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2-18F-PD153035 was synthesized by nucleophilic displacement of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline-2-trimethylammonium chloride with 18F−. Biodistribution and micro-PET of the tracer in normal mice were studied. The 2-18F-PD153035 was obtained in 20–30 % yields with more than 99 % radiochemical purity. Biodistribution and micro-PET showed that the liver and the intestines were the primary sites of excretion of this drug.

The preparation of 10-(2-[18F]fluoroethoxy)-20(S)-camptothecin, a potential positron emission tomography tracer for the imaging of topoisomerase I in cancers, is described. 10-(2-[18F]Fluoroethoxy)-20(S)-camptothecin was synthesized by the [18F]fluoroalkylation of the corresponding hydroxy precursor molecule with 2-[18F]fluoroethyl bromide ([18F]FEtBr) in dimethylsulfoxide (DMSO) at 55 °C for 20 min; this was followed by purification using high performance liquid chromatography (HPLC) with a total preparation time of 60 min. The overall radiochemical yield was approximately 5.4–12 % (uncorrected), and the radiochemical purity was above 96 %.

Two complexes [Cd2(dpe)3(H2O)8]·(dpe)·(hssal)2·(H2O)2 1, [Mn(dpe)2(Hpcmb)2·(H2O)2] 2, (dpe = trans-1,2-di(4-pyrindyl)ethylene; H2hssal = sulphosalicylic acid; H2pcmb = p-(carboxyl-methyloxy)-benzenecarboxylic acid) has been prepared, and was characterized by elemental analysis, FT-IR and single-crystal X-ray diffraction. Structure indicates in complex 1 that Cd(II) is a distorted octahedral coordination geometry. The hssal2− anions are localized between 2-D sheets {[Cd(dpe)2(H2O)4]2+(dpe)}n and {{[Cd(dpe)2(H2O)4]2+}n as count anions and bridge to further connect these 2-D sheets through hydrogen bond O–H···O to form 3-D structure. The complex 2 is a single molecule structure. In 2, Each Mn(II) atom is six-coordinated with a distorted octahedral coordination geometry. The single molecule units are extended into three-dimensional structure via π–π, hydrogen bonding interactions. The thermogravimetric behavior and luminescent property of complex 1 were investigated. Two complexes, [Cd2(dpe)3(H2O)8]·(dpe)·(hssal)2·(H2O)2 1, [Mn(dpe)2(Hpcmb)2(H2O)2] 2 have been prepared, and were characterized by elemental analysis, FT-IR and single-crystal X-ray diffraction. Structures indicate that two complexes are extended into three-dimensional structure via π–π, C–H···π and hydrogen bonding interactions. The thermogravimetric behavior and luminescent property of complex 1 were investigated.