1. A 60-s postconditioning protocol by percutaneous coronary intervention inhibits myocardial apoptosis in patients with acute myocardial infarction
- Author
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Lefeng Wang, Li Zhang, Wen-Shu Zhao, Liang Cui, Xiu-lan Liu, Xinchun Yang, Yu Liu, Lin Xu, Zhiyong Zhang, and Lin Zhang
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Fas Ligand Protein ,Time Factors ,medicine.medical_treatment ,Clinical Biochemistry ,Myocardial Infarction ,Ischemia ,Pharmaceutical Science ,Apoptosis ,Myocardial Reperfusion ,Balloon ,Fas ligand ,Internal medicine ,medicine ,Humans ,fas Receptor ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,Creatine Kinase ,Pharmacology ,business.industry ,Myocardium ,Troponin I ,Biochemistry (medical) ,Percutaneous coronary intervention ,Stroke Volume ,Cell Biology ,Middle Aged ,medicine.disease ,Solubility ,Case-Control Studies ,Conventional PCI ,Cardiology ,Female ,business ,Reperfusion injury - Abstract
Different postconditioning (Postcon) methods have been demonstrated to protect heart from ischemia/reperfusion injury. The relationship between Postcon by percutaneous coronary intervention (PCI) and apoptosis is not clear. Our objective was to test whether Postcon by PCI in patients with acute myocardial infarction (AMI) reduces myocardial apoptosis. Seventy-five patients were randomly assigned to one of three groups before stenting. The Routine group (n = 26) received no Postcon intervention prior to the onset of reperfusion; Postcon-30s (n = 25) and Postcon-60s groups (n = 24) underwent three cycles of 30- or 60-s balloon deflation and 30- or 60-s inflation. Additionally, 34 normal controls (NC) were enrolled in the study. Plasma concentrations of soluble Fas/APO-1 ([sFas]) and Fas ligand ([sFasL]) were determined at baseline and 7 days after PCI via ELISA. The [sFas] and [sFasL] in AMI patients were significantly elevated at baseline as compared with NC (P
- Published
- 2009