Search

Your search keyword '"Università degli Studi di Milano [Milano] (UNIMI)"' showing total 22 results
Start Over Author "Università degli Studi di Milano [Milano] (UNIMI)" Publisher springer science and business media llc
22 results on '"Università degli Studi di Milano [Milano] (UNIMI)"'

1. Reciprocal repression between P53 and TCTP

Author

Salvatore Pece, Jessika Wynendaele, Jean-Christophe Marine, Daniela Tosoni, Johan Hoebeke, Rajesh Vyas, Ivan Nicola Colaluca, Robert Amson, Pier Paolo Di Fiore, Sylvie Rodrigues-Ferreira, Giuseppe Viale, Alexandra Lespagnol, Adam Telerman, Giovanni Mazzarol, Olivier Chaloin, Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano [Milano] (UNIMI), CHU Pontchaillou [Rennes], Division of Pathology and Laboratory Medicine, European Institute of Oncology [Milan] (ESMO), Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie et chimie thérapeutiques (ICT), Cancéropôle du Grand Est-Centre National de la Recherche Scientifique (CNRS), Centre de Génétique Humaine, Université Catholique de Louvain = Catholic University of Louvain (UCL), Università degli studi di Milano [Milano], Università degli studi di Milano [Milano]-European Institute of Oncology [Milan] (ESMO), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Catholique de Louvain (UCL), and European Institute of Oncology

Subjects
[SDV]Life Sciences [q-bio], Apoptosis, Breast Neoplasms, Nerve Tissue Proteins, [SDV.CAN]Life Sciences [q-bio]/Cancer, Haploinsufficiency, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Translationally-controlled tumor protein, Biomarkers, Tumor, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Promoter Regions, Genetic, 030304 developmental biology, Feedback, Physiological, Mice, Knockout, Regulation of gene expression, Mice, Inbred BALB C, [SDV.GEN]Life Sciences [q-bio]/Genetics, 0303 health sciences, Gene knockdown, Mammary tumor, Ubiquitination, Membrane Proteins, Tumor Protein, Translationally-Controlled 1, Proto-Oncogene Proteins c-mdm2, General Medicine, HCT116 Cells, Prognosis, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Proteolysis, Cancer cell, Neoplastic Stem Cells, NUMB, biology.protein, Cancer research, Mdm2, Female, Translationally controlled tumour protein, Tumor Suppressor Protein p53, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Screening for genes that reprogram cancer cells for the tumor reversion switch identified TCTP (encoding translationally controlled tumor protein) as a crucial regulator of apoptosis. Here we report a negative feedback loop between P53 and TCTP. TCTP promotes P53 degradation by competing with NUMB for binding to P53-MDM2-containing complexes. TCTP inhibits MDM2 auto-ubiquitination and promotes MDM2-mediated ubiquitination and degradation of P53. Notably, Tctp haploinsufficient mice are sensitized to P53-dependent apoptosis. In addition, P53 directly represses TCTP transcription. In 508 breast cancers, high-TCTP status associates with poorly differentiated, aggressive G3-grade tumors, predicting poor prognosis (P < 0.0005). Tctp knockdown in primary mammary tumor cells from ErbB2 transgenic mice results in increased P53 expression and a decreased number of stem-like cancer cells. The pharmacological compounds sertraline and thioridazine increase the amount of P53 by neutralizing TCTP's action on the MDM2-P53 axis. This study links TCTP and P53 in a previously unidentified regulatory circuitry that may underlie the relevance of TCTP in cancer.

Published
2011

2. Effect of curve location on the severity index for adolescent idiopathic scoliosis: a longitudinal cohort study

Author

Jean-Claude Bernard, Raphaël Vialle, Ayman Assi, Jean Dubousset, Fabio Galbusera, Wafa Skalli, Mohammad Karam, Claudio Vergari, Isabelle Courtois, Marco Brayda-Bruno, Tristan Langlais, Kariman Abelin-Genevois, Tito Bassani, Ismat Ghanem, Eric Ebermeyer, Zongshan Hu, Luca Maria Sconfienza, Winnie C.W. Chu, Jack C. Y. Cheng, Institut de Biomécanique Humaine Georges Charpak (IBHGC), Université Sorbonne Paris Nord-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Department of Orthopaedic Surgery, Université Catholique de Louvain = Catholic University of Louvain (UCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), The Chinese University of Hong Kong [Hong Kong], Université Saint-Joseph de Beyrouth (USJ), IRCCS Istituto Ortopedico Galeazzi, Università degli Studi di Milano [Milano] (UNIMI), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service de pédiatrie orthopédique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)

Subjects
medicine.medical_specialty, Adolescent, [SDV]Life Sciences [q-bio], Scoliosis, 030218 nuclear medicine & medical imaging, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Lumbar, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Longitudinal Studies, Child, Pelvis, Retrospective Studies, Neuroradiology, Cobb angle, business.industry, General Medicine, medicine.disease, Spine, Confidence interval, Treatment Outcome, medicine.anatomical_structure, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Predictive value of tests, Cohort, Disease Progression, Sciences du vivant, Radiology, business
Abstract

Adolescent idiopathic scoliosis (AIS) is the most common spinal disorder in children. A severity index was recently proposed to identify the stable from the progressive scoliosis at the first standardized biplanar radiographic exam. The aim of this work was to extend the validation of the severity index and to determine if curve location influences its predictive capabilities. AIS patients with Cobb angle between 10° and 25°, Risser 0–2, and no previous treatment were included. They underwent standing biplanar radiography and 3D reconstruction of the spine and pelvis, which allowed to calculate their severity index. Patients were grouped by curve location (thoracic, thoracolumbar, lumbar). Patients were followed up until skeletal maturity (Risser ≥ 3) or brace prescription. Their outcome was compared to the prediction made by the severity index. In total, 205 AIS patients were included; 82% of them (155/189, 95% confidence interval [74–90%]) were correctly classified by the index, while 16 patients were unclassified. Positive predictive ratio was 78% and negative predictive ratio was 86%. Specificity (78%) was not significantly affected by curve location, while patients with thoracic and lumbar curves showed higher sensitivity (≥ 89%) than those with thoracolumbar curves (74%). In this multicentric cohort of 205 patients, the severity index was used to predict the risk of progression from mild to moderate scoliosis, with similar results of typical major curve types. This index represents a novel tool to aid the clinician and the patient in the modulation of the follow-up and, for progressive patients, their decision for brace treatment. • The severity index of adolescent idiopathic scoliosis has the potential to detect patients with progressive scoliosis as early as the first exam. • Out of 205 patients, 82% were correctly classified as either stable or progressive by the severity index. • The location of the main curve had small effect on the predictive capability of the index.

Published
2021

3. Non-integrable Dimers: Universal Fluctuations of Tilted Height Profiles

Author

Fabio Lucio Toninelli, Vieri Mastropietro, Alessandro Giuliani, Department of Mathematics and Physics, Università degli Studi Roma Tre, Università degli Studi di Milano [Milano] (UNIMI), Institut Camille Jordan [Villeurbanne] (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Probabilités, statistique, physique mathématique (PSPM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Vienna University of Technology (TU Wien), ANR-10-LABX-0070,MILYON,Community of mathematics and fundamental computer science in Lyon(2010), ANR-15-CE40-0020,LSD,Modèles stochastiques en grande dimension pour la physique statistique hors équilibre(2015), ANR-18-CE40-0033,DIMERS,Dimères : de la combinatoire à la mécanique quantique(2018), Giuliani, Alessandro, Mastropietro, Vieri, and Toninelli, Fabio Lucio

Subjects
Physics, Physical constant, Probability (math.PR), 010102 general mathematics, FOS: Physical sciences, Statistical and Nonlinear Physics, Mathematical Physics (math-ph), Renormalization group, Lambda, 01 natural sciences, Square lattice, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Massless particle, Amplitude, 0103 physical sciences, FOS: Mathematics, Exponent, Condensed Matter::Strongly Correlated Electrons, 0101 mathematics, 010306 general physics, Scaling, Mathematics - Probability, Mathematical Physics, Mathematical physics
Abstract

We study a class of close-packed dimer models on the square lattice, in the presence of small but extensive perturbations that make them non-determinantal. Examples include the 6-vertex model close to the free-fermion point, and the dimer model with plaquette interaction previously analyzed in \cite{A,AL,GMT17a,GMT17b}. By tuning the edge weights, we can impose a non-zero average tilt for the height function, so that the considered models are in general not symmetric under discrete rotations and reflections. In the determinantal case, height fluctuations in the massless (or `liquid') phase scale to a Gaussian log-correlated field and their amplitude is a universal constant, independent of the tilt. When the perturbation strength $\lambda$ is sufficiently small we prove, by fermionic constructive Renormalization Group methods, that log-correlations survive, with amplitude $A$ that, generically, depends non-trivially and non-universally on $\lambda$ and on the tilt. On the other hand, $A$ satisfies a universal scaling relation (`Haldane' or `Kadanoff' relation), saying that it equals the anomalous exponent of the dimer-dimer correlation., Comment: 78 pages, 5 figures. Version accepted for publication on Comm. Math. Phys. Compared to previous version, a few more details have been added in Sect.6.5 on the finite size corrections to the correlation functions, see in particular eqs.(6.132), (6.133) and following discussion

Published
2020

4. Transitioning the total hip arthroplasty technique from posterior approach in lateral position to direct anterior approach in supine position—risk factors for acetabular malpositioning and the learning curve

Author

Francesco Luceri, Cécile Batailler, Cam Fary, Constant Foissey, Elvire Servien, Sébastien Lustig, Service de Chirurgie Orthopédique [Centre Albert Trillat], Centre Albert Trillat [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), University of Melbourne, Università degli Studi di Milano [Milano] (UNIMI), Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406 ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Gustave Eiffel

Subjects
medicine.medical_specialty, Supine position, CUP POSITIONING, Arthroplasty, Replacement, Hip, Radiography, Antiviral Agents, Posterior approach, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Bearing surface, Supine Position, medicine, Humans, INSTRUMENTATION, Orthopedics and Sports Medicine, Retrospective Studies, 030203 arthritis & rheumatology, Orthodontics, 030222 orthopedics, business.industry, TOTAL HIP ARTHROPLASTY, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Acetabulum, Hepatitis C, Chronic, DIRECT ANTERIOR APPROACH, Learning curve, Orthopedic surgery, Female, Surgery, Hip Prosthesis, Anterior approach, business, Learning Curve, Total hip arthroplasty
Abstract

PURPOSE: Cup positioning is important for optimum hip stability, avoiding component impingement and decreasing both bearing surface wear and revision rate. Transitioning from posterior approach in a lateral position to direct anterior approach (DAA) in a supine presents unique challenges for surgeons. The aim of this study was to examine the learning curve when using standard instrumentation that was not specific to DAA. METHODS: A consecutive retrospective series of 537 total hip arthroplasty by DAA from May 2013 to December 2017. Cup positioning was analysed on radiographs and classified whether inside or outside two safe zones (inclination 30-50° and anteversion 10-30°). The demographic data (age, BMI, gender, neck shaft angle (NSA)), surgeon's dominant side and experience were assessed as risk factors. RESULTS: Eighty per cent of cups (n=426) were in the combined safe zones. Eighty-eight per cent (n=470) were in appropriate anteversion and 87% (n=463) abduction. Two factors that were significant were identified: Cups of left hips operated by right-handed surgeons were more anteverted (OR=4.06) and more vertical (OR=2.23); females had a higher anteversion of the cup (OR=2.42). Obesity, age and NSA were not risk factors for cup malposition. There was a spike of cups too horizontal at the beginning of the experience (OR=3.86), and no learning curve was observed in the other orientations. CONCLUSION: With our DAA technique using standard instrumentation, there were no risk factors linked to the patient identified for cup malposition. DAA-specific instrumentation is not required to achieve optimum positioning of the cup. Surgeon has to be aware of an excess of abduction at the beginning of his experience and an excess of anteversion and adduction when performing THA on the opposite side of his dominant hand.

Published
2020

5. Accessing tens-to-hundreds femtoseconds nuclear state lifetimes with low-energy binary heavy-ion reactions

Author

M. Zieblinski, J. Grebosz, K. Mazurek, Simone Coelli, S. Brambilla, H. J. Li, B. Million, M. Rejmund, Bertrand Jacquot, P. Bednarczyk, N. Cieplicka-Oryńczak, M. Ciemala, M. Bast, S. Ziliani, O. Dorvaux, S. Erturk, Eric Clément, Ł. W. Iskra, C. Fransen, S. M. Lenzi, B. Fornal, P. J. Napiorkowski, C. Müller-Gatermann, M. Zielińska, B. Wasilewska, I. Matea, A. Maj, M. Kmiecik, Y. H. Kim, M. Kicińska-Habior, C. Michelagnoli, I. Stefan, M. Beckers, F. C. L. Crespi, O. Wieland, M. Lewitowicz, R. Palit, D. R. Napoli, Ch. Schmitt, A. V. Karpov, M. Stanoiu, F. Camera, Emanuele Vardaci, M. Matejska-Minda, A. Bracco, G. Benzoni, S. Bottoni, S. Leoni, V. Nanal, C. Boiano, A. Lemasson, Mohsen Harakeh, Thomas Braunroth, A. Goldkuhle, Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Laue-Langevin (ILL), ILL, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Ciemala, M., Ziliani, S., Crespi, F. C. L., Leoni, S., Fornal, B., Maj, A., Bednarczyk, P., Benzoni, G., Bracco, A., Boiano, C., Bottoni, S., Brambilla, S., Bast, M., Beckers, M., Braunroth, T., Camera, F., Cieplicka-Orynczak, N., Clement, E., Coelli, S., Dorvaux, O., Erturk, S., De France, G., Fransen, C., Goldkuhle, A., Grebosz, J., Harakeh, M. N., Iskra, L. W., Jacquot, B., Karpov, A., Kicinska-Habior, M., Kim, Y. -H., Kmiecik, M., Lemasson, A., Lenzi, S. M., Lewitowicz, M., Li, H., Matea, I., Mazurek, K., Michelagnoli, C., Matejska-Minda, M., Million, B., Muller-Gatermann, C., Nanal, V., Napiorkowski, P., Napoli, D. R., Palit, R., Rejmund, M., Schmitt, C., Stanoiu, M., Stefan, I., Vardaci, E., Wasilewska, B., Wieland, O., Zieblinski, M., Zielinska, M., H. Niewodniczanski Institute of Nuclear Physics, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Dipartimento di Fisica (Milano), Università degli Studi di Milano [Milano] (UNIMI), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Istituto Nazionale di Fisica Nucleare (INFN), Institut für Kernphysik der Universität zu Köln, Universität zu Köln, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano = University of Milan (UNIMI), Universität zu Köln = University of Cologne, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Nuclear Energy

Subjects
Nuclear reaction, Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, Monte Carlo method, Hadron, FOS: Physical sciences, Binary number, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Excited state, 0103 physical sciences, Nuclear fusion, AGATA, Nuclear Experiment (nucl-ex), Connection (algebraic framework), Atomic physics, Nuclear Experiment, 010306 general physics
Abstract

A novel Monte Carlo technique has been developed to determine lifetimes of excited states in the tens-to-hundreds femtoseconds range in products of low-energy heavy-ion binary reactions, with complex velocity distributions. The method is based on a detailed study of Doppler-broadened $$\gamma $$ γ -ray lineshapes. Its relevance is demonstrated in connection with the $$^{18}\text {O}(7.0\, \text {MeV/u})+\,^{181}\text {Ta}$$ 18 O ( 7.0 MeV/u ) + 181 Ta experiment, performed at GANIL with the AGATA+VAMOS+PARIS setup, to study neutron-rich O, C, N, ... nuclei. Excited states in $$^{17}\text {O}$$ 17 O and $$^{19}\text {O}$$ 19 O , with known lifetimes, are used to validate the method over the $$\sim 20{-}400\,\text {fs}$$ ∼ 20 - 400 fs lifetime-sensitivity range. Emphasis is given to the unprecedented position resolution provided by $$\gamma $$ γ -tracking arrays, which turns out to be essential for reaching the required accuracy in Doppler-shift correction. The technique is anticipated to be an important tool for lifetime investigations in exotic neutron-rich nuclei, produced with intense ISOL-type beams.

Published
2021

6. The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

Author

Bruhn, Christopher, Ajazi, Arta, Ferrari, Elisa, Lanz, Michael Charles, Lanz, Michael, Batrin, Renaud, Choudhary, Ramveer, Walvekar, Adhish, Laxman, Sunil, Longhese, Maria Pia, Fabre, Emmanuelle, Bustamente Smolka, Marcus, Foiani, Marco, IFOM, Istituto FIRC di Oncologia Molecolare (IFOM), Cornell University [New York], Génomes, biologie cellulaire et thérapeutiques (GenCellDi (UMR_S_944)), Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institute for Stem Cell Science and Regenerative Medicine [Bangalore, Inde] (inStem), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Università degli Studi di Milano [Milano] (UNIMI), C.B. was supported by fellowships from Associazione Italiana per la Ricerca sul Cancro (AIRC) Fellowship i-Care (Marie Curie co-funded by the European Union, ID 16173) and the European Commission (EC-FP7-SIPOD, ID PCOFUND-GA-2012-600399). This work was supported by grants from Fondazione AIRC under IG 2015 (M.F., ID 16770), IG 2018 (M.F., ID 21416), and IG 2017 (M.P.L., ID 19783), by the Ministero dell'Istruzione/Ministero dell'Università e della Ricerca (M.F., MIUR-PRIN-15-FOIANI) and by Progetti di Ricerca di Interesse Nazionale (PRIN) 2015 (M.P.L.). E. Fabre acknowledges Labex 'Who am I?' (ANR-11-LABX-0071, Idex ANR-11-IDEX-0005-02) and Cancéropôle Ile de France (ORFOCRISE PME-2015)., ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011), Bruhn, C, Ajazi, A, Ferrari, E, Lanz, M, Batrin, R, Choudhary, R, Walvekar, A, Laxman, S, Longhese, M, Fabre, E, Smolka, M, Foiani, M, Génomes, biologie cellulaire et thérapeutiques (GenCellDi (U944 / UMR7212)), Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Università degli Studi di Milano = University of Milan (UNIMI), Bodescot, Myriam, and Université Sorbonne Paris Cité - - USPC2011 - ANR-11-IDEX-0005 - IDEX - VALID

Subjects
0301 basic medicine, DNA Repair, DNA damage, DNA repair, [SDV]Life Sciences [q-bio], Science, General Physics and Astronomy, Saccharomyces cerevisiae, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], 02 engineering and technology, Protein-Serine-Threonine Kinase, General Biochemistry, Genetics and Molecular Biology, Ataxia Telangiectasia Mutated Protein, 03 medical and health sciences, Histone Deacetylase, Cell Cycle Protein, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Serine, Gene Silencing, Epigenetics, Phosphorylation, lcsh:Science, Transcription factor, ComputingMilieux_MISCELLANEOUS, Multidisciplinary, biology, Chemistry, Acetylation, General Chemistry, Telomere, 021001 nanoscience & nanotechnology, Subtelomere, Chromatin, Cell biology, Checkpoint Kinase 2, Histone, Glucose, 030104 developmental biology, Intracellular Signaling Peptides and Protein, Mutation, biology.protein, lcsh:Q, 0210 nano-technology, Saccharomyces cerevisiae Protein, DNA Damage, Transcription Factors
Abstract

The DNA damage response (DDR) coordinates DNA metabolism with nuclear and non-nuclear processes. The DDR kinase Rad53CHK1/CHK2 controls histone degradation to assist DNA repair. However, Rad53 deficiency causes histone-dependent growth defects in the absence of DNA damage, pointing out unknown physiological functions of the Rad53-histone axis. Here we show that histone dosage control by Rad53 ensures metabolic homeostasis. Under physiological conditions, Rad53 regulates histone levels through inhibitory phosphorylation of the transcription factor Spt21NPAT on Ser276. Rad53-Spt21 mutants display severe glucose dependence, caused by excess histones through two separable mechanisms: dampening of acetyl-coenzyme A-dependent carbon metabolism through histone hyper-acetylation, and Sirtuin-mediated silencing of starvation-induced subtelomeric domains. We further demonstrate that repression of subtelomere silencing by physiological Tel1ATM and Rpd3HDAC activities coveys tolerance to glucose restriction. Our findings identify DDR mutations, histone imbalances and aberrant subtelomeric chromatin as interconnected causes of glucose dependence, implying that DDR kinases coordinate metabolism and epigenetic changes.

Published
2020

7. Permian magmatism and metamorphism in the Dent Blanche nappe: constraints from field observations and geochronology

Author

Michel Ballèvre, Afifé El Korh, Paola Manzotti, Michele Zucali, Martin Engi, Bénédicte Cenki-Tok, Daniela Rubatto, Institut des Sciences de la Terre, Université de Lausanne (UNIL), Australian National University (ANU), Università degli Studi di Milano [Milano] (UNIMI), University of Fribourg, Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), Terre, Temps, Traçage, Géosciences Rennes (GR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), Institute of Geological Sciences [Bern], University of Bern, 200020-146175, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, 200020-126946, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CH), Université de Lausanne = University of Lausanne (UNIL), Università degli Studi di Milano = University of Milan (UNIMI), Université de Fribourg = University of Fribourg (UNIFR), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Milano [Milano], Institute of Geological Sciences, University of Bern, and Universität Bern [Bern]

Subjects
Zircon, 010504 meteorology & atmospheric sciences, Metamorphic rock, Geochemistry, Metamorphism, Regional HT metamorphism, 010502 geochemistry & geophysics, 01 natural sciences, Allanite, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, 550 Earth sciences & geology, Petrology, Metamorphic facies, 0105 earth and related environmental sciences, [SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics, Alps, Permian magmatism, Geology, Sesia-Dent Blanche nappes, Magma, Geochronology, Gneiss
Abstract

International audience; In the Dent Blanche Tectonic System, the Mont Morion biotite-bearing granite is a km-scale intrusion preserved in a low-strain volume. Zircon saturation thermometry suggests that it crystallised from a melt that reached about 800 °C. U–Pb zircon and allanite geochronology indicates crystallization of the magma in the Permian (290 ± 3 Ma; 280 ± 8 Ma, respectively). Migmatitic biotite-gneiss and amphibolite are found as xenoliths within the Mont Morion granite and constitute its country-rocks. In two samples of migmatitic biotite-gneiss zircon has metamorphic overgrowths that yield U–Pb ages of 285 ± 3 Ma and 281 ± 4 Ma, and are thus contemporaneous with the intrusion of the granite. The Mont Morion granite with its country-rocks of migmatitic biotite-bearing gneiss and amphibolite was thus emplaced at middle crustal levels while amphibolite facies metamorphism affected its country rocks. The magmatic and metamorphic record in the Mont Morion area reflects the high-temperature regime and lithospheric thinning of the Adriatic continental margin during Permian.

Published
2017

8. A Model with Darwinian Dynamics on a Rugged Landscape

Author

Tommaso Brotto, Jorge Kurchan, Guy Bunin, Università degli Studi di Milano [Milano] (UNIMI), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire de Physique Statistique de l'ENS (LPS), Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Massachusetts Institute of Technology (MIT), Università degli Studi di Milano = University of Milan (UNIMI), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Optimization problem, Fitness landscape, Population, FOS: Physical sciences, 01 natural sciences, 03 medical and health sciences, Phase (matter), 0103 physical sciences, Quantitative Biology::Populations and Evolution, Physics - Biological Physics, Statistical physics, Quantitative Biology - Populations and Evolution, 010306 general physics, education, Condensed Matter - Statistical Mechanics, Mathematical Physics, Selection (genetic algorithm), Mathematics, [PHYS]Physics [physics], education.field_of_study, Statistical Mechanics (cond-mat.stat-mech), Populations and Evolution (q-bio.PE), Statistical and Nonlinear Physics, Constraint satisfaction, Active matter, 030104 developmental biology, Biological Physics (physics.bio-ph), FOS: Biological sciences, Constant (mathematics)
Abstract

We discuss the population dynamics with selection and random diffusion, keeping the total population constant, in a fitness landscape associated with Constraint Satisfaction, a paradigm for difficult optimization problems. We obtain a phase diagram in terms of the size of the population and the diffusion rate, with a glass phase inside which the dynamics keeps searching for better configurations, and outside which deleterious `mutations' spoil the performance. The phase diagram is analogous to that of dense active matter in terms of temperature and drive., Comment: arXiv admin note: substantial text overlap with arXiv:1507.07453

Published
2016

9. Superconducting Coplanar Switch and Phase Shifter for CMB Applications

Author

M. Zanonni, V. D. Cammilleri, B. Bélier, M. Piat, A. Tartari, F. Gadot, N. Bleurvacq, A. Ghribi, G. Bordier, Institut d'électronique fondamentale (IEF), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Dipartimento di Fisica (Milano), Università degli Studi di Milano [Milano] (UNIMI), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Università degli studi di Milano [Milano], Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano = University of Milan (UNIMI), and ANR-11-BS03-0014,COSMOS,COmposantS millimétriques Main gauche pour la détection des Ondes gravitationnelles primordialeS(2011)

Subjects
[PHYS]Physics [physics], Physics, business.industry, Cosmic microwave background, Phase (waves), Context (language use), Condensed Matter Physics, 01 natural sciences, Signal, Atomic and Molecular Physics, and Optics, 010305 fluids & plasmas, Electric power transmission, Optics, Amplitude, RF switch, 0103 physical sciences, General Materials Science, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010306 general physics, business, Phase shift module, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; The next generations of cosmic microwave background (CMB) instruments will be dedicated to the detection and characterization of CMB B-modes. To measure this tiny signal, instruments need to control and minimize systematics. Signal modulation is one way to achieve such a control. A new generation of focal planes will include the entire detection chain. In this context, we present a superconducting coplanar switch driven by DC current. It consists of a superconducting microbridge which commutes between its on (superconducting) and off (normal metal) states, depending on the amplitude of the injected current compared to the critical current. If the current injected inside the bridge is lower than the critical current, the phase of the signal passing through the bridge is tunable. A first prototype of this component working as a switch and as a phase shifter at 10 GHz has been made. The principle, the setup, and the first measurements made at 4 K will be shown.

Published
2016

10. Preface

Author

Alberto Dennunzio, Enrico Formenti, Università degli Studi di Milano [Milano] (UNIMI), Modèles Discrets pour les Systèmes Complexes (Laboratoire I3S - MDSC), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Subjects
010201 computation theory & mathematics, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], [NLIN.NLIN-CG]Nonlinear Sciences [physics]/Cellular Automata and Lattice Gases [nlin.CG], 020201 artificial intelligence & image processing, 0102 computer and information sciences, 02 engineering and technology, [INFO.INFO-DM]Computer Science [cs]/Discrete Mathematics [cs.DM], 01 natural sciences, ComputingMilieux_MISCELLANEOUS, Computer Science Applications
Abstract

International audience

Published
2020

11. Preoperative Magnetic Resonance Enterography in Predicting Findings and Optimizing Surgical Approach in Crohn's Disease

Author

Piero Bazzi, Matteo Sacchi, Laurent Peyrin-Biroulet, Cristiana Bonifacio, Marco Montorsi, Gionata Fiorino, Silvio Danese, Alberto Malesci, Sarah De Bastiani, Luca Balzarini, Antonino Spinelli, Department of Medical Biotechnologies and Translational Medicine [Milan], Università degli Studi di Milano [Milano] (UNIMI), Department of Surgical Oncology, Istituto Clinico Humanitas [Milan] (IRCCS Milan), Humanitas University [Milan] (Hunimed)-Humanitas University [Milan] (Hunimed), Division of Gastroenterology, Department of Radiology [Humanitas Research Hospital], Humanitas Research Hospital, Department of Gastroenterology [Humanitas Research Hospital], Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Spinelli, A., Fiorino, G., Bazzi, P., Sacchi, M., Bonifacio, C., De Bastiani, S., Malesci, A., Balzarini, L., Peyrin Biroulet, L., Montorsi, M., and Danese, S.

Subjects
Adult, Male, medicine.medical_specialty, Abdominal Abscess, Adolescent, [SDV]Life Sciences [q-bio], laparoscopy, Constriction, Pathologic, Disease, Surgical planning, Preoperative care, Patient Care Planning, surgery, Young Adult, Crohn Disease, Predictive Value of Tests, Preoperative Care, Intestinal Fistula, medicine, magnetic resonance imaging, Humans, Prospective Studies, Laparoscopy, Prospective cohort study, Crohn's disease, magnetic resonance enterography, medicine.diagnostic_test, business.industry, Gastroenterology, Magnetic resonance imaging, medicine.disease, Conversion to Open Surgery, Magnetic Resonance Imaging, digestive system diseases, 3. Good health, Surgery, Intestines, Predictive value of tests, Female, Radiology, business, Intestinal Obstruction
Abstract

International audience; BACKGROUND:Many Crohn's disease patients require surgery. Intraoperative detection of new lesions may lead to change in planned surgery. This study aimed to determine whether magnetic resonance enterography can optimize surgical planning and guide decision making in Crohn's disease.METHODS:Seventy-five patients with complicated Crohn's disease were enrolled and underwent preoperative magnetic resonance enterography. Analysis included imaging accuracy and change in surgical strategy due to discordance with imaging findings.RESULTS:Surgery was performed laparoscopically in 39/75 patients (52 %), with conversion to open surgery required in six (15 %). Concordance between observers was excellent (kappa value >0.8). Magnetic resonance enterography accuracy for stenosis, abscess, and fistula were all above 85 % in per-patient analysis. In 68/75 cases (90.7 %) surgery was correctly predicted. Conversely, in 7/75 cases (three false-positives and four false-negatives) surgical strategy (type of resection or strictureplasty, n = 5) and/or surgical approach (conversion from laparoscopy to open surgery, n = 2) changed due to discordance with magnetic resonance enterography findings.CONCLUSION:Surgical strategy and approach are correctly predicted by magnetic resonance enterography in the majority of patients with complicated Crohn's disease.

Published
2013

12. Existence and stability of ground states for fully discrete approximations of the nonlinear Schrödinger equation

Author

Benoît Grébert, Dario Bambusi, Erwan Faou, Dipartimento de Matematica [Milano], Università degli studi di Milano [Milano], Invariant Preserving SOlvers ( IPSO ), Institut de Recherche Mathématique de Rennes ( IRMAR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -AGROCAMPUS OUEST-École normale supérieure - Rennes ( ENS Rennes ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National des Sciences Appliquées ( INSA ) -Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ) -Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique ( Inria ), Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Mathématiques Jean Leray ( LMJL ), Université de Nantes ( UN ) -Centre National de la Recherche Scientifique ( CNRS ), Università degli Studi di Milano = University of Milan (UNIMI), Invariant Preserving SOlvers (IPSO), Institut de Recherche Mathématique de Rennes (IRMAR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Laboratoire de Mathématiques Jean Leray (LMJL), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano [Milano] (UNIMI), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-AGROCAMPUS OUEST, Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Inria Rennes – Bretagne Atlantique, Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Université de Nantes (UN)-Université de Nantes (UN)

Subjects
Mathematics::Analysis of PDEs, 010103 numerical & computational mathematics, 01 natural sciences, Discrete nonlinear Schrödinger equation, symbols.namesake, Modified Hamiltonian, FOS: Mathematics, Mathematics - Numerical Analysis, 0101 mathematics, Nonlinear Sciences::Pattern Formation and Solitons, Nonlinear Schrödinger equation, Real line, Mathematics, Spacetime, Applied Mathematics, Courant–Friedrichs–Lewy condition, Mathematical analysis, Numerical soliton, 37M15, 65P40, 37K40, Numerical Analysis (math.NA), [ MATH.MATH-NA ] Mathematics [math]/Numerical Analysis [math.NA], 010101 applied mathematics, Computational Mathematics, Norm (mathematics), Dirichlet boundary condition, Backward error analysis, symbols, Ground state, Stability, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Symplectic geometry
Abstract

In this paper we study the long time behavior of a discrete approximation in time and space of the cubic nonlinear Schr\"odinger equation on the real line. More precisely, we consider a symplectic time splitting integrator applied to a discrete nonlinear Schr\"odinger equation with additional Dirichlet boundary conditions on a large interval. We give conditions ensuring the existence of a numerical soliton which is close in energy norm to the continuous soliton. Such result is valid under a CFL condition between the time and space stepsizes. Furthermore we prove that if the initial datum is symmetric and close to the continuous soliton, then the associated numerical solution remains close to the orbit of the continuous soliton for very long times., Comment: 2012-25

Published
2012

13. Evaluation of respiration parameters in a few generations and clones of Simocephalus vetulus (Crustacea, Cladocera) under controlled conditions

Author

Forasacco Elena, Fontvieille Dominique, Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques (CARRTEL), Institut National de la Recherche Agronomique (INRA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Dipartimento di Biologia, and Università degli Studi di Milano [Milano] (UNIMI)-Sez. Zoologia Scienze Naturali

Subjects
0106 biological sciences, biology, Ecology, [SDV]Life Sciences [q-bio], 010604 marine biology & hydrobiology, Daphnia magna, Branchiopoda, OXYGEN CONTENT, Aquatic animal, SIMOCEPHALUS VELUTUS, Aquatic Science, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Crustacean, Cladocera, NADH CONTENT, Respiration, Littoral zone, RESPIRATION PARAMETERS, Respiration rate
Abstract

International audience; Cladocera use their thoracic filter limbs, animated by rhythmic and persistent movements, for food collecting and gas exchanges. Several researches have been performed on Daphnia magna in natural environments and in laboratory to identify the adaptations developed toward a decrease or a lack in oxygen. However, no experiment was performed on cladocerans living exclusively in littoral areas, which need efficient adaptations to survive an always changing environment especially regarding oxygen concentration. These changes require from organisms that they spend additional energy in order to satisfy their need in oxygen. The present laboratory experiments were based on a typical inhabitant of littoral areas, Simocephalus vetulus, and on individuals which came directly from natural environments. Respiration rate and NADH fluorescence in filter limb muscles, as a marker of tissue oxygenation, were analysed on 20 families distributed over five generations, all acclimated and cultured under constant food supply conditions. The results underlined differences among generations especially due to body dimensions, and consequently to filter dimensions. As opposed to our former hypothesis, small and young individuals appeared to be more active and thus display a more efficient respiration than big and old Simocephalus.

Published
2010

14. Symposium on organization, heterogeneity and trade

Author

Giovanni Facchini, Thierry Verdier, Aziendali e Statistiche, Università degli Studi di Milano [Milano] (UNIMI), University of Essex, Center for Economic Policy Research (CEPR), CEPR, CESifo, Paris-Jourdan Sciences Economiques (PJSE), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), École des Ponts ParisTech (ENPC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Departement of Economics, and University of Southampton

Subjects
Economics and Econometrics, business.industry, 05 social sciences, World trade, International trade, Foreign direct investment, International economics, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Multinational corporation, 0502 economics and business, 8. Economic growth, Economics, 050207 economics, Literature study, Settore SECS-P/01 - Economia Politica, business, Tertiary sector of the economy, 050205 econometrics, Public finance, Pace
Abstract

The growing importance of multinational corporations in world trade has been widely documented in the empirical literature. UNCTAD (2002), for instance, finds that the sales of foreign affiliates of multinational corporations have increased much faster than exports of goods and non-factor services. Trade in intermediate inputs has also expanded substantially and FDI in the service sector has grown at an unprecedented pace.

Published
2008

15. Effects of a cantaloupe melon extract/wheat gliadin biopolymer during aortic cross-clamping

Author

Hubert Schelzig, Catherine Garrel, Sukru Oter, Maura Albicini, Uwe B. Brückner, Hendrik Bracht, Günter Speit, Jörn Sträter, Florian Simon, Peter Radermacher, Xavier Leverve, Ulrich Ehrmann, Balázs Hauser, Jochen Kick, Claus-Martin Muth, Hamant, Sarah, Abteilung Thorax- und Gefässchirurgie, Universitätsklinikum Ulm - University Hospital of Ulm, Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Semmelweis Egyetem, Aneszteziológiai és Intenzív Terápiás Klinika, Istituto di Anestesiologia e Rianimazione, Università degli Studi di Milano = University of Milan (UNIMI), Fizyoloji Anabilim Dali, Gülhane Askeri Tip Akademisi, Département de biologie intégrée, CHU Grenoble-Hôpital Michallon, Abteilung Pathologie, Sektion Chirurgische Forschung, Bioénergétique fondamentale et appliquée, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Abteilung Humangenetik, and Università degli Studi di Milano [Milano] (UNIMI)

Subjects
Male, Swine, Apoptosis, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, medicine.disease_cause, Gliadin, chemistry.chemical_compound, 0302 clinical medicine, Cucumis melo, MESH: Animals, MESH: Hyperbaric Oxygenation, Food science, MESH: In Situ Nick-End Labeling, MESH: Swine, MESH: Cucumis melo, chemistry.chemical_classification, Hyperbaric Oxygenation, 0303 health sciences, MESH: Oxidative Stress, biology, Glutathione peroxidase, MESH: Gliadin, food and beverages, 3. Good health, Catalase, Reperfusion Injury, Anesthesia, Female, Comet Assay, DNA damage, MESH: Plant Extracts, MESH: Comet Assay, Nitric oxide, 03 medical and health sciences, Intensive care, In Situ Nick-End Labeling, medicine, Animals, 030304 developmental biology, MESH: DNA Damage, Plant Extracts, business.industry, MESH: Apoptosis, MESH: Male, Comet assay, Oxidative Stress, chemistry, biology.protein, MESH: Reperfusion Injury, business, MESH: Female, Oxidative stress, DNA Damage
Abstract

International audience; OBJECTIVE: We previously reported in healthy volunteers that a cantaloupe melon extract chemically combined with wheat gliadin (melon extract/gliadin) and containing SOD, catalase and residual glutathione peroxidase (GPx), protected against DNA strand-break damage induced by hyperbaric oxygen (HBO), a well-established model of DNA damage resulting from oxidative stress. Aortic cross-clamping is a typical example of ischemia/reperfusion injury-related oxidative stress, and therefore we investigated whether this melon extract/gliadin would also reduce DNA damage after aortic cross-clamping and reperfusion. DESIGN: Prospective, randomized, controlled experimental study. SETTING: Animal laboratory. PATIENTS AND PARTICIPANTS: 18 anesthetized, mechanically ventilated and instrumented pigs. INTERVENTIONS: After 14 days of oral administration of 1250 mg of the melon extract/gliadin (n=9) or vehicle (n=9), animals underwent 30 min of thoracic aortic cross-clamping and 4 h of reperfusion. MEASUREMENTS AND RESULTS: Before clamping, immediately before declamping, and at 2 and 4 h of reperfusion, we measured blood isoprostane (immunoassay) and malondialdehyde concentrations (fluorimetric thiobarbituric acid test), SOD, catalase and GPx activities (spectrophotometric kits), NO formation (nitrate+nitrite; chemoluminescence), DNA damage in whole blood samples and isolated lymphocytes exposed to hyperbaric oxygen (comet assay). Organ function was also evaluated. Kidney and spinal cord specimen were analysed for apoptosis (TUNEL assay). The melon extract/gliadin blunted the DNA damage, reduced spinal cord apoptosis and attenuated NO release, however, without any effect on lipid peroxidation and organ function. CONCLUSIONS: Pre-treatment with the oral melon extract/gliadin may be a therapeutic option to reduce oxidative cell injury affiliated with aortic cross-clamping.

Published
2007

16. Extremely localized molecular orbitals: theory and applications

Author

Stefano Pieraccini, Monica Civera, Maurizio Sironi, Alessandro Genoni, Michela Ghitti, Dipartimento di Chimica fisica ed Elettrochimica, and Università degli Studi di Milano [Milano] (UNIMI)

Subjects
hyperconjugation, VB approaches, 010304 chemical physics, Chemistry, transferability, Hartree–Fock method, Molecular orbital theory, Localized molecular orbitals, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Extremely Localized Molecular Orbitals, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Linear combination of atomic orbitals, 0103 physical sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, Molecular orbital, Statistical physics, Complete active space, Physical and Theoretical Chemistry, Atomic physics, Divide and Conquer, Basis set, Natural bond orbital
Abstract

International audience; Orbitals which are extremely localized on molecular fragments represent a powerful tool for a number of purposes: just to cite a few examples, they allow to strongly reduce the complexity of calculations on large systems and they are easily transferable from one molecule to another one, providing a suitable and efficient way to build up the electronic structure of large molecules. Recently, we have developed efficient algorithms to determine Extremely Localized Molecular Orbitals (ELMOs) that will be reviewed in this paper. As a rigorous localization is strictly connected to a reduction in the number of variational parameters, which reflects into an increased value of the associated energy with respect to the Hartree Fock value, we have developed a number of strategies to relax the wavefunction built up using transferred localized orbitals. The extreme localization has also been exploited in connection with the 'Divide & Conquer' technique to determine large polypeptides electron densities assembled from orbitals computed on small model molecules. Moreover, we will discuss the recent application of the ELMOs in the framework of the hybrid QM/MM methods to describe the frontier region. We will also show that the ELMOs can be used to extract chemical interpretations from numerical results. A variety of applications will be presented. 2

Published
2007

17. Osmotic stress affects functional properties of human melanoma cell lines

Author

Mikko J. Alava, Caterina A. M. La Porta, Anna Ghilardi, Maria Enrica Pasini, Stefano Zapperi, Martine Ben Amar, Lasse Laurson, Department of Biosciences [Milano], Università degli Studi di Milano [Milano] (UNIMI), COMP Centre of Excellence, Aalto University, Department of applied physics, Data Science Laboratory (ISI), ISI Foundation Institute for Scientific Interchange, Department of Physics [Milano], Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), CNR-IENI Milano, Institut Universitaire de Cancérologie [Paris] (IUC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Statistique de l'ENS (LPS), Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Institut Universitaire de Cancérologie [Sorbonne Université] (IUC), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], Osmotic shock, Chemistry, Cell growth, Melanoma, FOS: Physical sciences, General Physics and Astronomy, Cancer, Quantitative Biology - Tissues and Organs, Nanotechnology, PHENOTYPE, medicine.disease, ENDOTHELIAL-CELLS, Metastasis, Cell biology, HYDROSTATIC-PRESSURE, Biological Physics (physics.bio-ph), Cell culture, FOS: Biological sciences, Cancer cell, medicine, Osmotic pressure, Physics - Biological Physics, Tissues and Organs (q-bio.TO), [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Understanding the role of microenvironment in cancer growth and metastasis is a key issue for cancer research. Here, we study the effect of osmotic pressure on the functional properties of primary and metastatic melanoma cell lines. In particular, we experimentally quantify individual cell motility and transmigration capability. We then perform a circular scratch assay to study how a cancer cell front invades an empty space. Our results show that primary melanoma cells are sensitive to a low osmotic pressure, while metastatic cells are less. To better understand the experimental results, we introduce and study a continuous model for the dynamics of a cell layer and a stochastic discrete model for cell proliferation and diffusion. The two models capture essential features of the experimental results and allow to make predictions for a wide range of experimentally measurable parameters.

Published
2015

18. PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence

Author

David Sassoon, Giulio Cossu, Stefania Antonini, Graziella Messina, Monica Giannotta, Francesco Tedesco, Giuliana Rossi, Rossana Tonlorenzi, Elisabetta Dejana, Giovanna Marazzi, Chiara Bonfanti, Sara Benedetti, Administateur, HAL Sorbonne Université, Department of Biosciences [Milano], Università degli Studi di Milano = University of Milan (UNIMI), Department of Cell and Developmental Biology, University College of London [London] (UCL), IFOM, Istituto FIRC di Oncologia Molecolare (IFOM), Institute of Child Health [London], Division of neuroscience, San Raffaele Hospital, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institute of inflammation and repair, University of Manchester [Manchester], Università degli Studi di Milano [Milano] (UNIMI), and Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN)

Subjects
General Physics and Astronomy, Muscle Development, MyoD, Muscular Dystrophies, Mice, 0302 clinical medicine, Muscular dystrophy, Luciferases, Cells, Cultured, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Multidisciplinary, Reverse Transcriptase Polymerase Chain Reaction, Myogenesis, Stem Cells, Cell biology, Biological sciences, Stem cell, Chromatin Immunoprecipitation, Blotting, Western, Genetic Vectors, Kruppel-Like Transcription Factors, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Dogs, Medical research, MyoD Protein, medicine, Animals, Humans, Gene Silencing, Progenitor cell, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, DNA Primers, 030304 developmental biology, Progenitor, Mesoangioblast, General Chemistry, medicine.disease, Molecular biology, Retroviridae, Microscopy, Fluorescence, Blood Vessels, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

Mesoangioblasts are vessel-associated progenitor cells that show therapeutic promise for the treatment of muscular dystrophy. Mesoangioblasts have the ability to undergo skeletal muscle differentiation and cross the blood vessel wall regardless of the developmental stage at which they are isolated. Here we show that PW1/Peg3 is expressed at high levels in mesoangioblasts obtained from mouse, dog and human tissues and its level of expression correlates with their myogenic competence. Silencing PW1/Peg3 markedly inhibits myogenic potential of mesoangioblasts in vitro through MyoD degradation. Moreover, lack of PW1/Peg3 abrogates mesoangioblast ability to cross the vessel wall and to engraft into damaged myofibres through the modulation of the junctional adhesion molecule-A. We conclude that PW1/Peg3 function is essential for conferring proper mesoangioblast competence and that the determination of PW1/Peg3 levels in human mesoangioblasts may serve as a biomarker to identify the best donor populations for therapeutic application in muscular dystrophies., Mesoangioblasts are mesodermal stem cells with a therapeutic potential for treatment of muscular dystrophy due to their ability to differentiate into skeletal muscle. This study shows that the PW1/Peg3 protein is crucial for mesoangioblast myogenic and migratory potency and is a therapeutically relevant biomarker.

Published
2015

19. Hospital mortality of adults admitted to Intensive Care Units in hospitals with and without Intermediate Care Units: a multicentre European cohort study

Author

Maurizia Capuzzo, Carlo Alberto Volta, Tania Tassinati, Rui Paulo Moreno, Andreas Valentin, Bertrand Guidet, Gaetano Iapichino, Claude Martin, Thomas Perneger, Christophe Combescure, Antoine Poncet, Andrew Rhodes, and on behalf of the Working Group on Health Economics of the European Society of Intensive Care Medicine, Rita Melotti, Università degli Studi di Ferrara = University of Ferrara (UniFE), Centro Hospitalar de Lisboa Central E.P.E, Hospital Rudolfstiftung [Vienna], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins (DS3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Milano = University of Milan (UNIMI), Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Geneva University Hospital (HUG), St George's Hospital NHS Healthcare Trust, Service de Réanimation Médicale [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), HAL UPMC, Gestionnaire, Capuzzo, Maurizia, Carlo Alberto Volta, Tassinati, Tania, Rui Paulo Moreno, Valentin, Andrea, Guidet, Bertrand, Iapichino, Gaetano, Martin, Claude, Perneger, Thoma, Combescure, Christophe, Poncet, Antoine, Rhodes, Andrew, (, on behalf of the Working Group on Health Economics of the European Society of Intensive Care Medicine, Melotti, Rita, Università degli Studi di Ferrara (UniFE), Hospital Rudolfstiftung, and Università degli Studi di Milano [Milano] (UNIMI)

Subjects
Male, medicine.medical_specialty, health care facilities, manpower, and services, Critical Care and Intensive Care Medicine, Intermediate Care Facility, Cohort Studies, Patient Admission, Critical care nursing, Intensive care, medicine, Humans, Hospital Mortality, Mortality, Simplified Acute Physiology Score, Aged, Aged, 80 and over, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Research, Intensive Care, Odds ratio, Middle Aged, Hospitals, 3. Good health, Europe, Intensive Care Units, SAPS II, Emergency medicine, Female, Observational study, Intermediate Care Facilities, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cohort study
Abstract

Introduction The aim of the study was to assess whether adults admitted to hospitals with both Intensive Care Units (ICU) and Intermediate Care Units (IMCU) have lower in-hospital mortality than those admitted to ICUs without an IMCU. Methods An observational multinational cohort study performed on patients admitted to participating ICUs during a four-week period. IMCU was defined as any physically and administratively independent unit open 24 hours a day, seven days a week providing a level of care lower than an ICU but higher than a ward. Characteristics of hospitals, ICUs and patients admitted to study ICUs were recorded. The main outcome was all-cause in-hospital mortality until hospital discharge (censored at 90 days). Results One hundred and sixty-seven ICUs from 17 European countries enrolled 5,834 patients. Overall, 1,113 (19.1%) patients died in the ICU and 1,397 died in hospital, with a total of 1,397 (23.9%) deaths. The illness severity was higher for patients in ICUs with an IMCU (median Simplified Acute Physiology Score (SAPS) II: 37) than for patients in ICUs without an IMCU (median SAPS II: 29, P

Published
2014

20. Redescription of Cercopithifilaria bainae Almeida & Vicente, 1984 (Spirurida, Onchocercidae) from a dog in Sardinia, Italy

Author

Antonio Scala, Emanuele Brianti, Odile Bain, Yasen Mutafchiev, Antonio Varcasia, Filipe Dantas-Torres, C. Solinas, Giada Annoscia, Coralie Martin, Domenico Otranto, Dipartimento di Medicina Veterinaria, Università degli studi di Bari, Università degli studi di Milano [Milano], Dipartimento di Scienze Veterinarie, Università degli Studi di Messina, University of Bari Aldo Moro (UNIBA), Centre National de la Recherche Scientifique (CNRS), Molécules de Communication et Adaptation des Micro-organismes (MCAM), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Universités, Institut Cochin (UMR_S567 / UMR 8104), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Università degli studi di Bari Aldo Moro (UNIBA), Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano [Milano] (UNIMI), Sorbonne Université (SU), and Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Veterinary medicine, Molecular Sequence Data, 030231 tropical medicine, Zoology, Cercopithifilaria sp. II, 030308 mycology & parasitology, Cercopithifilaria bainae, 03 medical and health sciences, Monophyly, Dogs, 0302 clinical medicine, Sensu, Phylogenetics, parasitic diseases, Animals, Dog Diseases, Cercopithifilaria sp. I, Microfilariae, Filarioidea, Phylogeny, ComputingMilieux_MISCELLANEOUS, Cercopithifilaria grassii, Taxonomy, Spirurida, 0303 health sciences, Base Sequence, biology, Research, Holotype, Canine filarioids, Sequence Analysis, DNA, DNA, Helminth, biology.organism_classification, Onchocercidae, Filariasis, VET/06 Parassitologia e malattie parassitarie degli animali, Europe, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infectious Diseases, Italy, Female, Parasitology, Taxonomy (biology)
Abstract

Background Three species of the genus Cercopithifilaria have been morphologically and molecularly characterized in dog populations in southern Europe: Cercopithifilaria grassii (Noè, 1907), Cercopithifilaria sp. sensu Otranto et al., 2011 (reported as Cercopithifilaria sp. I), and Cercopithifilaria sp. II sensu Otranto et al., 2012. The adults of Cercopithifilaria sp. I have remained unknown until the present study. Methods The material originated from a dog from Sardinia (Italy) diagnosed with dermal microfilariae of Cercopithifilaria sp. I. The holotype and three paratypes of Cercopithifilaria bainae Almeida & Vicente, 1984, described from dogs in Brazil, were studied as comparative material. A cox1 (~689 bp) and 12S (~330 bp) gene fragments were amplified and phylogenetic analysis carried out. Results The highest numbers of adult nematodes (82%) were collected in the sediment of the subcutaneous tissues of the trunk (n = 37) and forelimbs (n = 36). The morphology of the adult nematodes and microfilariae collected from the dog in Sardinia corresponded to those of C. bainae. All cox1 and 12S gene sequences showed a high homology (99-100%) with sequences from microfilariae of Cercopithifilaria sp. I. Conclusions The morphological and molecular identity of the microfilariae of C. bainae overlap those described previously as Cercopithifilaria sp. sensu Otranto et al., 2011 (=Cercopithifilaria sp. I). Therefore, the present study reports the occurrence of C. bainae in Europe, for the first time after its description and the single record in Brazil. C. bainae appears to be highly diffused in dog populations in southern Europe. The phylogenetic analyses based on cox1 and 12S do not reveal the three species of Cercopithifilaria parasitizing dogs as a monophyletic group, which suggests that they have derived independently by host switching.

Published
2013

21. Time-dependent density anomalies in a stratified, viscoelastic mantle: Implications for the geoid, Earth's rotation and sea-level fluctuations

Author

Giorgio Spada, Yanick Ricard, Roberto Sabadini, Dipartimento di Scienze della Terra 'Ardito Desio', Università degli Studi di Milano [Milano] (UNIMI), Dipartimento di Scienze Pure et Applicate (DiSPea), Università degli Studi di Urbino 'Carlo Bo', Laboratoire de Sciences de la Terre (LST), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano = University of Milan (UNIMI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), R. Sabadini, SPADA, GIORGIO, and Y. Ricard

Subjects
true polar wander, 010504 meteorology & atmospheric sciences, Earth rotation, [PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph], geoid, viscoelastic mantle, sea level, Rotation, sea levels, rotation, 01 natural sciences, Mantle (geology), Physics::Geophysics, 03 medical and health sciences, density anomalies, density anomaly, mantle, mantle rheology, rheology, sea level variation, sea level variations, viscosity [Author keywords geoid, Rheology, viscosity and density jumps Indexed keywords GEOBASE Subject Index], Geochemistry and Petrology, Transition zone, Geoid, True polar wander, 030304 developmental biology, 0105 earth and related environmental sciences, Earth's rotation, 0303 health sciences, Subduction, Geophysics, Author keywords geoid, Geodesy, density anomalies [viscosity and density jumps Indexed keywords GEOBASE Subject Index], 13. Climate action, viscosity, Love number, viscosity and density jumps Indexed keywords GEOBASE Subject Index: density anomalie, Geology
Abstract

cited By 5; The effects on the ℓ = 2 geoid component and Earth's rotation due to internal mass anomalies are analyzed for a stratified viscoelastic mantle described by a Maxwell rheology. Our approach is appropriate for a simplified modeling of subduction. Sea-level fluctuations induced by long-term rotational instabilities are also considered. The displacement of the Earth's axis of rotation, called true polar wander (TPW) and the induced eustatic sea-level fluctuations, are extremely sensitive to viscosity and density stratification at the 670 km seismic discontinuity. Phase-change models for the transition zone generally allow for huge amount of TPW, except for large viscosity increases; the dominant contribution in Liouville equations comes from a secular term that reflects the viscous behaviour of the mantle. In chemically stratified models, TPW is drastically reduced due to dynamic compensation of the mass anomalies at the upper-lower mantle interface. When the source is embedded in the upper mantle close to the chemical density jump, transient rotational modes are the leading terms in the linear Liouville equations. Long-term rotation instabilities are valuable contributors to the third order cycles in the eustatic sea-level curves. Rates of sea-level fluctuations of the order of 0.05-0.1 mm/yr are induced by displacements of the Earth's axis of rotation compatible with paleomagnetic data. © 1993 Kluwer Academic Publishers.

Published
1993

22. Solving Unknown Complex Oxide Structures by Precession Electron Diffraction: AgCoO2, PbMnO2.75 and LiTi1.5Ni0.5O4

Author

H. Klein, Mauro Gemmi, Amélie Rageau, Matériaux, Rayonnements, Structure (MRS), Institut Néel (NEEL), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze della Terra 'Ardito Desio', and Università degli Studi di Milano [Milano] (UNIMI)

Subjects
010302 applied physics, Complex oxide, Materials science, Electron crystallography, Oxide, Structure (category theory), 02 engineering and technology, Crystal structure, 021001 nanoscience & nanotechnology, 01 natural sciences, chemistry.chemical_compound, Crystallography, chemistry, Simple (abstract algebra), 0103 physical sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, Precession electron diffraction, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS, Monoclinic crystal system
Abstract

Oxides synthesized in high temperature / high pressure conditions often show complex structures and contain several phases which makes a structure solution by X-ray crystallography very difficult or even impossible. Electron crystallography can then be a powerful alternative. We show here the structure solution of 3 oxides by precession electron diffraction. The phases include a simple hexagonal structure (AgCoO2), a complex monoclinic structure (PbMnO2.75) with a quasi 2-dimensional unit cell and a complex trigonal structure (LiTi1.5Ni0.5O4). In the last case even the positions for the light element Li were determined.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results