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39 results on '"Tyrosine kinase 2"'

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1. RB1CC1 functions as a tumor-suppressing gene in renal cell carcinoma via suppression of PYK2 activity and disruption of TAZ-mediated PDL1 transcription activation

2. Acrylamide-induced peripheral neuropathy: manifestations, mechanisms, and potential treatment modalities

3. The relationship between JAK2(V617F) mutation and dermatomyositis—a case report and literature review

4. Mendelian Susceptibility to Mycobacterial Disease (MSMD): Clinical and Genetic Features of 32 Iranian Patients

5. Delgocitinib: First Approval

6. JAK Inhibitors for Treatment of Psoriasis: Focus on Selective TYK2 Inhibitors

7. QSAR-guided pharmacophore modeling and subsequent virtual screening identify novel TYK2 inhibitor

8. Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling

9. Genetic mechanisms of critical illness in COVID-19

10. Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis

11. Exploring the mechanistic insights of Cas scaffolding protein family member 4 with protein tyrosine kinase 2 in Alzheimer’s disease by evaluating protein interactions through molecular docking and dynamic simulations

12. Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma

13. Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm

14. Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences

15. FAK and Pyk2 in disease

16. TYK2 inhibition halts SpA

17. Increased expression of claudin-17 promotes a malignant phenotype in hepatocyte via Tyk2/Stat3 signaling and is associated with poor prognosis in patients with hepatocellular carcinoma

18. Novel Therapeutics in Psoriatic Arthritis. What Is in the Pipeline?

19. Clinical, Immunological and Molecular Characterization of DOCK8 and DOCK8-like Deficient Patients: Single Center Experience of Twenty Five Patients

20. Heterodimeric JAK–STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

21. JAK–cytokine receptor recognition, unboxed

22. Strong Evidence of a Combination Polymorphism of the Tyrosine Kinase 2 Gene and the Signal Transducer and Activator of Transcription 3 Gene as a DNA-Based Biomarker for Susceptibility to Crohn’s Disease in the Japanese Population

23. Pathogenesis of Hyper IgE Syndrome

24. The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence

25. miR-744 enhances type I interferon signaling pathway by targeting PTP1B in primary human renal mesangial cells

26. Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

27. Arsenic inhibition of the JAK-STAT pathway

28. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

29. IL-10 Controls Aspergillus fumigatus??? and Pseudomonas aeruginosa???Specific T-Cell Response in Cystic Fibrosis

30. [Untitled]

31. IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells

32. Secondary resistance to sorafenib in two patients with acute myeloid leukemia (AML) harboring FLT3-ITD mutations

33. Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosis

34. Genetic origins of hyper-IgE syndrome

35. Interferon-induced nuclear signalling by Jak protein tyrosine kinases

36. Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms

37. Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

38. Tyrosine kinase inhibitors for diabetes

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