1. Effects of acute n-hexane and 2,5-hexanedione treatment on the striatal dopaminergic system in mice.
- Author
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Masotto C, Bisiani C, Camisasca C, Fusi R, Ricciardi S, Fonzi N, Perbellini L, Scatturin M, Mariani CB, and Canesi M
- Subjects
- 3,4-Dihydroxyphenylacetic Acid metabolism, Animals, Corpus Striatum metabolism, Dopamine metabolism, Homovanillic Acid metabolism, Injections, Intraperitoneal, Male, Mice, Mice, Inbred ICR, Time Factors, Corpus Striatum drug effects, Dopamine physiology, Hexanes pharmacology, Hexanones pharmacology
- Abstract
In order to investigate the effect of n-hexane and its metabolites on the Central Nervous System (CNS), we treated mice with n-hexane and 2,5-hexanedione (2,5-HD) by intraperitoneal (i.p.) administration. Gascromatographic mass spectrometric (GCMS) analyses of striatum and cerebellum revealed a consistent increase of 2,5-HD concentration at 0.5 and 2 hours after treatment and a decline to baseline levels at 24 hours. Traces of 2,5-HD were detected in the brain of control animals. Biochemical analyses revealed a precocious, short lasting, significant increase of striatal dopamine (DA) and homovanillic acid (HVA) levels. A significant increase of striatal synaptosomal DA uptake, suggesting a DA releasing effect on the dopaminergic terminals, was also observed. These results support the hypothesis of a possible role of n-hexane and its metabolites in inducing parkinsonism in humans and animals.
- Published
- 1995