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To investigate the influence of organic cation transporter 3 (OCT3) expression on the effect of the combination regimen of 5-fluorouracil, folinic acid and oxaliplatin ((m)FOLFOX6) in colorectal cancer (CRC) patients. This is a retrospective study conducted at a single centre (Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, China). Patients with stage IIb-IV resectable CRC who were being postoperatively treated with (m)FOLFOX6 as a first-line adjuvant chemotherapy regimen for at least 5 cycles and had resected primary tumour samples available were eligible for the study. Patients who preoperatively received chemotherapy and/or radiotherapy or were treated with targeted drugs or other anticancer drugs were excluded from the study. Immunohistochemical staining and digital image analysis were used to assess OCT3 expression in tumour samples. According to OCT3 expression level, the receiver operating characteristic curve (ROC curve) was used to divide the patients into two groups. Cox proportional risk regression was performed with the forward LR (forward stepwise regression based on maximum likelihood estimation) method using SPSS17.0 software. The primary endpoint was the 2-year progression-free survival. In total, 57 patients were included between 2014 and 2016 according to the inclusion and exclusion criteria (22 had low OCT3 expression, and 35 had high OCT3 expression). The mean age was 55.7 (30–74) years, and 37 of the total patients were male. According to TNM stage, 5 patients had stage IV disease, 44 patients had stage III disease, and 8 patients had stage II disease. Through Cox regression analysis, we found that among patients receiving the (m)FOLFOX6 regimen, those with higher OCT3 expression had a higher two-year progression-free survival rate than those with lower OCT3 expression (P = 0.038). The hazard ratio of patients with high OCT3 expression compared with patients with low OCT3 expression was 0.247. Besides, it was found that the age of patients was negatively correlated with expression level of OCT3, which can explain why patients over 70 years do not benefit from oxaliplatin-containing chemotherapy. High OCT3 expression in CRC tissues may be a protective factor for CRC patients treated with (m)FOLFOX6.

In mobile Ad Hoc network, nodes move freely, this can lead to frequent changes of network topology. Routing protocol algorithm is the strategy to establish communication links for network nodes, and its performance influences the availability of Ad Hoc network directly. By using wireless channel to transmit data in Ad Hoc network, the invaded malicious nodes will cause various attacks, aim to steal the transmission data or destroy the network. Based on the traditional proactive routing protocol for Ad Hoc network, an improved safe routing strategy SDSDV is put forward to resist attacks against routing protocols. The safe proactive routing protocol includes route request and route response two stages. When the network initialization is complete, after successful identity authentication by each other, secure communication paths are established between nodes and the encrypted data will be transmission through the path. The protocol integrates distributed authentication, encryption algorithm, hash check, and other security policy together. SDSDV protocol reduces the risk of malicious manipulation of routing information and ensures the safe and reliable routing between the source and destination nodes.

Sr3Al2O6:Ce3+ powders were synthesized using a solid state reaction method in air with addition of H3BO3. The effects of Ce3+ dopant concentrations and the weight ratio (wt) of H3BO3 to total raw materials weight on the formation of Sr3Al2O6:Ce3+ samples were investigated. Single-phase and well-crystallized Sr3Al2O6:Ce3+ samples can be obtained when the addition of H3BO3 is lower than 7 wt%. The excitation spectrum indicates that Sr3Al2O6:Ce3+ phosphor powders exhibit two excitation bands centered at 345 and 462 nm. The emission spectrum shows that Sr3Al2O6:Ce3+ phosphor powders exhibit an emission band peaked at 536 nm when excited at 462 nm. Sr3Al2O6:Ce3+ sample at the Ce3+ concentration of 5 mol% shows the strongest emission intensity. The addition of H3BO3 has obvious influence on phase and emission intensity of Sr3Al2O6:Ce3+ phosphors. The results show that the Sr2.95Ce0.05Al2O6 sample with the 7 wt% addition of H3BO3 has the highest emission intensity and the longest lifetime.