1. Association between depression and sleep quality in patients with systemic lupus erythematosus: a systematic review and meta-analysis
- Author
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Rong Xu, Wenjie Sui, Lan Xu, Chomphoonut Srirat, Mei'e Niu, Lin Li, and Rulan Yin
- Subjects
030203 arthritis & rheumatology ,medicine.medical_specialty ,Neurology ,business.industry ,CINAHL ,Cochrane Library ,Rheumatology ,Pittsburgh Sleep Quality Index ,03 medical and health sciences ,0302 clinical medicine ,Otorhinolaryngology ,Internal medicine ,Meta-analysis ,Inclusion and exclusion criteria ,medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Depression (differential diagnoses) - Abstract
Background Currently, there is no consistent understanding of the relationship between depression and sleep quality in patients with systemic lupus erythematosus (SLE). This study aimed to explore the correlation between depression and sleep quality in SLE patients. Methods Five English (PubMed, Web of Science, EMBASE, Cochrane Library, and CINAHL) databases were systematically searched from inception to January 12, 2021. Two authors independently screened publications and extracted data according to set inclusion and exclusion criteria. Statistical analyses were performed with STATA 16.0. Data were pooled using a random-effects model. Results A total of 9 identified studies matched the inclusion criteria, reporting on 514 patients with SLE in the analysis. A moderate correlation of depression with sleep quality was found (pooled r = 0.580 [0.473, 0.670]). Compared to good sleepers, patients with SLE and poor sleep quality had higher levels of depression (standardized mean difference = − 1.28 [− 1.87, − 0.69]). Depression was associated with subjective sleep quality (r = 0.332 [0.009, 0.592]), sleep latency (r = 0.412 [0.101, 0.649]), sleep disturbances (r = 0.405 [0.094, 0.645]), daytime dysfunction (r = 0.503 [0.214, 0.711]), the four dimensions of Pittsburgh Sleep Quality Index (PSQI), while no significant correlation was found in the other three PSQI dimensions. Conclusion Depression had a moderate correlation with sleep quality in patients with SLE. Patients with poor sleep quality tended to have higher level of depression than that of good sleepers. Awareness of the correlation may help rheumatology physicians and nurses to assess and prevent depression and improve sleep quality in patients with SLE.
- Published
- 2021