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86 results on '"Wei, Lixin"'

2. Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

Author

Yang, Xue, primary, Wang, Ying, additional, Rovella, Valentina, additional, Candi, Eleonora, additional, Jia, Wei, additional, Bernassola, Francesca, additional, Bove, Pierluigi, additional, Piacentini, Mauro, additional, Scimeca, Manuel, additional, Sica, Giuseppe, additional, Tisone, Giuseppe, additional, Mauriello, Alessandro, additional, Wei, Lixin, additional, Melino, Gerry, additional, and Shi, Yufang, additional

Published
2023
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13. LPS/Bcl3/YAP1 signaling promotes Sox9+HNF4α+ hepatocyte-mediated liver regeneration after hepatectomy

Author

Shao, Changchun, primary, Jing, Yingying, additional, Zhao, Shanmin, additional, Yang, Xue, additional, Hu, Yiming, additional, Meng, Yan, additional, Huang, Yihua, additional, Ye, Fei, additional, Gao, Lu, additional, Liu, Wenting, additional, Sheng, Dandan, additional, Li, Rong, additional, Zhang, Xiaoren, additional, and Wei, Lixin, additional

Published
2022
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17. An RNA–RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity

Author

Wei, Yanping, primary, Tang, Xuewu, additional, Ren, Yibin, additional, Yang, Yun, additional, Song, Fengliang, additional, Fu, Jingbo, additional, Liu, Shuowu, additional, Yu, Miao, additional, Chen, Jing, additional, Wang, Suyang, additional, Zhang, Kecheng, additional, Tan, Yexiong, additional, Han, Zhipeng, additional, Wei, Lixin, additional, Zhang, Baohua, additional, Cheng, Zhangjun, additional, Li, Liang, additional, and Wang, Hongyang, additional

Published
2021
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20. Effectiveness and Tolerability of Nifedipine GITS in Patients with Chronic Kidney Disease and Uncontrolled Hypertension: A Prospective, Multicenter, Observational Study (ADRENAL)

Author

Lv, Rong, primary, Chen, Jianghua, additional, Wang, Huamin, additional, Wang, Jijun, additional, Cheng, Hong, additional, Li, Rong, additional, Li, Wei, additional, Zhang, Tao, additional, Wei, Lixin, additional, Chen, Qinkai, additional, Huang, Jian, additional, Yu, Feng, additional, Shen, Shizhong, additional, Wu, Henglan, additional, Liu, Cuihong, additional, Hong, Fuyuan, additional, Liu, Jie, additional, Zhang, Xiaoru, additional, Xiao, Hua, additional, and Song, Wenbin, additional

Published
2021
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21. The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation

Author

Shao, Changchun, primary, Yang, Xue, additional, Jing, Yingying, additional, Hou, Xiaojuan, additional, Huang, Yihua, additional, Zong, Chen, additional, Gao, Lu, additional, Liu, Wenting, additional, Jiang, Jinghua, additional, Ye, Fei, additional, Shi, Junxia, additional, Zhao, Qiudong, additional, Li, Rong, additional, Zhang, Xiaoren, additional, and Wei, Lixin, additional

Published
2021
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22. pH-Dependent Effects of L-Cysteine on Mercury Dissolution of α-HgS and β-HgS

Author

Hongtao Bi, Wei Lixin, Li Cen, Yuzhi Du, and Zhang Ming

Subjects
0301 basic medicine, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Ph dependent, chemistry.chemical_element, Sulfides, 030226 pharmacology & pharmacy, Biochemistry, Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cysteine, Dissolution, chemistry.chemical_classification, Mercury sulfide, Mercury Compounds, Biochemistry (medical), Mercury, General Medicine, Hydrogen-Ion Concentration, Amino acid, Mercury (element), 030104 developmental biology, Inorganic mercury compound, Solubility, chemistry, Nuclear chemistry
Abstract

Mercury sulfide is an insoluble inorganic mercury compound, and it is the main chemical form in traditional oral mercury-containing medicines. Hg2+ has a high affinity for thiols, and small molecule thiols in the gastrointestinal tract may promote mercury dissolution of mercury sulfide by binding to Hg2+. L-cysteine is the only amino acid that possesses a reducing sulfhydryl group (-SH), out of the 20 amino acids. This study investigates the effect of L-cysteine on mercury dissolution of mercury sulfide at pHs ranging from 1.2 to 7.2. The results showed that L-cysteine had different pH-dependent effects on the mercury dissolution of α-HgS and β-HgS. For α-HgS, the dissolved mercury concentration increased from 5.47 ± 0.97 ng/mL to 12.49 ± 0.54 ng/mL when the pH rose from 1.2 to 4.2, and decreased to 3.37 ± 0.70 ng/mL at pH 6.0 and then increased to 9.36 ± 0.79 ng/mL at pH 7.2. For β-HgS, the dissolved mercury concentration increased from 151.09 ± 2.25 ng/mL to 2346.71 ± 62.62 ng/mL when the pH increased from 1.2 to 7.2. In conclusion, L-Cys was distinctly enhanced upon mercury dissolution of α-HgS and β-HgS with increasing pH. These results may contribute to our understanding of the mercury absorption mechanism of traditional oral mercury-containing medicines.

Published
2018

23. Effect of Cys, GSH, and pH on Mercury Release from Tibetan Medicine Zuotai, β-HgS, and α-HgS in Artificial Gastrointestinal Juices

Author

Zhiyuan Zheng, Wei Lixin, Zhang Ming, Li Cen, and Xiao Yuancan

Subjects
0301 basic medicine, Sulfide, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Biological Availability, chemistry.chemical_element, Tibetan medicine, 010501 environmental sciences, 01 natural sciences, Biochemistry, Dissociation (chemistry), Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Medicine, Tibetan Traditional, Cysteine, 0105 earth and related environmental sciences, chemistry.chemical_classification, Gastrointestinal tract, Gastric Juice, Chromatography, Mercury Compounds, Biochemistry (medical), Water, Mercury, General Medicine, Glutathione, Hydrogen-Ion Concentration, In vitro, Mercury (element), Bioavailability, Gastrointestinal Tract, Drug Liberation, 030104 developmental biology, chemistry
Abstract

Zuotai, also named as “gTso thal”, a known Tibetan medicinal mixture containing insoluble cubic crystal mercuric sulfide (β-HgS), has been used to treat diseases with long history. The mercury release ratio from Zuotai in gastrointestinal environment is one determinant factor for its bioavailability and biological effect. However, the information is still scarce now. Therefore, the study was designed to investigate the effect of sulfhydryl biomolecules [l-cysteine (Cys) and glutathione (GSH)] and pH on mercury dissociation from Zuotai, β-HgS, and hexagonal crystal mercuric sulfide (α-HgS) in artificial gastrointestinal juices or pure water with a 1:100 solid-liquid ratio. And, the digestion and peristalsis of gastrointestinal tract were simulated in vitro. The results showed the following trend for the mercury release ratio of Zuotai, artificial gastric juice > artificial intestinal juice > pure water, whereas the trend for β-HgS and α-HgS was as follows, artificial intestinal fluid > artificial gastric fluid > pure water. The mercury release ratios of Zuotai, β-HgS, and α-HgS significantly increased in artificial intestinal juice containing l-Cys or GSH compared to those without sulfhydryl biomolecules in the juice. However, in contrast to the results observed for β-HgS and α-HgS, the mercury release ratio of Zuotai was reduced remarkably in pure water and artificial gastric juice with Cys or GSH. And, we found that strong acidic or strong alkaline environments promoted the dissociation of mercury from Zuotai, β-HgS, and α-HgS. Taken together, current findings may contribute to other studies regarding clinical safety and bioavailability of the traditional drug Zuotai containing β-HgS.

Published
2017

34. DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo

Author

Meiyu Geng, Tao Zhang, Wei Lixin, Yi Chen, Rong Qu, Linjiang Tong, Yiming Sun, Mengyuan Li, Jian Ding, Yongcong Lv, Wenhu Duan, Ting Peng, and Hua Xie

Subjects
Male, 0301 basic medicine, Angiogenesis, VEGF receptors, Mice, Nude, Angiogenesis Inhibitors, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, In vivo, Cell Line, Tumor, Neoplasms, Human Umbilical Vein Endothelial Cells, Animals, Humans, Pharmacology (medical), Receptor, Cell Proliferation, Pharmacology, Mice, Inbred BALB C, biology, Traditional medicine, Chemistry, General Medicine, Small molecule, In vitro, Cancer treatment, Pyrimidines, Receptors, Vascular Endothelial Growth Factor, 030104 developmental biology, Cell culture, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Original Article, Glioblastoma, Chickens
Abstract

Targeting the VEGF/VEGF receptor (VEGFR) pathway has proved to be an effective antiangiogenic approach for cancer treatment. Here, we identified 6-((2-((3-acetamidophenyl)amino)pyrimidin-4-yl)oxy)-N-phenyl-1-naphthamide (designated herein as DW10075) as a novel and highly selective inhibitor of VEGFRs.In vitro tyrosine kinase activity was measured using ELISA, and intracellular signaling pathway proteins were detected by Western blot analysis. Endothelial cell proliferation was examined with CCK-8 assays, and tumor cell proliferation was determined with SRB assays. Cell migration, tube formation and rat aortic ring assays were used to detect antiangiogenic activity. Antitumor efficacy was further evaluated in U87-MG human glioblastoma xenograft tumors in nude mice receiving DW10075 (500 mg · kg(-1) · d(-1), po) for two weeks.Among a panel of 21 kinases tested, DW10075 selectively inhibited VEGFR-1, VEGFR-2 and VEGFR-3 (the IC50 values were 6.4, 0.69 and 5.5 nmol/L, respectively), but did not affect 18 other kinases including FGFR and PDGFR at 10 μmol/L. DW10075 significantly blocked VEGF-induced activation of VEGFR and its downstream signaling transduction in primary human umbilical vein endothelial cells (HUVECs), thus inhibited VEGF-induced HUVEC proliferation. DW10075 (1-100 nmol/L) dose-dependently inhibited VEGF-induced HUVEC migration and tube formation and suppressed angiogenesis in both the rat aortic ring model and the chicken chorioallantoic membrane model. Furthermore, DW10075 exhibited anti-proliferative activity against 22 different human cancer cell lines with IC50 values ranging from 2.2 μmol/L (for U87-MG human glioblastoma cells) to 22.2 μmol/L (for A375 melanoma cells). In U87-MG xenograft tumors in nude mice, oral administration of DW10075 significantly suppressed tumor growth, and reduced the expression of CD31 and Ki67 in the tumor tissues.DW10075 is a potent and highly selective inhibitor of VEGFR that deserves further development.

Published
2016

36. BabaoDan attenuates high-fat diet-induced non-alcoholic fatty liver disease via activation of AMPK signaling

Author

Sheng, Dandan, primary, Zhao, Shanmin, additional, Gao, Lu, additional, Zheng, Huifei, additional, Liu, Wenting, additional, Hou, Jing, additional, Jin, Yuxiang, additional, Ye, Fei, additional, Zhao, Qiudong, additional, Li, Rong, additional, Zhao, Naping, additional, Zhang, Li, additional, Han, Zhipeng, additional, and Wei, Lixin, additional

Published
2019
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