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Your search keyword '"Villa-Morales, María"' showing total 6 results
Start Over Author "Villa-Morales, María" Publisher springer science and business media llc
6 results on '"Villa-Morales, María"'

1. Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer

Author

Tundidor, Isabel, primary, Seijo-Vila, Marta, additional, Blasco-Benito, Sandra, additional, Rubert-Hernández, María, additional, Adámez, Sandra, additional, Andradas, Clara, additional, Manzano, Sara, additional, Álvarez-López, Isabel, additional, Sarasqueta, Cristina, additional, Villa-Morales, María, additional, González-Lois, Carmen, additional, Ramírez-Medina, Esther, additional, Almoguera, Belén, additional, Sánchez-López, Antonio J., additional, Bindila, Laura, additional, Hamann, Sigrid, additional, Arnold, Norbert, additional, Röcken, Christoph, additional, Heras-Murillo, Ignacio, additional, Sancho, David, additional, Moreno-Bueno, Gema, additional, Caffarel, María M., additional, Guzmán, Manuel, additional, Sánchez, Cristina, additional, and Pérez-Gómez, Eduardo, additional

Published
2023
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2. Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma

Author

López-Nieva, Pilar, primary, Fernández-Navarro, Pablo, additional, Graña-Castro, Osvaldo, additional, Andrés-León, Eduardo, additional, Santos, Javier, additional, Villa-Morales, María, additional, Cobos-Fernández, María Ángeles, additional, González-Sánchez, Laura, additional, Malumbres, Marcos, additional, Salazar-Roa, María, additional, and Fernández-Piqueras, José, additional

Published
2019
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3. Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma

Author

Vázquez-Domínguez, Irene, primary, González-Sánchez, Laura, additional, López-Nieva, Pilar, additional, Fernández-Navarro, Pablo, additional, Villa-Morales, María, additional, Cobos-Fernández, María Á., additional, Sastre, Isabel, additional, F. Fraga, Mario, additional, F. Fernández, Agustín, additional, Malumbres, Marcos, additional, Salazar-Roa, María, additional, Graña-Castro, Osvaldo, additional, Santos, Javier, additional, Llamas, Pilar, additional, López-Lorenzo, José L., additional, and Fernández-Piqueras, José, additional

Published
2019
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4. RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas

Author

López-Nieva, Pilar, primary, Fernández-Navarro, Pablo, additional, Vaquero-Lorenzo, Concepción, additional, Villa-Morales, María, additional, Graña-Castro, Osvaldo, additional, Cobos-Fernández, María Ángeles, additional, López-Lorenzo, José Luis, additional, Llamas, Pilar, additional, González-Sanchez, Laura, additional, Sastre, Isabel, additional, Pollan, Marina, additional, Malumbres, Marcos, additional, Santos, Javier, additional, and Fernández-Piqueras, José, additional

Published
2018
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6. Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma

Author

Javier Santos, Laura González-Sánchez, José Luis López-Lorenzo, Isabel Sastre, María Villa-Morales, Mario F. Fraga, María Salazar-Roa, Pilar Llamas, Agustín F. Fernández, Irene Vázquez-Domínguez, Osvaldo Graña-Castro, José Fernández-Piqueras, Pablo Fernández-Navarro, Pilar López-Nieva, María Ángeles Cobos-Fernández, Marcos Malumbres, Ministerio de Economía y Competitividad (España), European Commission, Comunidad de Madrid, Instituto de Salud Carlos III, Asociación Española Contra el Cáncer, Banco Santander, Fundación Ramón Areces, Villa-Morales, María [0000-0001-7906-0169], Fernández, Agustín F. [0000-0002-3792-4085], Fernández-Piqueras, José [0000-0003-4520-6785], Villa-Morales, María, Fernández, Agustín F., and Fernández-Piqueras, José

Subjects
0301 basic medicine, Gene isoform, Cancer Research, F-Box-WD Repeat-Containing Protein 7, T cell, Cell, Down-Regulation, Biology, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Gene Expression Regulation, Enzymologic, Epigenesis, Genetic, Jurkat Cells, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, microRNA, Genetics, medicine, Humans, Epigenetics, Molecular Biology, Gene Expression Regulation, Leukemic, Cell growth, Gene Expression Profiling, Microarray Analysis, Cell biology, Isoenzymes, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Cell culture, 030220 oncology & carcinogenesis
Abstract

FBXW7 is a driver gene in T-cell lymphoblastic neoplasia acting through proteasome degradation of key proto-oncogenes. FBXW7 encodes three isoforms, α, β and γ, which differ only in the N-terminus. In this work, massive sequencing revealed significant downregulation of FBXW7 in a panel of primary T-cell lymphoblastic lymphomas characterised by the absence of mutations in its sequence. We observed that decreased expression mainly affected the FBXW7β isoform and to a lesser extent FBXW7α and may be attributed to the combined effect of epigenetic changes, alteration of upstream factors and upregulation of miRNAs. Transient transfections with miRNA mimics in selected cell lines resulted in a significant decrease of total FBXW7 expression and its different isoforms separately, with the consequent increment of critical substrates and the stimulation of cell proliferation. Transient inhibition of endogenous miRNAs in a T-cell lymphoblastic-derived cell line (SUP-T1) was capable of reversing these proliferative effects. Finally, we show how FBXW7 isoforms display different roles within the cell. Simultaneous downregulation of the α and γ isoforms modulates the amount of CCNE1, whilst the β-isoform alone was found to have a prominent role in modulating the amount of c-MYC. Our data also revealed that downregulation of all isoforms is a sine qua non condition to induce a proliferative pattern in our cell model system. Taking these data into account, potential new treatments to reverse downregulation of all or a specific FBXW7 isoform may be an effective strategy to counteract the proliferative capacity of these tumour cells., Spanish Ministry of Economy and Competitiveness (SAF2015-70561-R; MINECO/FEDER, EU; BES-2013-065740); the Autonomous Community of Madrid, Spain (B2017/BMD-3778; LINFOMAS-CM); the Spanish Association against Cancer (AECC, 2018; PROYE18054PIRI) and the Instituto de Salud Carlos III (ISCIII) (ACCI-CIBERER-17). Institutional grants from the Fundación Ramón Areces and Banco de Santander to the CBMSO are also acknowledged.

Published
2019
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