Search

Background Chimeric antigen receptor T- Cell (CAR-T) immunotherapy has been a breakthrough treatment for various hematological malignancies. However, cardiotoxicities such as new-onset heart failure, arrhythmia, acute coronary syndrome and cardiovascular death occur in 10–15% of patients treated with CAR-T. This study aims to investigate the changes in cardiac and inflammatory biomarkers in CAR-T therapy to determine the role of pro-inflammatory cytokines. Methods In this observational study, ninety consecutive patients treated with CAR-T underwent baseline cardiac investigation with electrocardiogram (ECG), transthoracic echocardiogram (TTE), troponin-I, and B-type natriuretic peptide (BNP). Follow-up ECG, troponin-I and BNP were obtained five days post- CAR-T. In a subset of patients (N = 53), serum inflammatory cytokines interleukin (IL)-2, IL-6, IL-15, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), and angiopoietin 1 & 2 were tested serially, including baseline and daily during hospitalization. Adverse cardiac events were defined as new-onset cardiomyopathy/heart failure, acute coronary syndrome, arrhythmia and cardiovascular death. Results Eleven patients (12%) had adverse cardiac events (one with new-onset cardiomyopathy and ten with new-onset atrial fibrillation). Adverse cardiac events appear to have occurred among patients with advanced age (77 vs. 66 years; p = 0.002), higher baseline creatinine (0.9 vs. 0.7 mg/dL; 0.007) and higher left atrial volume index (23.9 vs. 16.9mL/m2; p = 0.042). Day 5 BNP levels (125 vs. 63pg/mL; p = 0.019), but not troponin-I, were higher in patients with adverse cardiac events, compared to those without. The maximum levels of IL-6 (3855.0 vs. 254.0 pg/mL; p = 0.021), IFN-γ (474.0 vs. 48.8pg/mL; p = 0.006) and IL-15 (70.2 vs. 39.2pg/mL; p = 0.026) were also higher in the adverse cardiac events group. However, cardiac and inflammatory biomarker levels were not associated with cardiac events. Patients who developed cardiac events did not exhibit worse survival compared to patients without cardiac events (Log-rank p = 0.200). Conclusion Adverse cardiac events, predominantly atrial fibrillation, occur commonly after CAR-T (12%). The changes in serial inflammatory cytokine after CAR-T in the setting of adverse cardiac events suggests pro-inflammation as a pathophysiology and require further investigation for their role in adverse cardiac events. Tweet brief handle CAR-T related Cardiotoxicity has elevated cardiac and inflammatory biomarkers. #CARTCell #CardioOnc #CardioImmunology.

This article describes the pilot study on the water reuse for agricultural irrigation in Korea. The project is a part of the application of wastewater reuse system for Agriculture project, a 21st Century Frontier R&D Program sponsored by the Ministry of Education, Science, and Technology and associated with the Sustainable Water Resources Research Program. The goal of the project was to develop infra-technologies necessary to reclaim wastewater for irrigation in agriculture. The project involved two phases: laboratory and field research. Reclamation techniques for irrigation and feasible reuse were developed as a first step in proposing appropriate water quality standards. Reclaimed wastewater of various qualities was used to irrigate cereal crops and vegetables, and possible adverse effects on crops, humans, and the environment were investigated. The optimal reclamation methods required to satisfy water quality standards were explored and the operational characteristics investigated. Moreover, an inventory of farmlands that could reuse reclaimed wastewater was established. Feasible delivery systems for irrigation were developed, and pilot project sites were identified. Finally, operational field data from pilot units were collected and analyzed. This research and development may help solve water shortage problems in Korea, which left unaddressed will have an adverse effect on future generations.

Erratum to: Paddy Water Environ (2010) 8:227–233DOI 10.1007/s10333-010-0203-9Due to an unfortunate turn of events this article has beenpublished with an erroneous version of one of the authorsnames and more specific the name of Dr Han-Pil Rhee.Please find below the correct author names listed thatshould be regarded by the reader as the final version.Taeil Jang Sae-Bom Lee Choung-Hyun Sung Han-Pil Rhee Seung-Woo Park