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Your search keyword '"Zhan, Meixiao"' showing total 23 results
Start Over Author "Zhan, Meixiao" Publisher springer science and business media llc
23 results on '"Zhan, Meixiao"'

1. Model containing sarcopenia and visceral adiposity can better predict the prognosis of hepatocellular carcinoma: a multicenter study

Author

Liu, Yao, primary, Fu, Sirui, additional, Yu, Xiangrong, additional, Zhang, Jinxiong, additional, Zhu, Siyu, additional, Yang, Yang, additional, Huang, Jianwen, additional, Luo, Hanlin, additional, Tang, Kai, additional, Zheng, Youbing, additional, Zhao, Yujie, additional, Chen, Xiaoqiong, additional, Zhan, Meixiao, additional, He, Xiaofeng, additional, Li, Qiyang, additional, Duan, Chongyang, additional, Chen, Yuan, additional, and Lu, Ligong, additional

Published
2023
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4. Two-stage hybrid network for segmentation of COVID-19 pneumonia lesions in CT images: a multicenter study

Author

Shang, Yaxin, primary, Wei, Zechen, additional, Hui, Hui, additional, Li, Xiaohu, additional, Li, Liang, additional, Yu, Yongqiang, additional, Lu, Ligong, additional, Li, Li, additional, Li, Hongjun, additional, Yang, Qi, additional, Wang, Meiyun, additional, Zhan, Meixiao, additional, Wang, Wei, additional, Zhang, Guanghao, additional, Wu, Xiangjun, additional, Wang, Li, additional, Liu, Jie, additional, Tian, Jie, additional, and Zha, Yunfei, additional

Published
2022
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7. Extracellular matrix-degrading STING nanoagonists for mild NIR-II photothermal-augmented chemodynamic-immunotherapy

Author

Zhan, Meixiao, Yu, Xiangrong, Zhao, Wei, Peng, Yongjun, Peng, Shaojun, Li, Jingchao, and Lu, Ligong

Subjects
Photoactivation, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, Applied Microbiology and Biotechnology, Fenton reaction, Mice, Medical technology, Animals, R855-855.5, Mice, Inbred BALB C, Research, Membrane Proteins, Phototherapy, Photochemical Processes, STING pathway, eye diseases, Extracellular Matrix, Nanoparticles, Molecular Medicine, Female, Immunotherapy, Nanoagonist, TP248.13-248.65, Biotechnology
Abstract

Regulation of stimulator of interferon genes (STING) pathway using agonists can boost antitumor immunity for cancer treatment, while the rapid plasma clearance, limited membrane permeability, and inefficient cytosolic transport of STING agonists greatly compromise their therapeutic efficacy. In this study, we describe an extracellular matrix (ECM)-degrading nanoagonist (dNAc) with second near-infrared (NIR-II) light controlled activation of intracellular STING pathway for mild photothermal-augmented chemodynamic-immunotherapy of breast cancer. The dNAc consists of a thermal-responsive liposome inside loading with ferrous sulfide (FeS2) nanoparticles as both NIR-II photothermal converters and Fenton catalysts, 2′3′-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) as the STING agonist, and an ECM-degrading enzyme (bromelain) on the liposome surface. Mild heat generated by dNAc upon NIR-II photoirradiation improves Fenton reaction efficacy to kill tumor cells and cause immunogenic cell death (ICD). Meanwhile, the generated heat triggers a controlled release of cGAMP from thermal-responsive liposomes to active STING pathway. The mild photothermal activation of STING pathway combined with ICD promotes anti-tumor immune responses, which leads to improved infiltration of effector T cells into tumor tissues after bromelain-mediated ECM degradation. As a result, after treatment with dNAc upon NIR-II photoactivation, both primary and distant tumors in a murine mouse model are inhibited and the liver and lung metastasis are effectively suppressed. This work presents a photoactivatable system for STING pathway and combinational immunotherapy with improved therapeutic outcome. Graphical Abstract

Published
2022

8. Near-infrared light-triggered nano-prodrug for cancer gas therapy

Author

Liu, Runcong, Peng, Yongjun, Lu, Ligong, Peng, Shaojun, Chen, Tianfeng, and Zhan, Meixiao

Subjects
Infrared Rays, Photothermal Therapy, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, Review, Nitric Oxide, Applied Microbiology and Biotechnology, Nanostructures, Neoplasms, Medical technology, Animals, Humans, Molecular Medicine, Prodrugs, Gases, Hydrogen Sulfide, R855-855.5, TP248.13-248.65, Biotechnology
Abstract

Gas therapy (GT) has attracted increasing attention in recent years as a new cancer treatment method with favorable therapeutic efficacy and reduced side effects. Several gas molecules, such as nitric oxide (NO), carbon monoxide (CO), hydrogen (H2), hydrogen sulfide (H2S) and sulfur dioxide (SO2), have been employed to treat cancers by directly killing tumor cells, enhancing drug accumulation in tumors or sensitizing tumor cells to chemotherapy, photodynamic therapy or radiotherapy. Despite the great progress of gas therapy, most gas molecules are prone to nonspecific distribution when administered systemically, resulting in strong toxicity to normal tissues. Therefore, how to deliver and release gas molecules to targeted tissues on demand is the main issue to be considered before clinical applications of gas therapy. As a specific and noninvasive stimulus with deep penetration, near-infrared (NIR) light has been widely used to trigger the cleavage and release of gas from nano-prodrugs via photothermal or photodynamic effects, achieving the on-demand release of gas molecules with high controllability. In this review, we will summarize the recent progress in cancer gas therapy triggered by NIR light. Furthermore, the prospects and challenges in this field are presented, with the hope for ongoing development.

Published
2021

10. Artificial intelligence for stepwise diagnosis and monitoring of COVID-19

Author

Liang, Hengrui, primary, Guo, Yuchen, additional, Chen, Xiangru, additional, Ang, Keng-Leong, additional, He, Yuwei, additional, Jiang, Na, additional, Du, Qiang, additional, Zeng, Qingsi, additional, Lu, Ligong, additional, Gao, Zebin, additional, Li, Linduo, additional, Li, Quanzheng, additional, Nie, Fangxing, additional, Ding, Guiguang, additional, Huang, Gao, additional, Chen, Ailan, additional, Li, Yimin, additional, Guan, Weijie, additional, Sang, Ling, additional, Xu, Yuanda, additional, Chen, Huai, additional, Chen, Zisheng, additional, Li, Shiyue, additional, Zhang, Nuofu, additional, Chen, Ying, additional, Huang, Danxia, additional, Li, Run, additional, Li, Jianfu, additional, Cheng, Bo, additional, Zhao, Yi, additional, Li, Caichen, additional, Xiong, Shan, additional, Wang, Runchen, additional, Liu, Jun, additional, Wang, Wei, additional, Huang, Jun, additional, Cui, Fei, additional, Xu, Tao, additional, Lure, Fleming Y. M., additional, Zhan, Meixiao, additional, Huang, Yuanyi, additional, Yang, Qiang, additional, Dai, Qionghai, additional, Liang, Wenhua, additional, He, Jianxing, additional, and Zhong, Nanshan, additional

Published
2022
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11. Identification of COPA as a potential prognostic biomarker and pharmacological intervention target of cervical cancer by quantitative proteomics and experimental verification

Author

Bao, Huiqiong, primary, Li, Xiaobin, additional, Cao, Zhixing, additional, Huang, Zhihong, additional, Chen, Li, additional, Wang, Mingbing, additional, Hu, Jiali, additional, Li, Wenting, additional, Sun, Hongwei, additional, Jiang, Xue, additional, Mei, Ping, additional, Li, Huawen, additional, Lu, Ligong, additional, and Zhan, Meixiao, additional

Published
2022
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13. Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells

Author

Meng, Ya, primary, Song, Chengcheng, additional, Ren, Zhili, additional, Li, Xiaohong, additional, Yang, Xiangyu, additional, Ai, Nana, additional, Yang, Yang, additional, Wang, Dongjin, additional, Zhan, Meixiao, additional, Wang, Jiaxian, additional, LEI, Chon Lok, additional, Liu, Weiwei, additional, Ge, Wei, additional, Lu, Ligong, additional, and Chen, Guokai, additional

Published
2021
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18. Sepiapterin reductase promotes hepatocellular carcinoma progression via FoxO3a/Bim signaling in a nonenzymatic manner

Author

Wu, Yao, primary, Du, Hongzhi, additional, Zhan, Meixiao, additional, Wang, Hongxv, additional, Chen, Peng, additional, Du, Danyu, additional, Liu, Xinyi, additional, Huang, Xingxv, additional, Ma, Pengcheng, additional, Peng, Dezheng, additional, Sun, Li, additional, Yuan, Shengtao, additional, Ding, Jian, additional, Lu, Ligong, additional, and Jiang, Jingwei, additional

Published
2020
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21. Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling

Author

Wei, Xiaohui, primary, Li, Sijing, additional, He, Jinyong, additional, Du, Hongzhi, additional, Liu, Yang, additional, Yu, Wei, additional, Hu, Haolin, additional, Han, Lifei, additional, Wang, Chenfei, additional, Li, Hongyang, additional, Shi, Xin, additional, Zhan, Meixiao, additional, Lu, Ligong, additional, Yuan, Shengtao, additional, and Sun, Li, additional

Published
2019
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23. PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC

Author

Du, Hongzhi, primary, Chen, Yulong, additional, Hou, Xiaoying, additional, Huang, Yue, additional, Wei, Xiaohui, additional, Yu, Xiaowen, additional, Feng, Shuyun, additional, Wu, Yao, additional, Zhan, Meixiao, additional, Shi, Xin, additional, Lin, Sensen, additional, Lu, Ligong, additional, Yuan, Shengtao, additional, and Sun, Li, additional

Published
2017
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