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16 results on '"Wolfensberger, Aline"'

4. Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

Author

Abela, Irene A., primary, Pasin, Chloé, additional, Schwarzmüller, Magdalena, additional, Epp, Selina, additional, Sickmann, Michèle E., additional, Schanz, Merle M., additional, Rusert, Peter, additional, Weber, Jacqueline, additional, Schmutz, Stefan, additional, Audigé, Annette, additional, Maliqi, Liridona, additional, Hunziker, Annika, additional, Hesselman, Maria C., additional, Niklaus, Cyrille R., additional, Gottschalk, Jochen, additional, Schindler, Eméry, additional, Wepf, Alexander, additional, Karrer, Urs, additional, Wolfensberger, Aline, additional, Rampini, Silvana K., additional, Meyer Sauteur, Patrick M., additional, Berger, Christoph, additional, Huber, Michael, additional, Böni, Jürg, additional, Braun, Dominique L., additional, Marconato, Maddalena, additional, Manz, Markus G., additional, Frey, Beat M., additional, Günthard, Huldrych F., additional, Kouyos, Roger D., additional, and Trkola, Alexandra, additional

Published
2021
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5. Correction to: Implementation and evaluation of a care bundle for prevention of non-ventilator associated hospital-acquired pneumonia (nvHAP) – a mixed-methods study protocol for a hybrid type 2 effectiveness-implementation trial

Author

Wolfensberger, Aline, primary, Clack, Lauren, additional, von Felten, Stefanie, additional, Kusejko, Katharina, additional, Faes Hesse, Mirjam, additional, Jakob, Werner, additional, Saleschus, Dirk, additional, Meier, Marie-Theres, additional, Kouyos, Roger, additional, Held, Leonhard, additional, and Sax, Hugo, additional

Published
2021
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8. Implementation and evaluation of a care bundle for prevention of non-ventilator-associated hospital-acquired pneumonia (nvHAP) – a mixed-methods study protocol for a hybrid type 2 effectiveness-implementation trial

Author

Wolfensberger, Aline, primary, Clack, Lauren, additional, von Felten, Stefanie, additional, Kusejko, Katharina, additional, Faes Hesse, Mirjam, additional, Jakob, Werner, additional, Saleschus, Dirk, additional, Meier, Marie-Theres, additional, Kouyos, Roger, additional, Held, Leonhard, additional, and Sax, Hugo, additional

Published
2020
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16. The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods

Author

Michael Hombach, Stefan P. Kuster, Martina Marchesi, Reinhard Zbinden, Aline Wolfensberger, University of Zurich, and Wolfensberger, Aline

Subjects
0301 basic medicine, Klebsiella pneumoniae, Antibiotics, Drug resistance, gram-negatives, medicine.disease_cause, 2726 Microbiology (medical), 10234 Clinic for Infectious Diseases, Hospitals, University, 0302 clinical medicine, Medical microbiology, ECDC, Drug Resistance, Multiple, Bacterial, Germany, 2736 Pharmacology (medical), Infection control, Pharmacology (medical), 030212 general & internal medicine, Cross Infection, biology, 10179 Institute of Medical Microbiology, Anti-Bacterial Agents, Acinetobacter baumannii, Infectious Diseases, Practice Guidelines as Topic, Switzerland, Microbiology (medical), KRINKO, medicine.medical_specialty, medicine.drug_class, 030106 microbiology, 610 Medicine & health, Multidrug-resistance, Microbial Sensitivity Tests, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Internal medicine, Gram-Negative Bacteria, medicine, Humans, lcsh:RC109-216, business.industry, Pseudomonas aeruginosa, Research, Public Health, Environmental and Occupational Health, 2739 Public Health, Environmental and Occupational Health, 2725 Infectious Diseases, MDRO, biology.organism_classification, Multiple drug resistance, Gram-Negative Bacterial Infections, business
Abstract

Background A multitude of definitions determining multidrug resistance (MDR) of Gram-negative organisms exist worldwide. The definitions differ depending on their purpose and on the issueing country or organization. The MDR definitions of the European Centre for Disease Prevention and Control (ECDC) were primarily chosen to harmonize epidemiological surveillance. The German Commission of Hospital Hygiene and Infection Prevention (KRINKO) issued a national guideline which is mainly used to guide infection prevention and control (IPC) measures. The Swiss University Hospital Zurich (UHZ) – in absentia of national guidelines – developed its own definition for IPC purposes. In this study we aimed to determine the effects of different definitions of multidrug-resistance on rates of Gram-negative multidrug-resistant organisms (GN-MDRO). Methods MDR definitions of the ECDC, the German KRINKO and the Swiss University Hospital Zurich were applied on a dataset comprising isolates of Escherichia coli, Klebsiella pneumoniae, Enterobacter sp., Pseudomonas aeruginosa, and Acinetobacter baumannii complex. Rates of GN-MDRO were compared and the percentage of patients with a GN-MDRO was calculated. Results In total 11′407 isolates from a 35 month period were included. For Enterobacterales and P. aeruginosa, highest MDR-rates resulted from applying the ‘ECDC-MDR’ definition. ‘ECDC-MDR’ rates were up to four times higher compared to ‘KRINKO-3/4MRGN’ rates, and up to six times higher compared to UHZ rates. Lowest rates were observed when applying the ‘KRINKO-4MRGN’ definitions. Comparing the ‘KRINKO-3/4MRGN’ with the UHZ definitions did not show uniform trends, but yielded higher rates for E. coli and lower rates for P. aeruginosa. On the patient level, the percentages of GN-MDRO carriers were 2.1, 5.5, 6.6, and 18.2% when applying the ‘KRINKO-4MRGN’, ‘UHZ-MDR’, ‘KRINKO-3/4MRGN’, and the ‘ECDC-MDR’ definition, respectively. Conclusions Different MDR-definitions lead to considerable variation in rates of GN-MDRO. Differences arise from the number of antibiotic categories required to be resistant, the categories and drugs considered relevant, and the antibiotic panel tested. MDR definitions should be chosen carefully depending on their purpose and local resistance rates, as definitions guiding isolation precautions have direct effects on costs and patient care.

Published
2019
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