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Due to a scarcity of observations and its long memory of uncertain past climate, the Antarctic Ice Sheet remains a largely unknown factor in the prediction of global sea level change. As the history of the ice sheet plays a key role in its future evolution, in this study we model the Antarctic Ice Sheet from the Last Glacial Maximum (21 kyr ago) until the year 2100 with the ice-dynamical model ANICE. We force the model with different temperature, surface mass balance and sea-level records to investigate the importance of these different aspects for the evolution of the ice sheet. Additionally, we compare the model output from 21 kyr ago until the present with observations to assess model performance in simulating the total grounded ice volume and the evolution of different regions of the Antarctic Ice Sheet. Although there are some clear limitations of the model, we conclude that sea-level change has driven the deglaciation of the ice sheet, whereas future temperature change and the history of the ice sheet are the primary cause of changes in ice volume in the future. We estimate the change in grounded ice volume between its maximum (around 15 kyr ago) and the present-day to be between 8.4 and 12.5 m sea-level equivalent and the contribution of the Antarctic Ice Sheet to the global mean sea level in 2100, with respect to 2000, to be −22 to 63 mm.

The excimer laser-assisted non-occlusive anastomosis (ELANA) technique facilitates the construction of anastomoses without temporary occlusion of the recipient artery. Experiments aimed at simplifying the technique eventually resulted in a sutureless ELANA slide (SEsl) anastomosis. After the first clinical use, new insights lead to the application of a clip at the back of the device, the SELANA clip (SEcl). The SEcl offers a distinct advantage over the SEsl since no sealant is necessary. In this study, we determine the feasibility of the SEcl anastomosis in an in vivo rabbit model. 15 SEcl anastomoses and 15 conventional ELANA anastomoses were created on the abdominal aorta in 5 rabbits. Mean application times, flap retrieval rates, hemostasis, and burst pressures were assessed. The mean application time of the SEcl anastomoses was 11.4 min versus 39.0 min for the ELANA anastomoses (mean difference, 27.6 min; 95% CI, 20.6–34.7). The flap retrieval rate of the SEcl anastomoses (14/15) was not inferior to the flap retrieval rate of the ELANA anastomoses (13/15). Direct hemostasis was achieved in 13/15 (87%) SEcl anastomoses and in 14/15 (94%) ELANA anastomoses. All SEcl anastomoses were resistant to provoked pressures until 250 mmHg. The SEcl anastomosis is technically feasible in in vivo experiments. Mean application time, flap retrieval rate, hemostasis, and burst pressure are not inferior to the conventional ELANA anastomosis. Further long term experiments should be performed to assess safety, patency, and reendothelialization.