7 results on '"Speedy, Helen"'
Number of results to display per page
Search Results
2. Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology
- Author
-
Went, Molly, primary, Sud, Amit, additional, Speedy, Helen, additional, Sunter, Nicola J., additional, Försti, Asta, additional, Law, Philip J., additional, Johnson, David C., additional, Mirabella, Fabio, additional, Holroyd, Amy, additional, Li, Ni, additional, Orlando, Giulia, additional, Weinhold, Niels, additional, van Duin, Mark, additional, Chen, Bowang, additional, Mitchell, Jonathan S., additional, Mansouri, Larry, additional, Juliusson, Gunnar, additional, Smedby, Karin E, additional, Jayne, Sandrine, additional, Majid, Aneela, additional, Dearden, Claire, additional, Allsup, David J., additional, Bailey, James R., additional, Pratt, Guy, additional, Pepper, Chris, additional, Fegan, Chris, additional, Rosenquist, Richard, additional, Kuiper, Rowan, additional, Stephens, Owen W., additional, Bertsch, Uta, additional, Broderick, Peter, additional, Einsele, Hermann, additional, Gregory, Walter M., additional, Hillengass, Jens, additional, Hoffmann, Per, additional, Jackson, Graham H., additional, Jöckel, Karl-Heinz, additional, Nickel, Jolanta, additional, Nöthen, Markus M., additional, da Silva Filho, Miguel Inacio, additional, Thomsen, Hauke, additional, Walker, Brian A., additional, Broyl, Annemiek, additional, Davies, Faith E., additional, Hansson, Markus, additional, Goldschmidt, Hartmut, additional, Dyer, Martin J. S., additional, Kaiser, Martin, additional, Sonneveld, Pieter, additional, Morgan, Gareth J., additional, Hemminki, Kari, additional, Nilsson, Björn, additional, Catovsky, Daniel, additional, Allan, James M., additional, and Houlston, Richard S., additional
- Published
- 2018
- Full Text
- View/download PDF
3. Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
- Author
-
Law, Philip J., primary, Berndt, Sonja I., additional, Speedy, Helen E., additional, Camp, Nicola J., additional, Sava, Georgina P., additional, Skibola, Christine F., additional, Holroyd, Amy, additional, Joseph, Vijai, additional, Sunter, Nicola J., additional, Nieters, Alexandra, additional, Bea, Silvia, additional, Monnereau, Alain, additional, Martin-Garcia, David, additional, Goldin, Lynn R., additional, Clot, Guillem, additional, Teras, Lauren R., additional, Quintela, Inés, additional, Birmann, Brenda M., additional, Jayne, Sandrine, additional, Cozen, Wendy, additional, Majid, Aneela, additional, Smedby, Karin E., additional, Lan, Qing, additional, Dearden, Claire, additional, Brooks-Wilson, Angela R., additional, Hall, Andrew G., additional, Purdue, Mark P., additional, Mainou-Fowler, Tryfonia, additional, Vajdic, Claire M., additional, Jackson, Graham H., additional, Cocco, Pierluigi, additional, Marr, Helen, additional, Zhang, Yawei, additional, Zheng, Tongzhang, additional, Giles, Graham G., additional, Lawrence, Charles, additional, Call, Timothy G., additional, Liebow, Mark, additional, Melbye, Mads, additional, Glimelius, Bengt, additional, Mansouri, Larry, additional, Glenn, Martha, additional, Curtin, Karen, additional, Diver, W Ryan, additional, Link, Brian K., additional, Conde, Lucia, additional, Bracci, Paige M., additional, Holly, Elizabeth A., additional, Jackson, Rebecca D., additional, Tinker, Lesley F., additional, Benavente, Yolanda, additional, Boffetta, Paolo, additional, Brennan, Paul, additional, Maynadie, Marc, additional, McKay, James, additional, Albanes, Demetrius, additional, Weinstein, Stephanie, additional, Wang, Zhaoming, additional, Caporaso, Neil E., additional, Morton, Lindsay M., additional, Severson, Richard K., additional, Riboli, Elio, additional, Vineis, Paolo, additional, Vermeulen, Roel C. H., additional, Southey, Melissa C., additional, Milne, Roger L., additional, Clavel, Jacqueline, additional, Topka, Sabine, additional, Spinelli, John J., additional, Kraft, Peter, additional, Ennas, Maria Grazia, additional, Summerfield, Geoffrey, additional, Ferri, Giovanni M., additional, Harris, Robert J., additional, Miligi, Lucia, additional, Pettitt, Andrew R., additional, North, Kari E., additional, Allsup, David J., additional, Fraumeni, Joseph F., additional, Bailey, James R., additional, Offit, Kenneth, additional, Pratt, Guy, additional, Hjalgrim, Henrik, additional, Pepper, Chris, additional, Chanock, Stephen J., additional, Fegan, Chris, additional, Rosenquist, Richard, additional, de Sanjose, Silvia, additional, Carracedo, Angel, additional, Dyer, Martin J. S., additional, Catovsky, Daniel, additional, Campo, Elias, additional, Cerhan, James R., additional, Allan, James M., additional, Rothman, Nathanial, additional, Houlston, Richard, additional, and Slager, Susan, additional
- Published
- 2017
- Full Text
- View/download PDF
4. Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci
- Author
-
Law, Philip J., primary, Sud, Amit, additional, Mitchell, Jonathan S., additional, Henrion, Marc, additional, Orlando, Giulia, additional, Lenive, Oleg, additional, Broderick, Peter, additional, Speedy, Helen E., additional, Johnson, David C., additional, Kaiser, Martin, additional, Weinhold, Niels, additional, Cooke, Rosie, additional, Sunter, Nicola J., additional, Jackson, Graham H., additional, Summerfield, Geoffrey, additional, Harris, Robert J., additional, Pettitt, Andrew R., additional, Allsup, David J., additional, Carmichael, Jonathan, additional, Bailey, James R., additional, Pratt, Guy, additional, Rahman, Thahira, additional, Pepper, Chris, additional, Fegan, Chris, additional, von Strandmann, Elke Pogge, additional, Engert, Andreas, additional, Försti, Asta, additional, Chen, Bowang, additional, Filho, Miguel Inacio da Silva, additional, Thomsen, Hauke, additional, Hoffmann, Per, additional, Noethen, Markus M., additional, Eisele, Lewin, additional, Jöckel, Karl-Heinz, additional, Allan, James M., additional, Swerdlow, Anthony J., additional, Goldschmidt, Hartmut, additional, Catovsky, Daniel, additional, Morgan, Gareth J., additional, Hemminki, Kari, additional, and Houlston, Richard S., additional
- Published
- 2017
- Full Text
- View/download PDF
5. Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
- Author
-
Jäger, Roland, primary, Migliorini, Gabriele, additional, Henrion, Marc, additional, Kandaswamy, Radhika, additional, Speedy, Helen E., additional, Heindl, Andreas, additional, Whiffin, Nicola, additional, Carnicer, Maria J., additional, Broome, Laura, additional, Dryden, Nicola, additional, Nagano, Takashi, additional, Schoenfelder, Stefan, additional, Enge, Martin, additional, Yuan, Yinyin, additional, Taipale, Jussi, additional, Fraser, Peter, additional, Fletcher, Olivia, additional, and Houlston, Richard S., additional
- Published
- 2015
- Full Text
- View/download PDF
6. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
- Author
-
Speedy, Helen E, primary, Di Bernardo, Maria Chiara, additional, Sava, Georgina P, additional, Dyer, Martin J S, additional, Holroyd, Amy, additional, Wang, Yufei, additional, Sunter, Nicola J, additional, Mansouri, Larry, additional, Juliusson, Gunnar, additional, Smedby, Karin E, additional, Roos, Göran, additional, Jayne, Sandrine, additional, Majid, Aneela, additional, Dearden, Claire, additional, Hall, Andrew G, additional, Mainou-Fowler, Tryfonia, additional, Jackson, Graham H, additional, Summerfield, Geoffrey, additional, Harris, Robert J, additional, Pettitt, Andrew R, additional, Allsup, David J, additional, Bailey, James R, additional, Pratt, Guy, additional, Pepper, Chris, additional, Fegan, Chris, additional, Rosenquist, Richard, additional, Catovsky, Daniel, additional, Allan, James M, additional, and Houlston, Richard S, additional
- Published
- 2013
- Full Text
- View/download PDF
7. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
- Author
-
Schmidt, Amand F, Holmes, Michael V, Preiss, David, Swerdlow, Daniel I, Denaxas, Spiros, Fatemifar, Ghazaleh, Faraway, Rupert, Finan, Chris, Valentine, Dennis, Fairhurst-Hunter, Zammy, Hartwig, Fernando Pires, Horta, Bernardo Lessa, Hypponen, Elina, Power, Christine, Moldovan, Max, Van Iperen, Erik, Hovingh, Kees, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina M, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Willeit, Karin, Mason, Dan, Wright, John, Morris, Richard, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Price, Jackie F, Kivimaki, Mika, Welch, Catherine, Sanchez-Galvez, Adelaida, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N Charlotte, Van Der Schouw, Yvonne T, Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Langenberg, Claudia, Scott, Robert A, Luan, Jian'an, Bobak, Martin, Malyutina, Sofia, Pająk, Andrzej, Kubinova, Ruzena, Tamosiunas, Abdonas, Pikhart, Hynek, Grarup, Niels, Pedersen, Oluf, Hansen, Torben, Linneberg, Allan, Jess, Tine, Cooper, Jackie, Humphries, Steve E, Brilliant, Murray, Kitchner, Terrie, Hakonarson, Hakon, Carrell, David S, McCarty, Catherine A, Lester, Kirchner H, Larson, Eric B, Crosslin, David R, De Andrade, Mariza, Roden, Dan M, Denny, Joshua C, Carty, Cara, Hancock, Stephen, Attia, John, Holliday, Elizabeth, Scott, Rodney, Schofield, Peter, O'Donnell, Martin, Yusuf, Salim, Chong, Michael, Pare, Guillaume, Van Der Harst, Pim, Said, M Abdullah, Eppinga, Ruben N, Verweij, Niek, Snieder, Harold, Lifelines Cohort Authors, Christen, Tim, Mook-Kanamori, DO, ICBP Consortium, Gustafsson, Stefan, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Hofman, Albert, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Lerch, Markus M, Völker, Uwe, Völzke, Henry, Ward, Joey, Pell, Jill P, Meade, Tom, Christophersen, Ingrid E, Maitland-Van Der Zee, Anke H, Baranova, Ekaterina V, Young, Robin, Ford, Ian, Campbell, Archie, Padmanabhan, Sandosh, Bots, Michiel L, Grobbee, Diederick E, Froguel, Philippe, Thuillier, Dorothée, Roussel, Ronan, Bonnefond, Amélie, Cariou, Bertrand, Smart, Melissa, Bao, Yanchun, Kumari, Meena, Mahajan, Anubha, Hopewell, Jemma C, Seshadri, Sudha, METASTROKE Consortium Of The ISGC, Dale, Caroline, Costa, Rui Providencia E, Ridker, Paul M, Chasman, Daniel I, Reiner, Alex P, Ritchie, Marylyn D, Lange, Leslie A, Cornish, Alex J, Dobbins, Sara E, Hemminki, Kari, Kinnersley, Ben, Sanson, Marc, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Law, Philip, Speedy, Helen, Allan, James, Li, Ni, Went, Molly, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, Nilsson, Björn, Goldschmidt, Hartmut, Sud, Amit, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert W, Patel, Riyaz S, Keating, Brendan J, Sattar, Naveed, Houlston, Richard, Casas, Juan P, and Hingorani, Aroon D
- Subjects
Genetic association studies ,Serine Proteinase Inhibitors ,Anticholesteremic Agents ,PCSK9 Inhibitors ,Myocardial Infarction ,Down-Regulation ,Cholesterol, LDL ,Polymorphism, Single Nucleotide ,Risk Assessment ,3. Good health ,Brain Ischemia ,Stroke ,Treatment Outcome ,Risk Factors ,LDL-cholesterol ,Humans ,Phenome-wide association scan ,Proprotein Convertase 9 ,Mendelian randomisation ,Biomarkers ,Dyslipidemias ,Genome-Wide Association Study ,Randomized Controlled Trials as Topic - Abstract
BACKGROUND: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. RESULTS: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. CONCLUSIONS: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.