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Start Over Author "YILMAZ, Sahin" Publisher springer science and business media llc
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4. Comparison of cyproterone acetate plus ethinyl estradiol and finasteride in the treatment of hirsutism

Author

Yilmaz Sahin, Iptisam Ipek Muderris, Fahrettin Kelestimur, and Fahri Bayram

Subjects
Hirsutism, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Ethinyl Estradiol, Antiandrogen, chemistry.chemical_compound, 5-alpha Reductase Inhibitors, Endocrinology, Sex Hormone-Binding Globulin, Internal medicine, Ethinylestradiol, medicine, Humans, Testosterone, Enzyme Inhibitors, Cyproterone Acetate, Menstrual Cycle, hirsutism, business.industry, Finasteride, Cyproterone acetate, Androgen Antagonists, medicine.disease, Blood chemistry, chemistry, Cyproterone, Drug Therapy, Combination, Female, business, medicine.drug
Abstract

The aim of this study was to compare the clinical efficacy and safety of low dose cyproterone acetate-estrogen combination (Diane(R)) and the 5 alpha-reductase inhibitor finasteride in the treatment of hirsutism. Fourty-two women with hirsutism were included in the study. Twenty-one patients treated with cyproterone acetate (CPA) 2 mg and ethinyl estradiol (E) 35 mu g daily on days 5-25 of the menstrual cycle, 21 with finasteride 5 mg daily. Hirsutism score, hormone levels, multiscreen blood chemistry and side effects were evaluated at three-monthly intervals for 9 months. A significant decrease in hirsutism score as compared to baseline was observed after 9 months with either CPA+E (Diane(R)) (mean +/- SE, 15.81+/-1.19 vs 8.38+/-1.21) or finasteride treatment (17.81+/-1.05 vs 10.86+/-0.91) (p

Published
1998

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