Search

Composites of SiO2 and polyphenols from plant raw materials and model composites based on amorphous SiO2 and dihydroquercetin and pyrocatechol were prepared by solid-state mechanochemistry. Results for the antiviral activities of these composites with respect to herpes simplex virus type 2 (HSV-2) and West Nile virus are presented and compared with those of several chemotherapeutics and chaga (Inonotus obliquus) extract.

We studied toxicity and antiviral activity of aqueous and ethanol extracts of bioactive substances from the biomass of nematophagous fungus Duddingtonia flagrans prepared by submerged culturing of the mycelium. It is found that both extracts were characterized by low toxicity for cultured Vero cells and inhibited reproduction of DNA-viruses in this cell line. Ethanol extract of the fungus exhibited higher in vitro antiviral activity against Herpes simplex virus type 2, ectromelia virus, and vaccinia virus than water extract, which can be due to higher content of proteins, polysaccharides, flavonols, catechins, or carotenes or more effective their combination. The extracts of cultured mycelium of Duddingtonia flagrans fungus containing a complex of bioactive substances can be used for creation of broad-spectrum antiviral drugs against DNA-viruses.