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Since the early 1980s, the Antarctic environment has served as a natural field laboratory for researchers to investigate the effects of stratospheric ozone depletion, which has resulted in increased surface ultraviolet radiation levels. However, its effective threats still present gaps. We report new pieces of evidence of increased ultraviolet radiation impacting West Antarctica sea salt aerosols. Salt aerosols, particularly in the Southern Ocean Sea, play an important role in the radiative earth balance. To disclose the molecular details of sea salt aerosols, we used a synchrotron-based multi-element microscopic speciation of individual microparticles (Scanning Transmission X-ray Microscopy with Near-Edge X-ray Absorption Fine Structure Spectroscopy combined with Computer-Controlled Scanning Electron Microscopy). Here we identified substantial abundances of chlorine-enriched aerosols in sea salt generated by photolytic products, whereas ice core records revealed increased chlorine depletion from the onset of ozone depletion. Our findings reveal that modern sea salt modification has no Holocene precedent.

In his work of 1969, Merle E. Manis introduced valuations on commutative rings. Recently, the class of totally quasi-ordered rings was developped by the second author. In the present paper, we establish the notion of compatibility between valuations and quasi-orders on rings, leading to a definition of the rank of a quasi-ordered ring. Moreover, we prove a Baer-Krull Theorem for quasi-ordered rings: fixing a Manis valuation v on R, we characterize all v-compatible quasi-orders of R by lifting the quasi-orders from the residue class ring to R itself., Comment: 26 pages

The Juno mission has provided an accurate determination of Jupiter's gravitational field, which has been used to obtain information about the planet's composition and internal structure. Several models of Jupiter's structure that fit the probe's data suggest that the planet has a diluted core, with a total heavy-element mass ranging from ten to a few tens of Earth masses (~5-15 % of the Jovian mass), and that heavy elements (elements other than H and He) are distributed within a region extending to nearly half of Jupiter's radius. Planet-formation models indicate that most heavy elements are accreted during the early stages of a planet's formation to create a relatively compact core and that almost no solids are accreted during subsequent runaway gas accretion. Jupiter's diluted core, combined with its possible high heavy-element enrichment, thus challenges standard planet-formation theory. A possible explanation is erosion of the initially compact heavy-element core, but the efficiency of such erosion is uncertain and depends on both the immiscibility of heavy materials in metallic hydrogen and on convective mixing as the planet evolves. Another mechanism that can explain this structure is planetesimal enrichment and vaporization during the formation process, although relevant models typically cannot produce an extended diluted core. Here we show that a sufficiently energetic head-on collision (giant impact) between a large planetary embryo and the proto-Jupiter could have shattered its primordial compact core and mixed the heavy elements with the inner envelope. Models of such a scenario lead to an internal structure that is consistent with a diluted core, persisting over billions of years. We suggest that collisions were common in the young Solar system and that a similar event may have also occurred for Saturn, contributing to the structural differences between Jupiter and Saturn., Published, author's version

Acute kidney injury (AKI) is a common and potentially lethal complication in the hospitalized patients, with hypoxic injury being as a major cause. The loss of renal tubular epithelial cells (TEC), one of the AKI hallmarks, is potentially followed by tubular regeneration process orchestrated by the remaining uninjured TECs that undergo proliferation and migration. In this study, we used human primary TEC to investigate the initiation of tubular cell migration and associated cytoskeletal alterations in response to pharmacological HIF stabilization which resembles the pathophysiology of hypoxia. Tubular cells have been shown to migrate as cohorts in a wound healing assay. Importantly, cells of distal tubular origin moved faster than those of proximal origin. HIF stabilization impaired TEC migration, which was confirmed by live single cell tracking. HIF stabilization significantly reduced tubular cell migration velocity and promoted cell spreading. In contrast to the control conditions, HIF stabilization induced actin filaments rearrangement and cell adhesion molecules including paxillin and focal adhesion kinase. Condensed bundling of keratin fibers was also observed, while the expression of different types of keratins, phosphorylation of keratin 18, and the microtubule structure were not altered. In summary, HIF stabilization reduced the ability of renal tubular cells to migrate and led to cytoskeleton reorganization. Our data suggested an important involvement of HIF stabilization during the epithelial migration underlying the mechanism of renal regeneration in response to AKI.

A command system for manual control of the longitudinal load factor in flight path direction of an aircraft is designed that completes existing flight control command systems (e.g. with sidesticks that command normal load factor). The system is called nxControl. It aims to assist pilots during manual flight by reducing the workload for monitoring flight parameters as well as for controlling thrust and airbrakes. Important for the nxControl concept is the direct flight mechanical relation between longitudinal load factor and changes of the total aircraft energy. This paper presents the system concept and a prototype realization. The nxControl system consists of the control law that combines the actuation commands for engines and airbrakes, a new input device for the longitudinal load factor command and augmented display elements informing pilots about aircraft energy states to assure situation awareness. In order to investigate the feasibility of the concept as well as to evaluate consequences on human performance, a flight simulator study with airline pilots was conducted. The nxControl prototype was used by the pilots as expected. Changes in instrument scanning behaviour and thrust lever usage confirmed this. After just a short familiarization and practice, the pilots were able to perform standard flight tasks with nxControl without exceeding given tolerance limits. So, the results provide first evidence for the feasibility of the concept.

Erstmalig kam in der Entwicklung bei General Motors Europe (GME) eine vollstandig automatisierte Testfallerzeugung zur Validierung der Diagnose zum Einsatz. Der Artikel von GME und Vector Informatik beschreibt die Einfuhrung automatisierter Tests der Diagnoseimplementierung am Beispiel des neuen Opel Insignia. Durch die Integration des Werkzeugs der Vector Informatik in die bestehende Tool-Landschaft ergaben sich wirtschaftliche, zeitliche und prozesstechnische Verbesserungen im Vergleich zur herkommlichen, manuellen Validierung beim Opel Corsa.

For the first time, a fully automated test case generator has been introduced in diagnostics validation at General Motors Europe (GME) Development. This article by GME and Vector Informatik describes the introduction of this automated testing of diagnostic implementations based on the example of the new Opel Insignia. Integrating the Vector Informatik tool into the existing tool environment resulted in improvements in the fields of economy, time and processes when com- pared to conventional, manual validation at the Opel Corsa.