1. Reduced Wide Local Excision Margins are Associated with Increased Risk of Relapse and Death from Merkel Cell Carcinoma
- Author
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Neal Andruska, Mackenzie Daly, Randall Brenneman, Lily Mahapatra, Wade L. Thorstad, Brian C. Baumann, Leigh A. Compton, and Jason T. Rich
- Subjects
medicine.medical_specialty ,Merkel cell carcinoma ,business.industry ,Wide local excision ,medicine.medical_treatment ,Hazard ratio ,medicine.disease ,Gastroenterology ,Confidence interval ,St louis ,03 medical and health sciences ,0302 clinical medicine ,Increased risk ,Oncology ,Surgical oncology ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,030211 gastroenterology & hepatology ,Surgery ,Relapse risk ,business - Abstract
Current recommendations regarding the size of wide local excision (WLE) margins for Merkel cell carcinoma (MCC) are not well established. WLE and pathologic margins were respectively reviewed from 79 patients with stage I or II MCC, who underwent WLE at Washington University in St Louis from 2005 to 2019. Outcomes included local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), distant recurrence-free survival (DRFS), disease-free survival (DFS), and disease-specific survival (DSS). Thirty-two percent of patients received adjuvant radiotherapy (aRT). At 1 year, DFS was 51.3%, 71.4%, and 87.8% for patients with WLE margins
- Published
- 2020
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