Doan Duy Tien, Nguyen Van Tuyen, Le Thi Tu Anh, Nguyen Thi Thu Ha, Tran Minh Hoi, Ha Thi Van Anh, Ba Thi Cham, Pham Thuy Linh, Ninh Khac Ban, Young Ho Kim, Nguyen Thanh Huong, Nguyen Thanh Tra, Lidziya Kukhareva, Phan Van Kiem, and Gill Tatiana
Six known compounds including α-amyrin 3-acetate (1), β-sitosterol (2), betulinic acid (3), friedelan-3-one (4), artochamin B (5), and 2-C-methyl-d-erythritol 4-O-α-d-glucopyranoside (6) were isolated from the stem barks and leaves of Artocarpus nigrifolius (Moraceae) for the first time. Their structures were identified by spectroscopic methods as well as comparison with literatures. Cytotoxicity and antibacterial activity of 1–6 were evaluated. Results showed that artochamin B (5) possessed the highest cytotoxicity towards MCF7, Lu, HepG2, and KB cell lines with IC50 values of 4.59, 20.00, 3.60, and 1.18 μg/mL, respectively. It also inhibited the growth of Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), whereas inactive on the growth of both Gram-negative bacteria and yeast.