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Your search keyword '"Yusufu Mayinuer"' showing total 7 results
Start Over Author "Yusufu Mayinuer" Publisher springer science and business media llc
7 results on '"Yusufu Mayinuer"'

2. TGF-β regulation of microRNA miR-497-5p and ocular lens epithelial cell mesenchymal transition

Author

Jing Zhao, Jinda Wang, Ying Xiong, Hailong He, Yusufu Mayinuer, Xiaoxia Li, Xiuhua Wan, Jingshang Zhang, Guyu Zhu, and Jing Li

Subjects
0301 basic medicine, Epithelial-Mesenchymal Transition, Fibroblast Growth Factor 7, General Biochemistry, Genetics and Molecular Biology, Cell Line, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Transforming Growth Factor beta, Cyclin E, Lens, Crystalline, microRNA, medicine, Humans, Cell Proliferation, General Environmental Science, Oncogene Proteins, biology, Chemistry, Cell growth, Mesenchymal stem cell, Epithelial Cells, Transforming growth factor beta, Capsule Opacification, Cell biology, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, 030220 oncology & carcinogenesis, Lens (anatomy), biology.protein, General Agricultural and Biological Sciences, Transforming growth factor
Abstract

The purpose of this study was to investigate the role of a human lens microRNA (miR-497-5p) in regulating epithelialmesenchymal transition (EMT) under the control of transforming growth factor beta (TGF-β). A microRNA array was used to evaluate the microRNA profiles of untreated and TGF-β-treated human lens epithelial cells in culture. This showed that TGF-β treatment led to the upregulation of 96 microRNAs and downregulation of 39 microRNAs. Thirteen microRNAs were predicted to be involved in the pathogenesis of posterior capsule opacification (PCO). Meanwhile, overexpression of miR-497-5p suppressed cell proliferation and EMT 48 h post-transfection, and inhibition of miR-497-5p accelerated cell proliferation and EMT. Treatment with TGF-β inhibited the expression of miR-497-5p, but not cell proliferation. miR-497-5p was also found to regulate the level of CCNE1 and FGF7, which are reported to be actively involved in EMT. CCNE1 and FGF7 were bona fide targets of miR-497-5p. The results suggest that miR-497-5p participates in the direct regulation of lens epithelial cell EMT and is regulated by TGF-β. miR-497-5p may be a novel target for PCO therapy.

Published
2020

4. The effect of retaining intact posterior capsule in congenital cataract surgery in children aged 4–8 years

Author

Zhang, Jing Shang, primary, Wang, Jin Da, additional, Yusufu, Mayinuer, additional, Cao, Kai, additional, Jin, Shan Shan, additional, Xiong, Ying, additional, Li, Jing, additional, Sun, Xiu Li, additional, Chen, Shu Ying, additional, Liu, Zhen Yu, additional, Fu, Jing, additional, Li, Li, additional, You, Qi Sheng, additional, and Wan, Xiu Hua, additional

Published
2021
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5. The association of myopia progression with the morphological changes of optic disc and β-peripapillary atrophy in primary school students

Author

Zhang, Jing-Shang, primary, Li, Jing, additional, Wang, Jin-Da, additional, Xiong, Ying, additional, Cao, Kai, additional, Hou, Si-Meng, additional, Yusufu, Mayinuer, additional, Wang, Kai-Jie, additional, Li, Meng, additional, Mao, Ying-Yan, additional, Sun, Xiu-Li, additional, Chen, Shu-Ying, additional, Liu, Zhen-Yu, additional, Jin, Zi-Bing, additional, Wang, Ning-Li, additional, and Wan, Xiu-Hua, additional

Published
2021
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7. Comparison of postoperative visual performance between bifocal and trifocal intraocular Lens based on randomized controlled trails: a meta-analysis

Author

Jin, Shanshan, primary, Friedman, David S., additional, Cao, Kai, additional, Yusufu, Mayinuer, additional, Zhang, Jingshang, additional, Wang, Jinda, additional, Hou, Simeng, additional, Zhu, Guyu, additional, Wang, Bingsong, additional, Xiong, Ying, additional, Li, Jing, additional, Li, Xiaoxia, additional, He, Hailong, additional, and Wan, Xiuhua, additional

Published
2019
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