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Your search keyword '"Sciarra, Amedeo"' showing total 9 results
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9 results on '"Sciarra, Amedeo"'

3. c-MYC amplification and c-myc protein expression in pancreatic acinar cell carcinomas. New insights into the molecular signature of these rare cancers

Author

La Rosa, Stefano, Bernasconi, Barbara, Vanoli, Alessandro, Sciarra, Amedeo, Notohara, Kenji, Albarello, Luca, Casnedi, Selenia, Billo, Paola, Zhang, Lizhi, Tibiletti, Maria Grazia, Sessa, Fausto, and LA ROSA, Stefano

Subjects
Male, 0301 basic medicine, Clone (cell biology), Acinar Cell, Aneuploidy, 0302 clinical medicine, Neoplasms, Gene duplication, 80 and over, Acinar cell carcinoma, Amplification, c-myc, MANEC, MiNEN, Pancreas, Prognosis, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Carcinoma, Acinar Cell, Cell Differentiation, Chromosomes, Human, Pair 8, Female, Genetic Predisposition to Disease, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Middle Aged, Neoplasms, Complex and Mixed, Neuroendocrine Tumors, Pancreatic Neoplasms, Phenotype, Proto-Oncogene Proteins c-myc, Gene Amplification, Transcriptome, 2734, Molecular Biology, Cell Biology, Nuclear protein, In Situ Hybridization, Biomarkers, Tumor/analysis, Biomarkers, Tumor/genetics, Carcinoma, Acinar Cell/chemistry, Carcinoma, Acinar Cell/genetics, Carcinoma, Acinar Cell/pathology, Carcinoma, Acinar Cell/therapy, Neoplasms, Complex and Mixed/chemistry, Neoplasms, Complex and Mixed/genetics, Neoplasms, Complex and Mixed/pathology, Neoplasms, Complex and Mixed/therapy, Neuroendocrine Tumors/chemistry, Neuroendocrine Tumors/genetics, Neuroendocrine Tumors/pathology, Neuroendocrine Tumors/therapy, Pancreatic Neoplasms/chemistry, Pancreatic Neoplasms/genetics, Pancreatic Neoplasms/pathology, Pancreatic Neoplasms/therapy, Proto-Oncogene Proteins c-myc/analysis, Proto-Oncogene Proteins c-myc/genetics, Tumor, medicine.diagnostic_test, General Medicine, 030220 oncology & carcinogenesis, Pair 8, Human, Biology, Chromosomes, Fluorescence, Pathology and Forensic Medicine, 03 medical and health sciences, medicine, Acinar cell, Polysomy, Carcinoma, Complex and Mixed, Chromosome, medicine.disease, Molecular biology, 030104 developmental biology, Biomarkers, Fluorescence in situ hybridization
Abstract

The molecular alterations of pancreatic acinar cell carcinomas (ACCs) and mixed acinar-neuroendocrine carcinomas (MANECs) are not completely understood, and the possible role of c-MYC amplification in tumor development, progression, and prognosis is not known. We have investigated c-MYC gene amplification in a series of 35 ACCs and 4 MANECs to evaluate its frequency and a possible prognostic role. Gene amplification was investigated using interphasic fluorescence in situ hybridization analysis simultaneously hybridizing c-MYC and the centromere of chromosome 8 probes. Protein expression was immunohistochemically investigated using a specific monoclonal anti-c-myc antibody. Twenty cases had clones with different polysomies of chromosome 8 in absence of c-MYC amplification, and 5 cases had one amplified clone and other clones with chromosome 8 polysomy, while the remaining 14 cases were diploid for chromosome 8 and lacked c-MYC amplification. All MANECs showed c-MYC amplification and/or polysomy which were observed in 54% pure ACCs. Six cases (15.3%) showed nuclear immunoreactivity for c-myc, but only 4/39 cases showed simultaneous c-MYC amplification/polysomy and nuclear protein expression. c-myc immunoreactivity as well as c-MYC amplification and/or chromosome 8 polysomy was not statistically associated with prognosis. Our study demonstrates that a subset of ACCs shows c-MYC alterations including gene amplification and chromosome 8 polysomy. Although they are not associated with a different prognostic signature, the fact that these alterations are present in all MANECs suggests a role in the acinar-neuroendocrine differentiation possibly involved in the pathogenesis of MANECs.

Published
2018
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4. Exploring the Prognostic Role of Ki67 Proliferative Index in Merkel Cell Carcinoma of the Skin: Clinico-Pathologic Analysis of 84 Cases and Review of the Literature

Author

La Rosa, Stefano, primary, Bonzini, Matteo, additional, Sciarra, Amedeo, additional, Asioli, Sofia, additional, Maragliano, Roberta, additional, Arrigo, Martina, additional, Foschini, Maria Pia, additional, Righi, Alberto, additional, Maletta, Francesca, additional, Motolese, Alberico, additional, Papotti, Mauro, additional, Sessa, Fausto, additional, and Uccella, Silvia, additional

Published
2020
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9. CXCL12 expression is a bona fide predictor of recurrence in lung neuroendocrine tumours; a multicentric study with emphasis on atypical carcinoids - a short report

Author

Del Gobbo, Alessandro, primary, Fusco, Nicola, additional, Barella, Marco, additional, Ercoli, Giulia, additional, Sciarra, Amedeo, additional, Palleschi, Alessandro, additional, Pagni, Fabio, additional, Marchiò, Caterina, additional, Papotti, Mauro, additional, and Ferrero, Stefano, additional

Published
2018
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