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3 results on '"Steven B. Wells"'

2. Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes

Author

Basak B. Ural, Daniel P. Caron, Pranay Dogra, Steven B. Wells, Peter A. Szabo, Tomer Granot, Takashi Senda, Maya M. L. Poon, Nora Lam, Puspa Thapa, Yoon Seung Lee, Masaru Kubota, Rei Matsumoto, and Donna L. Farber

Subjects
Immunity, Humans, Dust, Lymph Nodes, Disease Susceptibility, General Medicine, Lung, Article, General Biochemistry, Genetics and Molecular Biology, Aged
Abstract

The elderly are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function. In an analysis of human lymph nodes (LNs) from 84 organ donors aged 11-93years, we found a specific age-related decline in lung-associated, but not gut-associated, LN immune function linked to the accumulation of inhaled atmospheric particulate matter. Increasing densities of particulates were found in lung-associated LNs with age, but not in the corresponding gut-associated LNs. Particulates were specifically contained within CD68(+)CD169(−) macrophages, which exhibited reduced activation, phagocytic capacity, and altered cytokine production compared to non-particulate-containing macrophages. The structures of B cell follicles and lymphatic drainage were disrupted in lung-associated LN with particulates. Our results reveal that the cumulative effects of environmental exposure with age may compromise immune surveillance of the lung via direct effects on immune cell function and lymphoid architecture.

Published
2022
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3. Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Author

Rei Matsumoto, Yun Zhu, Emily M. Mace, Michael Chait, Wen-Hsuan W. Lin, Eldad A. Hod, Didier Decimo, Branka Horvat, Matthew R. Baldwin, Steven B. Wells, Stephen A. Ferrara, Stuart P. Weisberg, Julia Davis-Porada, Pranay Dogra, Donna L. Farber, Debora Stelitano, Emma Idzikowski, Flavia Dei Zotti, Cyrille Mathieu, Francesca T. Bovier, Matteo Porotto, Zachary C. Bitan, Sandeep N. Wontakal, Francesca La Carpia, Anne Moscona, Krystalyn E. Hudson, Joshua I. Gray, Thomas J. Connors, Peter A. Szabo, Joshua D. Milner, Maya Meimei Li Poon, Columbia University Irving Medical Center (CUIMC), University of the Study of Campania Luigi Vanvitelli, Columbia University [New York], Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-20-COVI-0053,CoVarImm,Variation de la réponse immune systémique et muqueuse pendant l'infection par le SRAS-CoV-2 et la convalescence(2020), Mathieu, Cyrille, Weisberg, S. P., Connors, T. J., Zhu, Y., Baldwin, M. R., Lin, W. -H., Wontakal, S., Szabo, P. A., Wells, S. B., Dogra, P., Gray, J., Idzikowski, E., Stelitano, D., Bovier, F. T., Davis-Porada, J., Matsumoto, R., Poon, M. M. L., Chait, M., Mathieu, C., Horvat, B., Decimo, D., Hudson, K. E., Zotti, F. D., Bitan, Z. C., La Carpia, F., Ferrara, S. A., Mace, E., Milner, J., Moscona, A., Hod, E., Porotto, M., and Farber, D. L.

Subjects
0301 basic medicine, ARDS, [SDV]Life Sciences [q-bio], Immunology, Population, medicine.disease_cause, Article, Serology, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Immunology and Allergy, Respiratory system, Young adult, education, Coronavirus, education.field_of_study, biology, business.industry, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], 030104 developmental biology, biology.protein, Antibody, business, 030215 immunology
Abstract

International audience; Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)3-5. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.

Published
2020
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