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Your search keyword '"Santagata, Sara"' showing total 5 results
Start Over Author "Santagata, Sara" Publisher springer science and business media llc
5 results on '"Santagata, Sara"'

1. Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study

Author

Ottaiano, Alessandro, primary, De Luca, Antonella, additional, Santorsola, Mariachiara, additional, Scognamiglio, Giosuè, additional, Di Mauro, Annabella, additional, Chiodini, Paolo, additional, Lambiase, Matilde, additional, Sacco, Alessandra, additional, Petrillo, Antonella, additional, Granata, Vincenza, additional, Fusco, Roberta, additional, Mercadante, Edoardo, additional, Martucci, Nicola, additional, De Luca, Giuseppe, additional, Rocca, Antonello La, additional, Celentano, Egidio, additional, Crispo, Anna, additional, Di Gennaro, Piergiacomo, additional, Tatangelo, Fabiana, additional, Ferrara, Gerardo, additional, Izzo, Francesco, additional, Belli, Andrea, additional, Patrone, Renato, additional, Delrio, Paolo, additional, Rega, Daniela, additional, De Franciscis, Silvia, additional, Muto, Paolo, additional, Ravo, Vincenzo, additional, Di Franco, Rossella, additional, Borzillo, Valentina, additional, Santagata, Sara, additional, Rea, Giuseppina, additional, Castaldo, Daniela, additional, Pace, Ugo, additional, De Feo, Gianfranco, additional, Scala, Stefania, additional, Nasti, Guglielmo, additional, and Normanno, Nicola, additional

Published
2023
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2. Hepatocellular carcinoma (HCC) tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) tumor microenvironment

Author

Santagata, Sara, primary, Rea, Giuseppina, additional, Castaldo, Daniela, additional, Napolitano, Maria, additional, Capiluongo, Anna, additional, D’Alterio, Crescenzo, additional, Trotta, Anna Maria, additional, Ieranò, Caterina, additional, Portella, Luigi, additional, Di Maro, Salvatore, additional, Tatangelo, Fabiana, additional, Albino, Vittorio, additional, Guarino, Rita, additional, Cutolo, Carmen, additional, Izzo, Francesco, additional, and Scala, Stefania, additional

Published
2023
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3. Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity

Author

Trotta, Anna Maria, primary, Santagata, Sara, additional, Zanotta, Serena, additional, D’Alterio, Crescenzo, additional, Napolitano, Maria, additional, Rea, Giuseppina, additional, Camerlingo, Rosa, additional, Esposito, Fabio, additional, Lamantia, Elvira, additional, Anniciello, Annamaria, additional, Botti, Giovanni, additional, Longo, Nicola, additional, Botti, Gerardo, additional, Pignata, Sandro, additional, Perdonà, Sisto, additional, and Scala, Stefania, additional

Published
2018
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4. A novel CXCR4-targeted near-infrared (NIR) fluorescent probe (Peptide R-NIR750) specifically detects CXCR4 expressing tumors

Author

Santagata, Sara, primary, Portella, Luigi, additional, Napolitano, Maria, additional, Greco, Adelaide, additional, D’Alterio, Crescenzo, additional, Barone, Maria Vittoria, additional, Luciano, Antonio, additional, Gramanzini, Matteo, additional, Auletta, Luigi, additional, Arra, Claudio, additional, Zannetti, Antonella, additional, and Scala, Stefania, additional

Published
2017
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5. A novel CXCR4-targeted near-infrared (NIR) fluorescent probe (Peptide R-NIR750) specifically detects CXCR4 expressing tumors

Author

Antonio Luciano, Luigi Portella, Claudio Arra, Stefania Scala, Adelaide Greco, Sara Santagata, Antonella Zannetti, Matteo Gramanzini, Maria Vittoria Barone, Maria Napolitano, Crescenzo D'Alterio, Luigi Auletta, Santagata, Sara, Portella, Luigi, Napolitano, Maria, Greco, Adelaide, D'Alterio, Crescenzo, Barone, Maria Vittoria, Luciano, Antonio, Gramanzini, Matteo, Auletta, Luigi, Arra, Claudio, Zannetti, Antonella, and Scala, Stefania

Subjects
0301 basic medicine, Receptors, CXCR4, Pathology, medicine.medical_specialty, Lung Neoplasms, Skin Neoplasms, Science, Fluorescent Dye, Melanoma, Experimental, Gene Expression, Mice, Nude, Peptide, CXCR4, Article, Mice, 03 medical and health sciences, Chemokine receptor, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, Skin Neoplasm, Tomography, Fluorescent Dyes, chemistry.chemical_classification, Spectroscopy, Near-Infrared, Multidisciplinary, Animal, Melanoma, Cancer, medicine.disease, 3. Good health, Lung Neoplasm, Spectrometry, Fluorescence, 030104 developmental biology, chemistry, Cancer research, Medicine, Oligopeptide, Molecular imaging, Oligopeptides, Preclinical imaging, Ex vivo, Human, Protein Binding
Abstract

C-X-C chemokine receptor 4 (CXCR4) is over-expressed in multiple human cancers and correlates with tumor aggressiveness, poor prognosis and increased risk for distant metastases. Imaging agents for CXCR4 are thus highly desirable. We developed a novel CXCR4-targeted near-infrared (NIR) fluorescent probe (Peptide R-NIR750) conjugating the new developed CXCR4 peptidic antagonist Peptide R with the NIR fluorescent dye VivoTag-S750. Specific CXCR4 binding was obtained in cells overexpressing human CXCR4 (B16-hCXCR4 and human melanoma cells PES43), but not in CXCR4 low expressing cells (FB-1). Ex vivo evaluation demonstrated that PepR-NIR750 specifically detects B16-hCXCR4-derived subcutaneous tumors and lung metastases. Fluorescence Molecular Tomography (FMT) in vivo imaging was performed on mice carrying subcutaneous CHO and CHO-CXCR4 tumors. PepR-NIR750 accumulates only in CXCR4-positive expressing subcutaneous tumors. Additionally, an intense NIR fluorescence signal was detected in PES43-derived lung metastases of nude mice injected with PepR-NIR750 versus mice injected with VivoTag-S750. With a therapeutic intent, mice bearing PES43-derived lung metastases were treated with Peptide R. A the dramatic reduction in PES43-derived lung metastases was detected through a decrease of the PepR-NIR750 signal. PepR-NIR750 is a specific probe for non-invasive detection of human high CXCR4-expressing tumors and metastatic lesion and thus a valuable tool for cancer molecular imaging.

Published
2017
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