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While substantial corpus-based studies have been performed on near synonyms in general texts from a wide variety of spoken and written languages, there have been few attempts to explore synonymous words in a specific genre. Using the subcorpus of academic writing in the 450-million-word Corpus of Contemporary American English (COCA) as the source data, this study is aimed at examining the syntactic and semantic environments of two frequent near-synonymous verbs, PROPOSE and SUGGEST, from three aspects: (i) frequency patterns, (ii) subject animacy, and (iii) the grammatical features of four verb forms. Hierarchical configural frequency analysis (HCFA) was employed to reveal the significant combinations of the interactions among these three factors. The major findings showed that the two verbs were somewhat similar in terms of preferred patterns; however, the distributions of their frequent animate/inanimate subjects and the grammatical features of the top patterns were different. This research will be beneficial in raising students’ awareness of the recurrent phraseologies in academic written discourse since it provides a systematic delineation of the different habitual collocations and syntactic constructions of two frequent and similar verbs in research articles.

Stereotactic radiosurgery (SRS) is a potential re-irradiation treatment for recurrent intracranial ependymoma after prior radiation therapy. The purpose of this study was to examine the efficacy and safety of repeated SRS in the treatment of recurrent intracranial ependymomas. This is a retrospective study of consecutive patients with residual or recurrent intracranial ependymomas who were treated with SRS between 1993 and 2018. Tumor progression was defined as a ≥ 10% increase in tumor volume. Tumor regression was defined as a ≥ 10% reduction in tumor volume. A tumor that remained within 10% of its original volume was defined as stable. Tumor control comprised tumor regression and stability. Time-dependent analyses were performed using two treatment failure endpoint definitions: (1) evidence of local tumor progression or distant metastasis (single SRS analysis), and (2) lack of tumor response to SRS (repeated SRS analysis). These analyses were adjusted for the competing risk of death. The study comprised 37 patients (65 intracranial ependymomas) who underwent multiple SRS sessions (range: 1–7). Median age was 10.2 years (range: 0.8–53.8 years), and median tumor volume was 1.5 mL (range: 0.01–22.5 mL). The median radiation dose was 13.3 Gy (range: 7.9–22.0 Gy) at a median isodose line of 57% (range: 50–90%). Overall tumor control rates in the single SRS analysis adjusting for the competing risk of death were 53.6%, 30.5%, and 23.6% at 1, 3, and 5 years, respectively. Overall tumor control rates in the repeated SRS analysis adjusting for the competing risk of death were 70.6%, 50.4%, and 43.1% at 1, 3, and 5 years, respectively. Prior gross total resection was the only independent predictor of overall tumor control after SRS (aHR = 25.62 (1.55–422.1), p = 0.02). Repeated GKRS appeared to be an effective treatment strategy for recurrent or residual intracranial ependymomas, with acceptable complication rates.

In order to learn video object segmentation models, conventional methods require a large amount of pixel-wise ground truth annotations. However, collecting such supervised data is time-consuming and labor-intensive. In this paper, we exploit existing annotations in source images and transfer such visual information to segment videos with unseen object categories. Without using any annotations in the target video, we propose a method to jointly mine useful segments and learn feature representations that better adapt to the target frames. The entire process is decomposed into three tasks: (1) refining the responses with fully-connected CRFs, (2) solving a submodular function for selecting object-like segments, and (3) learning a CNN model with a transferable module for adapting seen categories in the source domain to the unseen target video. We present an iterative update scheme between three tasks to self-learn the final solution for object segmentation. Experimental results on numerous benchmark datasets demonstrate that the proposed method performs favorably against the state-of-the-art algorithms.

This is a retrospective study examining the efficacy and safety of Gamma Knife radiosurgery (GKS) in treating patients with cerebral cavernous malformations (CCMs). Between 1993 and 2018, 261 patients with 331 symptomatic CCMs were treated by GKS. The median age was 39.9 years and females were predominant (54%). The median volume of CCMs was 3.1 mL. The median margin dose was 11.9 Gy treat to a median isodose level of 59%. Median clinical and imaging follow-up times were 69 and 61 months, respectively. After the initial hemorrhage that led to CCM diagnosis, 136 hemorrhages occurred in the period prior to GKS (annual incidence = 23.6%). After GKS, 15 symptomatic hemorrhages occurred within the first 2 years of follow-up (annual incidence = 3.22%), and 37 symptomatic hemorrhages occurred after the first 2 years of follow-up (annual incidence = 3.16%). Symptomatic radiation-induced complication was encountered in 8 patients (3.1%). Mortality related to GKS occurred in 1 patient (0.4%). In conclusion, GKS decreased the risk of hemorrhage in CCM patients presenting with symptomatic hemorrhage. GKS is a viable alternative treatment option for patients with surgically-inaccessible CCMs or significant medical comorbidities.

Despite a moderate magnitude, M_w = 6.4, the 5 February 2016 Meinong, Taiwan, earthquake caused significant damage in Tainan City and the surrounding areas. Several seismograms display an impulsive S-wave velocity pulse with an amplitude of about 1 m s-1, which is similar to large S-wave pulses recorded for the past several larger damaging earthquakes, such as the 1995 Kobe, Japan, earthquake (M_w = 6.9) and the 1994 Northridge, California, earthquake (M_w = 6.7). The observed PGV in the Tainan area is about 10 times larger than the median PGV of M_w = 6.4 crustal earthquakes in Taiwan. We investigate the cause of the localized strong ground motions. The peak-to-peak ground-motion displacement at the basin sites near Tainan is about 35 times larger than that at a mountain site with a similar epicentral distance. At some frequency bands (0.9 - 1.1 Hz), the amplitude ratio is as large as 200. Using the focal mechanism of this earthquake, typical “soft” and “hard” crustal structures, and directivity inferred from the observed waveforms and the slip distribution, we show that the combined effect yields an amplitude ratio of 17 to 34. The larger amplitude ratios at higher frequency bands can be probably due to the effects of complex 3-D basin structures. The result indicates that even from a moderate event, if these effects simultaneously work together toward amplifying ground motions, the extremely large ground motions as observed in Tainan can occur. Such occurrences should be taken into consideration in hazard mitigation measures in the place with frequent moderate earthquakes.

The mechanisms of aquatic plant defense against salinity were studied by long-term exposure of Spirodela polyrhiza (greater duckweed) to NaCl. In this study, the effects of 200 mM NaCl on greater duckweed were evaluated after 6 and 12 days of treatment, while plant growth was measured every day. High concentration of NaCl caused an inhibition of plant growth, reduced in the content of photosynthetic pigments, increased lipid peroxidation, and enhanced the entire antioxidant defense. The responses of five antioxidant enzymes showed that ascorbate peroxidase, guaiacol peroxidase, and superoxide dismutase activities were the most enhanced after NaCl exposure, catalase moderately, and glutathione reductase least. The content of soluble proteins was decreased, while ascorbic acid was drastically increased. In NaCl-treated fronds, the appearance of two NaCl-induced polypeptides with apparent molecular weight of 16 and 21 kDa, as well as the accumulation of two polypeptides with molecular weights 18 and 27 kDa, were observed in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). NaCl also led to accumulation of the heat shock protein 70 (HSP70) and induced an isoform of the glutamine synthetase (GS1) expression. Our results suggest that in S. polyrhiza, different adaptive mechanisms are involved in counter balancing high doses of a particular toxicant (sodium chloride). The possible application of the examined biomarkers in ecotoxicological research is discussed.

Background The in vivo infectious clone of Turnip mosaic virus (TuMV), p35S-TuMV, was used on plant pathology research for many years. To activate p35S-TuMV, the plasmid was mechanically introduced to the local lesion host Chenopodium quinoa. However, low infectivity occurred when the TuMV from C. quinoa was transferred to the systemic host Nicotiana benthamiana. Results To increase the efficiency of initial infectivity on N. benthamiana, the expression of the TuMV infectious clone by a binary vector that directly activates viral RNA through agro-infiltration is considered to be a good alternative. The size of the binary vector by agro-infiltration is usually large and its backbone has numerous restriction sites that increase difficulty for construction. In this study, we attempted to construct a mini binary vector (pBD003) with less restriction sites. The full-length cDNA of TuMV genome, with or without green fluorescence protein, was inserted in pBD003 to generate pBD-TuMV constructs, which were then individually introduced to N. benthamiana plants by agro-infiltration. Symptom development and ELISA positivity with TuMV antiserum indicated that the pBD-TuMV constructs are infectious. Moreover, the initial infectivity of a mild strain TuMV-GK, which contains an R182K mutation on HC-Pro, constructed in the pBD003 vector was significantly increased by agro-infiltration. Conclusion Thus, we concluded that the newly constructed mini binary vector provides a more feasible tool for TuMV researches in areas, such as creating a mild strain for cross-protection, or a viral vector for foreign gene expression. In addition, the multiple cloning sites will be further cloned in pBD003 for convenience in constructing other viral infectious clones. Electronic supplementary material The online version of this article (doi:10.1186/1999-3110-54-22) contains supplementary material, which is available to authorized users.

The 2013 M_L 6.4 Ruisui earthquake struck a seismic gap around the northern part of the Longitudinal Valley where rare earthquakes have occurred for at least two decades. Seismic data with different frequency bands connote a diverse scale of source characteristics. The slip model derived by a previous study using long-period seismic data provided us with the preliminary earthquake source properties in low-frequency energy radiation. However, the high-frequency part of the seismic energy needs to be considered for the strong motions in the comprehensive frequency band. As a case study, we carried out broadband strong motion simulations through the hybrid scheme, which simulated waveforms combining the low-frequency motions (frequency-wavenumber integration method) and high-frequency motions (empirical Green's function method) to reveal the strong ground motion and source characteristics of the 2013 Ruisui earthquake. The results show that even though the local structure is complicated this hybrid simulation can effectively rebuild the overall broadband strong ground motion characteristics for the 2013 Ruisui earthquake. Additional study issues are required to better understand the nature of localized high peak ground acceleration and the related seismic hazards for future earthquakes.