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Your search keyword '"Wheeler, Nicole E."' showing total 10 results
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3. Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae

Author

Ma, Kevin C., primary, Mortimer, Tatum D., additional, Hicks, Allison L., additional, Wheeler, Nicole E., additional, Sánchez-Busó, Leonor, additional, Golparian, Daniel, additional, Taiaroa, George, additional, Rubin, Daniel H. F., additional, Wang, Yi, additional, Williamson, Deborah A., additional, Unemo, Magnus, additional, Harris, Simon R., additional, and Grad, Yonatan H., additional

Published
2020
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5. An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation

Author

Van Puyvelde, Sandra, primary, Pickard, Derek, additional, Vandelannoote, Koen, additional, Heinz, Eva, additional, Barbé, Barbara, additional, de Block, Tessa, additional, Clare, Simon, additional, Coomber, Eve L., additional, Harcourt, Katherine, additional, Sridhar, Sushmita, additional, Lees, Emily A., additional, Wheeler, Nicole E., additional, Klemm, Elizabeth J., additional, Kuijpers, Laura, additional, Mbuyi Kalonji, Lisette, additional, Phoba, Marie-France, additional, Falay, Dadi, additional, Ngbonda, Dauly, additional, Lunguya, Octavie, additional, Jacobs, Jan, additional, Dougan, Gordon, additional, and Deborggraeve, Stijn, additional

Published
2019
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6. Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Author

Lees, John A., primary, Ferwerda, Bart, additional, Kremer, Philip H. C., additional, Wheeler, Nicole E., additional, Serón, Mercedes Valls, additional, Croucher, Nicholas J., additional, Gladstone, Rebecca A., additional, Bootsma, Hester J., additional, Rots, Nynke Y., additional, Wijmega-Monsuur, Alienke J., additional, Sanders, Elisabeth A. M., additional, Trzciński, Krzysztof, additional, Wyllie, Anne L., additional, Zwinderman, Aeilko H., additional, van den Berg, Leonard H., additional, van Rheenen, Wouter, additional, Veldink, Jan H., additional, Harboe, Zitta B., additional, Lundbo, Lene F., additional, de Groot, Lisette C. P. G. M., additional, van Schoor, Natasja M., additional, van der Velde, Nathalie, additional, Ängquist, Lars H., additional, Sørensen, Thorkild I. A., additional, Nohr, Ellen A., additional, Mentzer, Alexander J., additional, Mills, Tara C., additional, Knight, Julian C., additional, du Plessis, Mignon, additional, Nzenze, Susan, additional, Weiser, Jeffrey N., additional, Parkhill, Julian, additional, Madhi, Shabir, additional, Benfield, Thomas, additional, von Gottberg, Anne, additional, van der Ende, Arie, additional, Brouwer, Matthijs C., additional, Barrett, Jeffrey C., additional, Bentley, Stephen D., additional, and van de Beek, Diederik, additional

Published
2019
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9. An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation

Author

Van Puyvelde, Sandra, Pickard, Derek, Vandelannoote, Koen, Heinz, Eva, Barbé, Barbara, De Block, Tessa, Clare, Simon, Coomber, Eve L, Harcourt, Katherine, Sridhar, Sushmita, Lees, Emily A, Wheeler, Nicole E, Klemm, Elizabeth J, Kuijpers, Laura, Mbuyi Kalonji, Lisette, Phoba, Marie-France, Falay, Dadi, Ngbonda, Dauly, Lunguya, Octavie, Jacobs, Jan, Dougan, Gordon, and Deborggraeve, Stijn

Subjects
Salmonella typhimurium, Whole Genome Sequencing, THP-1 Cells, Microbial Sensitivity Tests, Azithromycin, Adaptation, Physiological, 3. Good health, Anti-Bacterial Agents, Cell Line, Mice, Inbred C57BL, Mice, Ciprofloxacin, Biofilms, Drug Resistance, Multiple, Bacterial, Democratic Republic of the Congo, Animals, Humans, Plasmids
Abstract

Bloodstream infections by Salmonella enterica serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal (iNTS) infections are dominated by isolates of the antibiotic resistance-associated sequence type (ST) 313. Here, we report emergence of ST313 sublineage II.1 in the Democratic Republic of the Congo. Sublineage II.1 exhibits extensive drug resistance, involving a combination of multidrug resistance, extended spectrum β-lactamase production and azithromycin resistance. ST313 lineage II.1 isolates harbour an IncHI2 plasmid we name pSTm-ST313-II.1, with one isolate also exhibiting decreased ciprofloxacin susceptibility. Whole genome sequencing reveals that ST313 II.1 isolates have accumulated genetic signatures potentially associated with altered pathogenicity and host adaptation, related to changes observed in biofilm formation and metabolic capacity. Sublineage II.1 emerged at the beginning of the 21st century and is involved in on-going outbreaks. Our data provide evidence of further evolution within the ST313 clade associated with iNTS in SSA.

10. Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Author

Lees, John A, Ferwerda, Bart, Kremer, Philip HC, Wheeler, Nicole E, Serón, Mercedes Valls, Croucher, Nicholas J, Gladstone, Rebecca A, Bootsma, Hester J, Rots, Nynke Y, Wijmega-Monsuur, Alienke J, Sanders, Elisabeth AM, Trzciński, Krzysztof, Wyllie, Anne L, Zwinderman, Aeilko H, Van Den Berg, Leonard H, Van Rheenen, Wouter, Veldink, Jan H, Harboe, Zitta B, Lundbo, Lene F, De Groot, Lisette CPGM, Van Schoor, Natasja M, Van Der Velde, Nathalie, Ängquist, Lars H, Sørensen, Thorkild IA, Nohr, Ellen A, Mentzer, Alexander J, Mills, Tara C, Knight, Julian C, Du Plessis, Mignon, Nzenze, Susan, Weiser, Jeffrey N, Parkhill, Julian, Madhi, Shabir, Benfield, Thomas, Von Gottberg, Anne, Van Der Ende, Arie, Brouwer, Matthijs C, Barrett, Jeffrey C, Bentley, Stephen D, and Van De Beek, Diederik

Subjects
Adult, Male, Genome, Human, Meningitis, Pneumococcal, Genetic Variation, Proteins, Middle Aged, 3. Good health, Streptococcus pneumoniae, Bacterial Proteins, Host-Pathogen Interactions, Humans, Female, Genetic Predisposition to Disease, Prospective Studies, Genome, Bacterial, Aged, Genome-Wide Association Study
Abstract

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, identifying variants in CCDC33 associated with susceptibility. Pneumococcal genetic variation explains a large amount of invasive potential (70%), but has no effect on severity. Serotype alone is insufficient to explain invasiveness, suggesting other pneumococcal factors are involved in progression to invasive disease. We identify pneumococcal genes involved in invasiveness including pspC and zmpD, and perform a human-bacteria interaction analysis. These genes are potential candidates for the development of more broadly-acting pneumococcal vaccines.

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