans, Laura, Martin, Susan, Busch, Alexander S, Erzurumluoglu, A Mesut, Hollis, Benjamin, O'Mara, Tracy A, Endometrial Cancer Association Consortium, McCarthy, Mark I, Langenberg, Claudia, Easton, Douglas F, Wareham, Nicholas J, Burgess, Stephen, Murray, Anna, Ong, Ken K, Frayling, Timothy M, Perry, John RB, Day, Felix R [0000-0003-3789-7651], Martin, Susan [0000-0001-8746-0947], Busch, Alexander S [0000-0003-4417-569X], Erzurumluoglu, A Mesut [0000-0003-1322-8138], O'Mara, Tracy A [0000-0002-5436-3232], Langenberg, Claudia [0000-0002-5017-7344], Easton, Douglas F [0000-0003-2444-3247], Burgess, Stephen [0000-0001-5365-8760], and Apollo - University of Cambridge Repository

Subjects
Male, Estradiol, Genotype, Prostatic Neoplasms, Breast Neoplasms, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, United Kingdom, Endometrial Neoplasms, Phenotype, Sex Factors, Diabetes Mellitus, Type 2, Haplotypes, Body Composition, Odds Ratio, Cluster Analysis, Humans, Female, Testosterone, Biomarkers, Software, Biological Specimen Banks, Genome-Wide Association Study, Polycystic Ovary Syndrome
Abstract

Testosterone supplementation is commonly used for its effects on sexual function, bone health and body composition, yet its effects on disease outcomes are unknown. To better understand this, we identified genetic determinants of testosterone levels and related sex hormone traits in 425,097 UK Biobank study participants. Using 2,571 genome-wide significant associations, we demonstrate that the genetic determinants of testosterone levels are substantially different between sexes and that genetically higher testosterone is harmful for metabolic diseases in women but beneficial in men. For example, a genetically determined 1 s.d. higher testosterone increases the risks of type 2 diabetes (odds ratio (OR) = 1.37 (95% confidence interval (95% CI): 1.22-1.53)) and polycystic ovary syndrome (OR = 1.51 (95% CI: 1.33-1.72)) in women, but reduces type 2 diabetes risk in men (OR = 0.86 (95% CI: 0.76-0.98)). We also show adverse effects of higher testosterone on breast and endometrial cancers in women and prostate cancer in men. Our findings provide insights into the disease impacts of testosterone and highlight the importance of sex-specific genetic analyses.

Published
2019
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20. Genetic basis of falling risk susceptibility in the UK Biobank Study

Author

Trajanoska, Katerina, primary, Seppala, Lotta J., additional, Medina-Gomez, Carolina, additional, Hsu, Yi-Hsiang, additional, Zhou, Sirui, additional, van Schoor, Natasja M., additional, de Groot, Lisette C. P. G. M., additional, Karasik, David, additional, Richards, J. Brent, additional, Kiel, Douglas P., additional, Uitterlinden, Andre G., additional, Perry, John R. B., additional, van der Velde, Nathalie, additional, Day, Felix R., additional, and Rivadeneira, Fernando, additional

Published
2020
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22. Overcoming Wnt–β-catenin dependent anticancer therapy resistance in leukaemia stem cells

Author

Perry, John M., primary, Tao, Fang, additional, Roy, Anuradha, additional, Lin, Tara, additional, He, Xi C., additional, Chen, Shiyuan, additional, Lu, Xiuling, additional, Nemechek, Jacqelyn, additional, Ruan, Linhao, additional, Yu, Xiazhen, additional, Dukes, Debra, additional, Moran, Andrea, additional, Pace, Jennifer, additional, Schroeder, Kealan, additional, Zhao, Meng, additional, Venkatraman, Aparna, additional, Qian, Pengxu, additional, Li, Zhenrui, additional, Hembree, Mark, additional, Paulson, Ariel, additional, He, Zhiquan, additional, Xu, Dong, additional, Tran, Thanh-Huyen, additional, Deshmukh, Prashant, additional, Nguyen, Chi Thanh, additional, Kasi, Rajeswari M., additional, Ryan, Robin, additional, Broward, Melinda, additional, Ding, Sheng, additional, Guest, Erin, additional, August, Keith, additional, Gamis, Alan S., additional, Godwin, Andrew, additional, Sittampalam, G. Sitta, additional, Weir, Scott J., additional, and Li, Linheng, additional

Published
2020
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23. The UK10K project identifies rare variants in health and disease

Author

UK10K Consortium, Walter, Klaudia, Min, Josine L, Huang, Jie, Crooks, Lucy, Memari, Yasin, McCarthy, Shane, Perry, John RB, Xu, ChangJiang, Futema, Marta, Lawson, Daniel, Iotchkova, Valentina, Schiffels, Stephan, Hendricks, Audrey E, Danecek, Petr, Li, Rui, Floyd, James, Wain, Louise V, Barroso, Inês, Humphries, Steve E, Hurles, Matthew E, Zeggini, Eleftheria, Barrett, Jeffrey C, Plagnol, Vincent, Richards, J Brent, Greenwood, Celia MT, Timpson, Nicholas J, Durbin, Richard, Soranzo, Nicole, McCarthy, Shane [0000-0002-2715-4187], Durbin, Richard [0000-0002-9130-1006], and Apollo - University of Cambridge Repository

Subjects
Male, Genome, Human, Genetics, Medical, Genetic Variation, Molecular Sequence Annotation, Genomics, Sequence Analysis, DNA, Reference Standards, Lipid Metabolism, United Kingdom, Cohort Studies, Genetics, Population, Receptors, LDL, Health, Humans, Disease, Exome, Female, Genetic Predisposition to Disease, Adiponectin, Alleles, Triglycerides, Genome-Wide Association Study
Abstract

The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes (high read depth, 80×) of nearly 10,000 individuals from population-based and disease collections. In extensively phenotyped cohorts we characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with levels of triglycerides (APOB), adiponectin (ADIPOQ) and low-density lipoprotein cholesterol (LDLR and RGAG1) from single-marker and rare variant aggregation tests. We describe population structure and functional annotation of rare and low-frequency variants, use the data to estimate the benefits of sequencing for association studies, and summarize lessons from disease-specific collections. Finally, we make available an extensive resource, including individual-level genetic and phenotypic data and web-based tools to facilitate the exploration of association results.

Published
2018
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24. Genome-wide association study for risk taking propensity indicates shared pathways with body mass index

Author

Clifton, Emma AD, Perry, John RB, Imamura, Fumiaki, Lotta, Luca A, Brage, Soren, Forouhi, Nita G, Griffin, Simon J, Wareham, Nicholas J, Ong, Ken K, Day, Felix R, Imamura, Fumiaki [0000-0002-6841-8396], Day, Felix R [0000-0003-3789-7651], and Apollo - University of Cambridge Repository

Subjects
Population & Society, 0604 Genetics, Generic Health Relevance, FOS: Biological sciences, Prevention, Human Genome, Genetics, 2.1 Biological and endogenous factors, Public Health
Abstract

Risk-taking propensity is a trait of significant public health relevance but few specific genetic factors are known. Here we perform a genome-wide association study of self-reported risk-taking propensity among 436,236 white European UK Biobank study participants. We identify genome-wide associations at 26 loci (P < 5 × 10-8), 24 of which are novel, implicating genes enriched in the GABA and GABA receptor pathways. Modelling the relationship between risk-taking propensity and body mass index (BMI) using Mendelian randomisation shows a positive association (0.25 approximate SDs of BMI (SE: 0.06); P = 6.7 × 10-5). The impact of individual SNPs is heterogeneous, indicating a complex relationship arising from multiple shared pathways. We identify positive genetic correlations between risk-taking and waist-hip ratio, childhood obesity, ever smoking, attention-deficit hyperactivity disorder, bipolar disorder and schizophrenia, alongside a negative correlation with women's age at first birth. These findings highlight that behavioural pathways involved in risk-taking propensity may play a role in obesity, smoking and psychiatric disorders.

Published
2018

25. Associations of autozygosity with a broad range of human phenotypes

Author

Clark, David W, primary, Okada, Yukinori, additional, Moore, Kristjan H S, additional, Mason, Dan, additional, Pirastu, Nicola, additional, Gandin, Ilaria, additional, Mattsson, Hannele, additional, Barnes, Catriona L K, additional, Lin, Kuang, additional, Zhao, Jing Hua, additional, Deelen, Patrick, additional, Rohde, Rebecca, additional, Schurmann, Claudia, additional, Guo, Xiuqing, additional, Giulianini, Franco, additional, Zhang, Weihua, additional, Medina-Gomez, Carolina, additional, Karlsson, Robert, additional, Bao, Yanchun, additional, Bartz, Traci M, additional, Baumbach, Clemens, additional, Biino, Ginevra, additional, Bixley, Matthew J, additional, Brumat, Marco, additional, Chai, Jin-Fang, additional, Corre, Tanguy, additional, Cousminer, Diana L, additional, Dekker, Annelot M, additional, Eccles, David A, additional, van Eijk, Kristel R, additional, Fuchsberger, Christian, additional, Gao, He, additional, Germain, Marine, additional, Gordon, Scott D, additional, de Haan, Hugoline G, additional, Harris, Sarah E, additional, Hofer, Edith, additional, Huerta-Chagoya, Alicia, additional, Igartua, Catherine, additional, Jansen, Iris E, additional, Jia, Yucheng, additional, Kacprowski, Tim, additional, Karlsson, Torgny, additional, Kleber, Marcus E, additional, Li, Shengchao Alfred, additional, Li-Gao, Ruifang, additional, Mahajan, Anubha, additional, Matsuda, Koichi, additional, Meidtner, Karina, additional, Meng, Weihua, additional, Montasser, May E, additional, van der Most, Peter J, additional, Munz, Matthias, additional, Nutile, Teresa, additional, Palviainen, Teemu, additional, Prasad, Gauri, additional, Prasad, Rashmi B, additional, Priyanka, Tallapragada Divya Sri, additional, Rizzi, Federica, additional, Salvi, Erika, additional, Sapkota, Bishwa R, additional, Shriner, Daniel, additional, Skotte, Line, additional, Smart, Melissa C, additional, Smith, Albert Vernon, additional, van der Spek, Ashley, additional, Spracklen, Cassandra N, additional, Strawbridge, Rona J, additional, Tajuddin, Salman M, additional, Trompet, Stella, additional, Turman, Constance, additional, Verweij, Niek, additional, Viberti, Clara, additional, Wang, Lihua, additional, Warren, Helen R, additional, Wootton, Robyn E, additional, Yanek, Lisa R, additional, Yao, Jie, additional, Yousri, Noha A, additional, Zhao, Wei, additional, Adeyemo, Adebowale A, additional, Afaq, Saima, additional, Aguilar-Salinas, Carlos Alberto, additional, Akiyama, Masato, additional, Albert, Matthew L, additional, Allison, Matthew A, additional, Alver, Maris, additional, Aung, Tin, additional, Azizi, Fereidoun, additional, Bentley, Amy R, additional, Boeing, Heiner, additional, Boerwinkle, Eric, additional, Borja, Judith B, additional, de Borst, Gert J, additional, Bottinger, Erwin P, additional, Broer, Linda, additional, Campbell, Harry, additional, Chanock, Stephen, additional, Chee, Miao-Li, additional, Chen, Guanjie, additional, Chen, Yii-Der I, additional, Chen, Zhengming, additional, Chiu, Yen-Feng, additional, Cocca, Massimiliano, additional, Collins, Francis S, additional, Concas, Maria Pina, additional, Corley, Janie, additional, Cugliari, Giovanni, additional, van Dam, Rob M, additional, Damulina, Anna, additional, Daneshpour, Maryam S, additional, Day, Felix R, additional, Delgado, Graciela E, additional, Dhana, Klodian, additional, Doney, Alexander S F, additional, Dörr, Marcus, additional, Doumatey, Ayo P, additional, Dzimiri, Nduna, additional, Ebenesersdóttir, S Sunna, additional, Elliott, Joshua, additional, Elliott, Paul, additional, Ewert, Ralf, additional, Felix, Janine F, additional, Fischer, Krista, additional, Freedman, Barry I, additional, Girotto, Giorgia, additional, Goel, Anuj, additional, Gögele, Martin, additional, Goodarzi, Mark O, additional, Graff, Mariaelisa, additional, Granot-Hershkovitz, Einat, additional, Grodstein, Francine, additional, Guarrera, Simonetta, additional, Gudbjartsson, Daniel F, additional, Guity, Kamran, additional, Gunnarsson, Bjarni, additional, Guo, Yu, additional, Hagenaars, Saskia P, additional, Haiman, Christopher A, additional, Halevy, Avner, additional, Harris, Tamara B, additional, Hedayati, Mehdi, additional, van Heel, David A, additional, Hirata, Makoto, additional, Höfer, Imo, additional, Hsiung, Chao Agnes, additional, Huang, Jinyan, additional, Hung, Yi-Jen, additional, Ikram, M Arfan, additional, Jagadeesan, Anuradha, additional, Jousilahti, Pekka, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Kerrison, Nicola D, additional, Kessler, Thorsten, additional, Khaw, Kay-Tee, additional, Khor, Chiea Chuen, additional, de Kleijn, Dominique P V, additional, Koh, Woon-Puay, additional, Kolcic, Ivana, additional, Kraft, Peter, additional, Krämer, Bernhard K, additional, Kutalik, Zoltán, additional, Kuusisto, Johanna, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lawlor, Deborah A, additional, Lee, I-Te, additional, Lee, Wen-Jane, additional, Lerch, Markus M, additional, Li, Liming, additional, Liu, Jianjun, additional, Loh, Marie, additional, London, Stephanie J, additional, Loomis, Stephanie, additional, Lu, Yingchang, additional, Luan, Jian’an, additional, Mägi, Reedik, additional, Manichaikul, Ani W, additional, Manunta, Paolo, additional, Másson, Gísli, additional, Matoba, Nana, additional, Mei, Xue W, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Milani, Lili, additional, Millwood, Iona Y, additional, Momozawa, Yukihide, additional, Moore, Amy, additional, Morange, Pierre-Emmanuel, additional, Moreno-Macías, Hortensia, additional, Mori, Trevor A, additional, Morrison, Alanna C, additional, Muka, Taulant, additional, Murakami, Yoshinori, additional, Murray, Alison D, additional, de Mutsert, Renée, additional, Mychaleckyj, Josyf C, additional, Nalls, Mike A, additional, Nauck, Matthias, additional, Neville, Matt J, additional, Nolte, Ilja M, additional, Ong, Ken K, additional, Orozco, Lorena, additional, Padmanabhan, Sandosh, additional, Pálsson, Gunnar, additional, Pankow, James S, additional, Pattaro, Cristian, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Poulter, Neil, additional, Pramstaller, Peter P, additional, Quintana-Murci, Lluis, additional, Räikkönen, Katri, additional, Ralhan, Sarju, additional, Rao, Dabeeru C, additional, van Rheenen, Wouter, additional, Rich, Stephen S, additional, Ridker, Paul M, additional, Rietveld, Cornelius A, additional, Robino, Antonietta, additional, van Rooij, Frank J A, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sabanayagam, Charumathi, additional, Sabater-Lleal, Maria, additional, Sala, Cinzia Felicita, additional, Salomaa, Veikko, additional, Sandow, Kevin, additional, Schmidt, Helena, additional, Scott, Laura J, additional, Scott, William R, additional, Sedaghati-Khayat, Bahareh, additional, Sennblad, Bengt, additional, van Setten, Jessica, additional, Sever, Peter J, additional, Sheu, Wayne H-H, additional, Shi, Yuan, additional, Shrestha, Smeeta, additional, Shukla, Sharvari Rahul, additional, Sigurdsson, Jon K, additional, Sikka, Timo Tonis, additional, Singh, Jai Rup, additional, Smith, Blair H, additional, Stančáková, Alena, additional, Stanton, Alice, additional, Starr, John M, additional, Stefansdottir, Lilja, additional, Straker, Leon, additional, Sulem, Patrick, additional, Sveinbjornsson, Gardar, additional, Swertz, Morris A, additional, Taylor, Adele M, additional, Taylor, Kent D, additional, Terzikhan, Natalie, additional, Tham, Yih-Chung, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tillander, Annika, additional, Tracy, Russell P, additional, Tusié-Luna, Teresa, additional, Tzoulaki, Ioanna, additional, Vaccargiu, Simona, additional, Vangipurapu, Jagadish, additional, Veldink, Jan H, additional, Vitart, Veronique, additional, Völker, Uwe, additional, Vuoksimaa, Eero, additional, Wakil, Salma M, additional, Waldenberger, Melanie, additional, Wander, Gurpreet S, additional, Wang, Ya Xing, additional, Wareham, Nicholas J, additional, Wild, Sarah, additional, Yajnik, Chittaranjan S, additional, Yuan, Jian-Min, additional, Zeng, Lingyao, additional, Zhang, Liang, additional, Zhou, Jie, additional, Amin, Najaf, additional, Asselbergs, Folkert W, additional, Bakker, Stephan J L, additional, Becker, Diane M, additional, Lehne, Benjamin, additional, Bennett, David A, additional, van den Berg, Leonard H, additional, Berndt, Sonja I, additional, Bharadwaj, Dwaipayan, additional, Bielak, Lawrence F, additional, Bochud, Murielle, additional, Boehnke, Mike, additional, Bouchard, Claude, additional, Bradfield, Jonathan P, additional, Brody, Jennifer A, additional, Campbell, Archie, additional, Carmi, Shai, additional, Caulfield, Mark J, additional, Cesarini, David, additional, Chambers, John C, additional, Chandak, Giriraj Ratan, additional, Cheng, Ching-Yu, additional, Ciullo, Marina, additional, Cornelis, Marilyn, additional, Cusi, Daniele, additional, Smith, George Davey, additional, Deary, Ian J, additional, Dorajoo, Rajkumar, additional, van Duijn, Cornelia M, additional, Ellinghaus, David, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Evangelou, Evangelos, additional, Evans, Michele K, additional, Faul, Jessica D, additional, Feenstra, Bjarke, additional, Feitosa, Mary, additional, Foisy, Sylvain, additional, Franke, Andre, additional, Friedlander, Yechiel, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Gonzalez, Clicerio, additional, Goyette, Philippe, additional, Grant, Struan F A, additional, Griffiths, Lyn R, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hakonarson, Hakon, additional, Hamsten, Anders, additional, van der Harst, Pim, additional, Heng, Chew-Kiat, additional, Hicks, Andrew A, additional, Hochner, Hagit, additional, Huikuri, Heikki, additional, Hunt, Steven C, additional, Jaddoe, Vincent W V, additional, De Jager, Philip L, additional, Johannesson, Magnus, additional, Johansson, Åsa, additional, Jonas, Jost B, additional, Jukema, J Wouter, additional, Junttila, Juhani, additional, Kaprio, Jaakko, additional, Kardia, Sharon L. R., additional, Karpe, Fredrik, additional, Kumari, Meena, additional, Laakso, Markku, additional, van der Laan, Sander W, additional, Lahti, Jari, additional, Laudes, Matthias, additional, Lea, Rodney A, additional, Lieb, Wolfgang, additional, Lumley, Thomas, additional, Martin, Nicholas G, additional, März, Winfried, additional, Matullo, Giuseppe, additional, McCarthy, Mark I, additional, Medland, Sarah E, additional, Merriman, Tony R, additional, Metspalu, Andres, additional, Meyer, Brian F, additional, Mohlke, Karen L, additional, Montgomery, Grant W, additional, Mook-Kanamori, Dennis, additional, Munroe, Patricia B, additional, North, Kari E, additional, Nyholt, Dale R, additional, O’connell, Jeffery R, additional, Ober, Carole, additional, Oldehinkel, Albertine J, additional, Palmas, Walter, additional, Palmer, Colin, additional, Pasterkamp, Gerard G, additional, Patin, Etienne, additional, Pennell, Craig E, additional, Perusse, Louis, additional, Peyser, Patricia A, additional, Pirastu, Mario, additional, Polderman, Tinca J. C., additional, Porteous, David J, additional, Posthuma, Danielle, additional, Psaty, Bruce M, additional, Rioux, John D, additional, Rivadeneira, Fernando, additional, Rotimi, Charles, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Den Ruijter, Hester M, additional, Sanghera, Dharambir K, additional, Sattar, Naveed, additional, Schmidt, Reinhold, additional, Schulze, Matthias B, additional, Schunkert, Heribert, additional, Scott, Robert A, additional, Shuldiner, Alan R, additional, Sim, Xueling, additional, Small, Neil, additional, Smith, Jennifer A, additional, Sotoodehnia, Nona, additional, Tai, E-Shyong, additional, Teumer, Alexander, additional, Timpson, Nicholas J, additional, Toniolo, Daniela, additional, Tregouet, David-Alexandre, additional, Tuomi, Tiinamaija, additional, Vollenweider, Peter, additional, Wang, Carol A, additional, Weir, David R, additional, Whitfield, John B, additional, Wijmenga, Cisca, additional, Wong, Tien-Yin, additional, Wright, John, additional, Yang, Jingyun, additional, Yu, Lei, additional, Zemel, Babette S, additional, Zonderman, Alan B, additional, Perola, Markus, additional, Magnusson, Patrik K. E., additional, Uitterlinden, André G, additional, Kooner, Jaspal S, additional, Chasman, Daniel I, additional, Loos, Ruth J. F., additional, Franceschini, Nora, additional, Franke, Lude, additional, Haley, Chris S, additional, Hayward, Caroline, additional, Walters, Robin G, additional, Perry, John R. B., additional, Esko, Tōnu, additional, Helgason, Agnar, additional, Stefansson, Kari, additional, Joshi, Peter K, additional, Kubo, Michiaki, additional, and Wilson, James F, additional

Published
2019
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26. GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

Author

Terao, Chikashi, primary, Momozawa, Yukihide, additional, Ishigaki, Kazuyoshi, additional, Kawakami, Eiryo, additional, Akiyama, Masato, additional, Loh, Po-Ru, additional, Genovese, Giulio, additional, Sugishita, Hiroki, additional, Ohta, Tazro, additional, Hirata, Makoto, additional, Perry, John R. B., additional, Matsuda, Koichi, additional, Murakami, Yoshinori, additional, Kubo, Michiaki, additional, and Kamatani, Yoichiro, additional

Published
2019
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27. Elevated urine IL-10 concentrations associate with Escherichia coli persistence in older patients susceptible to recurrent urinary tract infections

Author

Drage, Lauren K. L., primary, Robson, Wendy, additional, Mowbray, Catherine, additional, Ali, Ased, additional, Perry, John D., additional, Walton, Katherine E., additional, Harding, Christopher, additional, Pickard, Robert, additional, Hall, Judith, additional, and Aldridge, Phillip D., additional

Published
2019
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29. Author Correction: Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion

Author

Li, Zhenrui, primary, Qian, Pengxu, additional, Shao, Wanqing, additional, Shi, Hailing, additional, He, Xi C., additional, Gogol, Madelaine, additional, Yu, Zulin, additional, Wang, Yongfu, additional, Qi, Meijie, additional, Zhu, Yunfei, additional, Perry, John M., additional, Zhang, Kai, additional, Tao, Fang, additional, Zhou, Kun, additional, Hu, Deqing, additional, Han, Yingli, additional, Zhao, Chongbei, additional, Alexander, Richard, additional, Xu, Hanzhang, additional, Chen, Shiyuan, additional, Peak, Allison, additional, Hall, Kathyrn, additional, Peterson, Michael, additional, Perera, Anoja, additional, Haug, Jeffrey S., additional, Parmely, Tari, additional, Li, Hua, additional, Shen, Bin, additional, Zeitlinger, Julia, additional, He, Chuan, additional, and Li, Linheng, additional

Published
2018
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30. Identification of nine new susceptibility loci for endometrial cancer

Author

O’Mara, Tracy A., primary, Glubb, Dylan M., additional, Amant, Frederic, additional, Annibali, Daniela, additional, Ashton, Katie, additional, Attia, John, additional, Auer, Paul L., additional, Beckmann, Matthias W., additional, Black, Amanda, additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brinton, Louise, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Chen, Maxine M., additional, Cheng, Timothy H. T., additional, Clarke, Christine L., additional, Clendenning, Mark, additional, Cook, Linda S., additional, Couch, Fergus J., additional, Cox, Angela, additional, Crous-Bous, Marta, additional, Czene, Kamila, additional, Day, Felix, additional, Dennis, Joe, additional, Depreeuw, Jeroen, additional, Doherty, Jennifer Anne, additional, Dörk, Thilo, additional, Dowdy, Sean C., additional, Dürst, Matthias, additional, Ekici, Arif B., additional, Fasching, Peter A., additional, Fridley, Brooke L., additional, Friedenreich, Christine M., additional, Fritschi, Lin, additional, Fung, Jenny, additional, García-Closas, Montserrat, additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Goode, Ellen L., additional, Gorman, Maggie, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hankison, Susan E., additional, Healey, Catherine S., additional, Hein, Alexander, additional, Hillemanns, Peter, additional, Hodgson, Shirley, additional, Hoivik, Erling A., additional, Holliday, Elizabeth G., additional, Hopper, John L., additional, Hunter, David J., additional, Jones, Angela, additional, Krakstad, Camilla, additional, Kristensen, Vessela N., additional, Lambrechts, Diether, additional, Marchand, Loic Le, additional, Liang, Xiaolin, additional, Lindblom, Annika, additional, Lissowska, Jolanta, additional, Long, Jirong, additional, Lu, Lingeng, additional, Magliocco, Anthony M., additional, Martin, Lynn, additional, McEvoy, Mark, additional, Meindl, Alfons, additional, Michailidou, Kyriaki, additional, Milne, Roger L., additional, Mints, Miriam, additional, Montgomery, Grant W., additional, Nassir, Rami, additional, Olsson, Håkan, additional, Orlow, Irene, additional, Otton, Geoffrey, additional, Palles, Claire, additional, Perry, John R. B., additional, Peto, Julian, additional, Pooler, Loreall, additional, Prescott, Jennifer, additional, Proietto, Tony, additional, Rebbeck, Timothy R., additional, Risch, Harvey A., additional, Rogers, Peter A. W., additional, Rübner, Matthias, additional, Runnebaum, Ingo, additional, Sacerdote, Carlotta, additional, Sarto, Gloria E., additional, Schumacher, Fredrick, additional, Scott, Rodney J., additional, Setiawan, V. Wendy, additional, Shah, Mitul, additional, Sheng, Xin, additional, Shu, Xiao-Ou, additional, Southey, Melissa C., additional, Swerdlow, Anthony J., additional, Tham, Emma, additional, Trovik, Jone, additional, Turman, Constance, additional, Tyrer, Jonathan P., additional, Vachon, Celine, additional, VanDen Berg, David, additional, Vanderstichele, Adriaan, additional, Wang, Zhaoming, additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Werner, Henrica M. J., additional, Winham, Stacey J., additional, Wolk, Alicja, additional, Xia, Lucy, additional, Xiang, Yong-Bing, additional, Yang, Hannah P., additional, Yu, Herbert, additional, Zheng, Wei, additional, Pharoah, Paul D. P., additional, Dunning, Alison M., additional, Kraft, Peter, additional, De Vivo, Immaculata, additional, Tomlinson, Ian, additional, Easton, Douglas F., additional, Spurdle, Amanda B., additional, and Thompson, Deborah J., additional

Published
2018
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31. Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion

Author

Li, Zhenrui, primary, Qian, Pengxu, additional, Shao, Wanqing, additional, Shi, Hailing, additional, He, Xi C., additional, Gogol, Madelaine, additional, Yu, Zulin, additional, Wang, Yongfu, additional, Qi, Meijie, additional, Zhu, Yunfei, additional, Perry, John M., additional, Zhang, Kai, additional, Tao, Fang, additional, Zhou, Kun, additional, Hu, Deqing, additional, Han, Yingli, additional, Zhao, Chongbei, additional, Alexander, Richard, additional, Xu, Hanzhang, additional, Chen, Shiyuan, additional, Peak, Allison, additional, Hall, Kathyrn, additional, Peterson, Michael, additional, Perera, Anoja, additional, Haug, Jeffrey S., additional, Parmely, Tari, additional, Li, Hua, additional, Shen, Bin, additional, Zeitlinger, Julia, additional, He, Chuan, additional, and Li, Linheng, additional

Published
2018
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34. Elucidating the genetic architecture of reproductive ageing in the Japanese population

Author

Horikoshi, Momoko, primary, Day, Felix R., additional, Akiyama, Masato, additional, Hirata, Makoto, additional, Kamatani, Yoichiro, additional, Matsuda, Koichi, additional, Ishigaki, Kazuyoshi, additional, Kanai, Masahiro, additional, Wright, Hollis, additional, Toro, Carlos A., additional, Ojeda, Sergio R., additional, Lomniczi, Alejandro, additional, Kubo, Michiaki, additional, Ong, Ken K., additional, and Perry, John. R. B., additional

Published
2018
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38. GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Author

Lu, Ake T., primary, Xue, Luting, additional, Salfati, Elias L., additional, Chen, Brian H., additional, Ferrucci, Luigi, additional, Levy, Daniel, additional, Joehanes, Roby, additional, Murabito, Joanne M., additional, Kiel, Douglas P., additional, Tsai, Pei-Chien, additional, Yet, Idil, additional, Bell, Jordana T., additional, Mangino, Massimo, additional, Tanaka, Toshiko, additional, McRae, Allan F., additional, Marioni, Riccardo E., additional, Visscher, Peter M., additional, Wray, Naomi R., additional, Deary, Ian J., additional, Levine, Morgan E., additional, Quach, Austin, additional, Assimes, Themistocles, additional, Tsao, Philip S., additional, Absher, Devin, additional, Stewart, James D., additional, Li, Yun, additional, Reiner, Alex P., additional, Hou, Lifang, additional, Baccarelli, Andrea A., additional, Whitsel, Eric A., additional, Aviv, Abraham, additional, Cardona, Alexia, additional, Day, Felix R., additional, Wareham, Nicholas J., additional, Perry, John R. B., additional, Ong, Ken K., additional, Raj, Kenneth, additional, Lunetta, Kathryn L., additional, and Horvath, Steve, additional

Published
2018
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39. Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Author

Flannick, Jason, primary, Fuchsberger, Christian, additional, Mahajan, Anubha, additional, Teslovich, Tanya M., additional, Agarwala, Vineeta, additional, Gaulton, Kyle J., additional, Caulkins, Lizz, additional, Koesterer, Ryan, additional, Ma, Clement, additional, Moutsianas, Loukas, additional, McCarthy, Davis J., additional, Rivas, Manuel A., additional, Perry, John R. B., additional, Sim, Xueling, additional, Blackwell, Thomas W., additional, Robertson, Neil R., additional, Rayner, N William, additional, Cingolani, Pablo, additional, Locke, Adam E., additional, Tajes, Juan Fernandez, additional, Highland, Heather M., additional, Dupuis, Josee, additional, Chines, Peter S., additional, Lindgren, Cecilia M., additional, Hartl, Christopher, additional, Jackson, Anne U., additional, Chen, Han, additional, Huyghe, Jeroen R., additional, van de Bunt, Martijn, additional, Pearson, Richard D., additional, Kumar, Ashish, additional, Müller-Nurasyid, Martina, additional, Grarup, Niels, additional, Stringham, Heather M., additional, Gamazon, Eric R., additional, Lee, Jaehoon, additional, Chen, Yuhui, additional, Scott, Robert A., additional, Below, Jennifer E., additional, Chen, Peng, additional, Huang, Jinyan, additional, Go, Min Jin, additional, Stitzel, Michael L., additional, Pasko, Dorota, additional, Parker, Stephen C. J., additional, Varga, Tibor V., additional, Green, Todd, additional, Beer, Nicola L., additional, Day-Williams, Aaron G., additional, Ferreira, Teresa, additional, Fingerlin, Tasha, additional, Horikoshi, Momoko, additional, Hu, Cheng, additional, Huh, Iksoo, additional, Ikram, Mohammad Kamran, additional, Kim, Bong-Jo, additional, Kim, Yongkang, additional, Kim, Young Jin, additional, Kwon, Min-Seok, additional, Lee, Juyoung, additional, Lee, Selyeong, additional, Lin, Keng-Han, additional, Maxwell, Taylor J., additional, Nagai, Yoshihiko, additional, Wang, Xu, additional, Welch, Ryan P, additional, Yoon, Joon, additional, Zhang, Weihua, additional, Barzilai, Nir, additional, Voight, Benjamin F., additional, Han, Bok-Ghee, additional, Jenkinson, Christopher P., additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Manning, Alisa, additional, Ng, Maggie C. Y., additional, Palmer, Nicholette D., additional, Balkau, Beverley, additional, Stančáková, Alena, additional, Abboud, Hanna E., additional, Boeing, Heiner, additional, Giedraitis, Vilmantas, additional, Prabhakaran, Dorairaj, additional, Gottesman, Omri, additional, Scott, James, additional, Carey, Jason, additional, Kwan, Phoenix, additional, Grant, George, additional, Smith, Joshua D., additional, Neale, Benjamin M., additional, Purcell, Shaun, additional, Butterworth, Adam S., additional, Howson, Joanna M. M., additional, Lee, Heung Man, additional, Lu, Yingchang, additional, Kwak, Soo-Heon, additional, Zhao, Wei, additional, Danesh, John, additional, Lam, Vincent K. L., additional, Park, Kyong Soo, additional, Saleheen, Danish, additional, So, Wing Yee, additional, Tam, Claudia H. T., additional, Afzal, Uzma, additional, Aguilar, David, additional, Arya, Rector, additional, Aung, Tin, additional, Chan, Edmund, additional, Navarro, Carmen, additional, Cheng, Ching-Yu, additional, Palli, Domenico, additional, Correa, Adolfo, additional, Curran, Joanne E., additional, Rybin, Dennis, additional, Farook, Vidya S., additional, Fowler, Sharon P., additional, Freedman, Barry I., additional, Griswold, Michael, additional, Hale, Daniel Esten, additional, Hicks, Pamela J., additional, Khor, Chiea-Chuen, additional, Kumar, Satish, additional, Lehne, Benjamin, additional, Thuillier, Dorothée, additional, Lim, Wei Yen, additional, Liu, Jianjun, additional, Loh, Marie, additional, Musani, Solomon K., additional, Puppala, Sobha, additional, Scott, William R., additional, Yengo, Loïc, additional, Tan, Sian-Tsung, additional, Taylor, Herman A., additional, Thameem, Farook, additional, Wilson, Gregory, additional, Wong, Tien Yin, additional, Njølstad, Pål Rasmus, additional, Levy, Jonathan C., additional, Mangino, Massimo, additional, Bonnycastle, Lori L., additional, Schwarzmayr, Thomas, additional, Fadista, João, additional, Surdulescu, Gabriela L., additional, Herder, Christian, additional, Groves, Christopher J., additional, Wieland, Thomas, additional, Bork-Jensen, Jette, additional, Brandslund, Ivan, additional, Christensen, Cramer, additional, Koistinen, Heikki A., additional, Doney, Alex S .F., additional, Kinnunen, Leena, additional, Esko, Tõnu, additional, Farmer, Andrew J., additional, Hakaste, Liisa, additional, Hodgkiss, Dylan, additional, Kravic, Jasmina, additional, Lyssenko, Valeri, additional, Hollensted, Mette, additional, Jørgensen, Marit E., additional, Jørgensen, Torben, additional, Ladenvall, Claes, additional, Justesen, Johanne Marie, additional, Käräjämäki, Annemari, additional, Kriebel, Jennifer, additional, Rathmann, Wolfgang, additional, Lannfelt, Lars, additional, Lauritzen, Torsten, additional, Narisu, Narisu, additional, Linneberg, Allan, additional, Melander, Olle, additional, Milani, Lili, additional, Neville, Matt, additional, Orho-Melander, Marju, additional, Qi, Lu, additional, Qi, Qibin, additional, Roden, Michael, additional, Rolandsson, Olov, additional, Swift, Amy, additional, Rosengren, Anders H., additional, Stirrups, Kathleen, additional, Wood, Andrew R., additional, Mihailov, Evelin, additional, Blancher, Christine, additional, Carneiro, Mauricio O., additional, Maguire, Jared, additional, Poplin, Ryan, additional, Shakir, Khalid, additional, Fennell, Timothy, additional, DePristo, Mark, additional, de Angelis, Martin Hrabé, additional, Deloukas, Panos, additional, Gjesing, Anette P., additional, Jun, Goo, additional, Nilsson, Peter, additional, Murphy, Jacquelyn, additional, Onofrio, Robert, additional, Thorand, Barbara, additional, Hansen, Torben, additional, Meisinger, Christa, additional, Hu, Frank B., additional, Isomaa, Bo, additional, Karpe, Fredrik, additional, Liang, Liming, additional, Peters, Annette, additional, Huth, Cornelia, additional, O'Rahilly, Stephen P., additional, Palmer, Colin N. A., additional, Pedersen, Oluf, additional, Rauramaa, Rainer, additional, Tuomilehto, Jaakko, additional, Salomaa, Veikko, additional, Watanabe, Richard M., additional, Syvänen, Ann-Christine, additional, Bergman, Richard N., additional, Bharadwaj, Dwaipayan, additional, Bottinger, Erwin P., additional, Cho, Yoon Shin, additional, Chandak, Giriraj R., additional, Chan, Juliana C. N., additional, Chia, Kee Seng, additional, Daly, Mark J., additional, Ebrahim, Shah B., additional, Langenberg, Claudia, additional, Elliott, Paul, additional, Jablonski, Kathleen A., additional, Lehman, Donna M., additional, Jia, Weiping, additional, Ma, Ronald C. W., additional, Pollin, Toni I., additional, Sandhu, Manjinder, additional, Tandon, Nikhil, additional, Froguel, Philippe, additional, Barroso, Inês, additional, Teo, Yik Ying, additional, Zeggini, Eleftheria, additional, Loos, Ruth J. F., additional, Small, Kerrin S, additional, Ried, Janina S., additional, DeFronzo, Ralph A., additional, Grallert, Harald, additional, Glaser, Benjamin, additional, Metspalu, Andres, additional, Wareham, Nicholas J., additional, Walker, Mark, additional, Banks, Eric, additional, Gieger, Christian, additional, Ingelsson, Erik, additional, Im, Hae Kyung, additional, Illig, Thomas, additional, Franks, Paul W., additional, Buck, Gemma, additional, Trakalo, Joseph, additional, Buck, David, additional, Prokopenko, Inga, additional, Mägi, Reedik, additional, Lind, Lars, additional, Farjoun, Yossi, additional, Owen, Katharine R., additional, Gloyn, Anna L., additional, Strauch, Konstantin, additional, Tuomi, Tiinamaija, additional, Kooner, Jaspal Singh, additional, Lee, Jong-Young, additional, Park, Taesung, additional, Donnelly, Peter, additional, Morris, Andrew D., additional, Hattersley, Andrew T., additional, Bowden, Donald W., additional, Collins, Francis S., additional, Atzmon, Gil, additional, Chambers, John C., additional, Spector, Timothy D., additional, Laakso, Markku, additional, Strom, Tim M., additional, Bell, Graeme I., additional, Blangero, John, additional, Duggirala, Ravindranath, additional, Tai, E Shyong, additional, McVean, Gilean, additional, Hanis, Craig L., additional, Wilson, James G., additional, Seielstad, Mark, additional, Frayling, Timothy M., additional, Meigs, James B., additional, Cox, Nancy J., additional, Sladek, Rob, additional, Lander, Eric S., additional, Gabriel, Stacey, additional, Mohlke, Karen L., additional, Meitinger, Thomas, additional, Groop, Leif, additional, Abecasis, Goncalo, additional, Scott, Laura J., additional, Morris, Andrew P., additional, Kang, Hyun Min, additional, Altshuler, David, additional, Burtt, Noël P., additional, Florez, Jose C., additional, Boehnke, Michael, additional, and McCarthy, Mark I., additional

Published
2018
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40. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Author

Flannick, Jason, primary, Fuchsberger, Christian, additional, Mahajan, Anubha, additional, Teslovich, Tanya M., additional, Agarwala, Vineeta, additional, Gaulton, Kyle J., additional, Caulkins, Lizz, additional, Koesterer, Ryan, additional, Ma, Clement, additional, Moutsianas, Loukas, additional, McCarthy, Davis J., additional, Rivas, Manuel A., additional, Perry, John R. B., additional, Sim, Xueling, additional, Blackwell, Thomas W., additional, Robertson, Neil R., additional, Rayner, N William, additional, Cingolani, Pablo, additional, Locke, Adam E., additional, Tajes, Juan Fernandez, additional, Highland, Heather M., additional, Dupuis, Josee, additional, Chines, Peter S., additional, Lindgren, Cecilia M., additional, Hartl, Christopher, additional, Jackson, Anne U., additional, Chen, Han, additional, Huyghe, Jeroen R., additional, van de Bunt, Martijn, additional, Pearson, Richard D., additional, Kumar, Ashish, additional, Müller-Nurasyid, Martina, additional, Grarup, Niels, additional, Stringham, Heather M., additional, Gamazon, Eric R., additional, Lee, Jaehoon, additional, Chen, Yuhui, additional, Scott, Robert A., additional, Below, Jennifer E., additional, Chen, Peng, additional, Huang, Jinyan, additional, Go, Min Jin, additional, Stitzel, Michael L., additional, Pasko, Dorota, additional, Parker, Stephen C. J., additional, Varga, Tibor V., additional, Green, Todd, additional, Beer, Nicola L., additional, Day-Williams, Aaron G., additional, Ferreira, Teresa, additional, Fingerlin, Tasha, additional, Horikoshi, Momoko, additional, Hu, Cheng, additional, Huh, Iksoo, additional, Ikram, Mohammad Kamran, additional, Kim, Bong-Jo, additional, Kim, Yongkang, additional, Kim, Young Jin, additional, Kwon, Min-Seok, additional, Lee, Juyoung, additional, Lee, Selyeong, additional, Lin, Keng-Han, additional, Maxwell, Taylor J., additional, Nagai, Yoshihiko, additional, Wang, Xu, additional, Welch, Ryan P., additional, Yoon, Joon, additional, Zhang, Weihua, additional, Barzilai, Nir, additional, Voight, Benjamin F., additional, Han, Bok-Ghee, additional, Jenkinson, Christopher P., additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Manning, Alisa, additional, Ng, Maggie C. Y., additional, Palmer, Nicholette D., additional, Balkau, Beverley, additional, Stančáková, Alena, additional, Abboud, Hanna E., additional, Boeing, Heiner, additional, Giedraitis, Vilmantas, additional, Prabhakaran, Dorairaj, additional, Gottesman, Omri, additional, Scott, James, additional, Carey, Jason, additional, Kwan, Phoenix, additional, Grant, George, additional, Smith, Joshua D., additional, Neale, Benjamin M., additional, Purcell, Shaun, additional, Butterworth, Adam S., additional, Howson, Joanna M. M., additional, Lee, Heung Man, additional, Lu, Yingchang, additional, Kwak, Soo-Heon, additional, Zhao, Wei, additional, Danesh, John, additional, Lam, Vincent K. L., additional, Park, Kyong Soo, additional, Saleheen, Danish, additional, So, Wing Yee, additional, Tam, Claudia H. T., additional, Afzal, Uzma, additional, Aguilar, David, additional, Arya, Rector, additional, Aung, Tin, additional, Chan, Edmund, additional, Navarro, Carmen, additional, Cheng, Ching-Yu, additional, Palli, Domenico, additional, Correa, Adolfo, additional, Curran, Joanne E., additional, Rybin, Dennis, additional, Farook, Vidya S., additional, Fowler, Sharon P., additional, Freedman, Barry I., additional, Griswold, Michael, additional, Hale, Daniel Esten, additional, Hicks, Pamela J., additional, Khor, Chiea-Chuen, additional, Kumar, Satish, additional, Lehne, Benjamin, additional, Thuillier, Dorothée, additional, Lim, Wei Yen, additional, Liu, Jianjun, additional, Loh, Marie, additional, Musani, Solomon K., additional, Puppala, Sobha, additional, Scott, William R., additional, Yengo, Loïc, additional, Tan, Sian-Tsung, additional, Taylor, Herman A., additional, Thameem, Farook, additional, Wilson, Gregory, additional, Wong, Tien Yin, additional, Njølstad, Pål Rasmus, additional, Levy, Jonathan C., additional, Mangino, Massimo, additional, Bonnycastle, Lori L., additional, Schwarzmayr, Thomas, additional, Fadista, João, additional, Surdulescu, Gabriela L., additional, Herder, Christian, additional, Groves, Christopher J., additional, Wieland, Thomas, additional, Bork-Jensen, Jette, additional, Brandslund, Ivan, additional, Christensen, Cramer, additional, Koistinen, Heikki A., additional, Doney, Alex S. F., additional, Kinnunen, Leena, additional, Esko, Tõnu, additional, Farmer, Andrew J., additional, Hakaste, Liisa, additional, Hodgkiss, Dylan, additional, Kravic, Jasmina, additional, Lyssenko, Valeri, additional, Hollensted, Mette, additional, Jørgensen, Marit E., additional, Jørgensen, Torben, additional, Ladenvall, Claes, additional, Justesen, Johanne Marie, additional, Käräjämäki, Annemari, additional, Kriebel, Jennifer, additional, Rathmann, Wolfgang, additional, Lannfelt, Lars, additional, Lauritzen, Torsten, additional, Narisu, Narisu, additional, Linneberg, Allan, additional, Melander, Olle, additional, Milani, Lili, additional, Neville, Matt, additional, Orho-Melander, Marju, additional, Qi, Lu, additional, Qi, Qibin, additional, Roden, Michael, additional, Rolandsson, Olov, additional, Swift, Amy, additional, Rosengren, Anders H., additional, Stirrups, Kathleen, additional, Wood, Andrew R., additional, Mihailov, Evelin, additional, Blancher, Christine, additional, Carneiro, Mauricio O., additional, Maguire, Jared, additional, Poplin, Ryan, additional, Shakir, Khalid, additional, Fennell, Timothy, additional, DePristo, Mark, additional, de Angelis, Martin Hrabé, additional, Deloukas, Panos, additional, Gjesing, Anette P., additional, Jun, Goo, additional, Nilsson, Peter, additional, Murphy, Jacquelyn, additional, Onofrio, Robert, additional, Thorand, Barbara, additional, Hansen, Torben, additional, Meisinger, Christa, additional, Hu, Frank B., additional, Isomaa, Bo, additional, Karpe, Fredrik, additional, Liang, Liming, additional, Peters, Annette, additional, Huth, Cornelia, additional, O'Rahilly, Stephen P, additional, Palmer, Colin N. A., additional, Pedersen, Oluf, additional, Rauramaa, Rainer, additional, Tuomilehto, Jaakko, additional, Salomaa, Veikko, additional, Watanabe, Richard M., additional, Syvänen, Ann-Christine, additional, Bergman, Richard N., additional, Bharadwaj, Dwaipayan, additional, Bottinger, Erwin P., additional, Cho, Yoon Shin, additional, Chandak, Giriraj R., additional, Chan, Juliana CN, additional, Chia, Kee Seng, additional, Daly, Mark J., additional, Ebrahim, Shah B., additional, Langenberg, Claudia, additional, Elliott, Paul, additional, Jablonski, Kathleen A., additional, Lehman, Donna M., additional, Jia, Weiping, additional, Ma, Ronald C. W., additional, Pollin, Toni I., additional, Sandhu, Manjinder, additional, Tandon, Nikhil, additional, Froguel, Philippe, additional, Barroso, Inês, additional, Teo, Yik Ying, additional, Zeggini, Eleftheria, additional, Loos, Ruth J. F., additional, Small, Kerrin S., additional, Ried, Janina S., additional, DeFronzo, Ralph A., additional, Grallert, Harald, additional, Glaser, Benjamin, additional, Metspalu, Andres, additional, Wareham, Nicholas J., additional, Walker, Mark, additional, Banks, Eric, additional, Gieger, Christian, additional, Ingelsson, Erik, additional, Im, Hae Kyung, additional, Illig, Thomas, additional, Franks, Paul W., additional, Buck, Gemma, additional, Trakalo, Joseph, additional, Buck, David, additional, Prokopenko, Inga, additional, Mägi, Reedik, additional, Lind, Lars, additional, Farjoun, Yossi, additional, Owen, Katharine R., additional, Gloyn, Anna L., additional, Strauch, Konstantin, additional, Tuomi, Tiinamaija, additional, Kooner, Jaspal Singh, additional, Lee, Jong-Young, additional, Park, Taesung, additional, Donnelly, Peter, additional, Morris, Andrew D., additional, Hattersley, Andrew T., additional, Bowden, Donald W., additional, Collins, Francis S., additional, Atzmon, Gil, additional, Chambers, John C., additional, Spector, Timothy D., additional, Laakso, Markku, additional, Strom, Tim M., additional, Bell, Graeme I., additional, Blangero, John, additional, Duggirala, Ravindranath, additional, Tai, E. Shyong, additional, McVean, Gilean, additional, Hanis, Craig L., additional, Wilson, James G., additional, Seielstad, Mark, additional, Frayling, Timothy M., additional, Meigs, James B., additional, Cox, Nancy J., additional, Sladek, Rob, additional, Lander, Eric S., additional, Gabriel, Stacey, additional, Mohlke, Karen L., additional, Meitinger, Thomas, additional, Groop, Leif, additional, Abecasis, Goncalo, additional, Scott, Laura J., additional, Morris, Andrew P., additional, Kang, Hyun Min, additional, Altshuler, David, additional, Burtt, Noël P., additional, Florez, Jose C., additional, Boehnke, Michael, additional, and McCarthy, Mark I., additional

Published
2017
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41. Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes

Author

Ruth, Katherine S, Campbell, Purdey J, Chew, Shelby, Lim, Ee Mun, Hadlow, Narelle, Stuckey, Bronwyn GA, Brown, Suzanne J, Feenstra, Bjarke, Joseph, John, Surdulescu, Gabriela L, Zheng, Hou Feng, Richards, J Brent, Murray, Anna, Spector, Tim D, Wilson, Scott G, Perry, John RB, Feenstra, Bjarke [0000-0003-1478-649X], and Apollo - University of Cambridge Repository

Subjects
Male, Estradiol, Genotype, Dehydroepiandrosterone Sulfate, Genome, Human, Luteinizing Hormone, Polymorphism, Single Nucleotide, Prolactin, Phenotype, Sex Hormone-Binding Globulin, Humans, Female, Testosterone, Follicle Stimulating Hormone, Gonadal Steroid Hormones, Progesterone, Genome-Wide Association Study
Abstract

Genetic factors contribute strongly to sex hormone levels, yet knowledge of the regulatory mechanisms remains incomplete. Genome-wide association studies (GWAS) have identified only a small number of loci associated with sex hormone levels, with several reproductive hormones yet to be assessed. The aim of the study was to identify novel genetic variants contributing to the regulation of sex hormones. We performed GWAS using genotypes imputed from the 1000 Genomes reference panel. The study used genotype and phenotype data from a UK twin register. We included 2913 individuals (up to 294 males) from the Twins UK study, excluding individuals receiving hormone treatment. Phenotypes were standardised for age, sex, BMI, stage of menstrual cycle and menopausal status. We tested 7,879,351 autosomal SNPs for association with levels of dehydroepiandrosterone sulphate (DHEAS), oestradiol, free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, progesterone, sex hormone-binding globulin and testosterone. Eight independent genetic variants reached genome-wide significance (P

Published
2016

42. Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations

Author

Prins, Bram P., primary, Kuchenbaecker, Karoline B., additional, Bao, Yanchun, additional, Smart, Melissa, additional, Zabaneh, Delilah, additional, Fatemifar, Ghazaleh, additional, Luan, Jian’an, additional, Wareham, Nick J., additional, Scott, Robert A., additional, Perry, John R. B., additional, Langenberg, Claudia, additional, Benzeval, Michaela, additional, Kumari, Meena, additional, and Zeggini, Eleftheria, additional

Published
2017
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43. Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls

Author

Stewart, Christopher J., primary, Embleton, Nicholas D., additional, Marrs, Emma C. L., additional, Smith, Daniel P., additional, Fofanova, Tatiana, additional, Nelson, Andrew, additional, Skeath, Tom, additional, Perry, John D., additional, Petrosino, Joseph F., additional, Berrington, Janet E., additional, and Cummings, Stephen P., additional

Published
2017
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44. Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility

Author

Wright, Daniel J, primary, Day, Felix R, additional, Kerrison, Nicola D, additional, Zink, Florian, additional, Cardona, Alexia, additional, Sulem, Patrick, additional, Thompson, Deborah J, additional, Sigurjonsdottir, Svanhvit, additional, Gudbjartsson, Daniel F, additional, Helgason, Agnar, additional, Chapman, J Ross, additional, Jackson, Steve P, additional, Langenberg, Claudia, additional, Wareham, Nicholas J, additional, Scott, Robert A, additional, Thorsteindottir, Unnur, additional, Ong, Ken K, additional, Stefansson, Kari, additional, and Perry, John R B, additional

Published
2017
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45. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Author

Burton, Paul R., Clayton, David G., Cardon, Lon R., Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P., McCarthy, Mark I., Ouwehand, Willem H., Samani, Nilesh J., Todd, John A., Donnelly, Peter, Barrett, Jeffrey C., Davison, Dan, Easton, Doug, Evans, David, Leung, Hin-Tak, Marchini, Jonathan L., Morris, Andrew P., Spencer, Chris C. A., Tobin, Martin D., Attwood, Antony P., Boorman, James P., Cant, Barbara, Everson, Ursula, Hussey, Judith M., Jolley, Jennifer D., Knight, Alexandra S., Koch, Kerstin, Meech, Elizabeth, Nutland, Sarah, Prowse, Christopher V., Stevens, Helen E., Taylor, Niall C., Walters, Graham R., Walker, Neil M., Watkins, Nicholas A., Winzer, Thilo, Jones, Richard W., McArdle, Wendy L., Ring, Susan M., Strachan, David P., Pembrey, Marcus, Breen, Gerome, St Clair, David, Caesar, Sian, Gordon-Smith, Katherine, Jones, Lisa, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian L., Holmans, Peter A., Jones, Ian R., Kirov, George, Moskvina, Valentina, Nikolov, Ivan, O'Donovan, Michael C., Owen, Michael J., Collier, David A., Elkin, Amanda, Farmer, Anne, Williamson, Richard, McGuffin, Peter, Young, Allan H., Ferrier, I. Nicol, Ball, Stephen G., Balmforth, Anthony J., Barrett, Jennifer H., Bishop, D. Timothy, Iles, Mark M., Maqbool, Azhar, Yuldasheva, Nadira, Hall, Alistair S., Braund, Peter S., Dixon, Richard J., Mangino, Massimo, Stevens, Suzanne, Thompson, John R., Bredin, Francesca, Tremelling, Mark, Parkes, Miles, Drummond, Hazel, Lees, Charles W., Nimmo, Elaine R., Satsangi, Jack, Fisher, Sheila A., Forbes, Alastair, Lewis, Cathryn M., Onnie, Clive M., Prescott, Natalie J., Sanderson, Jeremy, Mathew, Christopher G., Barbour, Jamie, Mohiuddin, M. Khalid, Todhunter, Catherine E., Mansfield, John C., Ahmad, Tariq, Cummings, Fraser R., Jewell, Derek P., Webster, John, Brown, Morris J., Lathrop, G. Mark, Connell, John, Dominiczak, Anna, Marcano, Carolina A. Braga, Burke, Beverley, Dobson, Richard, Gungadoo, Johannie, Lee, Kate L., Munroe, Patricia B., Newhouse, Stephen J., Onipinla, Abiodun, Wallace, Chris, Xue, Mingzhan, Caulfield, Mark, Farrall, Martin, Barton, Anne, and Genomics (BRAGGS), The Biologics in RA Genetics, Bruce, Ian N., Donovan, Hannah, Eyre, Steve, Gilbert, Paul D., Hider, Samantha L., Hinks, Anne M., John, Sally L., Potter, Catherine, Silman, Alan J., Symmons, Deborah P. M., Thomson, Wendy, Worthington, Jane, Dunger, David B., Widmer, Barry, Frayling, Timothy M., Freathy, Rachel M., Lango, Hana, Perry, John R. B., Shields, Beverley M., Weedon, Michael N., Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Elliott, Kate S., Groves, Christopher J., Lindgren, Cecilia M., Rayner, Nigel W., Timpson, Nicholas J., Zeggini, Eleftheria, Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Hill, Adrian V. S., Bradbury, Linda A., Farrar, Claire, Pointon, Jennifer J., Wordsworth, Paul, Brown, Matthew A., Franklyn, Jayne A., Heward, Joanne M., Simmonds, Matthew J., Gough, Stephen C. L., Seal, Sheila, Susceptibility Collaboration (UK), Breast Cancer, Stratton, Michael R., Rahman, Nazneen, Ban, Maria, Goris, An, Sawcer, Stephen J., Compston, Alastair, Conway, David, Jallow, Muminatou, Rockett, Kirk A., Bumpstead, Suzannah J., Chaney, Amy, Downes, Kate, Ghori, Mohammed J. R., Gwilliam, Rhian, Hunt, Sarah E., Inouye, Michael, Keniry, Andrew, King, Emma, McGinnis, Ralph, Potter, Simon, Ravindrarajah, Rathi, Whittaker, Pamela, Widden, Claire, Withers, David, Cardin, Niall J., Ferreira, Teresa, Pereira-Gale, Joanne, Hallgrimsdóttir, Ingileif B., Howie, Bryan N., Su, Zhan, Teo, Yik Ying, Vukcevic, Damjan, Bentley, David, and Compston, Alistair

Subjects
Genetic Markers, Bipolar Disorder, Population, Genome-wide association study, Single-nucleotide polymorphism, Coronary Artery Disease, Disease, Biology, Population stratification, Article, Arthritis, Rheumatoid, Crohn Disease, Gene Frequency, Diabetes Mellitus, Chromosomes, Human, Humans, Genetic Predisposition to Disease, education, Allele frequency, Genetics, education.field_of_study, Multidisciplinary, Geography, Genome, Human, CDKN2BAS, United Kingdom, Human genetics, C431 Medical Genetics, Genetics, Population, Case-Control Studies, Hypertension
Abstract

There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study ( using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined similar to 2,000 individuals for each of 7 major diseases and a shared set of similar to 3,000 controls. Case-control comparisons identified 24 independent association signals at P < 5 X 10(-7): 1 in bipolar disorder, 1 in coronary artery disease, 9 in Crohn's disease, 3 in rheumatoid arthritis, 7 in type 1 diabetes and 3 in type 2 diabetes. On the basis of prior findings and replication studies thus-far completed, almost all of these signals reflect genuine susceptibility effects. We observed association at many previously identified loci, and found compelling evidence that some loci confer risk for more than one of the diseases studied. Across all diseases, we identified a large number of further signals ( including 58 loci with single-point P values between 10(-5) and 5 X 10(-7)) likely to yield additional susceptibility loci. The importance of appropriately large samples was confirmed by the modest effect sizes observed at most loci identified. This study thus represents a thorough validation of the GWA approach. It has also demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; has generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in the British population is generally modest. Our findings offer new avenues for exploring the pathophysiology of these important disorders. We anticipate that our data, results and software, which will be widely available to other investigators, will provide a powerful resource for human genetics research.

Published
2007

46. Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome

Author

Day, Felix R., Hinds, David A., Tung, Joyce Y., Stolk, Lisette, Styrkarsdottir, Unnur, Saxena, Richa, Bjonnes, Andrew, Broer, Linda, Dunger, David B., Halldorsson, Bjarni V., Lawlor, Debbie A., Laval, Guillaume, Mathieson, Iain, McCardle, Wendy L., Louwers, Yvonne, Meun, Cindy, Ring, Susan, Scott, Robert A., Sulem, Patrick, Uitterlinden, André G., Wareham, Nicholas J., Thorsteinsdottir, Unnur, Welt, Corrine, Stefansson, Kari, Laven, Joop S. E., Ong, Ken K., Perry, John R. B., Day, Felix R [0000-0003-3789-7651], Styrkarsdottir, Unnur [0000-0001-8146-8278], Dunger, David B [0000-0002-2566-9304], Sulem, Patrick [0000-0001-7123-6123], Apollo - University of Cambridge Repository, Internal Medicine, and Obstetrics & Gynecology

Subjects
Aging, Ovary, YAP-Signaling Proteins, Phosphoproteins, Article, White People, Acid Anhydride Hydrolases, Neoplasm Proteins, DNA-Binding Proteins, ErbB Receptors, DNA Repair Enzymes, Case-Control Studies, Follicle Stimulating Hormone, beta Subunit, Humans, Female, Selection, Genetic, Adaptor Proteins, Signal Transducing, Genome-Wide Association Study, Polycystic Ovary Syndrome, Transcription Factors
Abstract

Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet there is little consensus regarding its aetiology. Here we perform a genome-wide association study of PCOS in up to 5,184 self-reported cases of White European ancestry and 82,759 controls, with follow-up in a further ∼2,000 clinically validated cases and ∼100,000 controls. We identify six signals for PCOS at genome-wide statistical significance (P, This paper describes the largest genome-wide association study to date on polycystic ovary syndrome (PCOS), a common reproductive disorder in women. Six genetic loci—including known targets of cancer chemotherapy—were identified, and the authors infer causal and balancing selection mechanisms involved in PCOS risk and susceptibility.

Published
2015

47. Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease

Author

Stewart, Christopher J., primary, Embleton, Nicholas D., additional, Marrs, Emma C. L., additional, Smith, Daniel P., additional, Nelson, Andrew, additional, Abdulkadir, Bashir, additional, Skeath, Tom, additional, Petrosino, Joseph F., additional, Perry, John D., additional, Berrington, Janet E., additional, and Cummings, Stephen P., additional

Published
2016
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48. The genetic architecture of type 2 diabetes

Author

Fuchsberger, Christian, primary, Flannick, Jason, additional, Teslovich, Tanya M., additional, Mahajan, Anubha, additional, Agarwala, Vineeta, additional, Gaulton, Kyle J., additional, Ma, Clement, additional, Fontanillas, Pierre, additional, Moutsianas, Loukas, additional, McCarthy, Davis J., additional, Rivas, Manuel A., additional, Perry, John R. B., additional, Sim, Xueling, additional, Blackwell, Thomas W., additional, Robertson, Neil R., additional, Rayner, N. William, additional, Cingolani, Pablo, additional, Locke, Adam E., additional, Tajes, Juan Fernandez, additional, Highland, Heather M., additional, Dupuis, Josee, additional, Chines, Peter S., additional, Lindgren, Cecilia M., additional, Hartl, Christopher, additional, Jackson, Anne U., additional, Chen, Han, additional, Huyghe, Jeroen R., additional, van de Bunt, Martijn, additional, Pearson, Richard D., additional, Kumar, Ashish, additional, Müller-Nurasyid, Martina, additional, Grarup, Niels, additional, Stringham, Heather M., additional, Gamazon, Eric R., additional, Lee, Jaehoon, additional, Chen, Yuhui, additional, Scott, Robert A., additional, Below, Jennifer E., additional, Chen, Peng, additional, Huang, Jinyan, additional, Go, Min Jin, additional, Stitzel, Michael L., additional, Pasko, Dorota, additional, Parker, Stephen C. J., additional, Varga, Tibor V., additional, Green, Todd, additional, Beer, Nicola L., additional, Day-Williams, Aaron G., additional, Ferreira, Teresa, additional, Fingerlin, Tasha, additional, Horikoshi, Momoko, additional, Hu, Cheng, additional, Huh, Iksoo, additional, Ikram, Mohammad Kamran, additional, Kim, Bong-Jo, additional, Kim, Yongkang, additional, Kim, Young Jin, additional, Kwon, Min-Seok, additional, Lee, Juyoung, additional, Lee, Selyeong, additional, Lin, Keng-Han, additional, Maxwell, Taylor J., additional, Nagai, Yoshihiko, additional, Wang, Xu, additional, Welch, Ryan P., additional, Yoon, Joon, additional, Zhang, Weihua, additional, Barzilai, Nir, additional, Voight, Benjamin F., additional, Han, Bok-Ghee, additional, Jenkinson, Christopher P., additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Manning, Alisa, additional, Ng, Maggie C. Y., additional, Palmer, Nicholette D., additional, Balkau, Beverley, additional, Stančáková, Alena, additional, Abboud, Hanna E., additional, Boeing, Heiner, additional, Giedraitis, Vilmantas, additional, Prabhakaran, Dorairaj, additional, Gottesman, Omri, additional, Scott, James, additional, Carey, Jason, additional, Kwan, Phoenix, additional, Grant, George, additional, Smith, Joshua D., additional, Neale, Benjamin M., additional, Purcell, Shaun, additional, Butterworth, Adam S., additional, Howson, Joanna M. M., additional, Lee, Heung Man, additional, Lu, Yingchang, additional, Kwak, Soo-Heon, additional, Zhao, Wei, additional, Danesh, John, additional, Lam, Vincent K. L., additional, Park, Kyong Soo, additional, Saleheen, Danish, additional, So, Wing Yee, additional, Tam, Claudia H. T., additional, Afzal, Uzma, additional, Aguilar, David, additional, Arya, Rector, additional, Aung, Tin, additional, Chan, Edmund, additional, Navarro, Carmen, additional, Cheng, Ching-Yu, additional, Palli, Domenico, additional, Correa, Adolfo, additional, Curran, Joanne E., additional, Rybin, Denis, additional, Farook, Vidya S., additional, Fowler, Sharon P., additional, Freedman, Barry I., additional, Griswold, Michael, additional, Hale, Daniel Esten, additional, Hicks, Pamela J., additional, Khor, Chiea-Chuen, additional, Kumar, Satish, additional, Lehne, Benjamin, additional, Thuillier, Dorothée, additional, Lim, Wei Yen, additional, Liu, Jianjun, additional, van der Schouw, Yvonne T., additional, Loh, Marie, additional, Musani, Solomon K., additional, Puppala, Sobha, additional, Scott, William R., additional, Yengo, Loïc, additional, Tan, Sian-Tsung, additional, Taylor, Herman A., additional, Thameem, Farook, additional, Wilson, Gregory, additional, Wong, Tien Yin, additional, Njølstad, Pål Rasmus, additional, Levy, Jonathan C., additional, Mangino, Massimo, additional, Bonnycastle, Lori L., additional, Schwarzmayr, Thomas, additional, Fadista, João, additional, Surdulescu, Gabriela L., additional, Herder, Christian, additional, Groves, Christopher J., additional, Wieland, Thomas, additional, Bork-Jensen, Jette, additional, Brandslund, Ivan, additional, Christensen, Cramer, additional, Koistinen, Heikki A., additional, Doney, Alex S. F., additional, Kinnunen, Leena, additional, Esko, Tõnu, additional, Farmer, Andrew J., additional, Hakaste, Liisa, additional, Hodgkiss, Dylan, additional, Kravic, Jasmina, additional, Lyssenko, Valeriya, additional, Hollensted, Mette, additional, Jørgensen, Marit E., additional, Jørgensen, Torben, additional, Ladenvall, Claes, additional, Justesen, Johanne Marie, additional, Käräjämäki, Annemari, additional, Kriebel, Jennifer, additional, Rathmann, Wolfgang, additional, Lannfelt, Lars, additional, Lauritzen, Torsten, additional, Narisu, Narisu, additional, Linneberg, Allan, additional, Melander, Olle, additional, Milani, Lili, additional, Neville, Matt, additional, Orho-Melander, Marju, additional, Qi, Lu, additional, Qi, Qibin, additional, Roden, Michael, additional, Rolandsson, Olov, additional, Swift, Amy, additional, Rosengren, Anders H., additional, Stirrups, Kathleen, additional, Wood, Andrew R., additional, Mihailov, Evelin, additional, Blancher, Christine, additional, Carneiro, Mauricio O., additional, Maguire, Jared, additional, Poplin, Ryan, additional, Shakir, Khalid, additional, Fennell, Timothy, additional, DePristo, Mark, additional, Hrabé de Angelis, Martin, additional, Deloukas, Panos, additional, Gjesing, Anette P., additional, Jun, Goo, additional, Nilsson, Peter, additional, Murphy, Jacquelyn, additional, Onofrio, Robert, additional, Thorand, Barbara, additional, Hansen, Torben, additional, Meisinger, Christa, additional, Hu, Frank B., additional, Isomaa, Bo, additional, Karpe, Fredrik, additional, Liang, Liming, additional, Peters, Annette, additional, Huth, Cornelia, additional, O’Rahilly, Stephen P., additional, Palmer, Colin N. A., additional, Pedersen, Oluf, additional, Rauramaa, Rainer, additional, Tuomilehto, Jaakko, additional, Salomaa, Veikko, additional, Watanabe, Richard M., additional, Syvänen, Ann-Christine, additional, Bergman, Richard N., additional, Bharadwaj, Dwaipayan, additional, Bottinger, Erwin P., additional, Cho, Yoon Shin, additional, Chandak, Giriraj R., additional, Chan, Juliana C. N., additional, Chia, Kee Seng, additional, Daly, Mark J., additional, Ebrahim, Shah B., additional, Langenberg, Claudia, additional, Elliott, Paul, additional, Jablonski, Kathleen A., additional, Lehman, Donna M., additional, Jia, Weiping, additional, Ma, Ronald C. W., additional, Pollin, Toni I., additional, Sandhu, Manjinder, additional, Tandon, Nikhil, additional, Froguel, Philippe, additional, Barroso, Inês, additional, Teo, Yik Ying, additional, Zeggini, Eleftheria, additional, Loos, Ruth J. F., additional, Small, Kerrin S., additional, Ried, Janina S., additional, DeFronzo, Ralph A., additional, Grallert, Harald, additional, Glaser, Benjamin, additional, Metspalu, Andres, additional, Wareham, Nicholas J., additional, Walker, Mark, additional, Banks, Eric, additional, Gieger, Christian, additional, Ingelsson, Erik, additional, Im, Hae Kyung, additional, Illig, Thomas, additional, Franks, Paul W., additional, Buck, Gemma, additional, Trakalo, Joseph, additional, Buck, David, additional, Prokopenko, Inga, additional, Mägi, Reedik, additional, Lind, Lars, additional, Farjoun, Yossi, additional, Owen, Katharine R., additional, Gloyn, Anna L., additional, Strauch, Konstantin, additional, Tuomi, Tiinamaija, additional, Kooner, Jaspal Singh, additional, Lee, Jong-Young, additional, Park, Taesung, additional, Donnelly, Peter, additional, Morris, Andrew D., additional, Hattersley, Andrew T., additional, Bowden, Donald W., additional, Collins, Francis S., additional, Atzmon, Gil, additional, Chambers, John C., additional, Spector, Timothy D., additional, Laakso, Markku, additional, Strom, Tim M., additional, Bell, Graeme I., additional, Blangero, John, additional, Duggirala, Ravindranath, additional, Tai, E. Shyong, additional, McVean, Gilean, additional, Hanis, Craig L., additional, Wilson, James G., additional, Seielstad, Mark, additional, Frayling, Timothy M., additional, Meigs, James B., additional, Cox, Nancy J., additional, Sladek, Rob, additional, Lander, Eric S., additional, Gabriel, Stacey, additional, Burtt, Noël P., additional, Mohlke, Karen L., additional, Meitinger, Thomas, additional, Groop, Leif, additional, Abecasis, Goncalo, additional, Florez, Jose C., additional, Scott, Laura J., additional, Morris, Andrew P., additional, Kang, Hyun Min, additional, Boehnke, Michael, additional, Altshuler, David, additional, and McCarthy, Mark I., additional

Published
2016
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50. Physical and neurobehavioral determinants of reproductive onset and success

Author

Day, Felix R, primary, Helgason, Hannes, additional, Chasman, Daniel I, additional, Rose, Lynda M, additional, Loh, Po-Ru, additional, Scott, Robert A, additional, Helgason, Agnar, additional, Kong, Augustine, additional, Masson, Gisli, additional, Magnusson, Olafur Th, additional, Gudbjartsson, Daniel, additional, Thorsteinsdottir, Unnur, additional, Buring, Julie E, additional, Ridker, Paul M, additional, Sulem, Patrick, additional, Stefansson, Kari, additional, Ong, Ken K, additional, and Perry, John R B, additional

Published
2016
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