1. [Untitled]
- Author
-
Hiroyuki Suzuki, Manabu Okuyama, Satoru Motoyama, Hiroshi Imano, Reijiro Saito, Jun-ichi Ogawa, Shuichi Kamata, Michihiko Kitamura, Susumu Omokawa, Yutaka Motohashi, and Masakatsu Nakamura
- Subjects
medicine.medical_specialty ,Blood transfusion ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Retrospective cohort study ,General Medicine ,Esophageal cancer ,medicine.disease ,Surgery ,Esophagectomy ,Surgical oncology ,medicine ,Lymph ,business ,Survival rate - Abstract
Purpose: There is evidence that blood transfusion is associated with an increased rate of tumor recurrence. This study was conducted to assess the survival advantage of giving autologous blood instead of allogeneic blood during surgery for esophageal cancer. Methods: We retrospectively analyzed 62 patients who underwent esophagectomy for thoracic esophageal cancer between January 1991 and February 1995 and received allogeneic blood transfusion, and 61 patients operated on between March 1995 and February 1998, who received autologous blood transfusion. The clinicopathological factors and survival rates were compared between the two groups. Results: The clinicopathological factors that influenced prognosis were similar in the two groups; however, a definite survival advantage was evident in the autologous blood transfusion group. According to multivariate analyses, the transfusion of allogeneic blood was an independent prognostic factor (P = 0.0222), as was the presence of metastatic lymph nodes. Patients who received allogeneic blood transfusions perioperatively had more than a twofold greater risk (Hazard ration 2.406) of death over patients who received autologous blood transfusions. Conclusion: Autologous blood transfusion appears to be an independent prognostic factor for the survival of patients with esophageal cancer.
- Published
- 2002