18 results on '"van Rheenen, Wouter"'
Search Results
2. Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis
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Al Khleifat, Ahmad, primary, Iacoangeli, Alfredo, additional, van Vugt, Joke J. F. A., additional, Bowles, Harry, additional, Moisse, Matthieu, additional, Zwamborn, Ramona A. J., additional, van der Spek, Rick A. A., additional, Shatunov, Aleksey, additional, Cooper-Knock, Johnathan, additional, Topp, Simon, additional, Byrne, Ross, additional, Gellera, Cinzia, additional, López, Victoria, additional, Jones, Ashley R., additional, Opie-Martin, Sarah, additional, Vural, Atay, additional, Campos, Yolanda, additional, van Rheenen, Wouter, additional, Kenna, Brendan, additional, Van Eijk, Kristel R., additional, Kenna, Kevin, additional, Weber, Markus, additional, Smith, Bradley, additional, Fogh, Isabella, additional, Silani, Vincenzo, additional, Morrison, Karen E., additional, Dobson, Richard, additional, van Es, Michael A., additional, McLaughlin, Russell L., additional, Vourc’h, Patrick, additional, Chio, Adriano, additional, Corcia, Philippe, additional, de Carvalho, Mamede, additional, Gotkine, Marc, additional, Panades, Monica P., additional, Mora, Jesus S., additional, Shaw, Pamela J., additional, Landers, John E., additional, Glass, Jonathan D., additional, Shaw, Christopher E., additional, Basak, Nazli, additional, Hardiman, Orla, additional, Robberecht, Wim, additional, Van Damme, Philip, additional, van den Berg, Leonard H., additional, Veldink, Jan H., additional, and Al-Chalabi, Ammar, additional
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- 2022
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3. Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
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Restuadi, Restuadi, primary, Steyn, Frederik J., additional, Kabashi, Edor, additional, Ngo, Shyuan T., additional, Cheng, Fei-Fei, additional, Nabais, Marta F., additional, Thompson, Mike J., additional, Qi, Ting, additional, Wu, Yang, additional, Henders, Anjali K., additional, Wallace, Leanne, additional, Bye, Chris R., additional, Turner, Bradley J., additional, Ziser, Laura, additional, Mathers, Susan, additional, McCombe, Pamela A., additional, Needham, Merrilee, additional, Schultz, David, additional, Kiernan, Matthew C., additional, van Rheenen, Wouter, additional, van den Berg, Leonard H., additional, Veldink, Jan H., additional, Ophoff, Roel, additional, Gusev, Alexander, additional, Zaitlen, Noah, additional, McRae, Allan F., additional, Henderson, Robert D., additional, Wray, Naomi R., additional, Giacomotto, Jean, additional, and Garton, Fleur C., additional
- Published
- 2022
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4. Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia
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Restuadi, Restuadi, primary, Garton, Fleur C., additional, Benyamin, Beben, additional, Lin, Tian, additional, Williams, Kelly L., additional, Vinkhuyzen, Anna, additional, van Rheenen, Wouter, additional, Zhu, Zhihong, additional, Laing, Nigel G., additional, Mather, Karen A., additional, Sachdev, Perminder S., additional, Ngo, Shyuan T., additional, Steyn, Frederik J., additional, Wallace, Leanne, additional, Henders, Anjali K., additional, Visscher, Peter M., additional, Needham, Merrilee, additional, Mathers, Susan, additional, Nicholson, Garth, additional, Rowe, Dominic B., additional, Henderson, Robert D., additional, McCombe, Pamela A., additional, Pamphlett, Roger, additional, Blair, Ian P., additional, Wray, Naomi R., additional, and McRae, Allan F., additional
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- 2021
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5. Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
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Bakker, Mark K, van der Spek, Rick A A, Terao, Chikashi, Bulters, Diederik, Kitchen, Neil, Brown, Martin, Grieve, Joan, Matsuda, Koichi, Walters, Robin G, Lin, Kuang, Li, Liming, Millwood, Iona Y, Chen, Zhengming, Rouleau, Guy A, Zhou, Sirui, Rannikmäe, Kristiina, van Rheenen, Wouter, Sudlow, Cathie L M, Houlden, Henry, van den Berg, Leonard H, Dina, Christian, Naggara, Olivier, Gentric, Jean-Christophe, Shotar, Eimad, Eugène, François, Desal, Hubert, Winsvold, Bendik S, Morel, Sandrine, Børte, Sigrid, Johnsen, Marianne Bakke, Brumpton, Ben M, Sandvei, Marie Søfteland, Willer, Cristen J, Hveem, Kristian, Zwart, John-Anker, Verschuren, W M Monique, Friedrich, Christoph M, Hirsch, Sven, Bourcier, Romain, Schilling, Sabine, Dauvillier, Jérôme, Martin, Olivier, Stroke, HUNT All-In, Group, China Kadoorie Biobank Collaborative, Consortium, BioBank Japan Project, Group, ICAN Study, Group, CADISP, Genetics, Haemorrhage, Observational Subarachnoid, Hostettler, Isabel C, Consortium, International Stroke Genetics, Jones, Gregory T, Bown, Matthew J, Ko, Nerissa U, Kim, Helen, Coleman, Jonathan R I, Breen, Gerome, Zaroff, Jonathan G, Klijn, Catharina J M, Malik, Rainer, Alg, Varinder S, Dichgans, Martin, Sargurupremraj, Muralidharan, Tatlisumak, Turgut, Amouyel, Philippe, Debette, Stéphanie, Rinkel, Gabriel J E, Worrall, Bradford B, Pera, Joanna, Slowik, Agnieszka, Gaál-Paavola, Emília I, van Eijk, Kristel R, Niemelä, Mika, Jääskeläinen, Juha E, von Und Zu Fraunberg, Mikael, Lindgren, Antti, Broderick, Joseph P, Werring, David J, Woo, Daniel, Redon, Richard, Bijlenga, Philippe, Kamatani, Yoichiro, Koido, Masaru, Veldink, Jan H, Ruigrok, Ynte M, Bian, Zheng, Chen, Junshi, Chen, Yiping, Clarke, Robert, Collins, Rory, Guo, Yu, Han, Xiao, Hill, Michael, Akiyama, Masato, Liu, Depei, Lv, Jun, Millwood, Iona, Peto, Richard, Sansome, Sam, Walters, Robin, Yang, Xiaoming, Yu, Canqing, Bonner, Stephen, and Walsh, Daniel
- Subjects
572: Biochemie ,ddc:570 ,Medizin ,Genetics ,MEDLINE ,Genome-wide association study ,Computational biology ,Biology ,Clinical risk factor ,616: Innere Medizin und Krankheiten - Abstract
In the version of this article initially published, the following statement was missing from the Acknowledgements: “We are grateful to the GenoBiRD core facility (Biogenouest), the Clinical Investigation Center (INSERM CIC1413) and the Center of Biological Resources in Nantes (BB-0033-00040; CHU Nantes, France) for their assistance in managing and genotyping the ICAN and PREGO biobanks. R.R. was supported by the French Regional Council of Pays-de-la-Loire (VaCaRMe program) and the Agence Nationale de la Recherche (ANR-15-CE17-0008-01 to G.L). H.D. and R.B. were supported by the French Ministry of Health (clinical trial NCT02848495 to H.D.), the Genavie Foundation, the Société Française de Radiologie and the Société Française de Neuroradiologie.” The error has been corrected in the HTML and PDF versions of the article. *Lists of authors and their affiliations appear online. Korrektur zu 10.1038/s41588-020-00725-7
- Published
- 2020
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6. Associations of autozygosity with a broad range of human phenotypes
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Clark, David W, primary, Okada, Yukinori, additional, Moore, Kristjan H S, additional, Mason, Dan, additional, Pirastu, Nicola, additional, Gandin, Ilaria, additional, Mattsson, Hannele, additional, Barnes, Catriona L K, additional, Lin, Kuang, additional, Zhao, Jing Hua, additional, Deelen, Patrick, additional, Rohde, Rebecca, additional, Schurmann, Claudia, additional, Guo, Xiuqing, additional, Giulianini, Franco, additional, Zhang, Weihua, additional, Medina-Gomez, Carolina, additional, Karlsson, Robert, additional, Bao, Yanchun, additional, Bartz, Traci M, additional, Baumbach, Clemens, additional, Biino, Ginevra, additional, Bixley, Matthew J, additional, Brumat, Marco, additional, Chai, Jin-Fang, additional, Corre, Tanguy, additional, Cousminer, Diana L, additional, Dekker, Annelot M, additional, Eccles, David A, additional, van Eijk, Kristel R, additional, Fuchsberger, Christian, additional, Gao, He, additional, Germain, Marine, additional, Gordon, Scott D, additional, de Haan, Hugoline G, additional, Harris, Sarah E, additional, Hofer, Edith, additional, Huerta-Chagoya, Alicia, additional, Igartua, Catherine, additional, Jansen, Iris E, additional, Jia, Yucheng, additional, Kacprowski, Tim, additional, Karlsson, Torgny, additional, Kleber, Marcus E, additional, Li, Shengchao Alfred, additional, Li-Gao, Ruifang, additional, Mahajan, Anubha, additional, Matsuda, Koichi, additional, Meidtner, Karina, additional, Meng, Weihua, additional, Montasser, May E, additional, van der Most, Peter J, additional, Munz, Matthias, additional, Nutile, Teresa, additional, Palviainen, Teemu, additional, Prasad, Gauri, additional, Prasad, Rashmi B, additional, Priyanka, Tallapragada Divya Sri, additional, Rizzi, Federica, additional, Salvi, Erika, additional, Sapkota, Bishwa R, additional, Shriner, Daniel, additional, Skotte, Line, additional, Smart, Melissa C, additional, Smith, Albert Vernon, additional, van der Spek, Ashley, additional, Spracklen, Cassandra N, additional, Strawbridge, Rona J, additional, Tajuddin, Salman M, additional, Trompet, Stella, additional, Turman, Constance, additional, Verweij, Niek, additional, Viberti, Clara, additional, Wang, Lihua, additional, Warren, Helen R, additional, Wootton, Robyn E, additional, Yanek, Lisa R, additional, Yao, Jie, additional, Yousri, Noha A, additional, Zhao, Wei, additional, Adeyemo, Adebowale A, additional, Afaq, Saima, additional, Aguilar-Salinas, Carlos Alberto, additional, Akiyama, Masato, additional, Albert, Matthew L, additional, Allison, Matthew A, additional, Alver, Maris, additional, Aung, Tin, additional, Azizi, Fereidoun, additional, Bentley, Amy R, additional, Boeing, Heiner, additional, Boerwinkle, Eric, additional, Borja, Judith B, additional, de Borst, Gert J, additional, Bottinger, Erwin P, additional, Broer, Linda, additional, Campbell, Harry, additional, Chanock, Stephen, additional, Chee, Miao-Li, additional, Chen, Guanjie, additional, Chen, Yii-Der I, additional, Chen, Zhengming, additional, Chiu, Yen-Feng, additional, Cocca, Massimiliano, additional, Collins, Francis S, additional, Concas, Maria Pina, additional, Corley, Janie, additional, Cugliari, Giovanni, additional, van Dam, Rob M, additional, Damulina, Anna, additional, Daneshpour, Maryam S, additional, Day, Felix R, additional, Delgado, Graciela E, additional, Dhana, Klodian, additional, Doney, Alexander S F, additional, Dörr, Marcus, additional, Doumatey, Ayo P, additional, Dzimiri, Nduna, additional, Ebenesersdóttir, S Sunna, additional, Elliott, Joshua, additional, Elliott, Paul, additional, Ewert, Ralf, additional, Felix, Janine F, additional, Fischer, Krista, additional, Freedman, Barry I, additional, Girotto, Giorgia, additional, Goel, Anuj, additional, Gögele, Martin, additional, Goodarzi, Mark O, additional, Graff, Mariaelisa, additional, Granot-Hershkovitz, Einat, additional, Grodstein, Francine, additional, Guarrera, Simonetta, additional, Gudbjartsson, Daniel F, additional, Guity, Kamran, additional, Gunnarsson, Bjarni, additional, Guo, Yu, additional, Hagenaars, Saskia P, additional, Haiman, Christopher A, additional, Halevy, Avner, additional, Harris, Tamara B, additional, Hedayati, Mehdi, additional, van Heel, David A, additional, Hirata, Makoto, additional, Höfer, Imo, additional, Hsiung, Chao Agnes, additional, Huang, Jinyan, additional, Hung, Yi-Jen, additional, Ikram, M Arfan, additional, Jagadeesan, Anuradha, additional, Jousilahti, Pekka, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Kerrison, Nicola D, additional, Kessler, Thorsten, additional, Khaw, Kay-Tee, additional, Khor, Chiea Chuen, additional, de Kleijn, Dominique P V, additional, Koh, Woon-Puay, additional, Kolcic, Ivana, additional, Kraft, Peter, additional, Krämer, Bernhard K, additional, Kutalik, Zoltán, additional, Kuusisto, Johanna, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lawlor, Deborah A, additional, Lee, I-Te, additional, Lee, Wen-Jane, additional, Lerch, Markus M, additional, Li, Liming, additional, Liu, Jianjun, additional, Loh, Marie, additional, London, Stephanie J, additional, Loomis, Stephanie, additional, Lu, Yingchang, additional, Luan, Jian’an, additional, Mägi, Reedik, additional, Manichaikul, Ani W, additional, Manunta, Paolo, additional, Másson, Gísli, additional, Matoba, Nana, additional, Mei, Xue W, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Milani, Lili, additional, Millwood, Iona Y, additional, Momozawa, Yukihide, additional, Moore, Amy, additional, Morange, Pierre-Emmanuel, additional, Moreno-Macías, Hortensia, additional, Mori, Trevor A, additional, Morrison, Alanna C, additional, Muka, Taulant, additional, Murakami, Yoshinori, additional, Murray, Alison D, additional, de Mutsert, Renée, additional, Mychaleckyj, Josyf C, additional, Nalls, Mike A, additional, Nauck, Matthias, additional, Neville, Matt J, additional, Nolte, Ilja M, additional, Ong, Ken K, additional, Orozco, Lorena, additional, Padmanabhan, Sandosh, additional, Pálsson, Gunnar, additional, Pankow, James S, additional, Pattaro, Cristian, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Poulter, Neil, additional, Pramstaller, Peter P, additional, Quintana-Murci, Lluis, additional, Räikkönen, Katri, additional, Ralhan, Sarju, additional, Rao, Dabeeru C, additional, van Rheenen, Wouter, additional, Rich, Stephen S, additional, Ridker, Paul M, additional, Rietveld, Cornelius A, additional, Robino, Antonietta, additional, van Rooij, Frank J A, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sabanayagam, Charumathi, additional, Sabater-Lleal, Maria, additional, Sala, Cinzia Felicita, additional, Salomaa, Veikko, additional, Sandow, Kevin, additional, Schmidt, Helena, additional, Scott, Laura J, additional, Scott, William R, additional, Sedaghati-Khayat, Bahareh, additional, Sennblad, Bengt, additional, van Setten, Jessica, additional, Sever, Peter J, additional, Sheu, Wayne H-H, additional, Shi, Yuan, additional, Shrestha, Smeeta, additional, Shukla, Sharvari Rahul, additional, Sigurdsson, Jon K, additional, Sikka, Timo Tonis, additional, Singh, Jai Rup, additional, Smith, Blair H, additional, Stančáková, Alena, additional, Stanton, Alice, additional, Starr, John M, additional, Stefansdottir, Lilja, additional, Straker, Leon, additional, Sulem, Patrick, additional, Sveinbjornsson, Gardar, additional, Swertz, Morris A, additional, Taylor, Adele M, additional, Taylor, Kent D, additional, Terzikhan, Natalie, additional, Tham, Yih-Chung, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tillander, Annika, additional, Tracy, Russell P, additional, Tusié-Luna, Teresa, additional, Tzoulaki, Ioanna, additional, Vaccargiu, Simona, additional, Vangipurapu, Jagadish, additional, Veldink, Jan H, additional, Vitart, Veronique, additional, Völker, Uwe, additional, Vuoksimaa, Eero, additional, Wakil, Salma M, additional, Waldenberger, Melanie, additional, Wander, Gurpreet S, additional, Wang, Ya Xing, additional, Wareham, Nicholas J, additional, Wild, Sarah, additional, Yajnik, Chittaranjan S, additional, Yuan, Jian-Min, additional, Zeng, Lingyao, additional, Zhang, Liang, additional, Zhou, Jie, additional, Amin, Najaf, additional, Asselbergs, Folkert W, additional, Bakker, Stephan J L, additional, Becker, Diane M, additional, Lehne, Benjamin, additional, Bennett, David A, additional, van den Berg, Leonard H, additional, Berndt, Sonja I, additional, Bharadwaj, Dwaipayan, additional, Bielak, Lawrence F, additional, Bochud, Murielle, additional, Boehnke, Mike, additional, Bouchard, Claude, additional, Bradfield, Jonathan P, additional, Brody, Jennifer A, additional, Campbell, Archie, additional, Carmi, Shai, additional, Caulfield, Mark J, additional, Cesarini, David, additional, Chambers, John C, additional, Chandak, Giriraj Ratan, additional, Cheng, Ching-Yu, additional, Ciullo, Marina, additional, Cornelis, Marilyn, additional, Cusi, Daniele, additional, Smith, George Davey, additional, Deary, Ian J, additional, Dorajoo, Rajkumar, additional, van Duijn, Cornelia M, additional, Ellinghaus, David, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Evangelou, Evangelos, additional, Evans, Michele K, additional, Faul, Jessica D, additional, Feenstra, Bjarke, additional, Feitosa, Mary, additional, Foisy, Sylvain, additional, Franke, Andre, additional, Friedlander, Yechiel, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Gonzalez, Clicerio, additional, Goyette, Philippe, additional, Grant, Struan F A, additional, Griffiths, Lyn R, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hakonarson, Hakon, additional, Hamsten, Anders, additional, van der Harst, Pim, additional, Heng, Chew-Kiat, additional, Hicks, Andrew A, additional, Hochner, Hagit, additional, Huikuri, Heikki, additional, Hunt, Steven C, additional, Jaddoe, Vincent W V, additional, De Jager, Philip L, additional, Johannesson, Magnus, additional, Johansson, Åsa, additional, Jonas, Jost B, additional, Jukema, J Wouter, additional, Junttila, Juhani, additional, Kaprio, Jaakko, additional, Kardia, Sharon L. R., additional, Karpe, Fredrik, additional, Kumari, Meena, additional, Laakso, Markku, additional, van der Laan, Sander W, additional, Lahti, Jari, additional, Laudes, Matthias, additional, Lea, Rodney A, additional, Lieb, Wolfgang, additional, Lumley, Thomas, additional, Martin, Nicholas G, additional, März, Winfried, additional, Matullo, Giuseppe, additional, McCarthy, Mark I, additional, Medland, Sarah E, additional, Merriman, Tony R, additional, Metspalu, Andres, additional, Meyer, Brian F, additional, Mohlke, Karen L, additional, Montgomery, Grant W, additional, Mook-Kanamori, Dennis, additional, Munroe, Patricia B, additional, North, Kari E, additional, Nyholt, Dale R, additional, O’connell, Jeffery R, additional, Ober, Carole, additional, Oldehinkel, Albertine J, additional, Palmas, Walter, additional, Palmer, Colin, additional, Pasterkamp, Gerard G, additional, Patin, Etienne, additional, Pennell, Craig E, additional, Perusse, Louis, additional, Peyser, Patricia A, additional, Pirastu, Mario, additional, Polderman, Tinca J. C., additional, Porteous, David J, additional, Posthuma, Danielle, additional, Psaty, Bruce M, additional, Rioux, John D, additional, Rivadeneira, Fernando, additional, Rotimi, Charles, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Den Ruijter, Hester M, additional, Sanghera, Dharambir K, additional, Sattar, Naveed, additional, Schmidt, Reinhold, additional, Schulze, Matthias B, additional, Schunkert, Heribert, additional, Scott, Robert A, additional, Shuldiner, Alan R, additional, Sim, Xueling, additional, Small, Neil, additional, Smith, Jennifer A, additional, Sotoodehnia, Nona, additional, Tai, E-Shyong, additional, Teumer, Alexander, additional, Timpson, Nicholas J, additional, Toniolo, Daniela, additional, Tregouet, David-Alexandre, additional, Tuomi, Tiinamaija, additional, Vollenweider, Peter, additional, Wang, Carol A, additional, Weir, David R, additional, Whitfield, John B, additional, Wijmenga, Cisca, additional, Wong, Tien-Yin, additional, Wright, John, additional, Yang, Jingyun, additional, Yu, Lei, additional, Zemel, Babette S, additional, Zonderman, Alan B, additional, Perola, Markus, additional, Magnusson, Patrik K. E., additional, Uitterlinden, André G, additional, Kooner, Jaspal S, additional, Chasman, Daniel I, additional, Loos, Ruth J. F., additional, Franceschini, Nora, additional, Franke, Lude, additional, Haley, Chris S, additional, Hayward, Caroline, additional, Walters, Robin G, additional, Perry, John R. B., additional, Esko, Tōnu, additional, Helgason, Agnar, additional, Stefansson, Kari, additional, Joshi, Peter K, additional, Kubo, Michiaki, additional, and Wilson, James F, additional
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- 2019
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7. Genetic correlations of polygenic disease traits: from theory to practice
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van Rheenen, Wouter, primary, Peyrot, Wouter J., additional, Schork, Andrew J., additional, Lee, S. Hong, additional, and Wray, Naomi R., additional
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- 2019
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8. Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
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Lees, John A., primary, Ferwerda, Bart, additional, Kremer, Philip H. C., additional, Wheeler, Nicole E., additional, Serón, Mercedes Valls, additional, Croucher, Nicholas J., additional, Gladstone, Rebecca A., additional, Bootsma, Hester J., additional, Rots, Nynke Y., additional, Wijmega-Monsuur, Alienke J., additional, Sanders, Elisabeth A. M., additional, Trzciński, Krzysztof, additional, Wyllie, Anne L., additional, Zwinderman, Aeilko H., additional, van den Berg, Leonard H., additional, van Rheenen, Wouter, additional, Veldink, Jan H., additional, Harboe, Zitta B., additional, Lundbo, Lene F., additional, de Groot, Lisette C. P. G. M., additional, van Schoor, Natasja M., additional, van der Velde, Nathalie, additional, Ängquist, Lars H., additional, Sørensen, Thorkild I. A., additional, Nohr, Ellen A., additional, Mentzer, Alexander J., additional, Mills, Tara C., additional, Knight, Julian C., additional, du Plessis, Mignon, additional, Nzenze, Susan, additional, Weiser, Jeffrey N., additional, Parkhill, Julian, additional, Madhi, Shabir, additional, Benfield, Thomas, additional, von Gottberg, Anne, additional, van der Ende, Arie, additional, Brouwer, Matthijs C., additional, Barrett, Jeffrey C., additional, Bentley, Stephen D., additional, and van de Beek, Diederik, additional
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- 2019
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9. Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis
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Dekker, Annelot M., primary, Diekstra, Frank P., additional, Pulit, Sara L., additional, Tazelaar, Gijs H. P., additional, van der Spek, Rick A., additional, van Rheenen, Wouter, additional, van Eijk, Kristel R., additional, Calvo, Andrea, additional, Brunetti, Maura, additional, Damme, Philip Van, additional, Robberecht, Wim, additional, Hardiman, Orla, additional, McLaughlin, Russell, additional, Chiò, Adriano, additional, Sendtner, Michael, additional, Ludolph, Albert C., additional, Weishaupt, Jochen H., additional, Pardina, Jesus S. Mora, additional, van den Berg, Leonard H., additional, and Veldink, Jan H., additional
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- 2019
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10. Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis
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Benyamin, Beben, primary, He, Ji, additional, Zhao, Qiongyi, additional, Gratten, Jacob, additional, Garton, Fleur, additional, Leo, Paul J., additional, Liu, Zhijun, additional, Mangelsdorf, Marie, additional, Al-Chalabi, Ammar, additional, Anderson, Lisa, additional, Butler, Timothy J., additional, Chen, Lu, additional, Chen, Xiang-Ding, additional, Cremin, Katie, additional, Deng, Hong-Weng, additional, Devine, Matthew, additional, Edson, Janette, additional, Fifita, Jennifer A., additional, Furlong, Sarah, additional, Han, Ying-Ying, additional, Harris, Jessica, additional, Henders, Anjali K., additional, Jeffree, Rosalind L., additional, Jin, Zi-Bing, additional, Li, Zhongshan, additional, Li, Ting, additional, Li, Mengmeng, additional, Lin, Yong, additional, Liu, Xiaolu, additional, Marshall, Mhairi, additional, McCann, Emily P., additional, Mowry, Bryan J., additional, Ngo, Shyuan T., additional, Pamphlett, Roger, additional, Ran, Shu, additional, Reutens, David C., additional, Rowe, Dominic B., additional, Sachdev, Perminder, additional, Shah, Sonia, additional, Song, Sharon, additional, Tan, Li-Jun, additional, Tang, Lu, additional, van den Berg, Leonard H., additional, van Rheenen, Wouter, additional, Veldink, Jan H., additional, Wallace, Robyn H., additional, Wheeler, Lawrie, additional, Williams, Kelly L., additional, Wu, Jinyu, additional, Wu, Xin, additional, Yang, Jian, additional, Yue, Weihua, additional, Zhang, Zong-Hong, additional, Zhang, Dai, additional, Noakes, Peter G., additional, Blair, Ian P., additional, Henderson, Robert D., additional, McCombe, Pamela A., additional, Visscher, Peter M., additional, Xu, Huji, additional, Bartlett, Perry F., additional, Brown, Matthew A., additional, Wray, Naomi R., additional, and Fan, Dongsheng, additional
- Published
- 2017
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11. No association between gluten sensitivity and amyotrophic lateral sclerosis
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Visser, Anne E., primary, Pazoki, Raha, additional, Pulit, Sara L., additional, van Rheenen, Wouter, additional, Raaphorst, Joost, additional, van der Kooi, Anneke J., additional, Ricaño-Ponce, Isis, additional, Wijmenga, Cisca, additional, Otten, Henny G., additional, Veldink, Jan H., additional, and van den Berg, Leonard H., additional
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- 2017
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12. Genomic signals of migration and continuity in Britain before the Anglo-Saxons
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Martiniano, Rui, primary, Caffell, Anwen, additional, Holst, Malin, additional, Hunter-Mann, Kurt, additional, Montgomery, Janet, additional, Müldner, Gundula, additional, McLaughlin, Russell L., additional, Teasdale, Matthew D., additional, van Rheenen, Wouter, additional, Veldink, Jan H., additional, van den Berg, Leonard H., additional, Hardiman, Orla, additional, Carroll, Maureen, additional, Roskams, Steve, additional, Oxley, John, additional, Morgan, Colleen, additional, Thomas, Mark G., additional, Barnes, Ian, additional, McDonnell, Christine, additional, Collins, Matthew J., additional, and Bradley, Daniel G., additional
- Published
- 2016
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13. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis
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El Oussini, Hajer, primary, Bayer, Hanna, additional, Scekic-Zahirovic, Jelena, additional, Vercruysse, Pauline, additional, Sinniger, Jérôme, additional, Dirrig-Grosch, Sylvie, additional, Dieterlé, Stéphane, additional, Echaniz-Laguna, Andoni, additional, Larmet, Yves, additional, Müller, Kathrin, additional, Weishaupt, Jochen H., additional, Thal, Dietmar R., additional, van Rheenen, Wouter, additional, van Eijk, Kristel, additional, Lawson, Roland, additional, Monassier, Laurent, additional, Maroteaux, Luc, additional, Roumier, Anne, additional, Wong, Philip C., additional, van den Berg, Leonard H., additional, Ludolph, Albert C., additional, Veldink, Jan H., additional, Witting, Anke, additional, and Dupuis, Luc, additional
- Published
- 2016
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14. Population genetic differentiation of height and body mass index across Europe
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Robinson, Matthew R, primary, Hemani, Gibran, additional, Medina-Gomez, Carolina, additional, Mezzavilla, Massimo, additional, Esko, Tonu, additional, Shakhbazov, Konstantin, additional, Powell, Joseph E, additional, Vinkhuyzen, Anna, additional, Berndt, Sonja I, additional, Gustafsson, Stefan, additional, Justice, Anne E, additional, Kahali, Bratati, additional, Locke, Adam E, additional, Pers, Tune H, additional, Vedantam, Sailaja, additional, Wood, Andrew R, additional, van Rheenen, Wouter, additional, Andreassen, Ole A, additional, Gasparini, Paolo, additional, Metspalu, Andres, additional, Berg, Leonard H van den, additional, Veldink, Jan H, additional, Rivadeneira, Fernando, additional, Werge, Thomas M, additional, Abecasis, Goncalo R, additional, Boomsma, Dorret I, additional, Chasman, Daniel I, additional, de Geus, Eco J C, additional, Frayling, Timothy M, additional, Hirschhorn, Joel N, additional, Hottenga, Jouke Jan, additional, Ingelsson, Erik, additional, Loos, Ruth J F, additional, Magnusson, Patrik K E, additional, Martin, Nicholas G, additional, Montgomery, Grant W, additional, North, Kari E, additional, Pedersen, Nancy L, additional, Spector, Timothy D, additional, Speliotes, Elizabeth K, additional, Goddard, Michael E, additional, Yang, Jian, additional, and Visscher, Peter M, additional
- Published
- 2015
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- View/download PDF
15. Associations of autozygosity with a broad range of human phenotypes
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Clark, David W, Okada, Yukinori, Moore, Kristjan HS, Mason, Dan, Pirastu, Nicola, Gandin, Ilaria, Mattsson, Hannele, Barnes, Catriona LK, Lin, Kuang, Zhao, Jing Hua, Deelen, Patrick, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M, Baumbach, Clemens, Biino, Ginevra, Bixley, Matthew J, Brumat, Marco, Chai, Jin-Fang, Corre, Tanguy, Cousminer, Diana L, Dekker, Annelot M, Eccles, David A, Van Eijk, Kristel R, Fuchsberger, Christian, Gao, He, Germain, Marine, Gordon, Scott D, De Haan, Hugoline G, Harris, Sarah E, Hofer, Edith, Huerta-Chagoya, Alicia, Igartua, Catherine, Jansen, Iris E, Jia, Yucheng, Kacprowski, Tim, Karlsson, Torgny, Kleber, Marcus E, Li, Shengchao Alfred, Li-Gao, Ruifang, Mahajan, Anubha, Matsuda, Koichi, Meidtner, Karina, Meng, Weihua, Montasser, May E, Van Der Most, Peter J, Munz, Matthias, Nutile, Teresa, Palviainen, Teemu, Prasad, Gauri, Prasad, Rashmi B, Priyanka, Tallapragada Divya Sri, Rizzi, Federica, Salvi, Erika, Sapkota, Bishwa R, Shriner, Daniel, Skotte, Line, Smart, Melissa C, Smith, Albert Vernon, Van Der Spek, Ashley, Spracklen, Cassandra N, Strawbridge, Rona J, Tajuddin, Salman M, Trompet, Stella, Turman, Constance, Verweij, Niek, Viberti, Clara, Wang, Lihua, Warren, Helen R, Wootton, Robyn E, Yanek, Lisa R, Yao, Jie, Yousri, Noha A, Zhao, Wei, Adeyemo, Adebowale A, Afaq, Saima, Aguilar-Salinas, Carlos Alberto, Akiyama, Masato, Albert, Matthew L, Allison, Matthew A, Alver, Maris, Aung, Tin, Azizi, Fereidoun, Bentley, Amy R, Boeing, Heiner, Boerwinkle, Eric, Borja, Judith B, De Borst, Gert J, Bottinger, Erwin P, Broer, Linda, Campbell, Harry, Chanock, Stephen, Chee, Miao-Li, Chen, Guanjie, Chen, Yii-Der I, Chen, Zhengming, Chiu, Yen-Feng, Cocca, Massimiliano, Collins, Francis S, Concas, Maria Pina, Corley, Janie, Cugliari, Giovanni, Van Dam, Rob M, Damulina, Anna, Daneshpour, Maryam S, Day, Felix R, Delgado, Graciela E, Dhana, Klodian, Doney, Alexander SF, Dörr, Marcus, Doumatey, Ayo P, Dzimiri, Nduna, Ebenesersdóttir, S Sunna, Elliott, Joshua, Elliott, Paul, Ewert, Ralf, Felix, Janine F, Fischer, Krista, Freedman, Barry I, Girotto, Giorgia, Goel, Anuj, Gögele, Martin, Goodarzi, Mark O, Graff, Mariaelisa, Granot-Hershkovitz, Einat, Grodstein, Francine, Guarrera, Simonetta, Gudbjartsson, Daniel F, Guity, Kamran, Gunnarsson, Bjarni, Guo, Yu, Hagenaars, Saskia P, Haiman, Christopher A, Halevy, Avner, Harris, Tamara B, Hedayati, Mehdi, Van Heel, David A, Hirata, Makoto, Höfer, Imo, Hsiung, Chao Agnes, Huang, Jinyan, Hung, Yi-Jen, Ikram, M Arfan, Jagadeesan, Anuradha, Jousilahti, Pekka, Kamatani, Yoichiro, Kanai, Masahiro, Kerrison, Nicola D, Kessler, Thorsten, Khaw, Kay-Tee, Khor, Chiea Chuen, De Kleijn, Dominique PV, Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter, Krämer, Bernhard K, Kutalik, Zoltán, Kuusisto, Johanna, Langenberg, Claudia, Launer, Lenore J, Lawlor, Deborah A, Lee, I-Te, Lee, Wen-Jane, Lerch, Markus M, Li, Liming, Liu, Jianjun, Loh, Marie, London, Stephanie J, Loomis, Stephanie, Lu, Yingchang, Luan, Jian'an, Mägi, Reedik, Manichaikul, Ani W, Manunta, Paolo, Másson, Gísli, Matoba, Nana, Mei, Xue W, Meisinger, Christa, Meitinger, Thomas, Mezzavilla, Massimo, Milani, Lili, Millwood, Iona Y, Momozawa, Yukihide, Moore, Amy, Morange, Pierre-Emmanuel, Moreno-Macías, Hortensia, Mori, Trevor A, Morrison, Alanna C, Muka, Taulant, Murakami, Yoshinori, Murray, Alison D, De Mutsert, Renée, Mychaleckyj, Josyf C, Nalls, Mike A, Nauck, Matthias, Neville, Matt J, Nolte, Ilja M, Ong, Ken K, Orozco, Lorena, Padmanabhan, Sandosh, Pálsson, Gunnar, Pankow, James S, Pattaro, Cristian, Pattie, Alison, Polasek, Ozren, Poulter, Neil, Pramstaller, Peter P, Quintana-Murci, Lluis, Räikkönen, Katri, Ralhan, Sarju, Rao, Dabeeru C, Van Rheenen, Wouter, Rich, Stephen S, Ridker, Paul M, Rietveld, Cornelius A, Robino, Antonietta, Van Rooij, Frank JA, Ruggiero, Daniela, Saba, Yasaman, Sabanayagam, Charumathi, Sabater-Lleal, Maria, Sala, Cinzia Felicita, Salomaa, Veikko, Sandow, Kevin, Schmidt, Helena, Scott, Laura J, Scott, William R, Sedaghati-Khayat, Bahareh, Sennblad, Bengt, Van Setten, Jessica, Sever, Peter J, Sheu, Wayne H-H, Shi, Yuan, Shrestha, Smeeta, Shukla, Sharvari Rahul, Sigurdsson, Jon K, Sikka, Timo Tonis, Singh, Jai Rup, Smith, Blair H, Stančáková, Alena, Stanton, Alice, Starr, John M, Stefansdottir, Lilja, Straker, Leon, Sulem, Patrick, Sveinbjornsson, Gardar, Swertz, Morris A, Taylor, Adele M, Taylor, Kent D, Terzikhan, Natalie, Tham, Yih-Chung, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tillander, Annika, Tracy, Russell P, Tusié-Luna, Teresa, Tzoulaki, Ioanna, Vaccargiu, Simona, Vangipurapu, Jagadish, Veldink, Jan H, Vitart, Veronique, Völker, Uwe, Vuoksimaa, Eero, Wakil, Salma M, Waldenberger, Melanie, Wander, Gurpreet S, Wang, Ya Xing, Wareham, Nicholas J, Wild, Sarah, Yajnik, Chittaranjan S, Yuan, Jian-Min, Zeng, Lingyao, Zhang, Liang, Zhou, Jie, Amin, Najaf, Asselbergs, Folkert W, Bakker, Stephan JL, Becker, Diane M, Lehne, Benjamin, Bennett, David A, Van Den Berg, Leonard H, Berndt, Sonja I, Bharadwaj, Dwaipayan, Bielak, Lawrence F, Bochud, Murielle, Boehnke, Mike, Bouchard, Claude, Bradfield, Jonathan P, Brody, Jennifer A, Campbell, Archie, Carmi, Shai, Caulfield, Mark J, Cesarini, David, Chambers, John C, Chandak, Giriraj Ratan, Cheng, Ching-Yu, Ciullo, Marina, Cornelis, Marilyn, Cusi, Daniele, Smith, George Davey, Deary, Ian J, Dorajoo, Rajkumar, Van Duijn, Cornelia M, Ellinghaus, David, Erdmann, Jeanette, Eriksson, Johan G, Evangelou, Evangelos, Evans, Michele K, Faul, Jessica D, Feenstra, Bjarke, Feitosa, Mary, Foisy, Sylvain, Franke, Andre, Friedlander, Yechiel, Gasparini, Paolo, Gieger, Christian, Gonzalez, Clicerio, Goyette, Philippe, Grant, Struan FA, Griffiths, Lyn R, Groop, Leif, Gudnason, Vilmundur, Gyllensten, Ulf, Hakonarson, Hakon, Hamsten, Anders, Van Der Harst, Pim, Heng, Chew-Kiat, Hicks, Andrew A, Hochner, Hagit, Huikuri, Heikki, Hunt, Steven C, Jaddoe, Vincent WV, De Jager, Philip L, Johannesson, Magnus, Johansson, Åsa, Jonas, Jost B, Jukema, J Wouter, Junttila, Juhani, Kaprio, Jaakko, Kardia, Sharon LR, Karpe, Fredrik, Kumari, Meena, Laakso, Markku, Van Der Laan, Sander W, Lahti, Jari, Laudes, Matthias, Lea, Rodney A, Lieb, Wolfgang, Lumley, Thomas, Martin, Nicholas G, März, Winfried, Matullo, Giuseppe, McCarthy, Mark I, Medland, Sarah E, Merriman, Tony R, Metspalu, Andres, Meyer, Brian F, Mohlke, Karen L, Montgomery, Grant W, Mook-Kanamori, Dennis, Munroe, Patricia B, North, Kari E, Nyholt, Dale R, O'connell, Jeffery R, Ober, Carole, Oldehinkel, Albertine J, Palmas, Walter, Palmer, Colin, Pasterkamp, Gerard G, Patin, Etienne, Pennell, Craig E, Perusse, Louis, Peyser, Patricia A, Pirastu, Mario, Polderman, Tinca JC, Porteous, David J, Posthuma, Danielle, Psaty, Bruce M, Rioux, John D, Rivadeneira, Fernando, Rotimi, Charles, Rotter, Jerome I, Rudan, Igor, Den Ruijter, Hester M, Sanghera, Dharambir K, Sattar, Naveed, Schmidt, Reinhold, Schulze, Matthias B, Schunkert, Heribert, Scott, Robert A, Shuldiner, Alan R, Sim, Xueling, Small, Neil, Smith, Jennifer A, Sotoodehnia, Nona, Tai, E-Shyong, Teumer, Alexander, Timpson, Nicholas J, Toniolo, Daniela, Tregouet, David-Alexandre, Tuomi, Tiinamaija, Vollenweider, Peter, Wang, Carol A, Weir, David R, Whitfield, John B, Wijmenga, Cisca, Wong, Tien-Yin, Wright, John, Yang, Jingyun, Yu, Lei, Zemel, Babette S, Zonderman, Alan B, Perola, Markus, Magnusson, Patrik KE, Uitterlinden, André G, Kooner, Jaspal S, Chasman, Daniel I, Loos, Ruth JF, Franceschini, Nora, Franke, Lude, Haley, Chris S, Hayward, Caroline, Walters, Robin G, Perry, John RB, Esko, Tōnu, Helgason, Agnar, Stefansson, Kari, Joshi, Peter K, Kubo, Michiaki, and Wilson, James F
- Subjects
Consanguinity ,Cognition ,Fertility ,Inbreeding Depression ,Risk-Taking ,Haplotypes ,Health Status ,Homozygote ,Body Size ,Humans ,Alleles ,3. Good health - Abstract
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
16. Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
- Author
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Lees, John A, Ferwerda, Bart, Kremer, Philip HC, Wheeler, Nicole E, Serón, Mercedes Valls, Croucher, Nicholas J, Gladstone, Rebecca A, Bootsma, Hester J, Rots, Nynke Y, Wijmega-Monsuur, Alienke J, Sanders, Elisabeth AM, Trzciński, Krzysztof, Wyllie, Anne L, Zwinderman, Aeilko H, Van Den Berg, Leonard H, Van Rheenen, Wouter, Veldink, Jan H, Harboe, Zitta B, Lundbo, Lene F, De Groot, Lisette CPGM, Van Schoor, Natasja M, Van Der Velde, Nathalie, Ängquist, Lars H, Sørensen, Thorkild IA, Nohr, Ellen A, Mentzer, Alexander J, Mills, Tara C, Knight, Julian C, Du Plessis, Mignon, Nzenze, Susan, Weiser, Jeffrey N, Parkhill, Julian, Madhi, Shabir, Benfield, Thomas, Von Gottberg, Anne, Van Der Ende, Arie, Brouwer, Matthijs C, Barrett, Jeffrey C, Bentley, Stephen D, and Van De Beek, Diederik
- Subjects
Adult ,Male ,Genome, Human ,Meningitis, Pneumococcal ,Genetic Variation ,Proteins ,Middle Aged ,3. Good health ,Streptococcus pneumoniae ,Bacterial Proteins ,Host-Pathogen Interactions ,Humans ,Female ,Genetic Predisposition to Disease ,Prospective Studies ,Genome, Bacterial ,Aged ,Genome-Wide Association Study - Abstract
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, identifying variants in CCDC33 associated with susceptibility. Pneumococcal genetic variation explains a large amount of invasive potential (70%), but has no effect on severity. Serotype alone is insufficient to explain invasiveness, suggesting other pneumococcal factors are involved in progression to invasive disease. We identify pneumococcal genes involved in invasiveness including pspC and zmpD, and perform a human-bacteria interaction analysis. These genes are potential candidates for the development of more broadly-acting pneumococcal vaccines.
17. Genetic correlations of polygenic disease traits: from theory to practice
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Andrew J. Schork, S. Hong Lee, Naomi R. Wray, Wouter J. Peyrot, Wouter van Rheenen, van Rheenen, Wouter, Peyrot, Wouter J, Schork, Andrew J, Lee, S Hong, and Wray, Naomi R
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0303 health sciences ,psychiatric diseases ,Genome-wide association study ,Genetic relationship ,Disease ,Biology ,Causality ,Genetic correlation ,03 medical and health sciences ,0302 clinical medicine ,Evolutionary biology ,Genetics ,Trait ,Multifactorial Inheritance ,therapeutic interventions ,Molecular Biology ,030217 neurology & neurosurgery ,Genetics (clinical) ,genetic correlations ,030304 developmental biology ,Genetic association - Abstract
The genetic correlation describes the genetic relationship between two traits and can contribute to a better understanding of the shared biological pathways and/or the causality relationships between them. The rarity of large family cohorts with recorded instances of two traits, particularly disease traits, has made it difficult to estimate genetic correlations using traditional epidemiological approaches. However, advances in genomic methodologies, such as genome-wide association studies, and widespread sharing of data now allow genetic correlations to be estimated for virtually any trait pair. Here, we review the definition, estimation, interpretation and uses of genetic correlations, with a focus on applications to human disease Refereed/Peer-reviewed
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- 2019
- Full Text
- View/download PDF
18. Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
- Author
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Anne von Gottberg, Jan H. Veldink, Wouter van Rheenen, Nynke Y. Rots, Lars Ängquist, Anne L. Wyllie, Lisette C. P. G. M. de Groot, Hester J. Bootsma, Ellen A. Nohr, Lene Fogt Lundbo, Rebecca A. Gladstone, Susan A. Nzenze, Thomas Benfield, Aeilko H. Zwinderman, Julian C. Knight, Jeffrey N. Weiser, Krzysztof Trzciński, Nicholas J. Croucher, Shabir Madhi, Mignon du Plessis, Thorkild I. A. Sørensen, Tara C. Mills, Bart Ferwerda, Elisabeth A. M. Sanders, Nicole E. Wheeler, Diederik van de Beek, Philip H. C. Kremer, Jeffrey C. Barrett, Alexander J. Mentzer, Stephen D. Bentley, Matthijs C. Brouwer, Mercedes Valls Serón, Nathalie van der Velde, Alienke J. Wijmega-Monsuur, Leonard H. van den Berg, Arie van der Ende, Zitta Barrella Harboe, Natasja M. van Schoor, Julian Parkhill, John A. Lees, Lees, John A [0000-0001-5360-1254], Ferwerda, Bart [0000-0002-7050-5931], Croucher, Nicholas J [0000-0001-6303-8768], Zwinderman, Aeilko H [0000-0003-0361-3139], van Rheenen, Wouter [0000-0002-5860-1533], de Groot, Lisette CPGM [0000-0003-2778-2789], Sørensen, Thorkild IA [0000-0003-4821-430X], Mentzer, Alexander J [0000-0002-4502-2209], Knight, Julian C [0000-0002-0377-5536], du Plessis, Mignon [0000-0001-9186-0679], Weiser, Jeffrey N [0000-0001-7168-8090], Parkhill, Julian [0000-0002-7069-5958], Barrett, Jeffrey C [0000-0002-1152-370X], van de Beek, Diederik [0000-0002-4571-044X], Apollo - University of Cambridge Repository, Internal Medicine, Epidemiology and Data Science, Neurology, AII - Infectious diseases, ANS - Neuroinfection & -inflammation, Graduate School, APH - Methodology, Geriatrics, AMS - Ageing & Morbidty, APH - Aging & Later Life, and Medical Microbiology and Infection Prevention
- Subjects
0301 basic medicine ,Serotype ,Male ,General Physics and Astronomy ,Genome-wide association study ,02 engineering and technology ,medicine.disease_cause ,Genome ,0302 clinical medicine ,Prospective Studies ,lcsh:Science ,Pathogen ,Genetics ,0303 health sciences ,Multidisciplinary ,Meningitis, Pneumococcal ,Middle Aged ,021001 nanoscience & nanotechnology ,Nutritional Biology ,Host-Pathogen Interactions/genetics ,3. Good health ,Streptococcus pneumoniae ,Proteins/genetics ,Host-Pathogen Interactions ,Female ,0210 nano-technology ,Meningitis ,bacterial genes ,Adult ,Lineage (genetic) ,Meningitis, Pneumococcal/genetics ,Science ,Genomics ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,Bacterial Proteins ,Genetic variation ,medicine ,Life Science ,Humans ,Genetic Predisposition to Disease ,VLAG ,030304 developmental biology ,Streptococcus pneumoniae/genetics ,Aged ,Bacterial Proteins/genetics ,Genome, Human ,bacterial infection ,Genetic Variation ,Proteins ,General Chemistry ,Genome, Bacterial/genetics ,medicine.disease ,bacterial infections and mycoses ,immunogenetics ,030104 developmental biology ,Bacteremia ,Immunology ,genome-wide association studies ,Genome, Human/genetics ,lcsh:Q ,030217 neurology & neurosurgery ,Genome, Bacterial ,Genome-Wide Association Study - Abstract
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, identifying variants in CCDC33 associated with susceptibility. Pneumococcal genetic variation explains a large amount of invasive potential (70%), but has no effect on severity. Serotype alone is insufficient to explain invasiveness, suggesting other pneumococcal factors are involved in progression to invasive disease. We identify pneumococcal genes involved in invasiveness including pspC and zmpD, and perform a human-bacteria interaction analysis. These genes are potential candidates for the development of more broadly-acting pneumococcal vaccines., Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility.
- Published
- 2019
- Full Text
- View/download PDF
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