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Your search keyword '"Ullrich, O."' showing total 23 results
Start Over Author "Ullrich, O." Publisher springer science and business media llc
23 results on '"Ullrich, O."'

1. Cells´ Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight

Author

Moser, D., primary, Sun, S. J., additional, Li, N., additional, Biere, K., additional, Hoerl, M., additional, Matzel, S., additional, Feuerecker, M., additional, Buchheim, J.-I., additional, Strewe, C., additional, Thiel, C. S., additional, Gao, Y. X., additional, Wang, C. Z., additional, Ullrich, O., additional, Long, M., additional, and Choukèr, A., additional

Published
2019
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23. Signal transduction in cells of the immune system in microgravity

Author

Oliver Ullrich, Kerstin Lang, Kathrin Huber, University of Zurich, and Ullrich, O

Subjects
Gravity (chemistry), 1303 Biochemistry, 10017 Institute of Anatomy, ved/biology.organism_classification_rank.species, lcsh:Medicine, Immune Cell Function, 610 Medicine & health, Nanotechnology, Review, Biology, Biochemistry, Space exploration, Astrobiology, 1307 Cell Biology, Immune system, 1312 Molecular Biology, lcsh:QH573-671, Model organism, Molecular Biology, Organism, lcsh:Cytology, ved/biology, lcsh:R, Cell Biology, Living systems, 570 Life sciences, biology, Signal transduction
Abstract

Life on Earth developed in the presence and under the constant influence of gravity. Gravity has been present during the entire evolution, from the first organic molecule to mammals and humans. Modern research revealed clearly that gravity is important, probably indispensable for the function of living systems, from unicellular organisms to men. Thus, gravity research is no more or less a fundamental question about the conditions of life on Earth. Since the first space missions and supported thereafter by a multitude of space and ground-based experiments, it is well known that immune cell function is severely suppressed in microgravity, which renders the cells of the immune system an ideal model organism to investigate the influence of gravity on the cellular and molecular level. Here we review the current knowledge about the question, if and how cellular signal transduction depends on the existence of gravity, with special focus on cells of the immune system. Since immune cell function is fundamental to keep the organism under imnological surveillance during the defence against pathogens, to investigate the effects and possible molecular mechanisms of altered gravity is indispensable for long-term space flights to Earth Moon or Mars. Thus, understanding the impact of gravity on cellular functions on Earth will provide not only important informations about the development of life on Earth, but also for therapeutic and preventive strategies to cope successfully with medical problems during space exploration.

Published
2008
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