1. The one-pot four-component eco-friendly synthesis of spirooxindoles in deep eutectic solvent
- Author
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Thokchom Jeeta Devi, Thokchom Prasanta Singh, and Okram Mukherjee Singh
- Subjects
Four component ,010405 organic chemistry ,General Chemistry ,Pyrazole ,010402 general chemistry ,01 natural sciences ,Environmentally friendly ,Combinatorial chemistry ,0104 chemical sciences ,Catalysis ,Deep eutectic solvent ,chemistry.chemical_compound ,chemistry ,Moiety ,Eutectic system - Abstract
An efficient and facile synthesis of spirooxindole derivatives bearing pyrano[2,3-c]pyrazole moiety has been achieved using deep eutectic solvent (DES) promoting a four-component reaction. The protocol avoids the use of costly and toxic catalysts and organic solvents which encounters many side effects on the environment and human beings. The simplicity and versatility of this eco-friendly green method is described. Deep eutectic solvent (DES) promoted eco-friendly synthesis of spirooxindole derivatives involving a four-component reaction is described in this article. This procedure is highly sustainable because of the involvement of readily available and biodegradable deep eutectic solvent as a reaction medium and promoter.
- Published
- 2020
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