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Start Over Author "Yuan, Xiao" Publisher springer science and business media llc
355 results on '"Yuan, Xiao"'

1. Experimental quantum computational chemistry with optimized unitary coupled cluster ansatz

Author

Guo, Shaojun, primary, Sun, Jinzhao, additional, Qian, Haoran, additional, Gong, Ming, additional, Zhang, Yukun, additional, Chen, Fusheng, additional, Ye, Yangsen, additional, Wu, Yulin, additional, Cao, Sirui, additional, Liu, Kun, additional, Zha, Chen, additional, Ying, Chong, additional, Zhu, Qingling, additional, Huang, He-Liang, additional, Zhao, Youwei, additional, Li, Shaowei, additional, Wang, Shiyu, additional, Yu, Jiale, additional, Fan, Daojin, additional, Wu, Dachao, additional, Su, Hong, additional, Deng, Hui, additional, Rong, Hao, additional, Li, Yuan, additional, Zhang, Kaili, additional, Chung, Tung-Hsun, additional, Liang, Futian, additional, Lin, Jin, additional, Xu, Yu, additional, Sun, Lihua, additional, Guo, Cheng, additional, Li, Na, additional, Huo, Yong-Heng, additional, Peng, Cheng-Zhi, additional, Lu, Chao-Yang, additional, Yuan, Xiao, additional, Zhu, Xiaobo, additional, and Pan, Jian-Wei, additional

Published
2024
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6. The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans

Author

Maura, Francesco, primary, Coffey, David G., additional, Stein, Caleb K., additional, Braggio, Esteban, additional, Ziccheddu, Bachisio, additional, Sharik, Meaghen E., additional, Du, Megan T., additional, Tafoya Alvarado, Yuliza, additional, Shi, Chang-Xin, additional, Zhu, Yuan Xiao, additional, Meermeier, Erin W., additional, Morgan, Gareth J., additional, Landgren, Ola, additional, Bergsagel, P. Leif, additional, and Chesi, Marta, additional

Published
2024
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8. Expert consensus on pediatric orthodontic therapies of malocclusions in children

Author

Zhou, Chenchen, primary, Duan, Peipei, additional, He, Hong, additional, Song, Jinlin, additional, Hu, Min, additional, Liu, Yuehua, additional, Liu, Yan, additional, Guo, Jie, additional, Jin, Fang, additional, Cao, Yang, additional, Jiang, Lingyong, additional, Ye, Qingsong, additional, Zhu, Min, additional, Jiang, Beizhan, additional, Ruan, Wenhua, additional, Yuan, Xiao, additional, Li, Huang, additional, Zou, Rui, additional, Tian, Yulou, additional, Gao, Li, additional, Shu, Rui, additional, Chen, Jianwei, additional, Liu, Renkai, additional, Zou, Shujuan, additional, and Li, Xiaobing, additional

Published
2024
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15. A multicenter prospective study on the management of hepatoblastoma in children: a report from the Chinese Children’s Cancer Group

Author

Tang, Meng-Jie, primary, Ma, Xiao-Li, additional, He, Xiang-Ling, additional, Pan, Wei-Hua, additional, Zhang, Xiao-Hong, additional, Jiang, Sha-Yi, additional, Gao, Ju, additional, Li, Fu, additional, Yao, Wei, additional, Gu, Song, additional, Zhang, Wei-Ling, additional, Zhao, Qiang, additional, Huang, Shi-Hao, additional, Fang, Yong-Jun, additional, Liu, Wei, additional, Niu, Hui-Zhong, additional, Wang, Chun-Mei, additional, Sun, Li-Rong, additional, Gao, Hui, additional, Dai, Yun-Peng, additional, Huang, Shun-Gen, additional, Zhong, Zhi-Yong, additional, Wang, Xi-Ge, additional, Li, Zhong-Rong, additional, Yang, Liang-Chun, additional, Wu, Ye-Ming, additional, Wang, Huan-Min, additional, Sun, Xin, additional, and Yuan, Xiao-Jun, additional

Published
2023
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23. A novel risk model for predicting early relapse in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem-cell transplantation

Author

Yuan, Xiao-Lin, primary, Lai, Xiao-Yu, additional, Wu, Yi-Bo, additional, Yang, Lu-Xin, additional, Shi, Ji-Min, additional, Liu, Li-Zhen, additional, Yu, Jian, additional, Zhao, Yan-Min, additional, Zheng, Wei-Yan, additional, He, Jing-Song, additional, Sun, Jie, additional, Wu, Wen-Jun, additional, Zhao, Yi, additional, Ye, Yi-Shan, additional, Cai, Zhen, additional, Huang, He, additional, and Luo, Yi, additional

Published
2023
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29. Consensus for criteria of running a pediatric inflammatory bowel disease center using a modified Delphi approach

Author

You-You Luo, Kai-Chun Wu, Si-Tang Gong, Ying Huang, Hong Yang, Qing-Ya Tang, Ying-kit Leung, Jie Wu, Lan-Lan Geng, Wei Zhou, Mei Sun, Chao-Min Wan, Zai-Ling Li, Ying Fang, Xiao-Qin Li, Mei Li, Zhao-Xia Wang, Yuan Xiao, Xue-Mei Zhong, Xiao-Fei Chen, and Jie Chen

Subjects
Pediatrics, Perinatology and Child Health
Abstract

Background Good quality of care for inflammatory bowel disease (IBD) depends on high-standard management and facility in the IBD center. Yet, there are no clear measures or criteria for evaluating pediatric IBD (PIBD) center in China. The aim of this study was to develop a comprehensive set of quality indicators (QIs) for evaluating PIBD center in China. Methods A modified Delphi consensus-based approach was used to identify a set of QIs of structure, process, and outcomes for defining the criteria. The process included an exhaustive search using complementary approaches to identify potential QIs, and two web-based voting rounds to select the QIs defining the criteria for PIBD center. Results A total of 101 QIs (35 structures, 48 processes and 18 outcomes) were included in this consensus. Structure QIs focused on the composition of multidisciplinary team, facilities and services that PIBD center should provide. Process QIs highlight core requirements in diagnosing, evaluating, treating PIBD, and disease follow-up. Outcome QIs mainly included criteria evaluating effectiveness of various interventions in PIBD centers. Conclusion The present Delphi consensus developed a set of main QIs that may be useful for managing a PIBD center.

Published
2023

36. Integrating network pharmacology, UPLC-Q–TOF–MS and molecular docking to investigate the effect and mechanism of Chuanxiong Renshen decoction against Alzheimer's disease

Author

Zhuo Jun Shen, Yun Bo Fu, Jin Ling Hou, Lu Ning Lin, Xiao Yan Wang, Chang Yu Li, and Yuan Xiao Yang

Subjects
Pharmacology, Complementary and alternative medicine
Abstract

Background and aim Chuanxiong Renshen decoction (CRD) is a traditional Chinese medicine compound used to treat Alzheimer's disease (AD). However, the effects and active ingredients of CRD and its mechanism have not been clarified. We aimed to determine the neuroprotective effects of CRD in a triple-transgenic mouse model of AD (3 × Tg-AD) and investigate the possible active ingredients and their mechanisms. Methods Morris water maze (MWM) tests were used to determine the protective effect of CRD on learning and memory ability. Afterward, we used brain tissue staining, immunofluorescent staining and western blotting to detect the neuroprotective effects of CRD. Ultraperformance liquid-chromatography-quadrupole–time-of-flight tandem mass spectrometry (UPLC-Q–TOF–MS) was applied to determine the ingredients of CRD, and the potential AD targets were obtained from DisGeNET and the GeneCards database. The protein‒protein interaction (PPI) network was built with the additional use of STRING 11.0. Metascape was used in the pathway enrichment analysis. Discovery Studio 2016 (DS) software was used to analyze the binding ability of CRD and AD-related genes. Finally, we verified the regulatory effect of CRD on the predicted core targets EGFR and CASP3 by western blotting. Results Our study indicated that CRD can significantly improve learning and memory, reduce the expression of Aβ and protect neurons. A total of 95 ingredients were identified in the CRD. Then, 25 ingredients were identified in serum, and 5 ingredients were identified in the brain tissue homogenate. PPI network analysis identified CASP3, EGFR, APP, CNR1, HIF1A, PTGS2 and MTOR as hub targets. KEGG and GO analyses revealed that the TNF signaling pathway and MAPK signaling pathway were enriched in multiple targets. The results of molecular docking proved that the binding of the ingredients with potential key targets was excellent. The western blotting results showed that CRD could significantly reduce the expression of CASP3 and EGFR in the hippocampus of 3 × Tg-AD mice. Combined with literature analysis, we assumed the neuroprotective effect of CRD on AD may occur through regulation of the MAPK signaling pathway. Conclusion CRD significantly alleviated injury in 3 × Tg-AD mice. The possible active ingredients are ferulic acid, rutin, ginsenoside Rg1 and panaxydol. The therapeutic effect of CRD on AD is achieved through the downregulation of CASP3 and EGFR. The neuroprotective effect of CRD on AD may occur through regulation of the MAPK signaling pathway.

Published
2022

37. Subtypes of schizophrenia identified by multi-omic measures associated with dysregulated immune function

Author

Chunyan Luo, Xiao Wang, Su Lui, John A. Sweeney, Qiyong Gong, XueNan Pi, Na Hu, Jeffrey R. Bishop, Dan Xie, Siyi Li, and Yuan Xiao

Subjects
Genetic heterogeneity, T-cell receptor, Methylation, Biology, medicine.disease, White matter, Cellular and Molecular Neuroscience, Psychiatry and Mental health, medicine.anatomical_structure, Schizophrenia, DNA methylation, Immunology, medicine, Epigenetics, Molecular Biology, Gene
Abstract

Epigenetic modifications are plausible molecular sources of phenotypic heterogeneity across schizophrenia patients. The current study investigated biological heterogeneity in schizophrenia using peripheral epigenetic profiles to delineate illness subtypes independent of their phenomenological manifestations. We applied epigenome-wide profiling with a DNA methylation array from blood samples of 63 schizophrenia patients and 59 healthy controls. Non-negative matrix factorization (NMF) and k-means clustering were performed to identify DNA methylation-related patient subtypes. The validity of the partition was tested by assessing the profile of the T cell receptor (TCR) repertoires. The uniqueness of the identified subtypes in relation to brain structural and clinical measures were evaluated. Two distinct patterns of DNA methylation profiles were identified in patients. One subtype (60.3% of patients) showed relatively limited changes in methylation levels and cell composition compared to controls, while a second subtype (39.7% of patients) exhibited widespread methylation level alterations among genes enriched in immune cell activity, as well as a higher proportion of neutrophils and lower proportion of lymphocytes. Differentiation of the two patient subtypes was validated by TCR repertoires, which paralleled the partition based on DNA methylation profiles. The subtype with widespread methylation modifications had higher symptom severity, performed worse on cognitive measures, and displayed greater reductions in fractional anisotropy of white matter tracts and evidence of gray matter thickening compared to the other subtype. Identification of a distinct subtype of schizophrenia with unique molecular, cerebral, and clinical features provide a novel parcellation of the schizophrenia syndrome with potential to guide development of individualized therapeutics.

Published
2021

39. Structural insights into human CCAN complex assembled onto DNA

Author

Tian, Tian, primary, Chen, Lili, additional, Dou, Zhen, additional, Yang, Zhisen, additional, Gao, Xinjiao, additional, Yuan, Xiao, additional, Wang, Chengliang, additional, Liu, Ran, additional, Shen, Zuojun, additional, Gui, Ping, additional, Teng, Maikun, additional, Meng, Xianlei, additional, Hill, Donald L., additional, Li, Lin, additional, Zhang, Xuan, additional, Liu, Xing, additional, Sun, Linfeng, additional, Zang, Jianye, additional, and Yao, Xuebiao, additional

Published
2022
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46. Endoscopic submucosal dissection for colorectal lesions: outcomes from a United States experience

Author

Shu-Yuan Xiao, Gabriela Rodríguez-Ruiz, Kianoush Donboli, Irving Waxman, John Hart, Christopher G. Chapman, Uzma D. Siddiqui, and Nina Gupta

Subjects
medicine.medical_specialty, Endoscopic Mucosal Resection, Colorectal cancer, medicine.medical_treatment, Adenocarcinoma, Lesion, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Retrospective Studies, medicine.diagnostic_test, business.industry, Hepatology, medicine.disease, United States, Surgery, Endoscopy, Treatment Outcome, 030220 oncology & carcinogenesis, Colorectal Polyp, Therapeutic endoscopy, 030211 gastroenterology & hepatology, medicine.symptom, Colorectal Neoplasms, business, Learning Curve, Abdominal surgery
Abstract

Endoscopic submucosal dissection (ESD) is commonly used in Asia for resection of large non-pedunculated colorectal polyps (LNPCPs) and early (T1) colorectal cancers. It allows for en bloc removal and is often curative. We describe outcomes of colorectal ESD from a United States (US) academic medical center and compare this to international experiences. Retrospective review was performed of colonic lesions referred to the University of Chicago Medical Center for ESD from 2012 to 2020. Clinical and procedural data were collected. The study included 78 lesions with mean size of 29.7 mm (range 10–100 mm). The overall en bloc resection rate was 73.1% (n = 57). Between the first and second half of the study, it improved from 61.5 to 84.6% (p = 0.02). Histology showed adenocarcinoma in fifteen lesions (19.2%). Of all neoplastic lesions (n = 68), resection with negative margins (R0) was achieved in 54 cases (79.4%). Adverse events occurred in 9 cases (11.5%), but most (n = 6, 66.7%) were successfully treated endoscopically. Follow-up endoscopy was performed in 46 patients (59.0%) at a mean interval of 6.8 months (SD ± 5.0 months) with two case of recurrent lesion (4.3%). This study shows successful colorectal ESD outcomes at a US tertiary center. The en bloc resection rate was lower than other cohorts, but a learning curve was demonstrated. The R0 resection, lesion recurrence, and adverse event rates were similar to other non-Asian experiences, but not as favorable as in Asia [Fuccio et al. in Gastrointest Endosc 86:74–86.e17, 2017]. Increased ESD training in the US can help optimize utilization and outcomes.

Published
2021

47. Clinical Analysis of Primary Tracheobronchial Tumors in Children and Evaluation of the Predicting Models for Mucoepidermoid Carcinoma

Author

Zhang, Chen, primary, Fu, Wen-long, additional, Dai, Ji-hong, additional, Li, Yong-gang, additional, Tang, Xing-ye, additional, Ma, Xiao-feng, additional, Geng, Gang, additional, Li, Ying, additional, Yang, Ting, additional, Yan, Li, additional, Liu, Jing-yue, additional, Liu, Zheng, additional, Yuan, Xiao-ping, additional, and Tian, Dai-yin, additional

Published
2022
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50. A New Nodes-Based Model for Optimization of Heat Exchanger Network Synthesis

Author

Yue Xu, Guomin Cui, Ambonisye Kayange Heri, and Yuan Xiao

Subjects
Flexibility (engineering), Mathematical optimization, Scale (ratio), Matching (graph theory), Computer science, 020209 energy, Mode (statistics), 02 engineering and technology, Condensed Matter Physics, Random walk, Domain (software engineering), 020303 mechanical engineering & transports, 0203 mechanical engineering, Heat exchanger, 0202 electrical engineering, electronic engineering, information engineering, Integer (computer science)
Abstract

Searching the global optimal value in heat exchanger network synthesis (HENS) becomes more difficult along with the increasing scale of cases. In structural optimization model, such as stage-wise superstructure, solution domain can be enlarged by adding the stages of network, which would involve multiple integer and continuous variables in optimization and result in a decreasing computational efficiency. Thus, a new nodes-based model with stream splits is proposed, which can promote the quality of result and decrease time consumption at the same time. The characteristic of this model is that it changes the matching mode of heat exchangers by setting the number of nodes on streams to quantify the positions of heat exchangers. The proposed nodes-based model has more flexibility in generating and eliminating the heat exchangers and strong ductility in exploring the solution domain. The random walk with compulsive evolution is modified for enhancing its searching ability and applying modified random walk algorithm with compulsive evolution (RWCE) into the new proposed model. The obtained results of Case 1, Case 2 and Case 3 are superior to those reported in the literature, which decreases 106 USD·a−1, 1253 USD·a−1, 23 444 USD·a−1, respectively, verifying the robust effectiveness of this new model in solving HENS problem.

Published
2020

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