1. Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
- Author
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Alice Gustavsen, Robert Rieben, Helge Skulstad, Frédéric Courivaud, Tom Eirik Mollnes, Miles A. Nunn, Anjan K. Bongoni, Alain Despont, Andreas Barratt-Due, Hugues Fontenelle, Helge Scott, Tor Inge Tønnessen, Søren Erik Pischke, Kjetil H. Egge, and Hilde Lang Orrem
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0301 basic medicine ,Cardiac function curve ,medicine.medical_specialty ,Physiology ,Sus scrofa ,Myocardial Infarction ,Complement ,Infarction ,Fluorescent Antibody Technique ,Ischemia/reperfusion ,Complement factor I ,Contractility ,Arthropod Proteins ,03 medical and health sciences ,Complement inhibitor ,Random Allocation ,Tissue Doppler echocardiography ,Internal medicine ,Physiology (medical) ,medicine ,Animals ,Myocardial infarction ,C5 ,VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 ,Complement component 5 ,business.industry ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750 ,VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 ,Complement C5 ,Original Contribution ,medicine.disease ,Magnetic Resonance Imaging ,3. Good health ,Disease Models, Animal ,030104 developmental biology ,Echocardiography ,LTB4 ,Cardiology ,Animal studies ,business ,Carrier Proteins ,Cardiology and Cardiovascular Medicine - Abstract
Source at: http://doi.org/10.1007/s00395-017-0610-9. Licensed CC BY-NC-ND 4.0. Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors were used in animal and clinical studies. Coversin (Ornithodoros moubata complement inhibitor, OmCI) blocks C5 cleavage and binds leukotriene B4 in humans and pigs. We hypothesized that inhibition of C5 before reperfusion will decrease infarct size and improve ventricular function in a porcine model of myocardial infarction. In pigs (sus scrofa), the left anterior descending coronary artery was occluded (40 min) and reperfused (240 min). Coversin or placebo was infused 20 min after occlusion and throughout reperfusion in 16 blindly randomized pigs. Coversin significantly reduced myocardial infarction in the area at risk by 39% (p=0.03, triphenyl tetrazolium chloride staining) and by 19% (p=0.02) using magnetic resonance imaging. The methods correlated significantly (R=0.92, p
- Published
- 2017
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