1. Orthogonal diffusion-weighted MRI measures distinguish region-specific degeneration in cerebellar ataxia subtypes
- Author
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Shwetadwip Chowdhury, Sarah H. Ying, Jerry L. Prince, Anna Gambini, Alexander H. Sinofsky, David S. Zee, Susumu Mori, and Bennett A. Landman
- Subjects
Pathology ,medicine.medical_specialty ,Ataxia ,Cerebellar Ataxia ,Tegmentum Mesencephali ,Pyramidal Tracts ,Degeneration (medical) ,Biology ,Brain mapping ,Article ,Fractional anisotropy ,medicine ,Humans ,Neuroradiology ,Brain Mapping ,medicine.diagnostic_test ,Cerebellar ataxia ,Reproducibility of Results ,Neurodegenerative Diseases ,Magnetic resonance imaging ,Anatomy ,Cross-Sectional Studies ,Diffusion Magnetic Resonance Imaging ,Neurology ,Anisotropy ,Neurology (clinical) ,medicine.symptom ,Diffusion MRI - Abstract
The cerebellar peduncles are excellent candidates for composite indicators of regional degeneration in posterior fossa structures, as the peduncles show histopathological changes in degenerative ataxia. We postulate that magnetic resonance imaging will reveal evidence of disease specific peduncle degeneration through macro-structural (cross-sectional area) and microstructural (fractional anisotropy, mean diffusivity) measures. This study presents a “proof of principle” using orthogonal diffusion tensor imaging cross-sections of the cerebellar peduncles to distinguish categories of cerebellar disease.
- Published
- 2009
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