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Your search keyword '"Yamakawa, Yasuaki"' showing total 6 results
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6 results on '"Yamakawa, Yasuaki"'

2. Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression

Author

Sugiu, Kazuhisa, primary, Tazawa, Hiroshi, additional, Hasei, Joe, additional, Yamakawa, Yasuaki, additional, Omori, Toshinori, additional, Komatsubara, Tadashi, additional, Mochizuki, Yusuke, additional, Kondo, Hiroya, additional, Osaki, Shuhei, additional, Fujiwara, Tomohiro, additional, Yoshida, Aki, additional, Kunisada, Toshiyuki, additional, Ueda, Koji, additional, Urata, Yasuo, additional, Kagawa, Shunsuke, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2021
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3. Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression

Author

Sugiu, Kazuhisa, Tazawa, Hiroshi, Hasei, Joe, Yamakawa, Yasuaki, Omori, Toshinori, Komatsubara, Tadashi, Mochizuki, Yusuke, Kondo, Hiroya, Osaki, Shuhei, Fujiwara, Tomohiro, Yoshida, Aki, Kunisada, Toshiyuki, Ueda, Koji, Urata, Yasuo, Kagawa, Shunsuke, Ozaki, Toshifumi, Fujiwara, Toshiyoshi, Sugiu, Kazuhisa, Tazawa, Hiroshi, Hasei, Joe, Yamakawa, Yasuaki, Omori, Toshinori, Komatsubara, Tadashi, Mochizuki, Yusuke, Kondo, Hiroya, Osaki, Shuhei, Fujiwara, Tomohiro, Yoshida, Aki, Kunisada, Toshiyuki, Ueda, Koji, Urata, Yasuo, Kagawa, Shunsuke, Ozaki, Toshifumi, and Fujiwara, Toshiyoshi

Abstract

Background Osteosarcoma (OS) is a malignant bone tumor primarily affecting children and adolescents. The prognosis of chemotherapy-refractory OS patients is poor. We developed a tumor suppressor p53–expressing oncolytic adenovirus (OBP-702) that exhibits antitumor effects against human OS cells. Here, we demonstrate the chemosensitizing effect of OBP-702 in human OS cells. Materials and methods The in vitro and in vivo antitumor activities of doxorubicin (DOX) and OBP-702 were assessed using parental and DOX-resistant OS cells (U2OS, MNNG/HOS) and a DOX-resistant MNNG/HOS xenograft tumor model. Results DOX-resistant OS cells exhibited high multidrug resistant 1 (MDR1) expression, which was suppressed by OBP-702 or MDR1 siRNA, resulting in enhanced DOX-induced apoptosis. Compared to monotherapy, OBP-702 and DOX combination therapy significantly suppressed tumor growth in the DOX-resistant MNNG/HOS xenograft tumor model. Conclusion Our results suggest that MDR1 is attractive therapeutic target for chemoresistant OS. Tumor-specific virotherapy is thus a promising strategy for reversing chemoresistance in OS patients via suppression of MDR1 expression.

Published
2021

4. Clinical outcomes of treatment with locking compression plates for distal femoral fractures in a retrospective cohort

Author

Kiyono, Masahiro, primary, Noda, Tomoyuki, additional, Nagano, Hiroshi, additional, Maehara, Takashi, additional, Yamakawa, Yasuaki, additional, Mochizuki, Yusuke, additional, Uchino, Takahiko, additional, Yokoo, Suguru, additional, Demiya, Koji, additional, Saiga, Kenta, additional, Shimamura, Yasunori, additional, and Ozaki, Toshifumi, additional

Published
2019
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6. Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas

Author

Osaki, Shuhei, primary, Tazawa, Hiroshi, additional, Hasei, Joe, additional, Yamakawa, Yasuaki, additional, Omori, Toshinori, additional, Sugiu, Kazuhisa, additional, Komatsubara, Tadashi, additional, Fujiwara, Tomohiro, additional, Sasaki, Tsuyoshi, additional, Kunisada, Toshiyuki, additional, Yoshida, Aki, additional, Urata, Yasuo, additional, Kagawa, Shunsuke, additional, Ozaki, Toshifumi, additional, and Fujiwara, Toshiyoshi, additional

Published
2016
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