Search

Your search keyword '"Ward, Joey"' showing total 21 results
Start Over Author "Ward, Joey" Publisher springer science and business media llc
21 results on '"Ward, Joey"'

2. Consistent effects of the genetics of happiness across the lifespan and ancestries in multiple cohorts

Author

Ward, Joey, primary, Lyall, Laura M., additional, Cullen, Breda, additional, Strawbridge, Rona J., additional, Zhu, Xingxing, additional, Stanciu, Ioana, additional, Aman, Alisha, additional, Niedzwiedz, Claire L., additional, Anderson, Jana, additional, Bailey, Mark E. S., additional, Lyall, Donald M., additional, and Pell, Jill P., additional

Published
2023
Full Text
View/download PDF

4. Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion

Author

Patarrão, Rita S., primary, Duarte, Nádia, additional, Coelho, Inês, additional, Ward, Joey, additional, Ribeiro, Rogério T., additional, Meneses, Maria João, additional, Andrade, Rita, additional, Costa, João, additional, Correia, Isabel, additional, Boavida, José Manuel, additional, Duarte, Rui, additional, Gardete-Correia, Luís, additional, Medina, José Luís, additional, Pell, Jill, additional, Petrie, John, additional, Raposo, João F., additional, Macedo, Maria Paula, additional, and Penha-Gonçalves, Carlos, additional

Published
2022
Full Text
View/download PDF

7. Effects of increased body mass index on employment status: a Mendelian randomisation study

Author

Campbell, Desmond D., primary, Green, Michael, additional, Davies, Neil, additional, Demou, Evangelia, additional, Ward, Joey, additional, Howe, Laura D., additional, Harrison, Sean, additional, Johnston, Keira J. A., additional, Strawbridge, Rona J., additional, Popham, Frank, additional, Smith, Daniel J., additional, Munafò, Marcus R., additional, and Katikireddi, Srinivasa Vittal, additional

Published
2021
Full Text
View/download PDF

8. The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals

Author

Strawbridge, Rona J., primary, Johnston, Keira J. A., additional, Bailey, Mark E. S., additional, Baldassarre, Damiano, additional, Cullen, Breda, additional, Eriksson, Per, additional, deFaire, Ulf, additional, Ferguson, Amy, additional, Gigante, Bruna, additional, Giral, Philippe, additional, Graham, Nicholas, additional, Hamsten, Anders, additional, Humphries, Steve E., additional, Kurl, Sudhir, additional, Lyall, Donald M., additional, Lyall, Laura M., additional, Pell, Jill P., additional, Pirro, Matteo, additional, Savonen, Kai, additional, Smit, Andries J., additional, Tremoli, Elena, additional, Tomainen, Tomi-Pekka, additional, Veglia, Fabrizio, additional, Ward, Joey, additional, Sennblad, Bengt, additional, and Smith, Daniel J., additional

Published
2021
Full Text
View/download PDF

9. Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure

Author

Ward, Joey, primary, Lyall, Laura M., additional, Bethlehem, Richard A. I., additional, Ferguson, Amy, additional, Strawbridge, Rona J., additional, Lyall, Donald M., additional, Cullen, Breda, additional, Graham, Nicholas, additional, Johnston, Keira J. A., additional, Bailey, Mark E. S., additional, Murray, Graham K., additional, and Smith, Daniel J., additional

Published
2019
Full Text
View/download PDF

11. Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

Author

Ward, Joey, primary, Tunbridge, Elizabeth M., additional, Sandor, Cynthia, additional, Lyall, Laura M., additional, Ferguson, Amy, additional, Strawbridge, Rona J., additional, Lyall, Donald M., additional, Cullen, Breda, additional, Graham, Nicholas, additional, Johnston, Keira J. A., additional, Webber, Caleb, additional, Escott-Price, Valentina, additional, O’Donovan, Michael, additional, Pell, Jill P., additional, Bailey, Mark E. S., additional, Harrison, Paul J., additional, and Smith, Daniel J., additional

Published
2019
Full Text
View/download PDF

12. The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

Author

Ward, Joey, primary, Tunbridge, Elizabeth M., additional, Sandor, Cynthia, additional, Lyall, Laura M., additional, Ferguson, Amy, additional, Strawbridge, Rona J., additional, Lyall, Donald M., additional, Cullen, Breda, additional, Graham, Nicholas, additional, Johnston, Keira J. A., additional, Webber, Caleb, additional, Escott-Price, Valentina, additional, O’Donovan, Michael, additional, Pell, Jill P., additional, Bailey, Mark E. S., additional, Harrison, Paul J., additional, and Smith, Daniel J., additional

Published
2019
Full Text
View/download PDF

13. Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK Biobank study

Author

Celis-Morales, Carlos A., primary, Lyall, Donald M., additional, Petermann, Fanny, additional, Anderson, Jana, additional, Ward, Joey, additional, Iliodromiti, Stamatina, additional, Mackay, Daniel F., additional, Welsh, Paul, additional, Bailey, Mark E. S., additional, Pell, Jill, additional, Sattar, Naveed, additional, Gill, Jason M. R., additional, and Gray, Stuart R., additional

Published
2019
Full Text
View/download PDF

14. Genetic variation in CADM2 as a link between psychological traits and obesity

Author

Morris, Julia, primary, Bailey, Mark E. S., additional, Baldassarre, Damiano, additional, Cullen, Breda, additional, de Faire, Ulf, additional, Ferguson, Amy, additional, Gigante, Bruna, additional, Giral, Philippe, additional, Goel, Anuj, additional, Graham, Nicholas, additional, Hamsten, Anders, additional, Humphries, Steve E., additional, Johnston, Keira J. A., additional, Lyall, Donald M., additional, Lyall, Laura M., additional, Sennblad, Bengt, additional, Silveira, Angela, additional, Smit, Andries J., additional, Tremoli, Elena, additional, Veglia, Fabrizio, additional, Ward, Joey, additional, Watkins, Hugh, additional, Smith, Daniel J., additional, and Strawbridge, Rona J., additional

Published
2019
Full Text
View/download PDF

15. Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

Author

Lyall, Donald M., primary, Cox, Simon R., additional, Lyall, Laura M., additional, Celis-Morales, Carlos, additional, Cullen, Breda, additional, Mackay, Daniel F., additional, Ward, Joey, additional, Strawbridge, Rona J., additional, McIntosh, Andrew M., additional, Sattar, Naveed, additional, Smith, Daniel J., additional, Cavanagh, Jonathan, additional, Deary, Ian J., additional, and Pell, Jill P., additional

Published
2019
Full Text
View/download PDF

16. Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression

Author

Strawbridge, Rona J., primary, Ward, Joey, additional, Lyall, Laura M., additional, Tunbridge, Elizabeth M., additional, Cullen, Breda, additional, Graham, Nicholas, additional, Ferguson, Amy, additional, Johnston, Keira J. A., additional, Lyall, Donald M., additional, Mackay, Daniel, additional, Cavanagh, Jonathan, additional, Howard, David M., additional, Adams, Mark J., additional, Deary, Ian, additional, Escott-Price, Valentina, additional, O’Donovan, Michael, additional, McIntosh, Andrew M., additional, Bailey, Mark E. S., additional, Pell, Jill P., additional, Harrison, Paul J., additional, and Smith, Daniel J., additional

Published
2018
Full Text
View/download PDF

17. Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Author

Howard, David M., primary, Adams, Mark J., additional, Shirali, Masoud, additional, Clarke, Toni-Kim, additional, Marioni, Riccardo E., additional, Davies, Gail, additional, Coleman, Jonathan R. I., additional, Alloza, Clara, additional, Shen, Xueyi, additional, Barbu, Miruna C., additional, Wigmore, Eleanor M., additional, Gibson, Jude, additional, Hagenaars, Saskia P., additional, Lewis, Cathryn M., additional, Ward, Joey, additional, Smith, Daniel J., additional, Sullivan, Patrick F., additional, Haley, Chris S., additional, Breen, Gerome, additional, Deary, Ian J., additional, and McIntosh, Andrew M., additional

Published
2018
Full Text
View/download PDF

18. Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort

Author

Strawbridge, Rona J., primary, Ward, Joey, additional, Cullen, Breda, additional, Tunbridge, Elizabeth M., additional, Hartz, Sarah, additional, Bierut, Laura, additional, Horton, Amy, additional, Bailey, Mark E. S., additional, Graham, Nicholas, additional, Ferguson, Amy, additional, Lyall, Donald M., additional, Mackay, Daniel, additional, Pidgeon, Laura M., additional, Cavanagh, Jonathan, additional, Pell, Jill P., additional, O’Donovan, Michael, additional, Escott-Price, Valentina, additional, Harrison, Paul J., additional, and Smith, Daniel J., additional

Published
2018
Full Text
View/download PDF

19. Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia

Author

Ward, Joey, primary, Strawbridge, Rona J., additional, Bailey, Mark E. S., additional, Graham, Nicholas, additional, Ferguson, Amy, additional, Lyall, Donald M., additional, Cullen, Breda, additional, Pidgeon, Laura M., additional, Cavanagh, Jonathan, additional, Mackay, Daniel F., additional, Pell, Jill P., additional, O’Donovan, Michael, additional, Escott-Price, Valentina, additional, and Smith, Daniel J., additional

Published
2017
Full Text
View/download PDF

20. Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure

Author

Ward, Joey, Lyall, Laura M, Bethlehem, Richard AI, Ferguson, Amy, Strawbridge, Rona J, Lyall, Donald M, Cullen, Breda, Graham, Nicholas, Johnston, Keira JA, Bailey, Mark ES, Murray, Graham K, and Smith, Daniel J

Subjects
Adult, Male, Multifactorial Inheritance, Anhedonia, Databases, Factual, Mental Disorders, Brain, Middle Aged, behavioral disciplines and activities, Magnetic Resonance Imaging, 3. Good health, Cohort Studies, Genetic Loci, Humans, Female, psychological phenomena and processes, Aged, Genome-Wide Association Study
Abstract

Anhedonia is a core symptom of several psychiatric disorders but its biological underpinnings are poorly understood. We performed a genome-wide association study of state anhedonia in 375,275 UK Biobank participants and assessed for genetic correlation between anhedonia and neuropsychiatric conditions (major depressive disorder, schizophrenia, bipolar disorder, obsessive compulsive disorder and Parkinson's Disease). We then used a polygenic risk score approach to test for association between genetic loading for anhedonia and both brain structure and brain function. This included: magnetic resonance imaging (MRI) assessments of total grey matter volume, white matter volume, cerebrospinal fluid volume, and 15 cortical/subcortical regions of interest; diffusion tensor imaging (DTI) measures of white matter tract integrity; and functional MRI activity during an emotion processing task. We identified 11 novel loci associated at genome-wide significance with anhedonia, with a SNP heritability estimate (h2SNP) of 5.6%. Strong positive genetic correlations were found between anhedonia and major depressive disorder, schizophrenia and bipolar disorder; but not with obsessive compulsive disorder or Parkinson's Disease. Polygenic risk for anhedonia was associated with poorer brain white matter integrity, smaller total grey matter volume, and smaller volumes of brain regions linked to reward and pleasure processing, including orbito-frontal cortex. In summary, the identification of novel anhedonia-associated loci substantially expands our current understanding of the biological basis of state anhedonia and genetic correlations with several psychiatric disorders confirm the utility of this phenotype as a transdiagnostic marker of vulnerability to mental illness. We also provide the first evidence that genetic risk for state anhedonia influences brain structure, including in regions associated with reward and pleasure processing.

21. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Author

Schmidt, Amand F, Holmes, Michael V, Preiss, David, Swerdlow, Daniel I, Denaxas, Spiros, Fatemifar, Ghazaleh, Faraway, Rupert, Finan, Chris, Valentine, Dennis, Fairhurst-Hunter, Zammy, Hartwig, Fernando Pires, Horta, Bernardo Lessa, Hypponen, Elina, Power, Christine, Moldovan, Max, Van Iperen, Erik, Hovingh, Kees, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina M, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Willeit, Karin, Mason, Dan, Wright, John, Morris, Richard, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Price, Jackie F, Kivimaki, Mika, Welch, Catherine, Sanchez-Galvez, Adelaida, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N Charlotte, Van Der Schouw, Yvonne T, Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Langenberg, Claudia, Scott, Robert A, Luan, Jian'an, Bobak, Martin, Malyutina, Sofia, Pająk, Andrzej, Kubinova, Ruzena, Tamosiunas, Abdonas, Pikhart, Hynek, Grarup, Niels, Pedersen, Oluf, Hansen, Torben, Linneberg, Allan, Jess, Tine, Cooper, Jackie, Humphries, Steve E, Brilliant, Murray, Kitchner, Terrie, Hakonarson, Hakon, Carrell, David S, McCarty, Catherine A, Lester, Kirchner H, Larson, Eric B, Crosslin, David R, De Andrade, Mariza, Roden, Dan M, Denny, Joshua C, Carty, Cara, Hancock, Stephen, Attia, John, Holliday, Elizabeth, Scott, Rodney, Schofield, Peter, O'Donnell, Martin, Yusuf, Salim, Chong, Michael, Pare, Guillaume, Van Der Harst, Pim, Said, M Abdullah, Eppinga, Ruben N, Verweij, Niek, Snieder, Harold, Lifelines Cohort Authors, Christen, Tim, Mook-Kanamori, DO, ICBP Consortium, Gustafsson, Stefan, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Hofman, Albert, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Lerch, Markus M, Völker, Uwe, Völzke, Henry, Ward, Joey, Pell, Jill P, Meade, Tom, Christophersen, Ingrid E, Maitland-Van Der Zee, Anke H, Baranova, Ekaterina V, Young, Robin, Ford, Ian, Campbell, Archie, Padmanabhan, Sandosh, Bots, Michiel L, Grobbee, Diederick E, Froguel, Philippe, Thuillier, Dorothée, Roussel, Ronan, Bonnefond, Amélie, Cariou, Bertrand, Smart, Melissa, Bao, Yanchun, Kumari, Meena, Mahajan, Anubha, Hopewell, Jemma C, Seshadri, Sudha, METASTROKE Consortium Of The ISGC, Dale, Caroline, Costa, Rui Providencia E, Ridker, Paul M, Chasman, Daniel I, Reiner, Alex P, Ritchie, Marylyn D, Lange, Leslie A, Cornish, Alex J, Dobbins, Sara E, Hemminki, Kari, Kinnersley, Ben, Sanson, Marc, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Law, Philip, Speedy, Helen, Allan, James, Li, Ni, Went, Molly, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, Nilsson, Björn, Goldschmidt, Hartmut, Sud, Amit, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert W, Patel, Riyaz S, Keating, Brendan J, Sattar, Naveed, Houlston, Richard, Casas, Juan P, and Hingorani, Aroon D

Subjects
Genetic association studies, Serine Proteinase Inhibitors, Anticholesteremic Agents, PCSK9 Inhibitors, Myocardial Infarction, Down-Regulation, Cholesterol, LDL, Polymorphism, Single Nucleotide, Risk Assessment, 3. Good health, Brain Ischemia, Stroke, Treatment Outcome, Risk Factors, LDL-cholesterol, Humans, Phenome-wide association scan, Proprotein Convertase 9, Mendelian randomisation, Biomarkers, Dyslipidemias, Genome-Wide Association Study, Randomized Controlled Trials as Topic
Abstract

BACKGROUND: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. RESULTS: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. CONCLUSIONS: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.

Catalog

Books, media, physical & digital resources
See catalog results