Search

Your search keyword '"Tripathi, Amit Kumar"' showing total 12 results
Start Over Author "Tripathi, Amit Kumar" Publisher springer science and business media llc
12 results on '"Tripathi, Amit Kumar"'

1. In silico and network pharmacology analysis of fucosterol: a potent anticancer bioactive compound against HCC

Author

Singh, Kajal, primary, Kumar, Pradeep, additional, Singh, Amit Kumar, additional, Singh, Nancy, additional, Singh, Sakshi, additional, Tiwari, Kavindra Nath, additional, Agrawal, Shreni, additional, Das, Richa, additional, Singh, Anuradha, additional, Ram, Bhuwal, additional, Tripathi, Amit Kumar, additional, and Mishra, Sunil Kumar, additional

Published
2024
Full Text
View/download PDF

2. Network pharmacology of apigeniflavan: a novel bioactive compound of Trema orientalis Linn. in the treatment of pancreatic cancer through bioinformatics approaches

Author

Das, Richa, primary, Agrawal, Shreni, additional, Kumar, Pradeep, additional, Singh, Amit Kumar, additional, Shukla, Praveen Kumar, additional, Bhattacharya, Indrani, additional, Tiwari, Kavindra Nath, additional, Mishra, Sunil Kumar, additional, and Tripathi, Amit Kumar, additional

Published
2023
Full Text
View/download PDF

5. Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

Author

Tripathi, Amit Kumar, Ray, Anup Kumar, and Mishra, Sunil Kumar

Subjects
Medicine (General), Science, Piperine, COVID-19, Pharmaceutical Science, Medicine (miscellaneous), Review, Gut microbiota, Agricultural and Biological Sciences (miscellaneous), R5-920, Anticancer, Clinical trials, Extractions, Pharmacokinetics
Abstract

Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, neuroprotective and enhancing bioavailability and fertility-related activities. Piperine has the ability to alter gastrointestinal disorders, drug-metabolizing enzymes, and bioavailability of several drugs. The present review explores the available clinical and preclinical data, nanoformulations, extraction process, structure–activity relationships, molecular docking, bioavailability enhancement of phytochemicals and drugs, and brain penetration properties of piperine in the prevention, management, and treatment of various diseases and disorders. Main body Piperine provides therapeutic benefits in patients suffering from diabetes, obesity, arthritis, oral cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Parkinson's disease, Alzheimer’s disease, cerebral stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The molecular basis for the pleiotropic activities of piperine is based on its ability to regulate multiple signaling molecules such as cell cycle proteins, anti-apoptotic proteins, P-glycoprotein, cytochrome P450 3A4, multidrug resistance protein 1, breast cancer resistance protein, transient receptor potential vanilloid 1 proinflammatory cytokine, nuclear factor-κB, c-Fos, cAMP response element-binding protein, activation transcription factor-2, peroxisome proliferator-activated receptor-gamma, Human G-quadruplex DNA, Cyclooxygenase-2, Nitric oxide synthases-2, MicroRNA, and coronaviruses. Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5′-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCα/ERK1/2, NF-κB/AP-1/MMP-9, Wnt/β-catenin, JNK/P38 MAPK, and gut microbiota. Short conclusion Based on the current evidence, piperine can be the potential molecule for treatment of disease, and its significance of this molecule in the clinic is discussed. Graphical abstract

Published
2022
Full Text
View/download PDF

11. Attenuated neuroprotective effect of riboflavin under UV-B irradiation via miR-203/c-Jun signaling pathway in vivo and in vitro

Author

Tripathi, Amit Kumar, primary, Dwivedi, Ashish, additional, Pal, Manish Kumar, additional, Rastogi, Namrata, additional, Gupta, Priyanka, additional, Ali, Shakir, additional, BH, Manjunatha Prabhu, additional, Kushwaha, Hari Narayan, additional, Ray, Ratan Singh, additional, Singh, Shio Kumar, additional, Duggal, Shivali, additional, Narayan, Bhaskar, additional, and Mishra, Durga Prasad, additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results