1. Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
- Author
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Jérôme Salles, Audrey Chanet, Christelle Guillet, Anouk MM. Vaes, Elske M. Brouwer-Brolsma, Christophe Rocher, Christophe Giraudet, Véronique Patrac, Emmanuelle Meugnier, Christophe Montaurier, Philippe Denis, Olivier Le Bacquer, Adeline Blot, Marion Jourdan, Yvette Luiking, Matthew Furber, Miriam Van Dijk, Nicolas Tardif, Y. Yves Boirie, Stéphane Walrand, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Wageningen University and Research [Wageningen] (WUR), Laboratoire de biogenèse membranaire (LBM), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Danone Nutricia Research [Utrecht], Karolinska University Hospital [Stockholm], Salles, Jérôme, Université de Bordeaux (UB), Department of Earth Sciences [UNH Durham], University of New Hampshire (UNH), CHU Clermont-Ferrand, and Karolinska University Hospital [Solna, Sweden] (KUH)
- Subjects
Global Nutrition ,Wereldvoeding ,Sarcopenia ,[SDV]Life Sciences [q-bio] ,Medicine (miscellaneous) ,Vitamin D Deficiency ,General Biochemistry, Genetics and Molecular Biology ,Rats ,Mitochondria ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,Mice ,Oxidative Stress ,Humans ,Animals ,Life Science ,Vitamin D ,Muscle, Skeletal ,General Agricultural and Biological Sciences ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Aged - Abstract
Skeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial energy production during exercise is impaired in vitamin D-deficient subjects. In cultured myotubes, loss of vitamin D receptor (VDR) function decreases mitochondrial respiration rate and ATP production from oxidative phosphorylation. We aimed to examine the effects of vitamin D deficiency and supplementation on whole-body energy expenditure and muscle mitochondrial function in old rats, old mice, and human subjects. To gain further insight into the mechanisms involved, we used C2C12 and human muscle cells and transgenic mice with muscle-specific VDR tamoxifen-inducible deficiency. We observed that in vivo and in vitro vitamin D fluctuations changed mitochondrial biogenesis and oxidative activity in skeletal muscle. Vitamin D supplementation initiated in older people improved muscle mass and strength. We hypothesize that vitamin D supplementation is likely to help prevent not only sarcopenia but also sarcopenic obesity in vitamin D-deficient subjects.
- Published
- 2022
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