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Your search keyword '"Rajadas, Jayakumar"' showing total 20 results
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20 results on '"Rajadas, Jayakumar"'

1. Disrupting biological sensors of force promotes tissue regeneration in large organisms

Author

Chen, Kellen, primary, Kwon, Sun Hyung, additional, Henn, Dominic, additional, Kuehlmann, Britta A., additional, Tevlin, Ruth, additional, Bonham, Clark A., additional, Griffin, Michelle, additional, Trotsyuk, Artem A., additional, Borrelli, Mimi R., additional, Noishiki, Chikage, additional, Padmanabhan, Jagannath, additional, Barrera, Janos A., additional, Maan, Zeshaan N., additional, Dohi, Teruyuki, additional, Mays, Chyna J., additional, Greco, Autumn H., additional, Sivaraj, Dharshan, additional, Lin, John Q., additional, Fehlmann, Tobias, additional, Mermin-Bunnell, Alana M., additional, Mittal, Smiti, additional, Hu, Michael S., additional, Zamaleeva, Alsu I., additional, Keller, Andreas, additional, Rajadas, Jayakumar, additional, Longaker, Michael T., additional, Januszyk, Michael, additional, and Gurtner, Geoffrey C., additional

Published
2021
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6. Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix

Author

Lee, Andrew S., primary, Inayathullah, Mohammed, additional, Lijkwan, Maarten A., additional, Zhao, Xin, additional, Sun, Wenchao, additional, Park, Sujin, additional, Hong, Wan Xing, additional, Parekh, Mansi B., additional, Malkovskiy, Andrey V., additional, Lau, Edward, additional, Qin, Xulei, additional, Pothineni, Venkata Raveendra, additional, Sanchez-Freire, Verónica, additional, Zhang, Wendy Y., additional, Kooreman, Nigel G., additional, Ebert, Antje D., additional, Chan, Charles K. F., additional, Nguyen, Patricia K., additional, Rajadas, Jayakumar, additional, and Wu, Joseph C., additional

Published
2018
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8. Effect of Ca2+ on the self assembly of a nonionic peptide aggregate

Author

Mohammed Inayathullah, Meena Balasubramanian, Rajadas Jayakumar, Muthu Murugesan, Julia P. Moses, and Maneesha E. Andrews

Subjects
chemistry.chemical_classification, Circular dichroism, Aqueous solution, Conductometry, Metal ions in aqueous solution, Inorganic chemistry, Bioengineering, Peptide, Biochemistry, Micelle, Fluorescence spectroscopy, Analytical Chemistry, chemistry.chemical_compound, Crystallography, Monomer, chemistry, Drug Discovery, Molecular Medicine
Abstract

Conductometry, circular dichroism and fluorescence spectroscopy are thetechniques employed to investigate the effect of added calcium ions and other monovalent and divalent metal ions on aqueous solutions of nonionic peptide aggregates, Boc-Leu-Asn-OEt (1). It is observed that among all the metal ions studied, Ca2+ ions facilitate the aggregation of the peptide. The interior dielectric constant of the micelles (e) was found to depend upon the proportion of Ca2+ complexed peptide with the peptide monomers in the micelles. When Ca2+ ion becomes 1/4th of the peptide concentration, there is a structural transition leading to drastic change in the interior of the micro dielectric constant (em).

Published
2003
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9. Adiabatic compressibility and intrinsic viscosity studies on peptide aggregates

Author

Maneesha E. Andrews, C. Rakkappan, S. Sendhil, Julia P. Moses, and Rajadas Jayakumar

Subjects
chemistry.chemical_classification, Quantitative Biology::Biomolecules, Range (particle radiation), Aqueous solution, Tetrapeptide, Adiabatic compressibility, Intrinsic viscosity, Thermodynamics, Bioengineering, Peptide, Biochemistry, Analytical Chemistry, chemistry, Drug Discovery, Proton NMR, Molecular Medicine, Physical chemistry, Temperature coefficient
Abstract

Density and sound velocity measurements and1H NMR investigations were carried out in aqueous solution at various temperatures for determining the adiabatic compressibility (β) and hydration of the tetrapeptide, TFA. Tyr-Gly-Phe-Ala-Obz I. The present investigation showed changes in the temperature coefficient of adiabatic compressibility at 40°C,1H NMR studies indicated the inverse temperature transition in the concentration range studied.

Published
2002
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10. Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi

Author

Pothineni, Venkata Raveendra, primary, Wagh, Dhananjay, additional, Babar, Mustafeez Mujtaba, additional, Inayathullah, Mohammed, additional, Watts, R Edward, additional, Kim, Kwang-Min, additional, Parekh, Mansi B, additional, Gurjarpadhye, Abhijit Achyut, additional, Solow-Cordero, David, additional, Tayebi, Lobat, additional, and Rajadas, Jayakumar, additional

Published
2016
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12. [Untitled]

Author

Rengarajulu Puvanakrishnan, Shanmugasundaram Jayasundar, C.V. Ramesh, Rajadas Jayakumar, and Pannirselvam Malarvannan

Subjects
Cardioprotection, Cardiotoxicity, Tetrapeptide, Chemistry, Clinical chemistry, Double dose, Clinical Biochemistry, Cell Biology, General Medicine, Pharmacology, Ischemic preconditioning, Adrenergic agonist, Myocardial necrosis, Molecular Biology
Abstract

Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats. Cardiotoxicity of three different doses of ISO were studied using physiological, biochemical and histopathological parameters. The effects of single and double dose of ISO were analysed, which illustrated that single ISO dose was more cardiotoxic than double ISO dose due to ischemic preconditioning. The tetrapeptide derivatives L-lysine-L-arginine-L-aspartic acid-L-serine (tetrapeptide A) and di-tert.butyloxycarbonyl-L-lysine-L-arginine-L-aspartic acid-tert.butyl O-tert.butyl-L-serinate (tetrapeptide B) along with acetylsalicylic acid as positive control were analysed at different time points for their cardioprotective effect. The results demonstrated that optimal protective effects were observed by pretreatment with 5 mg/kg of tetrapeptide B and this was found to be slightly better than that of acetylsalicylic acid. A lesser degree of cardioprotection was noticed when low doses of tetrapeptide B were administered. This study clearly showed that single dose of ISO (50 mg/kg, s.c.) induced myocardial necrosis could be used as a model to assess cardiovascular drugs and in this model, it was demonstrated that the tetrapeptide B could exhibit optimal cardioprotective effect.

Published
1998
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13. Physicochemical characterization of a novel surfactant peptide containing an arginine cation and laurate anion

Author

C.V. Ramesh, Rengarajulu Puvanakrishnan, and Rajadas Jayakumar

Subjects
Aqueous solution, Aggregation number, Chromatography, Polymers and Plastics, Standard molar entropy, Chemistry, Inorganic chemistry, Micelle, Standard enthalpy of formation, Microviscosity, Colloid and Surface Chemistry, Pulmonary surfactant, Critical micelle concentration, Materials Chemistry, sense organs, Physical and Theoretical Chemistry
Abstract

A novel surfactant peptide consisting of an arginine cation with laurate anion has been synthesized, purified and characterized. The critical micellar concentration (cmc) of peptide in aqueous solutions has been determined using spectroscopic techniques and is found to increase from 0.06 to 0.11 mM with increasing temperature (15–45°C). Cmc is also determined in the presence of salts like NaCl, KCl and sodium acetate and it is found that these electrolytes hinder aggregation with a significant increase in the case of sodium acetate. The aggregation number of the surfactant peptide has been determined using fluorescence quenching measurements and is observed to decrease from 14 to 6 with increasing temperature (15–45°C). The standard free energy change (ΔG m 0 ) and standard enthalpy change (ΔH m 0 ) of the peptide aggregate are found to be negative with a small positive value for standard entropy change (ΔS m 0 ). The peptide aggregate seems to undergo phase transition above 50°C as observed from UV-vis and fluorescence spectroscopy. From pyrene binding studies, it is shown that the interior dielectric constant increases from 5.08 at 34°C to 8.77 at 50°C and further decreases with increase in temperature indicating a phase change at 50°C. Also, the ratio of excimer intensity to monomer intensity, which is a measure of microviscosity of the aggregate, decreases with increase in temperature with a change at 50°C indicating a phase change.

Published
1997
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15. Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations

Author

Rennert, Robert C, primary, Sorkin, Michael, additional, Januszyk, Michael, additional, Duscher, Dominik, additional, Kosaraju, Revanth, additional, Chung, Michael T, additional, Lennon, James, additional, Radiya-Dixit, Anika, additional, Raghvendra, Shubha, additional, Maan, Zeshaan N, additional, Hu, Michael S, additional, Rajadas, Jayakumar, additional, Rodrigues, Melanie, additional, and Gurtner, Geoffrey C, additional

Published
2014
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19. Vascular anastomosis using controlled phase transitions in poloxamer gels

Author

Chang, Edward I, primary, Galvez, Michael G, additional, Glotzbach, Jason P, additional, Hamou, Cynthia D, additional, El-ftesi, Samyra, additional, Rappleye, C Travis, additional, Sommer, Kristin-Maria, additional, Rajadas, Jayakumar, additional, Abilez, Oscar J, additional, Fuller, Gerald G, additional, Longaker, Michael T, additional, and Gurtner, Geoffrey C, additional

Published
2011
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