1. Synthesis of Cu (II) and Zn (II) Complexes of a Quinoline Based Flexible Amide Receptor as Fluorescent Probe for Dihydrogen Phosphate and Hydrogen Sulphate and Their Antibacterial Activity.
- Author
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Dey S, Ghosh S, Das A, Yadav RN, Chakrabarty R, Pradhan S, Saha D, Srivastava AK, and Hossain MF
- Subjects
- Sulfates chemistry, Sulfates pharmacology, Gram-Negative Bacteria drug effects, Molecular Structure, Copper chemistry, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Zinc chemistry, Fluorescent Dyes chemistry, Fluorescent Dyes chemical synthesis, Fluorescent Dyes pharmacology, Quinolines chemistry, Quinolines pharmacology, Quinolines chemical synthesis, Microbial Sensitivity Tests, Phosphates chemistry, Phosphates pharmacology, Amides chemistry, Amides pharmacology, Amides chemical synthesis, Coordination Complexes pharmacology, Coordination Complexes chemical synthesis, Coordination Complexes chemistry
- Abstract
A novel 8-hydroxy quinoline-derived amide receptor, in conjunction with its Cu (II) and Zn (II) complexes, has been strategically developed to function as remarkably efficient fluorescent receptors with a distinct capability for anion sensing. The comprehensive characterization of the synthesized compounds were achieved through UV-Vis, IR, NMR, and HRMS spectroscopic techniques. Among the Cu (II) and Zn (II) complexes, the latter exhibits superior selectivity for anions, specifically dihydrogen phosphate and hydrogen sulfate, as their tetrabutylammonium salts in a 9:1 acetonitrile-water (v/v) mixture. The Cu (II) complex demonstrates enhanced anion binding compared to the amide ligand, albeit with reduced selectivity. Furthermore, the affinity was evaluated using the Benesi-Hildebrand plot. The binding constants and Limit of Detection (LOD) for both complexes were precisely quantified. The Job plot illustrates a clear 1:1 binding interaction between the metal complexes and the guest anions. Significantly, both metal-complex receptors display a broad spectrum of antibacterial activity, against both gram-positive and gram-negative bacteria. It is worth highlighting that the Zn (II) complexed receptor outperforms the Cu (II) complexed receptor, as evidenced by its considerably lower Minimum Inhibitory Concentration (MIC) value against both bacterial strains., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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