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Your search keyword '"Sato, Kazunori"' showing total 21 results
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21 results on '"Sato, Kazunori"'

20. Usefulness of 11C-methionine-positron emission tomography for the diagnosis of progressive multifocal leukoencephalopathy.

Author

Shirai S, Yabe I, Kano T, Shimizu Y, Sasamori T, Sato K, Hirotani M, Nonaka T, Takahashi I, Matsushima M, Minami N, Nakamichi K, Saijo M, Hatanaka KC, Shiga T, Tanaka S, and Sasaki H

Subjects
Aged, Aged, 80 and over, Antimalarials therapeutic use, Brain diagnostic imaging, Brain pathology, Disease Progression, Female, Fluorodeoxyglucose F18, Humans, JC Virus pathogenicity, Leukoencephalopathy, Progressive Multifocal diagnosis, Leukoencephalopathy, Progressive Multifocal drug therapy, Leukoencephalopathy, Progressive Multifocal pathology, Leukoencephalopathy, Progressive Multifocal virology, Male, Mefloquine therapeutic use, Middle Aged, Prognosis, Treatment Outcome, Brain metabolism, Early Diagnosis, Leukoencephalopathy, Progressive Multifocal diagnostic imaging, Leukoencephalopathy, Progressive Multifocal metabolism, Methionine, Positron-Emission Tomography
Abstract

Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating disease of the brain caused by the JC virus that occurs mainly in immunocompromised patients. The prognosis is very poor. As the lesion looks like non- specific leukoencephalopathy, making a diagnosis at the early stage is very difficult. We report three PML cases in which there was a mismatch between (11)C-methionine-positron emission tomography (MET-PET) uptake and (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) uptake. All three cases demonstrated the hyper-uptake of MET around the white matter lesions and hypo-uptake of FDG inside the lesions. We speculate that the infection had ended inside the white matter lesions of these patients, while JC virus infection was ongoing around the lesions, resulting in the increase of methionine metabolism, and the glucose metabolism was reduced or intermediate because inflammatory cells infiltrate PML lesions rarely. Two patients who were diagnosed and treated with mefloquine while the JC virus was at a low level in the cerebrospinal fluid are still alive. We suggest the usefulness of MET-PET for the early diagnosis of PML and early treatment with mefloquine.

Published
2014
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21. Baló's concentric sclerosislike lesion in the brainstem of a multiple sclerosis patient.

Author

Kishimoto R, Yabe I, Niino M, Sato K, Tsuji S, Kikuchi S, and Sasaki H

Subjects
Anti-Inflammatory Agents therapeutic use, Ataxia etiology, Ataxia physiopathology, Brain Stem physiopathology, Cerebrum pathology, Cerebrum physiopathology, Diagnosis, Differential, Disease Progression, Dysarthria etiology, Dysarthria physiopathology, Female, Humans, Magnetic Resonance Imaging, Methylprednisolone therapeutic use, Middle Aged, Multiple Sclerosis complications, Multiple Sclerosis physiopathology, Ocular Motility Disorders etiology, Ocular Motility Disorders physiopathology, Paresis etiology, Paresis physiopathology, Spinal Cord pathology, Spinal Cord physiopathology, Treatment Outcome, Brain Stem pathology, Diffuse Cerebral Sclerosis of Schilder diagnosis, Multiple Sclerosis diagnosis
Published
2008
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