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12. The shape of breast cancer

Author

Byrd, Brook K., Krishnaswamy, Venkataramanan, Gui, Jiang, Rooney, Timothy, Zuurbier, Rebecca, Rosenkranz, Kari, Paulsen, Keith, and Barth, Jr, Richard J.

Published
2020
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21. Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study

Author

Konstantinides, Stavros V., Barco, Stefano, Rosenkranz, Stephan, Lankeit, Mareike, Held, Matthias, Gerhardt, Felix, Bruch, Leonard, Ewert, Ralf, Faehling, Martin, Freise, Julia, Ghofrani, Hossein-Ardeschir, Grünig, Ekkehard, Halank, Michael, Heydenreich, Nadine, Hoeper, Marius M., Leuchte, Hanno H., Mayer, Eckhard, Meyer, F. Joachim, Neurohr, Claus, Opitz, Christian, Pinto, Antonio, Seyfarth, Hans-Jürgen, Wachter, Rolf, Zäpf, Bianca, Wilkens, Heinrike, Binder, Harald, and Wild, Philipp S.

Published
2016
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26. Acute and Chronic Kidney Dysfunction and Outcome After Stroke Thrombectomy

Author

Thomas Gattringer, Simon Fandler-Höfler, Gerit Wünsch, Markus Beitzke, Birgit Poltrum, Markus Kneihsl, Balazs Odler, Christian Enzinger, Hannes Deutschmann, Melanie Haidegger, and Alexander R. Rosenkranz

Subjects
medicine.medical_specialty, Neurology, Endovascular therapy, Renal function, 030204 cardiovascular system & hematology, urologic and male genital diseases, Kidney, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Modified Rankin Scale, Risk Factors, Internal medicine, Chronic kidney disease, medicine, Humans, Stroke, Retrospective Studies, Thrombectomy, Ischemic stroke, business.industry, General Neuroscience, Endovascular Procedures, Acute kidney injury, Vascular surgery, medicine.disease, Treatment Outcome, Cohort, Original Article, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Mechanical thrombectomy, 030217 neurology & neurosurgery, Kidney disease, Glomerular Filtration Rate
Abstract

Data on the impact of kidney dysfunction on outcome in patients with stroke due to large vessel occlusion are scarce. The few available studies are limited by only considering single kidney parameters measured at one time point. We thus investigated the influence of both chronic kidney disease (CKD) and acute kidney injury (AKI) on outcome after mechanical thrombectomy. We included consecutive patients with anterior circulation large vessel occlusion stroke receiving mechanical thrombectomy at our center over an 8-year period. We extracted clinical data from a prospective registry and investigated kidney serum parameters at admission, the following day and throughout hospital stay. CKD and AKI were defined according to established nephrological criteria. Unfavorable outcome was defined as scores of 3–6 on the modified Rankin Scale 3 months post-stroke. Among 465 patients, 31.8% had an impaired estimated glomerular filtration rate (eGFR) at admission (2). Impaired admission eGFR was related to unfavorable outcome in univariable analysis (p = 0.003), but not after multivariable adjustment (p = 0.96). Patients frequently met AKI criteria at admission (24.5%), which was associated with unfavorable outcome in a multivariable model (OR 3.03, 95% CI 1.73–5.30, p p = 0.002 in multivariable analysis). While CKD was not associated with 3-month outcome, we identified AKI either at admission or throughout the hospital stay as an independent predictor of unfavorable prognosis in this study cohort. This finding warrants further investigation of kidney–brain crosstalk in the setting of acute stroke.

Published
2021

41. EURAMET.T-K7 Key Comparison of Water Triple-Point Cells

Author

Peruzzi, A., Bosma, R., Kerkhof, O., Rosenkranz, P., Del Campo Maldonado, M. D., Strnad, R., Nielsen, J., Anagnostou, M., Veliki, T., Zvizdic, D., Grudnewicz, E., Nedea, M., Neagu, D. M., Steur, P., Filipe, E., Lobo, I., Antonsen, I., Renaot, E., Heinonen, M., Weckstrom, T., Bojkovski, J., Turzo-Andras, E., Nemeth, S., White, M., Tegeler, E., Dobre, M., Duris, S., Kartal Dogan, A., Uytun, A., Augevicius, V., Pauzha, A., Pokhodun, A., and Simic, S.

Published
2011
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45. Intercomparison of the Realization of the ITS-90 at the Freezing Points of Al and Ag among European NMIs

Author

Heyer, D., Noatsch, U., Tegeler, E., Anagnostou, M., Turzo-Andras, E., Antonsen, I., Augevicius, V., Bojkovski, J., Bronnum, A., Chimenti, V., Duris, S., Filipe, E., Gaita, S., Gray, J., Head, D., Grudniewicz, E., Ivarsson, J., Kalemci, M., Kerkhof, O., Lobo, I., Nemeth, S., Pokhodun, A., Ranostaj, J., Renaot, E., Rosenkranz, P., Smid, M., Steur, P., Steiner, A., Valin, M., Veliki, T., and Weckström, T.

Published
2007
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48. Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study

Author

Christian Opitz, Harald Binder, Philipp S. Wild, Martin Faehling, Bianca Zäpf, Hanno Leuchte, Leonard Bruch, Mareike Lankeit, Ekkehard Grünig, Stephan Rosenkranz, Nadine Heydenreich, Hans-Jürgen Seyfarth, Stavros Konstantinides, Rolf Wachter, Felix Gerhardt, Michael Halank, Antonio Pinto, Julia Freise, Ralf Ewert, Claus Neurohr, Matthias Held, F. Joachim Meyer, Eckhard Mayer, Heinrike Wilkens, Stefano Barco, Marius M. Hoeper, and Hossein Ardeschir Ghofrani

Subjects
Quality of life, Male, medicine.medical_specialty, Pulmonary embolism, Chronic thromboembolic pulmonary hypertension, Functional impairment, Cohort study, Follow-up, Aftercare, 030204 cardiovascular system & hematology, Article, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Prospective Studies, Intensive care medicine, Prospective cohort study, Cause of death, business.industry, Sequela, Hematology, Guideline, medicine.disease, 3. Good health, Survival Rate, 030228 respiratory system, Acute Disease, Observational study, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Acute pulmonary embolism (PE) is a frequent cause of death and serious disability. The risk of PE-associated mortality and morbidity extends far beyond the acute phase of the disease. In earlier follow-up studies, as many as 30 % of the patients died during a follow-up period of up to 3 years, and up to 50 % of patients continued to complain of dyspnea and/or poor physical performance 6 months to 3 years after the index event. The most feared ‘late sequela’ of PE is chronic thromboembolic pulmonary hypertension (CTEPH), the true incidence of which remains obscure due to the large margin of error in the rates reported by mostly small, single-center studies. Moreover, the functional and hemodynamic changes corresponding to early, possibly reversible stages of CTEPH, have not been systematically investigated. The ongoing Follow-Up after acute pulmonary embolism (FOCUS) study will prospectively enroll and systematically follow, over a 2-year period and with a standardized comprehensive program of clinical, echocardiographic, functional and laboratory testing, a large multicenter prospective cohort of 1000 unselected patients (all-comers) with acute symptomatic PE. FOCUS will possess adequate power to provide answers to relevant remaining questions regarding the patients’ long-term morbidity and mortality, and the temporal pattern of post-PE abnormalities. It will hopefully provide evidence for future guideline recommendations regarding the selection of patients for long-term follow-up after PE, the modalities which this follow-up should include, and the findings that should be interpreted as indicating progressive functional and hemodynamic post-PE impairment, or the development of CTEPH. Electronic supplementary material The online version of this article (doi:10.1007/s11239-016-1415-7) contains supplementary material, which is available to authorized users.

Published
2016

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