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Your search keyword '"Simari, Robert D"' showing total 18 results
Start Over Author "Simari, Robert D" Publisher springer science and business media llc
18 results on '"Simari, Robert D"'

2. Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis

Author

Toledo-Flores, Deborah, primary, Williamson, Anna, additional, Schwarz, Nisha, additional, Fernando, Sanuja, additional, Dimasi, Catherine, additional, Witt, Tyra A., additional, Nguyen, Thao M., additional, Puranik, Amrutesh S., additional, Chue, Colin D., additional, Delacroix, Sinny, additional, Spoon, Daniel B., additional, Bonder, Claudine S., additional, Bursill, Christina A., additional, Di Bartolo, Belinda A., additional, Nicholls, Stephen J., additional, Simari, Robert D., additional, and Psaltis, Peter J., additional

Published
2019
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4. Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney

Author

Puranik, Amrutesh S., primary, Leaf, Irina A., additional, Jensen, Mark A., additional, Hedayat, Ahmad F., additional, Saad, Ahmad, additional, Kim, Ki-Wook, additional, Saadalla, Abdulrahman M., additional, Woollard, John R., additional, Kashyap, Sonu, additional, Textor, Stephen C., additional, Grande, Joseph P., additional, Lerman, Amir, additional, Simari, Robert D., additional, Randolph, Gwendalyn J., additional, Duffield, Jeremy S., additional, and Lerman, Lilach O., additional

Published
2018
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5. Xenoantigenicity of porcine decellularized valves

Author

Helder, Meghana R. K., primary, Stoyles, Nicholas J., additional, Tefft, Brandon J., additional, Hennessy, Ryan S., additional, Hennessy, Rebecca R. C., additional, Dyer, Roy, additional, Witt, Tyra, additional, Simari, Robert D., additional, and Lerman, Amir, additional

Published
2017
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7. Time course analysis of gene expression identifies multiple genes with differential expression in patients with in-stent restenosis

Author

Ganesh, Santhi K, primary, Joo, Jungnam, additional, Skelding, Kimberly, additional, Mehta, Laxmi, additional, Zheng, Gang, additional, O'Neill, Kathleen, additional, Billings, Eric M, additional, Helgadottir, Anna, additional, Andersen, Karl, additional, Thorgeirsson, Gudmundur, additional, Gudnason, Thorarinn, additional, Geller, Nancy L, additional, Simari, Robert D, additional, Holmes, David R, additional, O'Neill, William W, additional, and Nabel, Elizabeth G, additional

Published
2011
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18. Vasculogenic properties of adventitial Sca-1+CD45+ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis

Author

N. Schwarz, Christina A. Bursill, Robert D. Simari, Thao Nguyen, Claudine S. Bonder, Belinda A. Di Bartolo, S. Fernando, Peter J. Psaltis, Sinny Delacroix, Deborah Toledo-Flores, A. Williamson, Amrutesh S. Puranik, C. Dimasi, Stephen J. Nicholls, Tyra A. Witt, Daniel B. Spoon, Colin D. Chue, Toledo-Flores, Deborah, Williamson, Anna, Schwarz, Nisha, Fernando, Sanuja, Dimasi, Catherine, Witt, Tyra A, Nguyen, Thao M, Puranik, Amrutesh S, Chue, Colin D, Delacroix, Sinny, Spoon, Daniel B, Bonder, Claudine S, Bursill, Christina A, Di Bartolo, Belinda A, Nicholls, Stephen J, Simari, Robert D, and Psaltis, Peter J

Subjects
0301 basic medicine, CD31, Pathology, medicine.medical_specialty, Population, lcsh:Medicine, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, Adventitia, medicine, Macrophage, model of ischaemia, Progenitor cell, lcsh:Science, education, Aorta, education.field_of_study, Matrigel, Multidisciplinary, Chemistry, lcsh:R, endothelial cells, 030104 developmental biology, medicine.anatomical_structure, Vasa vasorum, cardiovascular system, lcsh:Q, cellular origins, 030217 neurology & neurosurgery
Abstract

The cellular origins of vasa vasorum are ill-defined and may involve circulating or local progenitor cells. We previously discovered that murine aortic adventitia contains Sca-1+CD45+ progenitors that produce macrophages. Here we investigated whether they are also vasculogenic. In aortas of C57BL/6 mice, Sca-1+CD45+ cells were localised to adventitia and lacked surface expression of endothelial markers (ApoE−/− aortas. Although Sca-1+CD45+ cells from C57BL/6 aorta did not express CD31, they formed CD31+ colonies in endothelial differentiation media and produced interconnecting vascular-like cords in Matrigel that contained both endothelial cells and a small population of macrophages, which were located at branch points. Transfer of aortic Sca-1+CD45+ cells generated endothelial cells and neovessels de novo in a hindlimb model of ischaemia and resulted in a 50% increase in perfusion compared to cell-free control. Similarly, their injection into the carotid adventitia of ApoE−/− mice produced donor-derived adventitial and peri-adventitial microvessels after atherogenic diet, suggestive of newly formed vasa vasorum. These findings show that beyond its content of macrophage progenitors, adventitial Sca-1+CD45+ cells are also vasculogenic and may be a source of vasa vasorum during atherogenesis.

Published
2019
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