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Purpose Apocrine carcinoma of the breast (APO) expresses HER2 in 30–50% of cases. This study explored the clinicopathological features and outcome of HER2+/APO and matched HER2+/NST cohort. Methods We used the SEER database to explore the cohorts. Univariate and multivariate analyses were used to assess the survival. Based on ER and PR [steroid receptors/SR/] and HER2 status, we divided the cohorts to match the intrinsic molecular subtypes for comparisons. Results We retrieved 259 cases of HER2+/APO. Most HER2+/APO were SR negative (65%). HER2+/APO were more prevalent in the 80+ age group (24.7% vs. 15.7%, p p p = 0.019). This was particularly evident between SR− subgroups (10.4% in HER2+/SR−/NST vs. 4.2% in HER2+/SR−/APO, p = 0.008) and was reaffirmed in breast cancer-specific survival in univariate analysis (p = 0.03). Other than race and SR status, HER2+/APO subgroups did not differ in clinicopathological parameters. Conclusions Our study confirms the rarity of the APO and reveals that SR status in APO does not affect these patients' prognosis. HER2+/APO tumors tend to have a less aggressive phenotype and a more favorable outcome despite a markedly lower ER/PR positivity.

This paper studied a system of two gas turbine engines with inlet guide vanes followed by a steam turbine. The steam turbine recovers energy from the exhaust gas of the gas turbine engines through heat recovery steam generators. An actual combined cycle is modeled; this system model takes into consideration the variation of specific heats of air and combustion gases, the polytropic efficiencies of gas turbines and compressors, and the isentropic efficiencies of the steam turbine and pumps. Moreover, pressure drops were taken into consideration for all different heat exchangers. Model performance predictions were then aligned with the field measurements of a Jordanian combined cycle power plant. This paper presents the comparison between the model predictions and actual performance, specifically for power output and fuel consumption. The relative error between the theoretical and actual output power from the plant is approximately 8%. Ambient air temperature has a major effect on the plant-produced power and fuel consumption. Under desert conditions between summer and winter, when the ambient temperature drops from 46 to 1 $$^\circ $$ C, an extra 47.2 MW could be generated, with the corresponding increase in efficiency of approximately 6.5%, while SFC decreases by 1.1%.